Claims
- 1. A micelle of a polyethylene oxide derivative in an aqueous solvent, said derivative being represented by the following formula (I): ##STR54## wherein A denotes a sugar residue represented by the following formula ##STR55## wherein one R denotes a covalent bond with the adjacent methylene group in formula (I); and the other R groups denote hydrogen atom, C.sub.1-5 alkyl, C.sub.1-5 alkylcarbonyl or tri-C.sub.1-5 alkylsilyl wherein the alkyl groups are the same or different or, optionally, two of said R groups in combination, while forming an acetal together with the oxygen atom to which the Rs are bound, denote C.sub.3-5 alkylidene or benzylidene whose methine may be substituted with C.sub.1-3 alkyl; a denotes an integer of 0 or 1, b denotes an integer of 2 or 3, and c denotes an integer of 0 or 1,
- n denotes an integer of 5-10,000,
- L denotes a linkage group represented by the following formula ##STR56## wherein R.sup.1 and R.sup.2 independently denote hydrogen atom, C.sub.1-6 alkyl, aryl or C.sub.1-3 alkylaryl,
- m denotes an integer of 2-10,000,
- X denotes a single bond or --CH.sub.2 CH.sub.2 --, and
- when X is a single bond, Z denotes hydrogen atom, alkali metal, acryloyl, methacryloyl, cinnamoyl, p-toluenesulfonyl, allyl, carboxymethyl, carboxyethyl, ethoxycarbonylmethyl, ethoxycarbonylethyl, 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, vinylbenzyl, di-C.sub.1-5 alkyloxy-C.sub.2-3 alkyl or aldehyde-C.sub.2-3 alkyl.
- 2. The micelle of claim 1 wherein the sugar residue A is derived by removing a hydrogen atom from one of the R positions of a monosaccharide selected from the group consisting of glucose, galactose, mannose, fructose, ribose and xylose.
- 3. The micelle of claim 1 wherein the groups R other than the linkage of the sugar residue to the remainder of formula (I) each denote a hydrogen atom.
- 4. The micelle of claim 1 wherein two R groups other than the linkage of the sugar residue to the remainder of formula (I) form, in combination, one or two linkages selected from the group consisting of isopropylidene, benzylidene, 1-butylidene, 2-butylidene, 3-pentylidene and methyl benzylidene.
- 5. The micelle of claim 1 wherein n denotes an integer of 10-200.
- 6. The micelle of claim 1 wherein X is a single bond and Z denotes a hydrogen atom or potassium.
- 7. The micelle of claim 1 wherein X is a single bond and Z denotes acryloyl, methacryloyl or p-toluene sulfonyl.
- 8. The micelle of claim 1 wherein X is a single bond and Z denotes allyl, carboxymethyl, carboxyethyl, ethoxycarbonylmethyl, ethoxycarbonylethyl, 2-aminoethyl or vinylbenzyl.
- 9. The micelle of claim 5 wherein n is 20-50.
- 10. The micelle of claim 1 wherein R.sup.1 and R.sup.2 are independently hydrogen or C.sub.1-6 alkyl.
- 11. The micelle of claim 10 wherein R.sup.1 and R.sup.2 are independently hydrogen, methyl or isopropyl.
- 12. The micelle of claim 1 wherein m is 5-200.
- 13. The micelle of claim 12 wherein m is 10-100.
- 14. The micelle of claim 1 wherein the sugar residue A is derived by removing a hydrogen atom from one of the R positions of glucose or glactose, the groups R other than the linkage of the sugar residue to the remainder of formula (I) are either a hydrogen atom or form one or two isopropylidene and benzylidene linkages, n denotes an integer of 10-200, m denotes an integer of 5-200, L represents a formula ##STR57## and Z denotes a hydrogen atom, potassium ion, acryloyl, methacryloyl or p-toluene sulfonyl, allyl, carboxymethyl, carboxyethyl, ethoxycarbonylmethyl, ethoxycarbonylethyl or vinylbenzyl.
- 15. A pharmaceutical carrier comprising the micelle of claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
7-89373 |
Apr 1995 |
JPX |
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CROSS REFERENCE TO RELATED APPLICATIONS
The present application is a divisional of application Ser. No. 08/930,855 filed Dec. 8, 1997 and now U.S. Pat. No. 5,973,069.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5037969 |
Minami et al. |
Aug 1991 |
|
5410016 |
Hubbell et al. |
Apr 1995 |
|
Foreign Referenced Citations (7)
Number |
Date |
Country |
0251304 |
Jul 1986 |
EPX |
152393 |
Jul 1986 |
JPX |
279469 |
Oct 1993 |
JPX |
48450 |
Feb 1995 |
JPX |
300521 |
Nov 1995 |
JPX |
316285 |
Dec 1995 |
JPX |
92366 |
Apr 1996 |
JPX |
Divisions (1)
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Number |
Date |
Country |
Parent |
930855 |
Dec 1997 |
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