Claims
- 1. A process for producing an antibiotic of the formula ##STR3## wherein either R and R.sup.1 are each hydrogen; R is hydrogen and R.sup.1 is methyl; or R and R.sup.1 are both methyl;
- wherein said process comprises cultivating the microorganism Actinomadura roseorufa Huang sp. nov. having all of the identifying characteristics of ATCC 39697 or a mutant form thereof having the ability to produce said antibiotic, in aqueous culture media containing an assimilable source of carbon, nitrogen and inorganic salts under submerged aerobic fermentation conditions until a recoverable amount of said antibiotic is obtained.
- 2. The process according to claim 1, which comprises the step of separating said antibiotic from the culture medium.
- 3. The process according to claim 1, which comprises the step of recovering said antibiotic as a mycelial preparation.
- 4. The process according to claim 1, which comprises the step of spray-drying the whole culture medium to recover said antibiotic.
- 5. A biologically pure culture of a strain of the genus Actinomadura having the identifying characteristics of ATCC 39697, or a mutant form thereof, said microorganism being capable of producing an antibiotic compound of the formula ##STR4## wherein either R and R.sup.1 are each hydrogen, R is hydrogen and R.sup.1 is methyl or R and R.sup.1 are both methyl, in recoverable quantity upon cultivation in an aqueous nutrient culture medium containing assimilable sources of carbon, nitrogen and inorganic salts.
- 6. The process according to claim 1, which comprises the step of forming a pharmaceutically acceptable cationic salt of said antibiotic by reaction with a base.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8417785 |
Jul 1984 |
GBX |
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a division of application Ser. No. 07/153,187, filed Feb. 8, 1988, now U.S. Pat. No. 4,992,423, which is a division of application Ser. No. 06/747,613, filed June 21, 1985, now U.S. Pat. No. 4,746,650, issued May 24, 1988.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4278663 |
Liu et al. |
Jul 1981 |
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4565862 |
Foley et al. |
Jan 1986 |
|
Non-Patent Literature Citations (1)
Entry |
Bergey's Manual of Systematic Bacteriology, vol. 2, p. 1459. |
Divisions (2)
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Number |
Date |
Country |
Parent |
153187 |
Feb 1988 |
|
Parent |
747613 |
Jun 1985 |
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