Claims
- 1. Porous polymer particles prepared by the process of polymerizing monomers comprising a compound according to formula (I): ##STR3## wherein R is hydrogen or methyl, n is 0 to 30, m is 0 to 30, with the proviso that m+n>1,
- and a hydrophilic monomer polymerizable with said compound according to formula (I),
- wherein the weight ratio of the compound according to formula (I) and the hydrophilic monomer is between 50:50 and 10:90, and
- wherein said pore size of said particles is between 30 and 5000 .ANG..
- 2. The polymer particles according to claim 1, in which m is 0 and n is a number of from 1 to 10.
- 3. The polymer particles according to claim 1, in which the hydrophilic monomer is an ester of polyhydric alcohol and a polymerizable monomer having .alpha., .beta.-ethylenic unsaturated bond.
- 4. The polymer particles according to claim 1, in which the hydrophilic monomer is the one selected from the class consisting of hydroxyethyl (meth)acrylate, hydroxypropyl (meth)acrylate, glycerine (meth)acrylate, pentaerythritol (meth)acrylate, oligoethylene glycol (meth)acrylate and oligopropylene glycol (meth)acrylate.
- 5. The polymer particles according to claim 1, in which the polymer of the monomer (I) is crosslinked by crosslinking agent.
- 6. The polymer particles according to claim 1, in which copolymer of the monomer (I) and the hydrophilic monomer is crosslinked by crosslinking agent.
- 7. The polymer particles according to claim 6, in which the monomer components comprise less than 20 percents by weight of the crosslinking agent based on the total weight of the monomer (I) and the crosslinking agent and weight ratio of the monomer (I) and the crosslinking agent to the hydrophilic monomer is from 50:50 to 10:90.
- 8. The polymer particles according to claim 1, in which mean grain size is from 1 to 1000.mu.m.
Priority Claims (1)
| Number |
Date |
Country |
Kind |
| 62-257896 |
Oct 1987 |
JPX |
|
SUMMARY OF THE INVENTION
This application is a continuation of application Ser. No. 256,805 filed Oct. 12, 1988, now abandoned.
BACKGROUND OF THE INVENTION
The present invention relates to polymer particles, in particular polymer particles which are useful as a packing material for liquid chromatography and preparation method thereof.
Recently, polymer particles are employed in various fields such as adsorbents, cosmetics, paints, building materials, pharmaceuticals, analytical chemistry and the like. In some fields, polymer particles having solvent resistance, mechanical strength and the like are required and crosslinked polymer particles have developed for this purpose.
For example, polymer particles having hydrophilicity derived from vinyl alcohol which are prepared in the presence of triazine and used as a packing material for liquid chromatography are disclosed in Japanese Patent Laid Open No. 190003/1982 and polymer particles having hydrophilicity derived from carboxyl group and vinyl alcohol residue which are prepared in the presence of triazine as a crosslinking agent and used as a packing material for liquid chromatography are described in Japanese Patent Laid-Open No.232102/1984.
Although mechanical strength and solvent resistance which are required for the packing materials for liquid chromatography are improved by the crosslinkage in these polymer particles, they have several disadvantages. For example, in the case of separation of physiological active substances such as protein and the like which have polar hydrophilic groups such as carboxyl group, amino group and the like in addition to hydrophobic groups, nonspecific adsorption to the polymer particles occurs and recovery rate of the adsorbed substances is lowered because the polymer particles contain triazine ring. Furthermore, in the case of elution of the adsorbed physical active substances, the physiological active substances are denaturated and recovery rate thereof is decreased because strong eluent such as alcohol, strong acid and strong base is necessary to elute the adsorbed substances.
The object of the present invention is to provide polymer particles which do not bring about the aforementioned problems.
The present invention relates to polymer particles prepared by polymerizing monomer components which comprise as at least a part of polymerizable components a monomer of the formula (I): ##STR2## wherein R is hydrogen atom or methyl group, n is a number of from 0 to 30 and m is a number of from 0 to 30 provided that m+n.gtoreq.1 and a process for preparing the polymer particles.
US Referenced Citations (1)
| Number |
Name |
Date |
Kind |
| 3992477 |
Dickie et al. |
Nov 1976 |
|
Foreign Referenced Citations (2)
| Number |
Date |
Country |
| 54-160300 |
Dec 1979 |
JPX |
| 62-53315 |
Mar 1987 |
JPX |
Continuations (1)
|
Number |
Date |
Country |
| Parent |
256805 |
Oct 1988 |
|
Patent Grant
4954399
