The technology described herein relates generally to devices, compositions, and methods for use in apportioning doses of solid products containing active ingredients.
Multi-cell molded plastic trays are useful in providing for discrete portioned amounts of a product. For example, ice trays are useful in creating ice cubes, and molded trays have found use in preparation of baked goods. Such items have not been found to be of use in the medicinal or herbal industries, which often require more concentrate and/or smaller portions.
Dosing of portions in medicine, including herbal medicine, requires, in many cases, that the product be liquid to allow for control of active ingredients. However, not all active ingredients are able to be dissolved or maintained in liquid form. In addition, liquid medicines or remedies are not always preferred as it may be more difficult to apportion small doses in liquid form. This may be especially true where the medicine or remedy may be administered in volatilized or vaporized form.
Applicants describe herein devices, systems, and methods that meet the present needs.
Disclosed herein are devices, compositions, and methods for use in maintaining the viability of therapeutic mammalian cells at low temperatures, the disclosed devices are also useful in reducing manipulation of cells prior to administration to a patient in need thereof. The disclosed compositions, devices, and methods maintain the cells' viability to help reduce loss of therapeutic effect.
In several embodiments, a polymeric container for apportioning an active ingredient is disclosed. The container may include a cavity defined by a cavity floor and a plurality of cavity walls. Two or more cells may be positioned within the cavity. The cells may include a cell floor and at least one cell divider extending from the cell floor to a cell divider top. Each cell of the two or more cells may define a volume defined by a cross-sectional area of the respective cell and the distance from the cell floor to the cell divider top of the respective cell.
In several embodiments, a method of apportioning a liquid is disclosed. The method includes adding a volume of a liquid to a polymeric container having a cavity defined by a container floor and a plurality of container walls, and two or more cells positioned within the cavity, the cells comprising a cell floor and at least one cell divider extending from the cell floor to a cell divider top, wherein each cell defines a volume defined by a cross-sectional area of the respective cell and the distance from the cell floor to the cell divider top of the respective cell, wherein the volume of the liquid is greater than the sum of the volumes defined by the two or more cells; allowing the liquid to form a planar surface generally positioned further from the cell floor than the level of the cell wall divider; treating the liquid in the container to aid in transitioning the liquid to a solid; and allowing the liquid to form a solid at room temperature.
In several embodiments, a container for apportioning equivalent doses of an active ingredient is disclosed. The container may include a plurality of primary cells, the primary cells defined by a primary cell wall and a primary cell floor, wherein each primary cell defines a first shape and an equivalent first volume, and adjacent primary cells are separated by a primary cell divider. The container may include a plurality of secondary cells, the secondary cells defined by a secondary cell wall and a secondary cell floor, wherein each secondary cell defines a second shape and an equivalent second volume, and adjacent secondary cells are separated by a secondary cell divider. The plurality of primary cells may be positioned within the plurality of secondary cells and the secondary cell divider may have a height greater than the primary cell divider.
Additional objects and advantages of the invention will be set forth, in part, in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention. The objects and advantages of the invention will be realized and attained by means of the elements and combinations, particularly pointed out in the appended claims.
The disclosed containers are useful in the dosing, storage, and transportation of dried extracts, for example shatter, resin, or wax. In most embodiments, liquid extract may be dispensed into the described containers and dried in place. After drying, the extract becomes brittle. The brittle solid product may have a generally flat first surface and a second, opposite surface that reflects the cavity structures of a plurality of cells formed in the bottom or cavity floor of the container. This creates a plurality of solid product in the shape of the cell's negative space. This scoring results in the ability to separate the shatter into multiple, uniform individual doses. While the doses may have different shapes, for example where the cells are not uniform, they will generally comprise substantially the same amount of active ingredient. The resulting similarity in amount of active ingredients permits the user to select the number of shatter doses and amount of active ingredient without having to weigh variously sized random fragments to determine the amount of active ingredient desired.
Molded polymeric containers having a plurality of individual cells or compartments are described. The shapes of the container and of individual cells within each container may vary, but each individual cell from a given container may describe a volume within and above the cell that is substantially equivalent to the other cells of the container.
Shatter is a term used to describe concentrated, dried extract. In most cases, the extract is herbal and derived from a botanical source including plants, leaves, flowers, etc. In some cases, shatter may refer to a cannabinoid-containing concentrate. The texture and form of the concentrate results in its breakage, or shattering, like glass.
Shatter may be manufactured by first extracting the botanical source. In some cases, the botanical source may first be dried, and then subjected to extraction with various solvents—for example butane, chloroform, dichloromethane, petroleum ether, naphtha, benzene, methanol, ethanol, isopropanol, etc. This results in an oil that is then vacuum dried to remove the solvent and other volatile compounds. Shatter is usually translucent and may have a generally amber color.
Shatter, resin, and wax are generally purchased and/or dispensed by weighing randomly shaped pieces or shards, until the desired amount is obtained. Thus, an individual user, wishing to consume a fraction of the dispensed amount, must reweigh fragments of the original purchase until the desired amount is achieved. Alternatively, if the user does not have access to a meter, the user must estimate the amount desired by selecting among the random pieces or shards.
As provided in more detail herein, a container 100 may have a plurality of cells 130 that define either generally uniform volumes or a plurality of identifiable volumes. The disclosed container 100, having a plurality of cells 130 defining a plurality of identifiable volumes (e.g., either generally uniform or variable), addresses the difficulty faced by users of shatter, wax, and resin, by creating easily separable, doses having generally identifiable amounts of an active ingredient in the product, whether equivalent or variable. In some embodiments, the container 100 may comprise between 5 and 100 cells 130. In many embodiments, the container 100 may comprise between about 10 and 30 cells 130. The cells 130 may be randomly shaped, or uniformly shaped. In various embodiments, the cell shape may have between three and 10 sides. In many embodiments, the shape of the cells is selected from triangular, square, hexagonal, and octagonal.
The container 100 may be of various shapes, having an exterior or outer surface 112. The outer surface 112 may extend from a base or bottom edge 116a to an upper or top edge 116b. In most embodiments, the underside of the container 100 may define a bottom surface 111 (See
As shown in
The cavity floor 124 may define a plurality of structures, cell dividers 136, extending upward from the cavity floor 124 toward the top surface 114. In many embodiments, such as that shown in
Individual cells may be various shapes and sizes. The cells of
Most cell dividers 136 of the disclosed container 100 define a first generally planar surface perpendicular to the cavity floor 124, and a second planar surface that is also generally perpendicular to the cell floor 134. In some embodiments, the first and second planar surfaces may be angled such that they intersect at or near a divider top or apex 138, which is positioned away from the cavity floor 124. In some embodiments, as seen in
The cell divider 136 may be positioned at or near the cavity wall 122, the structure may be referred to as an edge divider or shoulder 138. The edge divider 138 may define a shape that is similar to that of other cell dividers 136, but comprises only one generally planar surface perpendicular to the cavity floor 124. In most embodiments, the edge divider 138 may define a shape that is roughly half that of a cell divider 136. In this way, even the edge cells can have a similar shape and dose content to interior cells.
In accordance with one embodiment, as illustrated in
While in some embodiments, the entire cavity may be utilized for contents, in some embodiments, one or more of the primary cells or the secondary cells may be occupied by a marking surface 225, 625, as shown in
Referring now in more detail to
As shown in
In some embodiments, the cells may have a shape that is compatible with or conforms to the shape of the cavity such that uniform cells fill the cavity space. For example, as shown in
In some embodiments, a top surface of a container of the present disclosure may define a plurality of cavities. For example,
As shown, each cavity 720 may include a plurality of cells 730 that define a plurality of identifiable volumes (e.g., either generally uniform or variable). In the depicted embodiment, each cavity 720 includes 6 cells 730; however, more or less cells are contemplated. As shown, the container 700 includes 30 cells 730 total. Each cavity 720 is evenly divided, such that the cells 730 are uniformly shaped. The cells 730 are divided by cell dividers 736 extending upward from the cavity floor 724 part of the way up the cavity walls 722 toward the top surface 714. In many embodiments, such as that shown in
In many embodiments, the container may be configured to hold a substance having a volume (VS) that is greater than the sum of all individual cells (c1, c2, c3, c4 . . . cn) of the container (VC1-Cn). In many embodiments, the substance may be dried to create a solid, such as a waxy or crystalline substance, and the dried substance may also have a volume, VSd that is greater than VC1-Cn. In those embodiments, wherein the cells define a total collective volume that is less than that of the substance within the container, the excess volume may form a uniform layer above the level of the divider apex. As used herein, an equivalent volume may reflect a difference of less than 10% between two different volumes, for example less than 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, or 2%, and greater than about 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, and 9%.
In several embodiments, the container may be configured to hold two, three, or more different volumes. For example, primary cells 230, 730 may each define a first volume, secondary cells 240, 720 may each define a second volume, and optionally, tertiary cells 220 may each define a third volume. In some embodiments, the third volume is greater than the second volume, and the second volume is greater than the first volume. In the example shown in
Each container includes an arrangement of cells having approximately equivalent volumes. The cells are configured to define equivalent volumes, such that active ingredients, in liquid form, can be dispensed into the container, and, when solidified, an equivalent amount of active ingredient can be removed from each volume. In most embodiments, the dividers are intended to create a scoring or etching pattern in the solidified product, such that even if the volume of solid product is significantly greater than total volume of all cells, the user may break off individual, cell-shaped portions along the scoring lines. In embodiments lacking edge dividers, the cells located adjacent the cavity wall may be larger, or those cells may, alternatively, define doses with slightly less active ingredient. In accordance with some embodiments, the top of the cell wall or a portion thereof can extend high enough so that it is proud of the planer surface of the shatter. This enables a perforation to form in the shatter.
The polymer may be various materials. In some embodiments, the polymer comprises a polymeric siloxane, for example polysiloxane comprising a plurality of repeating units of siloxane. In most embodiments, the polymer is a silicone, for example a medical or food grade silicone known to those of skill in the art. The polymer may be cured or cross-linked to aid in solidifying the polymer. Thus, in many embodiments, the polymer may further include one or more cross-linking moieties connecting the polymer chains of, for example, siloxane.
Turning then to the embodiment shown in
In one example, as shown in
In another example, as shown in
The surface area to volume (SA/V) ratios depicted in the above examples are illustrative only and other SA/V relationships for the primary, secondary, and/or tertiary cells are contemplated. For example, the secondary cells may each have a surface area to volume ratio that ranges between 15-45, 20-40, 30-37, is about 20, is about 36, and the like.
Disclosed herein is a method of apportioning a product. In most embodiments, the product may be added to the container in liquid form and may solidify within the container. In some embodiments, the product may be liquid at high temperature and may solidify at ambient temperatures. In some embodiments, the product may solidify when a volatile solvent is removed. In some embodiments, removal of a volatile solvent may be removed by methods including increasing the temperature of the product and lowering the ambient pressure. In some embodiments, the product may be subjected to partial or complete lyophilization.
The disclosed methods are useful in creating a separable solid pharmaceutical, herbal, or nutraceutical product having individual portions that comprise similar amounts of an active ingredient. In some embodiments, the active ingredient may be an essential oil, terpene, terpenoid, cannabinoid (e.g., cannabinol), or the like. In some embodiments, the active ingredient may possess medicinal or homeopathic properties. In many embodiments, the active ingredient may be vaporized, volatilized, or atomized prior to administration.
The disclosed methods may include adding a liquid product containing an active ingredient to the container. The volume of liquid product added to the container is generally greater than the sum of the volumes of all cells 130, 230, 330, 430, 530, 630, 730 within the container 100, 200, 300, 400, 500, 600, 700. In most embodiments, the liquid product may form a sufficiently planar liquid surface within the container. In most embodiments, the planar liquid surface is at a distance from the floor 124, 224, 324, 424, 524, 624, 724 of the container 100, 200, 300, 400, 500, 600, 700 that is greater than the distance from the floor 124, 224, 324, 424, 524, 624, 724 to the cell divider top 138, 238, 338, 438, 538, 638, 738.
The disclosed methods may include allowing the liquid product to solidify within the container. In some embodiments, as the liquid product solidifies, the volume of the liquid product is reduced. In other embodiments, the volume of the liquid product in the container is not substantially reduced. In those embodiments, wherein the volume of the liquid product is greater than the volume of the solidified product, the solid product may define a planar surface at a distance from the container floor 124, 224, 324, 424, 524, 624, 724 that is less than that of the distance of the liquid planar surface from the container floor 124, 224, 324, 424, 524, 624, 724. In most of these embodiments, the distance from the container floor 124, 224, 324, 424, 524, 624, 724 to the solid planar surface is greater than that of the container floor 124, 324, 424, 524, 624, 724 to the top of the cell divider 138, 238, 338, 438, 538, 638, 738.
While multiple embodiments are disclosed, still other embodiments of the present invention will become apparent to those skilled in the art from the following detailed description. As will be apparent, the invention is capable of modifications in various obvious aspects, all without departing from the spirit and scope of the present invention. Accordingly, the detailed description is to be regarded as illustrative in nature and not restrictive.
All references disclosed herein, whether patent or non-patent, are hereby incorporated by reference as if each was included at its citation, in its entirety. In case of conflict between reference and specification, the present specification, including definitions, will control.
Although the present disclosure has been described with a certain degree of particularity, it is understood the disclosure has been made by way of example, and changes in detail or structure may be made without departing from the spirit of the disclosure as defined in the appended claims.
This application claims the benefit of U.S. Provisional Application No. 62/726,031, filed 31 Aug. 2018, and entitled “Polymeric container for dosing of solid products containing active ingredients,” the entirety of which is incorporated herein by reference for all purposes.
Number | Date | Country | |
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62726031 | Aug 2018 | US |