Claims
- 1. A medical device, comprising:
a dry sponge matrix defining pores, said sponge matrix stabilized in a compressed configuration and expansible when wetted.
- 2. The medical device of claim 1, wherein said sponge matrix is formed from matrix-forming material including collagen.
- 3. The medical device of claim 1, wherein said device is configured for percutaneous delivery.
- 4. The medical device of claim 2, wherein said device is configured for percutaneous delivery.
- 5. The medical device of claim 1, wherein said dry sponge matrix is expansible at least about 100% by volume when saturated with deionized water.
- 6. The medical device of claim 2, wherein said dry sponge matrix is expansible at least about 100% by volume when saturated with deionized water.
- 7. The medical device of claim 6, wherein said dry sponge matrix has a density of least about 0.05 g/cm3.
- 8. The medical device of claim 7, wherein said dry sponge matrix has a density in the range of about 0.05 g/cm3 to about 0.2 g/cm3.
- 9. The medical device of claim 8, wherein said dry sponge matrix has a density in the range of about 0.075 g/cm3 to about 0.2 g/cm3.
- 10. The medical device of claim 1, wherein said sponge matrix comprises at least one biotropic agent.
- 11. The medical device of claim 1, wherein said sponge matrix comprises collagen from an extracellular matrix.
- 12. The medical device of claim 11, wherein said sponge matrix comprises at least one active biotropic agent from said extracellular matrix.
- 13. The medical device of claim 11, wherein said extracellular matrix is submucosa or basement membrane.
- 14. The medical device of claim 12, wherein said extracellular matrix is submucosa or basement membrane.
- 15. The medical device of claim 2, wherein said sponge matrix is crosslinked.
- 16. The medical device of claim 15, wherein said sponge matrix is crosslinked with a chemical crosslinking agent providing polar groups in the matrix.
- 17. The medical device of claim 16, wherein said crosslinking agent is a polyepoxide compound.
- 18. The medical device of claim 17, wherein said polyexpoxide compound is a polyglycidyl ether compound.
- 19. The medical device of claim 18, wherein said polygylcidyl ether compound is a diglycidyl ether compound.
- 20. A method for preparing a compressed sponge matrix, comprising, comprising:
providing a wetted porous sponge matrix; compressing said wetted sponge matrix; and drying said sponge matrix to form a dry, compressed sponge matrix.
- 21. The method of claim 20, wherein said sponge matrix is formed from matrix-forming material including collagen.
- 22. The method of claim 20, wherein said dry sponge matrix is expansible at least about 100% by volume when saturated with deionized water.
- 23. The method of claim 21, wherein said dry sponge matrix is expansible at least about 100% by volume when saturated with deionized water.
- 24. The method of claim 23, wherein said dry, compressed sponge matrix has a density of least about 0.05 g/cm3.
- 25. The method of claim 24, wherein said dry, compressed sponge matrix has a density in the range of about 0.05 g/cm3 to about 0.2 g/cm3.
- 26. The method of claim 25, wherein said sponge matrix comprises at least one active biotropic agent.
- 27. The method of claim 20, wherein said sponge matrix comprises collagen from an extracellular matrix.
- 28. The method of claim 27, wherein said sponge matrix comprises at least one active biotropic agent from said extracellular matrix.
- 29. The method of claim 28, wherein said extracellular matrix is submucosa or basement membrane.
- 30. The method of claim 20, wherein said sponge matrix is crosslinked.
- 31. The method of claim 30, wherein said sponge matrix is crosslinked with a chemical crosslinking agent providing polar groups in the matrix.
- 32. The method of claim 31, wherein said crosslinking agent is a polyepoxide compound.
- 33. The method of claim 32, wherein said polyexpoxide compound is a polyglycidyl ether compound.
- 34. A device useful for providing hemostasis in a tissue biopsy site, comprising:
an element formed from a dry sponge matrix and configured for percutaneous delivery to the biopsy site, said sponge matrix stabilized in a compressed configuration and expansible when wetted.
- 35. The device of claim 34, wherein said sponge matrix comprises collagen and is crosslinked.
- 36. The device of claim 35, wherein said sponge matrix is crosslinked with a chemical crosslinking agent providing polar groups in the matrix.
- 37. The device of claim 36, wherein the chemical crosslinking agent is a polyepoxide compound.
- 38. The device of claim 37, wherein the polyepoxide compound is a polyglycidyl ether compound.
- 39. The device of claim 35, wherein said dry sponge matrix has a density of at least about 0.05 g/cm3 and is expansible at least 100% by volume when wetted.
- 40. A sponge device, comprising:
a dry, compressed sponge matrix defining pores, said sponge matrix having a density of at least about 0.05 g/cm3 and expansible at least about 100% by volume when saturated with deionized water.
- 41. A method for providing hemostasis in a biopsy site from which a biopsy tissue sample has been taken, comprising implanting in the biopsy tract a hemostatic element formed from a dry sponge matrix stabilized in a compressed configuration and expansible when wetted.
- 42. The method of claim 41, wherein said implanting is conducted percutaneously.
- 43. The method of claim 42, wherein said percutaneously implanting comprises delivering said hemostatic element through a cannula used in obtaining the biopsy tissue sample.
- 44. A tissue biopsy method, comprising:
inserting a cannula to extend to a tissue site for biopsy, said cannula having an associated cutting member for cutting a sample of tissue from the tissue site; cutting the sample of tissue with said cutting member; extracting the sample of tissue through said cannula; and delivering to the tissue site through the cannula a hemostatic element formed from a dry sponge matrix stabilized in a compressed configuration and expansible when wetted.
- 45. The method of claim 44, wherein said cannula comprises a needle cannula.
REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit of United States Provisional Patent Application Serial No. 60/302,245 entitled POROUS SPONGE MATRIX MEDICAL DEVICES AND METHODS filed Jun. 29, 2001, which is hereby incorporated by reference herein in its entirety.
Provisional Applications (1)
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Number |
Date |
Country |
|
60302245 |
Jun 2001 |
US |