Embodiments of the present disclosure relate generally to medical equipment, including, but not limited to the provision of portable utilities infrastructure to dialyzers and other medical equipment that requires power, water, and drainage to function, such as in dentistry. More specifically, aspects of the present disclosure relate to portable, modular systems that may supply water, electricity, data transmission, and drainage to one or a plurality of dialyzers or other medical equipment enabling the operation of dialysis or other systems free from fixed infrastructure disposed within permanent construction. Further aspects of the present disclosure include one or more drainage, data, and power redundancies in the event of a failure in any individual subsystem.
Hemodialysis and peritoneal dialysis have become increasingly prevalent as health trends in the United States and around the world have resulted in increasing diagnoses of kidney disease and corresponding treatments. Dialysis is a front-line treatment for end-stage kidney disease, chronic kidney disease, and renal failure, performing the essential function of the kidneys to remove undesirable substances from the patient's blood.
Peritoneal dialysis systems are known in the art, and operate as an artificial kidney system by using the patient's peritoneal membrane to filter blood. Peritoneal dialysis requires a peritoneal access device (usually a catheter), dialysate (an aqueous solution used to remove impurities), an apparatus capable of pumping and draining dialysate from the patient's peritoneal cavity, and various accessories. The peritoneal dialysis system removes impurities from the patient's blood by pumping dialysate into the patient's peritoneal cavity via the access device, where the dialysate dwells for a period of time while toxins and other undesirable substances pass through the peritoneal membrane and into the dialysate in the peritoneal cavity. The dialysate captures the toxins, which are removed from the body along with the dialysate. This process may be repeated over the course of a treatment. The machine that performs the pumping and draining of the dialysate or other wastewater requires a specialized power source and drainage pumping that is both reliable enough to be used in medical treatment and may be used to dispose of used dialysate, which is medical waste, or other medical wastewater. As used herein, “wastewater” may refer to used dialysate or other waste fluids generated by medical treatments.
Hemodialysis filters toxins directly out of the blood and usually consists of an extracorporeal blood system, a dialyzer, a dialysate delivery system, and various accessories. The patient's blood flows through the extracorporeal blood system to the filtration compartment of the dialyzer, which usually consists of two compartments, one for blood and the other for dialysate separated by a membrane. The toxins in the patient's blood pass through the membrane into the dialysate. Cleansed blood flows back into the patient while the used dialysate, which is medical waste, is cycled out to drain. The extracorporeal blood system includes mechanisms and alarms that keep blood moving safely from the patient, through the dialyzer, and back into the patient.
Diabetes, which has become increasingly prevalent in Americans, often results in chronic kidney disease or diabetic nephropathy and as a result has led to an increased demand for dialysis treatment. Approximately 1 in 3 adults with diabetes suffers from chronic kidney disease, and the prevalence of both type 1 and type 2 diabetes is expected to increase by more than 50% between 2015 and 2030. The costs of diabetes and complications thereof have a significant societal cost, owing in part to the cost of treatment for resulting kidney disease, which includes dialysis.
Complications from COVID-19 include kidney injuries, with an estimated 3-9% of COVID-19 patients developing acute kidney injuries. As a result, dialysis also has applications in the treatment of some cases of COVID-19 and what has come to be known as “long COVID.”
The utility of the present disclosure is not limited in scope to use in dialysis treatment, but may also be used to facilitate other medical treatments and other operations and activities requiring the use of reliable electric, water, and drainage utilities.
Because functional medical equipment that accomplishes dialysis treatment require specialized dialysate fluid supply equipment, specialized fluid drainage piping and collection equipment, and highly reliable conduits for electricity and patients' medical and other data collected by dialysis equipment, many dialysis providers integrate specialized utility infrastructure directly into the buildings where dialysis treatment takes place. This building infrastructure, which includes equipment capable of supporting the specialized mechanical, electrical, plumbing, and data needs of dialysis equipment, is both very expensive to construct and is confined to use only in the single location where it is installed.
The present disclosure improves over the prior art by eliminating reliance upon supplying required dialysis utilities infrastructure in a permanent, immovable building construction while also providing portable, interchangeable, reusable, and comparably inexpensive dialysis infrastructure capable of transforming a pre-existing space into one capable of supporting one or more dialysis treatments while still supporting multiple system redundancies that reduce to a near nullity the possibility of utility failures that could adversely affect dialysis or other medical treatments. In addition, the disclosed system's portability makes it advantageous to use in other applications, such as in a temporary or mobile facility. In an exemplary non-limiting application, the present disclosure may include a freely configurable modular cabinet with water supply, dialysate, or other medical wastewater drainage and/or storage plumbing, electrical utility hardware configured for use with dialysis equipment, and data transmission hardware that may be used to transmit patient medical data to medical providers. The disclosed apparatus may be portable and modular, capable of supporting one or more concurrent dialysis treatments with one or more consoles provided in electrical and fluid communication with one another. The disclosed system may also include additional assemblies used to control and extend the distance between multiple portable biomedical utilities consoles.
It is an object, feature, and/or advantage of the present disclosure to provide an improved portable biomedical utility apparatus and accessories and methods of use thereof that overcome deficiencies in the prior art. In accordance with one exemplary aspect, a portable cabinet is provided with biomedical utility subsystems, including but not limited to plumbing equipment directed to water supply and fluid dialysate or other wastewater drainage and/or collection, electrical equipment directed to the supply of reliable power and including electrical cabling, circuit breakers, standard and/or specialized electrical outlets, and uninterruptible power supply optionally including an inverter, battery, and power factor correction, control hardware including series of configured relays, contactors, and sensors that control and monitor some or all of the provided utility functions, equipment for data transmission, and connectors adapted to place each utility in respective communication with corresponding external utilities, equipment used in dialysis and other treatments, and to other portable biomedical utilities consoles and accessories.
It is an additional object, feature, and/or advantage of the present disclosure to provide a portable and modular biomedical utility apparatus and methods of use thereof that provide plumbing and electrical systemic redundancies for use in conjunction with dialysis or other medical equipment when a plurality of consoles are used in conjunction with one another such that, in the event of a failure of plumbing or electrical utility system of one console, another console may provide backup plumbing, data, and/or electrical utility service.
The accompanying drawings, which are incorporated in, and which constitute a part of this specification, illustrate exemplary constructions and procedures in accordance with the present disclosure and, together with the general description of the disclosure given above and the detailed description set forth below, serve to explain the principles of the disclosure wherein:
While constructions consistent with the present disclosure have been illustrated and generally described above and will hereinafter be described in connection with certain potentially preferred embodiments and practices, it is to be understood that in no event is the disclosure limited to such illustrated and described embodiments and practices. On the contrary, it is intended that the present disclosure shall extend to all alternatives and modifications as may embrace the general principles of this disclosure within the full and true spirit and scope thereof. Also, it is to be understood that the phraseology and terminology used herein are for purposes of description only and should not be regarded as limiting. The use herein of terms such as “including” and “comprising” and variations thereof is meant to encompass the items listed thereafter and equivalents thereof as well as additional items and equivalents thereof.
It is an object, feature, and/or advantage of the present disclosure to provide an improved and portable biomedical utilities infrastructure apparatus and methods of use thereof that overcome deficiencies in the prior art. The disclosed portable biomedical utilities console provides advantages over stationary utilities infrastructure built into dialysis treatment facilities provided in prior art.
A discussion of the prior art is helpful to illustrate how the present disclosure overcomes deficiencies in the prior art. In order to function, dialysis machines used in dialysis treatment typically require a supply of electricity and water, as well as a repository or drain into which used dialysate can drain and be collected or otherwise disposed of. A typical dialysis machine requires a source of water to be mixed with chemicals in order to form an aqueous solution, dialysate, which is used in dialysis. At present, these utilities are typically built into specialized facilities designed for the purpose of facilitating multiple simultaneous dialysis treatments.
The present disclosure overcomes deficiencies in the prior art by effectively removing the need for permanent utility infrastructure required by dialysis and other medical machines by effectively replacing it with a plurality of portable, non-permanent, and modular cabinets capable of the reliability demanded in medicine. In so doing, construction costs are reduced and the need for traditional construction (i.e., plumbing and electrical utilities disposed within the walls of the building housing the treatment room) is significantly reduced as the number of utility connections needed for dialysis and other medical treatment is reduced. In addition, the cost of converting an existing structure to one capable of supporting multiple simultaneous dialysis or other treatments is greatly reduced.
It is an object, feature, and/or advantage of the present disclosure to provide an improved biomedical utility console that includes plumbing infrastructure including piping disposed in fluid communication with an external water supply, drain piping provided in fluid communication with a valve disposed in the housing of the console and configured to receive an adapter capable of placing the drain piping in fluid communication with the dialysate output port of a dialyzer or wastewater output of another medical device, the drain piping in turn may be provided in fluid communication with an assembly including an electric pump and wastewater tank or a sloping drainage conduit and gravity-fed removable container, electrical hardware configured to provide electricity to sub-systems within the console and dialysis and other equipment connected thereto, the electricity subsystem including an uninterruptible power supply and surge protection integrated therein, electronic equipment configured to receive, convey, and transmit information and commands, control hardware including series of configured relays, contactors, and sensors that control and monitor some or all of the provided utility functions, and connectors adapted to place each utility in respective communication with corresponding external utilities and equipment used in dialysis treatment.
Multiple examples of the present disclosure may be adapted to be placed in fluid communication with one another. In one such exemplary configuration, a first portable biomedical utilities console may receive hot and cold water from an external source, and a second console may be placed in fluid communication with a first console such that water provided from an external source may be communicated to an exemplary second console from an exemplary first console, wherein both consoles may provide water to respective medical devices provided in fluid communication with a first and second console. Additional consoles may be added to an exemplary console system in a series or relay line. As used herein, “relay” means receive and pass on water, wastewater fluid, electricity, or data.
An exemplary portable biomedical utilities console may include hardware configured for power distribution from an external power source to dialysis or other medical equipment and other portable biomedical utilities consoles. In this exemplary embodiment, an electricity distribution system is disposed within a housing and is adapted to be placed in electrical communication with an external power source, one or more other portable biomedical utilities consoles, and dialysis or other medical equipment, including hemodialysis and peritoneal dialysis treatment delivery systems. An exemplary power distribution system disposed within a portable biomedical utilities console may include an electrical cable bus provided in electrical communication with external adapters capable of communicating an electrical current to and from the console, and providing a primary source of electricity to each exemplary console. An exemplary power cable bus may be provided in electrical communication to one or more sets of circuit breakers capable of preventing surge currents from damaging exemplary utilities systems disposed within a console and dialysis or other medical equipment in electrical communication therewith, which in turn are provided in electrical communication with the utilities systems disposed within the console housing. A power cable bus may communicate electricity through one or more circuit breakers or directly to subsystems within the console that require electricity to operate, including, but not limited to a pump, network hub, and data receiving and transmitting module, and to a means of communicating electricity to dialysis or other medical equipment, such as a ground-fault circuit interrupter outlet mounted to the housing of the console, which in turn may provide additional surge protection for dialysis or other medical equipment. One or a plurality of electric receptacle disposed in the exterior of each console unit to provide electricity to a dialyzer or other medical equipment.
An exemplary portable biomedical utilities console may also include additional subsystems configured to provide power redundancies in the event of a power loss from the external power source. An uninterruptible power supply (UPS) module, optionally including a battery, inverter, and surge protector may be provided within the housing of the console to provide protection from interruptions or imbalances to input power. In the event of an external power loss, a UPS module may be configured to provide electricity not only to any dialysis equipment in direct electrical communication with the console, but also to other consoles and corresponding dialysis equipment. Such a configuration provides additional redundancies corresponding to the number of exemplary consoles provided. Each UPS module may also be provided in communication with an alarm system to notify medical providers of an external power failure and/or a charge meter disposed on the console exterior communicating the level of charge of the UPS battery.
Exemplary circuit breakers provided in electrical communication with the main power bus and subsystem components or to an outlet adapted to provide electricity to a dialysis machine, other medical equipment, and other accessories may optionally be configured for the power capacity required for the specific configuration or application and/or to prevent damage or degraded performance caused by overcurrent or power surge.
One or more exemplary water supply lines may be disposed within the console housing and provided in fluid communication with a plurality of water ports disposed on the console housing. Exemplary water ports disposed on the console housing may be adapted to receive a plurality of water line connectors, which may be used to place the console in fluid communication with the water intake of a dialysis machine, the water line of another console, and/or an external source of water suitable for use in dialysis treatment. Each exemplary port may be provided in adjacent fluid communication with a valve as a means of controlling the flow of water through an exemplary console and to dialysis equipment provided in fluid communication therewith. An exemplary valve adapted to be placed in fluid communication with a dialysis machine may be provided in communication with a sensor configured to detect a number of water characteristics, including but not limited to temperature, pressure, and rate of flow. An exemplary water output sensor is placed downstream from any valve provided to control the flow of water to dialysis equipment. One or two water intake lines may be placed in fluid communication with an external source water lines of cold or hot and cold water, respectively. Water temperature control may be provided by an exemplary thermostat mixing valve placed in fluid communication with both hot and cold water lines. Water pressure conditioning may be provided by a reduced pressure zone (RPZ) assembly, including a backflow preventer disposed within the console and provided in fluid communication with an output valve configured to be placed in fluid communication with the water intake of dialysis or other medical equipment. Embodiments of the present disclosure include the use of some form of backflow prevention and pressure reduction to manage water pressure output to sensitive medical equipment. Each water intake or output port may be provided in fluid communication with a valve as a means of controlling the flow of water through an exemplary console and from dialysis equipment provided in fluid communication therewith.
One or more exemplary fluid drainage lines may be disposed within a console housing and provided in fluid communication with a plurality of ports disposed on the console housing. Exemplary drainage ports disposed on the console housing may be configured to place the console in fluid communication with the dialysate output of dialysis machine, the drainage line another console, and/or an external drain. Each exemplary port may be provided in fluid communication with a valve as a means of controlling the flow of used dialysate or other wastewater through an exemplary console and from dialysis equipment provided in fluid communication therewith. A sensor may be placed in adjacent fluid communication to a used dialysate intake port to detect a number of characteristics of used dialysate fluid or other wastewater, including but not limited to rate of flow, pressure, and temperature.
An exemplary portable biomedical utilities console may be configured for pump-assisted or gravity-assisted drainage of used dialysate or wastewater. An optional container for storing used dialysate may be provided within the console housing in either a pump-assisted or gravity-assisted drainage configuration. In an exemplary pump-assisted drainage configuration, continuous duty suction pumps extract used dialysate wastewater at the same rate the waste fluid enters the console. Additionally, in an exemplary pump-assisted drainage configuration, a repository for used dialysate, which may be a removable or fixed container, is disposed in the housing of the exemplary console and is provided in fluid communication with one or more pumps. Exemplary continuous duty suction pumps may include a self-priming pump mounted in-line and configured to operate at low revolutions per minute (RPMs) and at different speeds. An exemplary pump may be disposed on an exemplary wastewater tank disposed within the console housing.
In an exemplary gravity-assisted drainage configuration, the slope of the drain conduit may be adjusted such that used dialysate or wastewater flows toward a facility drain. In this exemplary gravity-assisted configuration, the slope of the drainage pipe within each modular cabinet may be adjusted, optionally through the use of a plurality of pipe collars within each cabinet. Such pipe collars may be raised to a higher or lower height within each cabinet such that the slope of the entire drainage conduit gradually descends toward the facility drain or other means of collecting wastewater. Exemplary pipe collars may include a protrusion that can be affixed to one of a series of vertical openings in a rail disposed inside each modular cabinet. Each rail has numerous vertical openings at various heights, allowing the slope and height of the drain pipe within each cabinet to be adjusted such that wastewater flows toward a facility drain.
An exemplary low-RPM pump is advantageous in dialysis applications because drainage of used dialysate or wastewater is typically slow and in terms of reliability as low-RPM function places lower stress on the motor of an exemplary pump. In the event used dialysate or other wastewater outpaces the drainage rate provided by the pump, a variable frequency drive (VFD) motor controller may be provided to adjust the speed of the pump, and therefore, the rate of drainage. In an exemplary embodiment, a VFD controller may be configured to increase pump speed when triggered by a sensor disposed within the interior of a wastewater tank. When wastewater accumulates above a certain amount, a sensor configured to monitor wastewater level in the tank and signals the VFD controller to increase the speed of a pump provided in fluid communication with the wastewater tank to compensate for additional wastewater. In another exemplary embodiment, a VFD controller is operated manually from an exemplary control panel disposed on the housing of a console. An exemplary sensor configured to monitor wastewater level in the tank may be a float sensor.
In one exemplary embodiment of a portable biomedical utilities console with pump-assisted drainage, two fluid drainage lines are disposed within a console housing to provide redundancy in the event of pump failure. A first drainage line is provided in fluid communication with a plurality of drainage ports disposed on the exterior of the console housing and an exemplary first pump. A second drainage line is provided in fluid communication with a plurality of drainage ports disposed on the exterior of the console housing and an exemplary second pump. An exemplary first pump may be provided in fluid communication with an emergency exterior drain port and an exterior port, which is, in turn, provided in fluid communication with the used dialysate output of a dialyzer or the wastewater output of another medical device. A first pump is provided in fluid communication with a second pump, a first emergency drain line in fluid communication with another drainage port disposed on the exterior of the console, and a second emergency drain line provided in fluid communication with a hose bib disposed on the exterior of an exemplary console. An exemplary second pump may also be provided in fluid communication with the fluid line connecting the used dialysate port to a first pump and an emergency drain line in fluid communication with a port disposed on the exterior of an exemplary console. Both pumps are provided in electronic communication with a wastewater level sensor capable of detecting the operability, speed, and other aspects of each respective pump. In this configuration, ordinary operation of the console occurs when the used dialysate or other wastewater is pumped through a first pump and out of an exemplary embodiment of a console via a first drainage line. If a first pump fails or operates at reduced capacity, the float of an exemplary sensor configured to monitor wastewater level is triggered when the wastewater tank associated therewith fills with wastewater because the wastewater is entering the tank faster than the pump is pushing it out of the tank. Triggering an exemplary float sensor activates the operation of a second exemplary pump. In this embodiment, the wastewater instead is pumped through a first tank provided in fluid communication with a first pump to a second tank provided in fluid communication with a second tank and out of an exemplary console via a second drainage line.
The exemplary embodiment of a console with pump-enabled drainage system gains additional redundancies when one console housing two pumps is placed in fluid communication to another exemplary such console. In such situations, if both pumps fail within one console, an exemplary electrically-actuated valve in fluid communication with a first emergency drainage line will open and used dialysate or other wastewater will flow from a dialyzer through an exemplary first tank provided in fluid communication with a first pump, and through a first emergency drainage line to a second pump of a second exemplary console provided in fluid communication with the first. A plurality of portable biomedical utilities consoles therefore provides redundancies in the event both pumps in a console fail. In an exemplary embodiment, an electrically actuated valve in fluid communication with a first emergency drainage line will open when a sensor configured to detect wastewater level disposed in a wastewater tank is triggered by wastewater within a wastewater tank rising to the level of the float sensor. In this exemplary configuration wherein a first emergency drainage line is provided in fluid communication to a second emergency drain line disposed in a second console, when the valve in fluid communication with a first emergency drainage line opens the wastewater is allowed to flow into the adjacent console, which receives the wastewater load of the failed console.
In the event of catastrophic failure of all pumps in a console relay-line, wastewater may flow by operation of gravity out of the console via a second emergency drain line in fluid communication via an exemplary hose bib, which may be provided in fluid communication with an external drain.
In another exemplary embodiment of a portable biomedical utilities console, drainage and collection of used dialysate or other medical-waste byproducts may be accomplished by action of gravity. In this exemplary embodiment, a port configured to receive used dialysate or other wastewater is disposed on the exterior of an exemplary console and is provided in fluid communication with a container disposed on the bottom of an exemplary console and a wastewater drainage conduit. A container may be provided in fluid communication with an opening disposed in the top of an exemplary console via an exemplary conduit, which may be used to communicate cleaning fluid to drain pipes and treat them for the buildup of proteins deposited thereto from wastewater. In an exemplary gravity-assisted drainage configuration, the slope of the drain conduit may be adjusted within each console such that used dialysate or wastewater flows toward a facility drain or other means of collecting wastewater once the wastewater conduits of each individual console are placed in fluid communication with one another in a relay line. In this exemplary gravity-assisted configuration, the slope and height of the wastewater conduit within each modular cabinet may be adjusted such that the overall slope of the relay line wastewater conduit descends toward a facility drain or other means of collecting wastewater.
A computerized module may be provided in electronic communication with all sensors and electrically-actuated valves disposed in an exemplary portable biomedical utilities console. An exemplary data module may be provided in electric communication with an appropriate breaker box as a power source, and in electronic communication with a network communication module capable of receiving and transmitting data and commands wirelessly and/or via wired data transmission to and from dialysis equipment, computers, and other medical equipment. Collected and transmitted data may include, but is not limited to, a patient's medical data. In addition to collecting and monitoring a patient's health data, an exemplary computerized module may also collect and monitor data related to the function of the console and any dialysis equipment used in conjunction therewith. An exemplary computerized module may also be used to receive and implement commands from a medical provider or other console operator, and to implement automated control programs such as the opening and closure of redundancy valves in the event of a drainage subsystem component failure.
In an exemplary embodiment of a portable biomedical utilities console, all fluid and electrical connection components are disposed in regular corresponding positions on an exterior console housing. In such an embodiment, when a plurality of consoles are lined up next to one another, corresponding utility connectors will be adjacent to one another. For example, a primary drain line of one exemplary console will align with the primary drain line of another exemplary console, a clean water line of one exemplary console will align with the clean water line of another exemplary console, and the main power bus of an exemplary console will align with the main power bus of another console. Such a configuration allows the consoles to be easily attached and detached within a given space, which in turn enables the layout of a dialysis treatment space to be easily configured.
An exemplary portable biomedical utilities console may include a control panel disposed on the exterior housing that both communicates information to the medical provider and can be used to operate the function of the utility subsystems within the console. An exemplary control panel may be provided in electronic or analog communication with all sensors disposed within a console housing and may be configured to communicate information such as the failure of a subsystem such as electrical (e.g., a circuit breaker trip or use of the UPS), drainage (e.g., pump failure of either the primary or backup pump, or both), and/or water supply (e.g., leak alarm). An exemplary control panel may also be used to monitor information localized to a given console, such as water pressure, water temperature, and power consumption.
An exemplary portable biomedical utilities console may be equipped with redundant 12-volt power supplies including a series of analog relays, contactors, and sensors configured to automatically control and monitor the subsystems within an exemplary console. Such a configuration ensures redundancy and ease of maintenance.
Additional features may be added to an exemplary portable biomedical utilities console for added convenience. Wheels may be affixed to the bottom of each console to allow for ease of placement or reconfiguration of a dialysis or other treatment room. Exemplary consoles need not be placed in direct connection with one another. When dialysis or other treatment room layouts call for additional space between dialysis or other treatment chairs, the space between consoles may be extended by placing between consoles an exemplary adjustable coupler panel. An exemplary adjustable coupler panel may include a cabinet assembly with utilities connectors disposed in locations corresponding to the placement of the same utility connectors in an exemplary portable biomedical utilities console. In such an embodiment, when a plurality of consoles are lined up next to one another in a relay, corresponding utility connectors will be adjacent to one another. For example, a primary drain line of one exemplary console will align with the primary drain line of an exemplary adjustable coupler pane, which may then be aligned with the primary drain line of another exemplary console, and so on.
An exemplary multipoint head control unit may be provided in wired or wireless electronic communication with all portable biomedical utilities consoles in a given console chain, dialysis treatment space, or dialysis treatment facility. An exemplary head control unit may be capable of receiving medical provider commands through digital or analog controls disposed on the exterior of the head control unit, or remotely from another digital computing device. The head control unit may also be capable of receiving information from system components of a plurality of consoles and transmitting that information back to the user through a provided control panel disposed on the exterior of the head control unit housing. Such information may include, but is not limited to, clean water pressure, rate of flow and temperature at all connected consoles, the temperature, rate of flow, and pressure of incoming externally-sourced water, whether any subsystem faults have been detected at any console, the status of each pump, network status, and various alarms for leak detection, the activation of a UPS, or a high level of used dialysate fluid or wastewater. A medical provider may input commands, such as a valve startup or shutoff command, various valve control commands, and alarm shutoff.
All references, including publications, patent applications, and patents, cited herein are hereby incorporated by reference to the same extent as if each reference were individually and specifically indicated to be incorporated by reference and were set forth in its entirety herein.
The use of the terms “a” and “an” and “the” and similar referents in the context of describing the disclosure (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The terms “comprising,” “having,” “including,” and “containing” are to be construed as open-ended terms (i.e., meaning “including, but not limited to,”) unless otherwise noted. Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., “such as”) provided herein, is intended merely to better illuminate the disclosure and does not pose a limitation on the scope of the disclosure unless otherwise claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the disclosure.
Preferred embodiments of this disclosure are described herein, including the best mode known to the inventors for carrying out the disclosure. Variations of those preferred embodiments may become apparent to those of ordinary skill in the art upon reading the foregoing description. The inventors expect skilled artisans to employ such variations as appropriate, and the inventors intend for the disclosure to be practiced otherwise than as specifically described herein. Accordingly, this disclosure includes all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law. Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by the disclosure unless otherwise indicated herein or otherwise clearly contradicted by context.
This application claims the benefit of, and priority from, U.S. Provisional Application No. 63/431,505, filed Dec. 9, 2022, the disclosures of which are hereby incorporated by reference in their entirety as if fully set forth herein.
Number | Date | Country | |
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63431505 | Dec 2022 | US |