Claims
- 1. A microcapsule for injectable sustained release which contains an effective amount of ingredient and a biodegradable high molecular polymer useful as an excipient in producing a pharmaceutical preparation comprising a copolymer or homopolymer of about 50-100 mole percent of lactic acid and about 50-0 mole percent of glycolic acid having a weight average molecular weight of about 2,000 to 50,000 and wherein the content of water-soluble low molecular compounds, as calculated on the assumption that each of said compounds is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer.
- 2. The microcapsule according to claim 1, wherein the ingredient is a water-soluble peptide.
- 3. The microcapsule according to claim 2, wherein the water-soluble peptide has luteinizing hormone releasing hormone-like activity or thyroid hormone releasing hormone-like activity.
- 4. The microcapsule according to claim 3, wherein the peptide having the luteinizing hormone releasing hormone-like activity has the formula:
- (Pyr)Glu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHCH.sub.2 CH.sub.3.
- 5. The microcapsule according to claim 1, wherein the biodegradable high molecular polymer has an inherent viscosity of about 0.05-0.5 dl/g as determined with a 0.5 weight percent chloroform solution thereof and a weight average molecular weight of about 5,000-35,000.
Priority Claims (1)
Number |
Date |
Country |
Kind |
60-97617 |
May 1985 |
JPX |
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Parent Case Info
This application is a divisional of Ser. No. 858,040, filed 5/1/86, now U.S. Pat. No. 4,728,721, filed 3/1/88.
US Referenced Citations (10)
Foreign Referenced Citations (6)
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Country |
0052510 |
May 1982 |
EPX |
0107591 |
Feb 1984 |
EPX |
2126270 |
Jun 1972 |
FRX |
2551072 |
Mar 1985 |
FRX |
1351409 |
May 1974 |
GBX |
2145422 |
Mar 1985 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Colin G. Pitt, et al, "Sustanined Drug Delivery Systems", I. The Permeablity of Poly(eta-Caprolactone), Poly (DL-Lactic Acid), and Their Copolymers, Journal of Biomedical Materials Research, vol. 13, pp. 498-507 (1979). |
Divisions (1)
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Number |
Date |
Country |
Parent |
858040 |
May 1986 |
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