Claims
- 1. A compound of the formula: ##STR118## wherein A is chloro, bromo or iodo;
- R.sub.1 is alkyl of 1 to 6 carbon atoms, unsubstituted or substituted with hydroxy, amino, alkanoylamido of 1 to 6 carbon atoms, benzyloxycarbonylamido or p-nitrobenzyloxycarbonylamido; phenyl; or phenyl substituted by one or more members selected from the group consisting of halo, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, amino, alkanoylamido of 1 to 6 carbon atoms, benzyloxycarbonylamido or p-nitrobenzyloxycarbonylamido;
- R is alkyl of 1 to 6 carbon atoms, benzyl, p-nitrobenzyl, p-methoxybenzyl, phenacyl, p-bromophenacyl, 2,2,2-trichloroethyl, phthalidyl, phthalimidomethyl, .alpha.-ethoxycarbonyloxyethyl or alkanoyloxymethyl of 1 to 6 carbon atoms, and
- G is hydrogen, alkyl or alkenyl, said alkyl and alkenyl being unsubstituted or substituted with hydroxy, oxy, methoxycarbonyl, phenyl or phenyl substituted with alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, nitro or halo.
- 2. A compound according to claim 1 wherein G is prop-2-en-1yl, 3-methylbut-2-en-1-yl or pent-2-en-1-yl.
- 3. A compound according to claim 1 wherein G is 4-oxopent-2-en-1-yl or 3-methoxy-carbonylprop-2-enyl.
- 4. A compound according to claim 1 wherein R.sub.1 is alkanoylamido of 1 to 6 carbon atoms, benzyloxycarbonylamido or p-nitrobenzyloxycarbonylamido.
- 5. A compound according to claim 1 wherein R.sub.1 is 2-acetylamidoethyl, phenyl, p-acetamidophenyl, ethyl, propyl, butyl or tertiary alkyl.
- 6. A compound according to claim 1 wherein G is hydrogen.
- 7. A compound according to claim 1 wherein R is alkyl of 1 to 6 carbon atoms, benzyl, p-nitrobenzyl, p-methoxybenzyl, phenacyl, p-bromophenacyl, 2,2,2-trichloroethyl, pthalidyl, pthalimidomethyl, .alpha.-ethoxycarbonyloxyethyl, pivaloyloxymethyl or acetoxymethyl.
- 8. A compound according to claim 1 wherein A is chloro.
- 9. The compound according to claim 1 which is benzyl 3-chloro-7-oxo-3-phenylsulphinyl-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 10. The compound according to claim 1 which is benzyl 3-chloro-3-ethylsulphinyl-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 11. The compound according to claim 1 which is p-nitrobenzyl 3-chloro-3-ethylsulphinyl-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 12. The compound according to claim 1 which is benzyl 3-(2-acetamidoethylsulphinyl)-3-chloro-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 13. The compound according to claim 1 which is benzyl 3-p-acetamidophenylsulphinyl-3-chloro-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 14. The compound according to claim 1 which is benzyl 3-chloro-6-(3-methoxycarbonylprop-2-ene-1-yl)-7-oxo-3-phenylsulphinyl-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 15. The compound according to claim 1 which is p-bromophenacyl 3-chloro-3-ethylsulphinyl-6-(3-methoxycarbonylprop-2-en-1-yl)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 16. The compound according to claim 1 which is phthalidyl 3-chloro-3-ethylsulphinyl-6-(3-methoxycarbonylprop-2-en-1-yl)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 17. The compound according to claim 1 which is benzyl 6-benzyl-3-chloro-3-ethylsulphinyl-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 18. The compound according to claim 1 which is benzyl 3-chloro-trans-6-(1-hydroxyethyl)-7-oxo-3-phenylsulphinyl-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 19. The compound according to claim 1 which is benzyl 3-chloro-3-ethylsulphinyl-6-(2-hydroxy-2-propyl)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
47201/77 |
Dec 1977 |
GBX |
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Parent Case Info
This is a division of Ser. No. 955,598 filed Oct. 30, 1978, now U.S. Pat. No. 4,223,038.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4011216 |
Menard et al. |
Mar 1977 |
|
4123547 |
Christensen et al. |
Oct 1978 |
|
4150145 |
Christensen et al. |
Apr 1979 |
|
4203902 |
Shih |
May 1980 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
955598 |
Oct 1978 |
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