Claims
- 1. A composition, comprising:
- a drug-polymer salt comprising a therapeutically effective amount of a nitrogen-containing drug, and comprising at least the following constituents:
- (a) a drug a having basic nitrogen group as part of its chemical structure, said basic group being capable of forming a salt with an acid; and,
- at least one hydrophilic polymer containing pendant carboxyl-amidine-carboxyl triads.
- 2. The composition of claim 1 wherein at least one of said hydrophilic polymers is a hydrolyzed polyacrylonitrile containing said triads.
- 3. The composition of claim 1 wherein said nitrogen containing drug is a drug selected from the group consisting of an anesthetic, antibiotic, antihistamine and cytostatic.
- 4. The composition of claim 1 wherein said composition is an emulsion containing additional dispersed water-insoluble components.
- 5. The composition of claim 4 wherein said emulsion is an ophthalmic formulation.
- 6. The composition of claim 4 wherein said drug is pilocarpine.
- 7. The composition of claim 1 wherein said composition is a viscous aqueous solution containing greater than 95% water.
- 8. The composition of claim 7 wherein said viscous aqueous solution is an ophthalmic formulation.
- 9. The composition of claim 8 wherein said drug is pilocarpine.
- 10. The composition of claim 1 wherein said composition is a spreadable aqueous gel containing greater than 95% water.
- 11. The composition of claim 10 wherein said spreadable aqueous gel is an ophthalmic solution.
- 12. The composition of claim 11 wherein said drug is pilocarpine.
REFERENCE TO RELATED APPLICATIONS
This application is a continuation of application Ser. No. 08/201,357 filed Feb. 24, 1994, now abandoned, which is a continuation-in-part of U.S. patent application Ser. No. 07/864,050 filed on Apr. 6, 1992 and now abandoned, entitled "Novel Drug Forms with Controlled Release Capabilities" by the inventors herewith.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4221778 |
Raghunathan |
Sep 1980 |
|
4943618 |
Stoy et al. |
Jul 1990 |
|
4997643 |
Partrain, III et al. |
Mar 1991 |
|
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts 111:12365, "New Type of Hydrogel for Controlled Drug Delivery", Vladimir A. Stoy, 1989. |
Continuations (1)
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Number |
Date |
Country |
Parent |
201357 |
Feb 1994 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
864050 |
Apr 1992 |
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