Claims
- 1. Microspheres having a diameter from 200 A to 10.mu. consisting essentially of polylutaraldehyde having a repeating conjugated aldehyde containing structural unit of the formula: ##STR4##
- 2. Micropheres according to claim 1 in which the diameter is from 500 A to 1.5.mu..
- 3. Microspheres according to claim 1 containing 0.5 to 40% of metal containing particles having a diameter below 1000 A.
- 4. Micropheres according to claim 3 in which the metal particles have a diameter from 25 A to 500 A and represent in an amount from 1% to 10% by weight.
- 5. Microspheres according to claim 3 in which the metal has an atomic number above 50.
- 6. Microspheres according to claim 5 in which the particles are magnetically attractable.
- 7. Microspheres according to claim 6 in which the particles comprise Fe.sub.3 O.sub.4.
- 8. Microspheres according to claim 1 in which the fluorogen groups are the reaction products of acrolein groups and a compound that forms a fluorogen on reaction with said groups.
- 9. Microspheres according to claim 1 containing fluorogen groups.
- 10. Microspheres according to claim 9 in which the fluorogen is the reaction product of aldehyde groups with an aldehyde reactive fluorochrome.
- 11. Microspheres according to claim 10 in which the fluorochrome is selected from aminofluorescein, 9-amino acridine, propidium bromide, or fluorescein isothiocyanate.
- 12. Microspheres according to claim 9 bound to protein.
- 13. Microspheres according to claim 12 in which the protein is selected from antibodies, antigens, immunoglobulins, lymphocytes or hemoglobin.
- 14. Microspheres according to claim 13 in which the protein is an antibody.
- 15. Microspheres according to claim 14 further comprising the fluorescent condensation product of polyglutaraldehyde and a non-fluorescent reagent.
- 16. Microspheres according to claim 15 in which the reagent is selected from anthrone, m-aminophenol and aminofluorescein.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of Ser. No. 887,825 filed Mar. 17, 1978 now abandoned.
ORIGIN OF THE INVENTION
The invention described herein was made in the course of work under a grant from the Department of Health, Education and Welfare.
US Referenced Citations (7)
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
887825 |
Mar 1978 |
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