N'Diaye et al., "Synthese et etude parasitologique de triazino-1,2,4[4,3-a]benzimidazoles", Eur. J. Med. Chem., vol. 22, pp. 403-409 (1987) (including English language abstract). |
Ricci et al., "Reattivita nucleofila di alcuni 2-cloro-5(6)-X-benzimidazoli", Bollettino, vol. 23, pp. 409-413 (1965) (English language abstract attached). |
Joseph et al., "Dialkylamination by Means of Dimethylformamide (DMF) 2-Dimethylaminobenzimidazoles (1)", J. Heterocyclic Chem., vol. 3(1), pp. 107-108 (1966). (Additional abstract attached). |
Zou, R., "Synthesis and Antiviral Activity of 1-.beta.-D-Ribofuranosyl-2,4,6-Tri-Chlorobenzimidazole," American Chemical Society, Apr. 1990. |
Devivar, R. V. et al., "The Formation of an Unusual Product During Studies on the Diazotization of Certain 2-Aminobenzimidazoles," American Chemical Society, Apr. 1990. |
Saluja, S et al., "Synthesis and Antiviral Activity of Certain 2-Substituted 4,5,6,7-Tetrachlorobenzimidazole Acyclic Nucleosides," American Chemical Society, Apr. 1990. |
Ramasamy, K. et al., "Total Synthesis of 2 2/3-Deoxytoyocamycin, 2 2/3-Deoxysangivamycin and Related 7-.beta.-D-Arabinofuranosyl-Pyrrolo[2,3-d]Pyrimidines via Ring Closure of Pyrrole Precursors Prepared by the Stereospecific Sodium Salt Glycosylation Procedure", Nucleic Acid Research Institute, (Abstract 65). |
Nassiri et al., "Kinetic Assessment by Flow Cytometry of the Effect of Two New Antiviral Drugs on the Cell Cycle", 3rd Annual Meeting Clinical Applications of Cytometry, Sep. 1988. |
Drach et al., "Comparison of Activity of Tubercidin Analogs Against Herpesviruses", 28th ICAAC, Los Angeles, Calif., Oct. 1988. |
Tamm, I., "Inhibitor of Influenza and Mumps Virus Multiplication by 4,5,6-(or 5,6,7,-) Trichloro-1-.beta.-D-Ribofuranosyl-benzimidazole," Science, 120:847-848 (1954) discloses DRB and TRB. |
Smith, C. M. et al., "Inhibitors of Hypoxanthine Metabolism in Ehrlich Ascites Tumor Cells in Vitro," Cancer Treat Rep., 60:1567-1584 (1976). |
Townsend, L. B. et al., "Benzimidazole Nucleosides, Nucleotides, and Related Derivatives," Chemical Reviews, 70:389-438 (1970). |
Bergstom, D. et al., "Antiviral Activity of C-5 Substituted Tubercidin, Analogues", J. Med Chem., 27:285-292 (1984). |
Turk, S. R. et al., "Pyrrolo[2,3-d]Pyrimidine Nucelosides as Inhibitors of Human Cytomegalovirus", Antimicrob. Agents Chemother., 31:544-550 (1987). |
DeClercq, E. et al., "Antirhinovirus Activity of Purine Nucleoside Analogs", Antimicrob. Agents Chemother., 29:482-487 (1986). |
Pudlo, J. S. et al., "Synthesis and Antiviral Activity of Certain 4-and 4,5-Disubstituted 7-[2-Hydroxyethoxy)methyl]pyrrolo[2,d-d]pyrrolo[2,d-d]pyrimidines", J. Med. Chem., 31:2086-2092 (1988). |
Shipman, C., Jr., "Antiviral Activity of Arabinosyladenine and Arabinosylhypoxanthine in Herpes Simplex Virus-Infected KB Cells: Selective Inhibition of Viral Deoxyribonucleic Acid Synthesis in Synchronized Suspension Cultures", Antimicrob. Agents Chemother., 9:120-127 (1976). |
Mitsuya, H. et al., "3'-Azido-3'deoxythymidine (BWA 5090): An Antiviral Agent That Inhibits the Infectivity and Cytopathic Effect of Human T-Lymphotropic Virus type III/Lymphadenopathy-Associated Virus in vitro", PNAS (U.S.A.), 82:7096-7100 (1985). |
Mitsuya, H. et al., "Inhibition of the in vitro Infectivity and Cytophatic Effect of Human T-Lymphotrophic Virus Type III/Lymphadenopathy-Associated Virus (HTLVL-III/LAV) by 2',3'-Dideoynucleosides", PNAS (U.S.A.), 83:1911-1915 (1986). |
Robins, M. J. et al., "Nucleic Acid Related Compounds.24. Transformation of Tubercidin 2 2/3,3 2/3-O-Orthoacetape Into Halo, Deoxy, Epoxide, and Unsaturated Sugar Nucleosides.sup.1,2n ", 55:1251-1259 (1977). |
Gupta, P. K. et al., "Synthesis, Cytotoxicity, and Antiviral Activity of Some Acyclic Analogues of Pyrrolo[2,3-d]Pyrimidine Nucleoside Antibiotics Tubercidin, Toyocamycin, and Sangivamycin", J. Med. Chem., 32:402-408, (1989). |
Saxena, N. K. et al., "Synthesis and Antiviral Activity of Certain 4-Substituted and 2,4-Disubstituted 7-[(-2-Hydroxyethoxy)methyl]Pyrrolo[2,3-d]Pyrimidines", J. Med. Chem., 31:1501-1506 (1988). |
Maruyama, T. et al., "Pyrrolopyrimidine Nucleosides. 18. Synthesis and Chemotherapeutic Activity of 4-Amino-7-(3-deoxy-.beta.-D-Ribofuransoyl)Pyrrolo[2-,3-d]Pyrimidine-5-Carboxamide (2 2/3-Deoxysangivamycin)", J. Med. Chem., 26:25-29 (1983). |
Drach, J. C. et al., "Tritiated Thymidine Incorporation Does Not Measure DNA Synthesis in Ribavirin-Treated Human Cells", Science, 212:549-511 (1981). |
DeClercq, E. et al., "Nucleic Acid Related Compounds 51. Synthesis and Biological Properties of Sugar-Modified Analogues of the Nucleoside Antibiotics Tubercidin, Toyocamycin, Sangivamycin, and Formycin", J. Med. Chem., 30:481-486 (1987). |
Robins, M. J. et al., "A Mild Conversion of Vicinal Doils to Alkenes, Efficient Transformation of Ribonucleosides into 2 2/3-ene and 2 2/3, 3 2/3-Dideoxynucleosides", Tetrahedron Letters, 25:367-370 (1984). |
Jain, T. C. et al., "Reactions of 2-Acyloxyisobutyryl Halides with Nucleosides. III. Reactions of Tubercidin and Formycin", J. Org. Chem., 38:3179-3186 (1973). |
Tolman, R. L. et al., "Pyrrolopyrimidine Nucleosides. III. The total Synthesis of Toyacamycin, Sangivamycin, Tubercidin, and Related Derivatives", J. Am. Chem. Soc. 91:2102-2108 (1969). |
Duffy, T. et al., "Pyrrolo[2,3-d]Pyrimidines, Synthesis from 4-Pyrimidyhydrazones, a 2-Bis(methylthio)methyleneaminopyrrolo-3-carbonitrile, and a Pyrrolo[2-3-d][1,3]Thiazine-2(H)-Thione", J. Chem. Soc., Perkin Trans I 16:1921-1929 (1974). |
Vindelov, L.L., "Flow Mirofluorometric Analysis of Nuclear DNA in Cells from Solid Tumors and Cells Suspensions", Virchow's Arch. Cell Pathol. 24:227-242 (1977). |
Gadler, H., "Nucleic Acid Hybridization for Measurement of Effects of Antiviral Compounds on Human Cytmegalovirus DNA Replication", Antimicrob. Agents Chemother., 24:370-374 (1983). |
Shipman, C., Jr. et al., "Evaluation of 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic Acid (HEPES) as a Tissue Culture Buffer", Proc. Soc. Exp. Biol. Med. 120:305-310 (1969). |
Sigma Chemical Co. Catalog, St. Louis, MO., 1984, p. 898. |
Hansske, F. et al., "2 2/3 and 3 2/3-Ketonucleosides and Their Arabino and Xylo Reduction Products", Tetrahedron 40:125-135 (1984). |
Hayflick, B. "Screening Tissue Cultures for Mycoplasma Infections," in P. F. Kruse, Jr. and M. K. Patterson, Jr. (ed), Tissue culture:methods and applications. Academic Press Inc., New York, 1973, pp. 722-728. |