Polysubstituted derivatives of naphthalene, their process of preparation and their application in the cosmetic and pharmaceutical fields

The object of this invention concerns polysubstituted naphthalene derivatives, their preparation process and their use in the pharmaceutical and cosmetic fields.
These new polysubstituted naphthalene derivatives are part of a class of compounds known as "retinoids", the best known exponents of which are the trans and cis retinoic acids (tretinoin and isotretinoin), and etretinate.
As compared with retinoids, naphthalene polysubstituted derivatives obtained through this invention have a greater stability to light and oxygen, due to their structure. They are also more effective in the topical and systemic treatment of dermatological ailments linked with keratinization disorders (differentation/proliferation) and of dermatological or other ailments with anti-inflammatory and/or immuno-allergic components, and they have an anti-tumoral activity as well.
These new naphthalene polysubstituted derivatives can be represented by the following general formula: ##STR8## in which:
n is 1 or 2
R.sub.1, R.sub.2, R.sub.3 and R.sub.4, identical or different, represent a hydrogen atom or a methyl radical,
R.sub.5 represents:
(i) the radical: ##STR9## (ii) the radical: --C.tbd.N (iii) the radical: ##STR10## (iv) the radical: 2-oxazolinyl in which:
m is 0 or 1
R represents:
(a) a hydrogen atom,
(b) a lower alkyl radical
(c) a radical-OR.sub.11, R.sub.11 representing a hydrogen atom, a lower alkyl radical, a- ##STR11## radical, R.sub.13 radical representing an alkyl radical having from 1 to 20 carbon atoms or an aryl radical; or
(d) a ##STR12## radical when m=1, r' and r" representing a hydrogen atom, a lower alkyl radical, a mono or polyhydroxy alkyl radical, an aryl radical eventually substituted or taken together form an heterocycle,
R.sub.9 represents a hydrogen atom or a lower alkyl radical,
R.sub.10 represents a hydrogen atom; a lower alkyl radical and the corresponding acetals of the said carbonyl compounds; a ##STR13## radical, r' and r" having the same meanings as above where r' represents a hydrogen atom and r" represents a residue of amino-acid or glucosamine; a --OR.sub.14 radical, R.sub.14 representing a hydrogen atom, an alkyl radical having from 1 to 20 carbon atoms, a mono or polyhydroxy alkyl, aryl or aralkyl radical eventually substituted, a residue of a sugar, or represents the radical ##STR14## p being 0, 1, 2 or 3 and r' and r" having the same meanings as above,
R.sub.6 represents a hydrogen atom or a lower alkyl radical and
R.sub.7 represents a hydrogen atom, a lower alkyl radical, a halogen atom, hydroxyl, a sulfhydryl radical, a lower alkoxy, a lower thioalkyl, a lower acyloxy, thioacyl or aminoacyl radical, or a primary, secondary or tertiary amino radical,
and the salts of the said compounds of Formula (I), excluding those compounds of Formula (I) in which R.sub.6 =H and R.sub.7 =H or a halogen atom simultaneously.
The expression "lower alkyl radical" designates radicals having from 1 to 6 carbon atoms, in particular methyl, ethyl, isopropyl, butyl and t-butyl radicals.
"Lower alkoxy, lower thioalkyl, and lower acyloxy, thioacyl or aminoacyl radicals" are radicals having from 1 to 4 carbon atoms.
"Mono-hydroxyalkyl radicals" are radicals having 2 or 3 carbon atoms, notably 2-hydroxy ethyl and 2-hydroxy propyl radicals.
"Polyhydroxyalkyl radicals" are radicals having from 3 to 6 carbon atoms and from 2 to 5 hydroxyl groups such as 2,3-dihydroxypropyl, 2,3,4-trihydroxybutyl and 2,3,4,5-tetrahydroxypentyl.
An aryl radical is a phenyl radical eventually substituted by a halogen atom, a hydroxyl or a nitro function.
As preferred aralkyl radicals, the benzyl and phenethyl radicals may be mentioned.
When the r' and r" radicals taken together form a heterocycle, the latter may be a piperidino, piperazino, morpholino or pyrrolidino radical.
When the R.sub.10 radical represents a hydrogen atom or a lower alkyl, acetals are lower dialkylacetals such as dimethyl- or diethylacetals.
The expression "residue of a sugar" means a radical derived from a sugar such as glucose, mannitol or pentaerythritol.
Among Formula (I) compounds, the following may be mentioned:
4-hydroxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) 2-naphthoic acid; 4-methoxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid; 4-acetoxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-methyl naphtoate; 4-acetoxy-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8,-tetramethyl-2-naphthyl)-2-methyl naphthoate; 4-hydroxy-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid; 4-hydroxy-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-methylnaphthoate; 4-mercapto-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid; 1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid; 1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthalene methanol; 1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthaldehyde; .alpha.-methyl[-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)]-2-naphthalene methanol; .alpha.-ethyl-[1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)]-2-naphthalene methanol; .alpha.-n-propyl[-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)]-2 -naphthalene methanol; methyl, 1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthylmethyl ether; ethyl, 1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthylmethyl ether; methyl, 1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthyl ketone; ethyl, 1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthyl ketone; 1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthylmethyl acetate; 1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthylmethyl propionate; .alpha.-methyl-[1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)]-2-naphthylmethyl acetate; and .alpha.-methyl[-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)]-2-naphthylmethyl propionate.
Formula (I) preferred compounds, according to the invention, are those corresponding to the following formula: ##STR15## in which:
R.sub.1, R.sub.2, R.sub.3, and R.sub.4 represent a methyl radical,
R.sub.14 represents a hydrogen atom or a lower alkyl radical,
R.sub.6 represents a hydrogen atom or a methyl radical, and
R.sub.7 represents an acetoxy, methoxy, hydroxy, sulfhydryl radical or a hydrogen atom when R.sub.6 represents a methyl radical.
Among these compounds, the following can be mentioned in particular:
4-hydroxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid; 4-methoxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphtoic acid; 4-acetoxy-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-methyl naphthoate; 4-acetoxy-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-methyl naphthoate; 4-hydroxy-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid; 4-hydroxy-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-methyl naphthoate; 4-mercapto-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl-2-naphthoic acid; and 1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid.
The compounds in this invention are obtained through a coupling reaction between a halogen compound corresponding to Formula (II) and a halogen derivative of naphthalene corresponding to Formula (III): ##STR16##
in which R.sub.1 to R.sub.7 and n have the same meanings as those given above for Formula (I) and X and Y represent Cl, Br, F or I.
With this coupling process, the Formula (II) halogen compound is transformed into its magnesian, lithium or zincic derivative to known recorded methods and it is bonded to the Formula (III) halogen derivative of naphthalene, using as a catalyst for the reaction a transition metal or one of its complexes.
As catalysts, those derived from nickel or palladium may be mentioned in particular, and especially the complexes of Ni.sup.II (NiCl.sub.2) with various phosphines.
The coupling reaction usually occurs at a temperature between -20.degree. and +30.degree. C. in an anhydrous solvent such as, for example, dimethylformamide or tetrahydrofurane.
The product obtained can be purified by recrystallization or by chromatography on silica column.
Obviously, the Formula (III) halogen derivative of naphthalene selected for the coupling reaction with the Formula (II) halogen compound must be such as to lead, through subsequent reaction, to the various meanings of the R.sub.5 radical.
Among particularly appropriate Formula (III) halogen derivatives of naphthalene are 4-acetoxy 6-bromo 2-methyl naphthoate and 4-acetoxy 6-bromo 1-methyl 2-methyl naphthoate.
Formula (II) halogen compounds are for the most part well known and have been described in U.S. Pat. No. 3,499,751, in particular those in which n=2, i.e. 2-chloro of 2-bromo-5,6,7,8 tetramethyl-5,5,8,8 tetra-hydronaphthalene.
When the compounds in this invention are in the form of salts, they may be either salts of an alkali or alkaline earth metal or an organic amine when they include at least one free acid function, or salts of a mineral or organic acid, in particular of hydrochlorides, hydrobromides or citrates, when they include at least one amine function.
Another object of this invention is the Formula (I) compounds and/or one of their salts defined above, as medicines.
These compounds prove to be quite active in the decarboxylase ornithin inhibition test after induction by tape stripping, in the rat. This test is accepted as a measure of the retinoids' action on cellular proliferation phenomena.
They also show improved activity in the differentiation test of F9 embryonic teratocarcinoma cells (Cancer Research 43, pages 5268, 1983).
These compounds are particularly suited for the treatment of dermatological ailments linked with a keratinization disorder (differentiation proliferation) as well as dermatological or other ailments with an inflammatory component, in particular:
ordinary acne, comedonian or polymorphic, solar senile acne, and professional or medicine-induced acnes,
extensive and/or severe forms of psoriasis, and other keratinization problems, in particular ichthyosis and ichthyosis-like states,
Darier's disease,
Palmo-plantar keratodermatosis,
leukoplasia and leukoplasia-like states,
all dermatological proliferations whether benign or malignant, severe or extensive.
They also have an action on certain rheumatoid ailments, in particular psoriatic rheumatism.
The object of this invention, therefore, is also medicinal preparations including at least one Formula (I) compound and/or one of its salts as defined above.
The object of this invention, therefore, is also a new medicinal preparation, designed in particular for the treatment of the above-mentioned ailments, characterized by the fact that it includes at least one Formula (I) compound, in an acceptable pharmaceutical base.
As previously indicated, derivatives obtained through this invention offer greater stability to light and oxygen, as compared to the usual retinoids, due essentially to the fact that they do not contain a double bond that can easily form isomers.
On the other hand, the irritation test done on rabbits showed that Formula (I) compounds were less irritating than retinoic acid.
Compounds obtained through the invention process are generally administered on the basis of a daily dose of approximately from 2 .mu.g/Kg to 2 mg/Kg and preferably from 10 to 100 .mu.g/Kg.
As a base for the preparations, any conventional excipient can be used, the active compound being in a state either dissolved or dispersed through the vehicle.
The medicine can be administered enterally, parenterally or topically. Enterally, medicines can be in the form of tablets, capsules, pills, syrups, suspensions, solutions, powders, granules or emulsions. Parenterally, the preparations can be in the form of solutions for perfusion or for injection.
For topical administration, the pharmaceutical preparations based on the compounds obtained according to the invention are in the form of liniments, tinctures, creams, solutions, lotions, gels, ointments, powders, impregnated stamps or pads, sprays, or even, suspensions.
Topical preparations contain preferably from 0.0005 to approximately 5% by weight of the Formula (I) compound.
These topical preparations can be either anhydrous or aqueous depending on clinical requirements and may contain other ingredients.
Formula (I) compounds and/or their salts obtained according to the invention have also an application in the field of cosmetics, in particular for capillary and bodily hygiene and notably against acne, for promoting hair growth and preventing hair fall, for fighting the greasy appearance of the skin or hair, or for protection against the ill-effects of sun exposure, or still to combat the skin's physiological dryness.
This invention, therefore, aims also at achieving a cosmetic preparation containing, in an acceptable cosmetic base, at least one Formula (I) compound, such preparation taking, in particular, the form of a lotion, gel, soap or shampoo.
The concentration in Formula (I) compound(s) in cosmetic preparations is from 0.0005 to 2% by weight, preferably from 0.01 to 1% by weight.
Medicinal and cosmetic preparations obtained according to this invention may contain inert additives or even pharmacodynamically or cosmetically active additives, in particular: moisturizing agents such as thiamorpholinone and its derivatives or urea, anti-seborrheic agents such as S-carboxymethylcystine, S-benzyl-cystamine and their derivatives, tioxolone, antibiotics such as erythromycin, neomycin and tetracycline; agents promoting hair growth, such as "Minoxidil" (diamino-2,4 piperidino-6 pyrimidine oxyde-3) and its derivatives; anthralin and its derivatives; Diasoxide, Phenytoin and oxapropanium iodide; steroid and non-steroid anti-inflammatory agents; carotenoids and, in particular, -carotene; antipsoriasis agents such as anthralin and its derivatives, eicosatetraynoic 5,8,11,14 acid and eicosatriynoic 5,8,11 acid.
Preparations obtained according to this invention may also contain flavor-improving agents, preserving agents, stabilizing agents, moisture-regulating agents, pH-regulating agents, osmotic pressure modifying agents, emulsifying agents, UV-A and UV-B filters, anti-oxidizing agents such as .alpha.-tocopherol, butylhydroxyanisole or butylhydroxy toluene.

As an illustration, the following non-restrictive examples of preparation of Formula (I) active compounds obtained according to this invention are given:
EXAMPLE 1
4-acetoxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoate
4.54 g (17 mmoles) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-bromo naphthalene are dissolved into 30 ml of tetrahydrofuran (THF) and treated with 0.62 g (25.5 mmoles) of magnesium. When the magnesium derivative is formed, it is cooled at 20.degree. C. and 2.3 g (17 mmoles) of anhydrous zinc chloride (ZnCl.sub.2) are added. After stirring for one hour at room temperature, 3.23 g (10 mmoles) of 4-acetoxy-6-bromo-2-methyl naphthoate and the NiCl.sub.2 /.phi..sub.2 P.sub.p .phi..sub.2, (90 mg, 0.17 mmole) complex are added. After stirring for one hour and then pouring into water (100 ml), extraction is performed with dichloromethane (2.times.100 ml). The organic phase of the product is washed with a solution saturated with sodium bicarbonate, then with water until neutral, then dried and evaporated. In that manner are obtained 2.50 g (58%) of methyl 4-acetoxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoate at 201.degree. C.
EXAMPLE 2
4-hydroxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid
1.7 g (3.95 mmoles) of ester obtained in Example 1 are added to a mixture of 100 ml of methanolic soda (2M) and 50 ml of water. The mixture is heated for 4 hours, evaporated dry, and, after 100 ml of water are added, extracted with ether (300 ml). The aqueous phase of the product is recuperated, brought to pH 1 with concentrated hydrochloric acid. After extraction of the precipitate with ether (300 ml), it is washed in water until neutral, then dried and evaporated. The solid obtained is recrystallized in acetonitrile. Thus is obtained 1.3 g (88%) of 4-hydroxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid which melts at 299.degree. C.
EXAMPLE 3
4-methoxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2naphthoic acid
0.8 g (2.1 mmoles) of the acid obtained in Example 2, dissolved in 10 ml of THF, are added drop by drop to a suspension of sodium hydride (0.113 g; 4.7 mmoles) in 10 ml of THF. After stirring for two hours at room temperature, 10 ml of dimethylformamide and 0.90 g (6.3 mmoles) of methyl iodide are added. After stirring for one hour, the mixture is poured into water and brought to pH 1 (concentrated hydrochloric acid). Following extraction by ether, the organic phase is decanted, then dried and evaporated. The solid thus formed is recrystallized in a mixture of diisopropyl ether (50%) and cyclohexane (50%). In this manner is obtained 0.60 g (74%) of 4-methoxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid which melts at 242.degree. C.
methyl-4-acetoxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoate;
(a) methyl 4-acetoxy-6-bromo-1-1 methyl-2-naphthoate
A solution of p-bromo-acetophenone (19.9 g; 100 mmoles) and methyl succinate (17.6 g; 120 mmoles) is added drop by drop in 40 ml of tertbutanol to a suspension of tert-butylate of potassium (12.4 g, 100 mmoles) in the terbutanol (50 ml). The mixture is heated for three hours by retort, then acidified to pH 4 with concentrated HCl. Dry evaporation and extraction by ether follow. The product is washed with water, then extracted with a solution of sodium carbonate, acidified and extracted with ether. It is dried and evaporated. A solid is obtained which is recrystallized in the cyclohexane. Thus is obtained 21.9 g (70%) of 5-p-bromophenyl-3-carbethoxy-5-methyl-3-pentenoic acid which melts at 107.degree. C. That acid (21.7 g; 69.3 mmoles) is heated by retort in a mixture of acetic anhydride (90 ml) and sodium acetate (11 g). After 3 hours, dry evaporation is effected, followed with extraction by ether. The organic phase is washed successively with water, a solution of sodium bicarbonate, then again with water. It is dried and evaporated. Thus is obtained an oil which crystallizes from cyclohexane. And thus is obtained methyl acetoxy-6-bromo-1-methyl-2-naphthoate which melts at 78.degree. C.
methyl 4-acetoxy-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoate
In the same manner as in Example 1, starting with 3.4 g (10 mmoles) of methyl 4-acetoxy-6-bromo-1-methyl-2-naphthoate, 1.6 g (36%) of methyl 4-acetoxy-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoate which melts at 170.degree. C. is obtained.
EXAMPLE 5
4-hydroxy-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid
In the same manner as in Example 2, starting with 1.3 g (2.9 mmoles) of the ester described in Example 4, 0.70 g (64%) of 4-hydroxy-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid which melts at 266.degree. C. is obtained.
EXAMPLE 6
methyl-4-hydroxy-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoate;
8.1 g (0.0209 mole) of the acid obtained in Example 5, 100 ml of methanol and 0.6 ml (0.0105 mole) of concentrated sulfuric acid are introduced in a balloon-flask, then heated by retort for 8 hours. After dry evaporation, water is added, neutralization is effected with sodium bicarbonate, followed with extraction with dichloromethane. After drying the organic phase on magnesium sulfate, the resulting solid is evaporated and then recrystallized in acetonitrile. Yield: 7.6 g (90.5%), fusion temperature: (224.degree.-225.degree. C.). RF: 0.5 [Merck silica plaques, the eluent being a mixture of ether-hexane (50:50)
EXAMPLE 7
4-mercapto-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid
Preparation of 4-(dimethylamino thiocarbonyloxy)-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-methyl naphthoate.
(a) In a balloon-flask 1.9 g (0.064 mole) of sodium hydride at 80% is introduced in 50 ml of dimethyl formamide (DMF). Drop by drop, 21.5 g (0.0534 mole) of the ester obtained in Example 6 are added to 50 ml of DMF then stirred for one hour at room temperature. Then, 9.3 g (0.0748 mole) of dimethyl thiocarbamoyl chloride are added to 50 ml of DMF and stirred for two hours at room temperature. The product is poured into 300 ml of HCl 1N, extracted with ethyl ether, the organic phase is decanted, washed with water to which sodium bicarbonate has been added, dried on magnesium sulfate and then evaporated.
After recrystallization in the hexane-cyclohexane mixture, 23 g of the expected product are obtained (88%), with a fusion temperature of 142.degree.-143.degree. C.
RF: 0.5 (MERCK silica plaques, the eluent being dichloromethane).
Preparation of 4-(dimethylamino carbonylthio)-1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-methyl naphthoate.
(b) In a balloon-flask under nitrogen, 23 g (0.047 mole) of the ester obtained above are introduced and heated at 260.degree. C. for 15 minutes. Then, the product is dissolved in the minimum quantity of dichloromethane and chromatography on silica column is effected with dichloromethane as the eluent. In this manner, 18.2 g of the expected intermediate are obtained (79.2%)
RF: 0.45 (MERCK silica plaques, dichloromethane being the eluent).
(c) In a balloon-flask, 18.2 g (0.0372 mole) of the preceeding ester and 400 ml of methanolic soda 2N are introduced. They are heated by retort for 8 hours, then evaporated dry. Water is added to the residue, then it is acidified to pH 1 with concentrated HCl and extracted with ethyl ether. After decanting the organic phase, it is dried on magnesium sulfate. After evaporation and recrystallization in acetonitrile, 11.5 g of the expected product (76%) are obtained.
RF: 0.25 (MERCK silica plaques, ether being the eluent).
EXAMPLE 8
1-methyl-6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-naphthoic acid
In a balloon-flask, 11.5 g (0.0284 mole) of the acid obtained in Example 7 and 300 ml of ethyl alcohol are introduced. Under nitrogen, 40 g of Raney nickel are added and the contents are heated for two hours by retort. The catalyst is filtered, the alcoholic phase is evaporated, then the resulting solid is chromatographed on silica column using an ether-hexane mixture (80:20).
After recrystallization in acetonitrile, 5.4 g of the expected product are obtained, with a fusion temperature of 243.degree.-244.degree. C. (Yield 52%)-RF: 0.2 (MERCK silica plaques, ether being the eluent).
EXAMPLES OF COMPOSITIONS
Example 1
______________________________________0.2 g Tablet______________________________________Compound from example 2 0.001 gStarch 0.114 gDicalcium phosphate 0.020 gSilica 0.020 gLactose 0.030 gTalcum 0.010 gMagnesium stearate 0.005 g______________________________________
In this example, the compound from example 2 may be replaced with the same quantity of the compound from example 8.
Example 2
______________________________________0.5 g Capsule - Powder formula______________________________________Compound from example 2 0.001 gCorn starch 0.150 gMagnesium stearate 0.250 gSaccharose QSP 0.500 g______________________________________
The powder is packaged in a capsule made of gelatin and titanium dioxide.
Example 3
______________________________________Liniment______________________________________Compound from example 5 0.001 gStearyl alcohol 3.000 gLanolin 5.000 gVaseline 15.000 gDistilled water QSP 100.000 g______________________________________
In this example, the compound from example 5 may be replaced with an equal quantity of the compound from example 8.
Example 4
______________________________________Gel______________________________________Compound from example 5 0.005 gHydroxy-propyl cellulose sold by theHercules Company under the name of"Klucel HF" 2.000 gWater: ethanol (50:50) QSP 100.000 g______________________________________
Example 5
______________________________________Non-ionic oil-in-water cream______________________________________Compound from example 5 0.050 gCetyl alcohol 3.000 gStearyl alcohol 3.400 gOxyethylated cetyl alcohol (20 moles) 0.630 gOxyethylated stearyl alcohol (20 moles) 1.470 gGlycerol monostearate 2.000 gVaseline oil 15.000 gGlycerin 10.000 gPreservatives qsDistilled water QSP 100.000 g______________________________________
Example 6
______________________________________Liniment______________________________________Compound from example 5 0.020 gIsopropyl myristate 81.700 gFluid vaseline oil 9.100 gSilica sold by theDegussa Company under thename of "AEROSIL 200" 9.180 g______________________________________

Number	Name	Date	Kind
4326055	Loeliger	Apr 1982
4454341	Dawson	Jun 1984

Polysubstituted derivatives of naphthalene, their process of preparation and their application in the cosmetic and pharmaceutical fields

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