Claims
- 1. An antiviral compound selected from the group consisting of compounds having the following formula, and pharmaceutically acceptable salts thereof: ##STR6## wherein: R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 2',3',5'-tri-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52a in the text); or
- R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 5'-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52b in the text).
- 2. The antiviral compound of claim 1, wherein R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 2',3',5'-tri-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52a in the text).
- 3. The antiviral compound of claim 1, wherein R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 5'-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52b in the text).
- 4. An antiviral composition comprising a pharmaceutically acceptable carrier and a compound selected from the group consisting of compounds having the following formula, and pharmaceutically acceptable salts thereof: ##STR7## wherein: R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 2',3',5'-tri-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52a in the text); or
- R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 5'-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52b in the text).
- 5. The antiviral composition of claim 4, wherein R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 2',3',5'-tri-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52a in the text).
- 6. The antiviral composition of claim 4, wherein R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 5'-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52b in the text).
- 7. The antiviral composition of claim 4, further comprising ganciclovir.
- 8. A method for treating a herpes viral infection comprising administering to the infected host a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt or formulation thereof, selected from the group consisting of compounds having the following formula: ##STR8## wherein: R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 2',3',5'-tri-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52a in the text); or
- R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 5'-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52b in the text).
- 9. The method of claim 8, wherein R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 2',3',5'-tri-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52a in the text).
- 10. The method of claim 8, wherein R.sub.1 is H, R.sub.2 is Cl, R.sub.3 is Cl, R.sub.4 is H, R.sub.5 is Br and R.sub.6 is 5'-O-acetyl-.beta.-D-ribofuranosyl (denoted compound 52b in the text).
RELATED APPLICATIONS
This application is a continuation of U.S. application Ser. No. 08/471,059 filed Jun. 6, 1995, now U.S. Pat. No. 5,705,490; which is a division of U.S. application Ser. No. 08/050,470 filed May 3, 1993, now U.S. Pat. No. 5,574,058 (which is itself a 35 U.S.C. .sctn. 371 application based on international application number PCT/US91/08124 filed Oct. 31, 1991), which is a continuation-in-part of U.S. application Ser. No. 07/607,899 filed Nov. 1, 1990, now U.S. Pat. No. 5,248,672.
SPONSORSHIP
This invention was made with government support under Contract No. NO1 Al 42554 and NO1 Al 72641 awarded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. The government has certain rights in this invention.
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Continuations (1)
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471059 |
Jun 1995 |
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