Claims
- 1. A compound having the formula: ##STR127## wherein A, B, Y and Z are each hydrogen, or the pair (1) A and B and/or the pair (2) Y and Z together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween; n is an integer of 1 to 3; and X is selected from the group consisting of:
- (1) a group of the formula ##STR128## wherein R.sup.22 is a group of the formula ##STR129## wherein R.sup.23 is hydrogen or lower alkyl and m is an integer of from 1 to 5,
- a group of the formula ##STR130## wherein k and l are the same or different and each is an integer of from 1 to 5,
- a group of the formula ##STR131## wherein p is an integer of from 0 to 5 and R.sup.24 and R.sup.25 are each hydrogen or lower alkyl,
- or a group of the formula ##STR132## wherein q and i are each an integer of 1 to 5 and R.sup.26, R.sup.27, R.sup.28 and R.sup.29 are each a lower alkyl, and R.sup.21 is hydrogen, a lower alkyl or a halogen atom,
- (2) a group of the formula ##STR133## wherein K and L are both hydrogen or represent a direct valence bond between the carbon atoms to which they are attached and R.sup.22 has the same meaning as defined above,
- (3) a group of the formula ##STR134## wherein R.sup.22 has the same meaning as defined above, (4) a group of the formula ##STR135## wherein R.sup.22 has the same meaning as defined above, (5) a group of the formula ##STR136## wherein R.sup.22 has the same meaining as defined above, (6) a group of the formula ##STR137## wherein a is zero or an integer of 1 to 5, and R.sup.30 is a lower alkyl, (7) a group of the formula ##STR138## wherein c is zero or an integer of 1 to 5, (8) a group of the formula ##STR139## wherein g is an integer of 1 to 5 and R.sup.39 and R.sup.40 are each hydrogen or a lower alkyl, and
- (9) a group of the formula ##STR140## wherein h is an integer of 1 to 5 and R.sup.41 and R.sup.42 are each hydrogen or a lower alkyl,
- or a pharmaceutically acceptable salt thereof.
- 2. A compound having the formula: ##STR141## wherein A, B, Y and Z are each hydrogen, or the pair (1) A and B and/or the pair (2) Y and Z together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween; n is an integer of 1 to 3; R.sup.21 is hydrogen, a lower alkyl or a halogen; R.sup.23 is hydrogen or lower alkyl and m is an integer from 1 to 5, or a pharmaceutically acceptable salt thereof.
- 3. A compound having the formula: ##STR142## wherein A, B, Y and Z are each hydrogen, or the pair (1) A and B and/or the pair (2) Y and Z together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween; n is an integer of 1 to 3; q and i are each an integer of 1 to 5; R.sup.21 is hydrogen, a lower alkyl or a halogen atom and R.sup.26, R.sup.27, R.sup.28 and R.sup.29 are each a lower alkyl, or a pharmaceutically acceptable salt thereof.
- 4. A compound having the formula: ##STR143## wherein A, B, Y and Z are each a hydrogen, or the pair (1) A and B and/or the pair (2) Y and Z together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween; n is an integer of 1 to 3; q and i are each an integer of 1 to 5; and R.sup.26, R.sup.27, R.sup.28 and R.sup.29 are each a lower alkyl, or a pharmaceutically acceptable salt thereof.
- 5. A compound having the formula: ##STR144## wherein A, B, Y and Z are each hydrogen, or the pair (1) A and B and/or the pair (2) Y and Z together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween; n is an integer of 1 to 3; q and i are each an integer of 1 to 5; and R.sup.26, R.sup.27, R.sup.28 and R.sup.29 are each a lower alkyl, or a pharmaceutically acceptable salt thereof.
- 6. A compound having the formula: ##STR145## wherein A, B, Y and Z are each hydrogen, or the pair (1) A and B and/or the pair (2) Y and Z together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween; n is an integer of 1 to 3; q and i are each an integer of 1 to 5; and R.sup.26, R.sup.27, R.sup.28 and R.sup.29 are each a lower alkyl, or a pharmaceutically acceptable salt thereof.
- 7. A compound having the formula: ##STR146## wherein A, B, Y and Z are each hydrogen, or the pair (1) A and B and/or the pair (2) Y and Z together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween; n is an integer of 1 to 3; p is an integer of from 0-5; R.sup.21 is hydrogen, a lower alkyl or a halogen atom and R.sup.24 and R.sup.25 are each hydrogen or a lower alkyl, or a pharmaceutically acceptable salt thereof.
- 8. A compound having the formula: ##STR147## wherein A, B, Y and Z are each hydrogen, or the pair (1) A and B and/or the pair (2) Y and Z together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween; n is an integer of 1 to 3 and R.sup.22 is a group of the formula ##STR148## wherein R.sup.23 is hydrogen or lower alkyl and m is an integer of from 1 to 5,
- a group of the formula ##STR149## wherein k and l are the same or different and each is an integer of from 1 to 5,
- a group of the formula ##STR150## wherein p is an integer of from 0 to 5 and R.sup.24 and R.sup.25 are each hydrogen or lower alkyl;
- and a group of the formula ##STR151## wherein q and i are each an integer of 1 to 5 and R.sup.26, R.sup.27, R.sup.28 and R.sup.29 are each a lower alkyl, and R.sup.21 is hydrogen, a lower alkyl or a halogen atom, or a pharmaceutically acceptable salt thereof.
- 9. A compound having the formula: ##STR152## wherein A, B, Y and Z are each hydrogen, or the pair (1) A and B and/or the pair (a) Y and Z together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween; n is an integer of 1 to 3; a is 0 or an integer of 1-5 and R.sup.30 is a lower alkyl group, or a pharmaceutically acceptable salt thereof.
- 10. A compound having the formula: ##STR153## wherein A, B, Y and Z are each hydrogen, or the pair (1) A and B and/or the pair (2) Y and Z together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween; n is an integer of 1 to 3; where g is an integer of 1 to 5 and R.sup.39 and R.sup.40 are each hydrogen or a lower alkyl, or a pharmaceutically acceptable salt thereof.
- 11. A compound having the formula: ##STR154## wherein A, B, Y and Z are each hydrogen, or the pair (1) A and B and/or the pair (2) Y and Z together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween; n is an integer of 1 to 3; h is an integer of 1 to 5 and R.sup.41 and R.sup.42 are each hydrogen or a lower alkyl, or a pharmaceutically acceptable salt thereof.
- 12. The compound according to claim 1 in which each of the pair A, B and the pair X, Y together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween.
- 13. The compound according to claim 12 in which n is 3.
- 14. The compound according to claim 2 in which each of the pair A, B and the pair X, Y together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween.
- 15. The compound according to claim 14 in which n is 3.
- 16. The compound according to claim 3 in which each of the pair A, B and the pair X, Y together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween.
- 17. The compound according to claim 16 in which n is 3.
- 18. The compound according to claim 4 in which each of the pair A, B and the pair X, Y together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween.
- 19. The compound according to claim 18 in which n is 3.
- 20. The compound according to claim 5 in which each of the pair A, B and the pair X, Y together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween.
- 21. The compound according to claim 20 in which n is 3.
- 22. The compound according to claim 6 in which each of the pair A, B and the pair X, Y together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween.
- 23. The compound according to claim 22 in which n is 3.
- 24. The compound according to claim 7 in which each of the pair A, B and the pair X, Y together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween.
- 25. The compound according to claim 24 in which n is 3.
- 26. The compound according to claim 8 in which each of the pair A, B and the pair X, Y together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween.
- 27. The compound according to claim 26 in which n is 3.
- 28. The compound according to claim 9 in which each of the pair A, B and the pair X, Y together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween.
- 29. The compound according to claim 28 in which n is 3.
- 30. The compound according to claim 10 in which each of the pair A, B and the pair X, Y together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween.
- 31. The compound according to claim 30 in which n is 3.
- 32. The compound according to claim 11 in which each of the pair A, B and the pair X, Y together represent a direct valence bond between the carbon atoms to which they are attached, thereby forming a double bond therebetween.
- 33. The compound according to claim 32 in which n is 3.
- 34. A pharmaceutical composition having antithrombic activity which comprises a therapeutically effective amount of a compound as defined in claim 1, in association with a pharmaceutically acceptable carrier, diluent or vehicle.
- 35. A pharmaceutical composition having anti-PAF activity which comprises a therapeutically effective amount of a compound as claimed in claim 1, in association with a pharmaceutically acceptable carrier, diluent or vehicle.
Priority Claims (1)
Number |
Date |
Country |
Kind |
57-208678 |
Nov 1982 |
JPX |
|
Parent Case Info
This application is a continuation of application Ser. No. 554,423, filed Nov. 23, 1983 and now abandoned.
US Referenced Citations (9)
Continuations (1)
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Number |
Date |
Country |
Parent |
554423 |
Nov 1983 |
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