Claims
- 1. An array of oligonucleotide probes for detecting a previously identified polymorphism in a target nucleic acid sequence, said array comprising at least one detection block of probes selected for detection of the previously identified polymorphism said detection block including first and second groups of probes that are complementary to said target nucleic acid sequence having first and second variants of said polymorphism, respectively, and further comprising third and fourth groups of probes, said third and fourth groups of probes having a sequence identical to said first and second groups of probes, respectively, except that said third and fourth groups of probes include all possible monosubstitutions of positions in said sequence that are within n bases of a base in said sequence that is complementary to said polymorphism, wherein n is from 1 to 5.
- 2. The array of claim 1, wherein n is 2.
- 3. The array of claim 1, wherein said first and second groups of probes comprise a plurality of different probes that are complementary to overlapping portions of said target nucleic acid sequence including the previously determined polymorphism.
- 4. The array of claim 1, wherein said monosubstitutions in said first and second groups of probes occur at a plurality of distances from a 3′ end of said probes.
- 5. The array of claim 1, wherein said detection block includes between about 8 and 88 probes.
- 6. The array of claim 1, comprising between 1 and 1,000 different detection blocks, each of said detection blocks including probes complementary to first and second variants of a different polymorphism in said target nucleic acid sequence.
RELATED APPLICATIONS
[0001] This application is a continuation of U.S. patent application Ser. No. 09/015,263, filed Jan. 29, 1998, which is a divisional of U.S. patent application Ser. No. 08/563,762, now U.S. Pat. No. 5,858,659, filed Nov. 29, 1995, the entire teachings of which are incorporated herein by reference.
[0002] This application is also a continuation-in-part of U.S. patent application Ser. No. 08/441,887, now U.S. Pat. No. 5,837,832, filed May 16, 1995, which is a continuation of U.S. patent application Ser. No. 08/143,312, filed Oct. 26, 1993, now abandoned, which is a continuation-in-part of U.S. patent application Ser. No. 08/82,937, filed Jun. 25, 1993, now abandoned.
[0003] This application is also a continuation-in-part of U.S. patent application Ser. No. 08/529,115, now U.S. Pat. No. 6,040,138, filed Sep. 15, 1995.
[0004] This application is also a continuation-in-part of U.S. patent application Ser. No. 08/544,381, now U.S. Pat. No. 6,027,880, filed Oct. 10, 1995, which is a continuation-in-part of U.S. patent application Ser. No. 08/510,521, filed Aug. 2, 1995, which is a continuation-in-part of application No. PCT/U.S. 94/12305, filed Oct. 26, 1994, which is a continuation-in-part of U.S. patent application Ser. No. 08/284,064, filed Aug. 2, 1994, now abandoned, which is a continuation-in-part of U.S. patent application Ser. No. 08/143,312, filed Oct. 26, 1993, now abandoned.
Divisions (2)
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Number |
Date |
Country |
Parent |
08563762 |
Nov 1995 |
US |
Child |
09015263 |
Jan 1998 |
US |
Parent |
08441887 |
May 1995 |
US |
Child |
09015263 |
Jan 1998 |
US |
Continuations (2)
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Number |
Date |
Country |
Parent |
09015263 |
Jan 1998 |
US |
Child |
10113885 |
Mar 2002 |
US |
Parent |
08143312 |
Oct 1993 |
US |
Child |
08441887 |
May 1995 |
US |
Continuation in Parts (6)
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Number |
Date |
Country |
Parent |
08082937 |
Jun 1993 |
US |
Child |
08143312 |
Oct 1993 |
US |
Parent |
08544381 |
Oct 1995 |
US |
Child |
09015263 |
|
US |
Parent |
08510521 |
Aug 1995 |
US |
Child |
08544381 |
Oct 1995 |
US |
Parent |
PCT/US94/12305 |
Oct 1994 |
US |
Child |
08510521 |
Aug 1995 |
US |
Parent |
08284064 |
Aug 1994 |
US |
Child |
PCT/US94/12305 |
Oct 1994 |
US |
Parent |
08143312 |
Oct 1993 |
US |
Child |
08284064 |
Aug 1994 |
US |