The invention relates to a polymer layer system pressure sensor device and to a polymer layer system pressure sensor method.
Although it can also be applied to any desired micromechanical components, the present invention and the problems it addresses are explained on the basis of integrated microfluidic components.
Integrated microfluidic components, for example lab-on-a-chip systems in medical technology, often consist of a polymeric layer structure with enclosed microfluidic structures, such as for example channels and chambers.
Microfluidic components based on polymeric layer systems are versatile in their use on account of the flexible machining and connecting technologies and are a very good platform for realizing disposable components thanks to low costs. To increase the control over processes in complex microfluidic systems, basic information on the physical state of the fluids in such systems is indispensable. Apart from the temperature, the pressures in microfluidic cavities or channels is of importance in particular, in order to be able to set exact flow rates, to be able to detect the blockage of a channel and to monitor the function of valves or pumps.
DE 10 2009 000 529 A1 describes a system for measuring pressure with a measuring channel that is open at one end, a connection with the liquid existing at the open end and a gas being enclosed at the closed end. When there is an increase in the pressure, gas is compressed and the gas-liquid boundary surface is displaced. By observing the meniscus, the change in volume can be determined and, if the initial pressure is known, the current pressure can be determined by applying the Boyle-Mariotte law. For detecting the position of the meniscus, a method which assesses the properties of a light beam that has crossed through the region of the likely position of the meniscus with the aid of deflecting mirrors is proposed.
In Sensor Actuat. A—Frisch 118 (205), pages 212 to 221, a silicon-based pressure sensor is presented. In it, the increase in the pressure deflects a silicon membrane, the deflection being determined by way of the reflection of a light beam.
Micromachined Channel/Pressure Sensor Systems for Microflow Studies, J. Liu et al., 7th International Conference on Solid-State Sensors and Actuators (Transducers '93) describes a silicon-based microfluidic channel with connected piezoresistive pressure sensors.
DE 10 2008 002 336 A1 discloses a pinch valve and a method for producing it, the pinch valve being used in microfluidic systems.
The invention provides a polymer layer system pressure sensor device according to claim 1 and a polymer layer system pressure sensor method according to claim 11.
Preferred developments are the subject of the respective subclaims.
The present invention is essentially based on a layer structure consisting of a polymer substrate with a microfluidic cavity, which is covered in one region by a flexible polymer membrane, the rear side having been metallized. At a distance above that there is a further metallization layer, which is connected to a polymer membrane lying above it and to a polymer substrate on top. Between the two metal layers there is a further cavity, which is connected by a channel that is led to the outside to a reference pressure and is filled with a fluid, preferably a gas. In the simplest case, the channel that is led to the outside is connected to the ambient atmosphere. A pressure difference between the microfluidic cavity in the lower polymer substrate and the cavity between the metal layers leads to a deformation of the metallized lower polymer membrane, which can be detected capacitively with the aid of the upper metal layer or, in the case of contact between the two metal layers, can be detected resistively. The metal layers are preferably brought into electrical contact by laterally led-out conductor tracks.
In the case of the device according to the invention, the electrical evaluation means that there is no need for a complex external apparatus to determine the pressure, for example an optical readout. As a result, costs and the overall size of an external controlling and reading-out unit can be significantly reduced.
The invention is specifically designed for a polymeric layer structure that is versatile in its use for microfluidic systems. The invention makes it possible for the pressure to be measured directly in situ. This avoids a falsification of the measuring signal being caused by the fluidic resistance/fluidic capacitance of an otherwise necessary connecting channel or connecting tube to the pressure sensor.
The invention can be coupled with additional functional elements. Thus, for example, the metallized lower polymer membrane can at the same time be used as a valve or active element of a diaphragm pump, and consequently monitor the valve or pump function directly.
Further features and advantages of the present invention are explained below on the basis of embodiments with reference to the figures, in which:
a)-c) show schematic views for the explanation of a polymer layer pressure sensor device according to a first embodiment of the present invention, specifically
a),b) show schematic views for the explanation of a polymer layer pressure sensor device according to a second embodiment of the present invention, specifically
In the figures, the same reference signs denote elements that are the same or functionally the same.
a)-c) are schematic views for the explanation of a polymer layer pressure sensor device according to a first embodiment of the present invention, specifically
In
Provided on the first polymer membrane 4, above and outside the first cavity 8, is a first membrane metallization layer 6, which together with the first polymer membrane 4 can be deflected in dependence on the pressure PM in the first cavity 8.
Arranged over the first polymer membrane 4 is a second polymer substrate 3 with a second cavity 9, the second cavity 9 being arranged over the first cavity 8 and a second polymer membrane 2 being stretched over the second cavity 9. Attached on the second polymer membrane 2, within the second cavity 9, is a second membrane metallization layer 7.
Finally, a third polymer substrate 1 is arranged on the second polymer membrane 2 and forms as it were an upper cover of the pressure sensor device.
As can be seen from
The first cavity 8 is connected to a first and a second pressure channel 19, 20, which run in the first polymer substrate 5.
The second cavity 9 is connected to a third pressure channel 10, which runs in the second polymer substrate 3 and is usually connected to a reference pressure PR, in the simplest case atmospheric pressure.
In the state according to
In this case it may be expedient to use a metal or some other material, for example a conductive polymer, a conductive paste or carbon nanotubes (CNTs), for example with a high resistivity, in order to lower the requirements for the evaluation electronics. In the exemplary embodiment as shown in
The necessary structures in the polymer substrates 1, 3, 5 may be produced for example by milling, injection molding or hot stamping. The joining of the polymer layer structure may be performed for example by means of laser transmission welding, ultrasonic welding or adhesive bonding techniques. The metallization may be performed for example by sputtering, inkjet printing or laser-based metallization technologies.
Suitable for example as the polymer substrate are thermoplastics, for example PC, PP, PE, PMMA, COP, COC, etc. Suitable as the elastic membrane are an elastomer, a thermoelastic elastomer, thermoplastics, etc. The metallization of the membrane metallization layers 6, 7 may be performed by metals, such as for example gold, copper, aluminum, etc. However, according to requirements, other materials, such as for example conductive polymer or CNTs, may also be used to increase the resistivity.
Dimensions given by way of example for the exemplary embodiment according to
In a variant of the evaluation, the only information used is that the two membrane metallization layers 6, 7 come into contact, that is to say a certain minimum pressure is exceeded. The exemplary embodiment may in this case function for example as a pressure switch, in order to establish that a fluid has reached a certain position in the microfluidic system. An advantage of this is that the requirements for the accuracy of the productions are relaxed, and for example the diameter of the cavities 8, 9 does not have to be set very accurately.
a),b) are schematic views for the explanation of a polymer layer pressure sensor device according to a second embodiment of the present invention, specifically
In the case of the second embodiment according to
As can be seen from
In the case of the third embodiment according to
The exemplary embodiment according to
In the case of this embodiment, the first polymer substrate 5a has two part-cavities 8a, 8b, which are separated by a web 16a, over which the first polymer membrane 4 with the first membrane metallization layer 6 is stretched. This structure allows the function of the pinch valve to be monitored by an electrical evaluation in real time and thus malfunctions, such as for example a blockage, to be detected at an early time. The pressure channel 10 may in this case be used for example for controlling the pinch valve by way of an external pressure PR.
In an analogous way, the displacement channel of a diaphragm pump may also be equipped on the basis of the shown principle according to the invention. In addition to the pure functional control, in this case the pumping rate can also be monitored and determined in real time from the deflection of the first polymer membrane.
Although the present invention has been described on the basis of preferred exemplary embodiments, it is not restricted to them. In particular, the materials and topologies mentioned are only given by way of example and are not restricted to the examples explained.
Number | Date | Country | Kind |
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10 2011 081 887.1 | Aug 2011 | DE | national |
Filing Document | Filing Date | Country | Kind | 371c Date |
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PCT/EP2012/062874 | 7/3/2012 | WO | 00 | 5/30/2014 |