Claims
- 1. A method of treating a pathology selected from the group consisting of an eating behavior disorder, obesity, diabetes, emotional, sexual, and mnemonic behavior disorders, and psychosis comprising administering to a patient in need thereof a compound of formula (I) ##STR28## in which R.sub.I is (i) hydrogen; (ii) a (C.sub.1 -C.sub.4) alkyl; (iii) a group --CH.sub.2 --CHOH--(CH.sub.2).sub.m --Z in which m is 0 or 1 and Z is a (C.sub.1 -C.sub.4) alkyl group, (C.sub.3 -C.sub.8) cycloalkyl group, (C.sub.6 -C.sub.10) carbocyclic aryl group optionally substituted with (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkoxy or halogen, saturated or unsaturated heterocycle selected from the group consisting of furan, thiophene, pyrrole, imidazole, pyrrolidine, piperidine, piperazine, pyridine, and morpholine, optionally substituted with a radical selected from the group consisting of (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkoxy, and halogen; or (iv) a group --(CH.sub.2).sub.n COR.sub.0 in which n is 1 to 3, R.sub.0 is OR.sub.2 or NR.sub.2, R.sub.3, R.sub.2 and R.sub.3, which may or may not be identical, being selected from the group consisting of H and (C.sub.1 -C.sub.4) alkyl or, alternatively, R.sub.2 and R.sub.3 forming, together with the nitrogen atom to which they are attached, a saturated or unsaturated heterocycle selected from the group consisting of furan, thiophene, pyrrole, imidazole, pyrrolidine, piperidine, piperazine, pyridine, and morpholine;
- R.sub.II is (i) a nitrogen-containing aromatic heterocycle selected from the group consisting of quinoline, isoquinoline, benzimidazole, indole, and indole substituted on the nitrogen with a group W where W is CO--(C.sub.1 -C.sub.4) alkyl or (CH.sub.2).sub.n COR.sub.0 in which n and R.sub.0 are as defined for R.sub.I ; or (ii) a group ##STR29## in which Y is a halogen atom, a (C.sub.1 -C.sub.3) alkyl group, or a (C.sub.1 -C.sub.3) alkoxy group;
- X.sub.1, X.sub.2 and X.sub.3 are identical or different and are selected from the group consisting of (C.sub.1 -C.sub.3) alkyl, (C.sub.1 -C.sub.3) alkoxy, a halogen atom, and a trifluoromethyl group;
- X.sub.4 is hydrogen or is identical to X.sub.1, X.sub.2 or X.sub.3 ; or a stereoisomer or addition salt, thereof.
- 2. A method of treating obesity comprising administering to a patient in need thereof the compound of formula (I) as defined in claim 1.
- 3. A method of treating diabetes comprising administering to a patient in need thereof the compound of formula (I) as defined in claim 1.
- 4. A method of treating emotional, sexual, or mnemonic behavior disorders comprising administering to a patient in need thereof the compound of formula (I) as defined in claim 1.
- 5. A method of treating psychosis comprising administering to a patient in need thereof the compound of formula (I) as defined in claim 1.
- 6. A method of treating schizophrenia comprising administering to a patient in need thereof the compound of formula (I) as defined in claim 1.
- 7. A method of treating Parkinson's disease comprising administering to a patient in need thereof the compound of formula (I) as defined in claim 1.
- 8. A method of treating gastrointestinal disorders comprising administering to a patient in need thereof the compound of formula (I) as defined in claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
94 01642 |
Feb 1994 |
FRX |
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94 08665 |
Jul 1994 |
FRX |
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Parent Case Info
This is a division of application Ser. No. 08/390,770, filed Feb. 14, 1995 now U.S. Pat No. 5,719,143.
Foreign Referenced Citations (2)
Number |
Date |
Country |
0167919 |
Jun 1985 |
EPX |
0376849 |
Dec 1989 |
EPX |
Non-Patent Literature Citations (4)
Entry |
Sato et al., Chemical Abstracts 117:69890 (1992). |
Tokarshi et al., Chemical Abstracts, vol. 121 entry 221049 (1994). |
Sato et al., Chemical Abstracts, vol. 113 entry 59237 (1990). |
Chemical Abstracts 72:79116k, 1970. |
Divisions (1)
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Number |
Date |
Country |
Parent |
390770 |
Feb 1995 |
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