POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1

Description

TECHNICAL FIELD

The present disclosure relates to compounds, compositions, and methods for treating muscarinic acetylcholine receptor M₁related diseases and/or disorders, such as neurological and psychiatric disorders.

BACKGROUND

Positive allosteric modulators are compounds that bind to a site distinct from that of the orthosteric agonist binding site of a target protein. These modulators enhance the affinity or efficacy of an orthosteric agonist. For example, a selective muscarinic M₁positive allosteric modulator would result in an increased affinity at the orthosteric binding site for acetylcholine (ACh), the endogenous agonist for the muscarinic M₁receptor, or an increase in the efficacy induced by ACh. In some systems, the compound may also have an intrinsic activity to activate the receptor in the absence of orthosteric ligand. Positive allosteric modulation (potentiation), therefore, can be an attractive mechanism for enhancing appropriate physiological receptor activation.

Cholinergic neurotransmission involves the activation of nicotinic acetylcholine receptors (nAChRs) or the muscarinic acetylcholine receptors (mAChRs) by the binding of the endogenous orthosteric agonist ACh. Acetylcholinesterase (AChE) inhibitors, which inhibit the hydrolysis of ACh, have been approved in the United States for use in the palliative, but not disease-modifying, treatment of the cognitive deficits in Alzheimer's disease (AD) patients.

mAChRs are members of the family A GPCRs, and include five subtypes, designated M₁, M₂, M₃, M₄, and M₅. M₁, M₃and M₅mainly couple to Gq and activate phospholipase C, whereas M₂and M₄mainly couple to G_i/oand associated effector systems. These five distinct mAChR subtypes have been identified in the mammalian central nervous system where they are prevalent and differentially expressed. M₁-M₅mAChRs have varying roles in cognitive, sensory, motor and autonomic functions. Activation of various muscarinic receptors, particularly the M₁subtype, has been proposed as a mechanism to enhance cognition in disorders such as AD and schizophrenia (as well as negative symptoms). Thus, selective positive allosteric modulators of mAChR subtypes that regulate processes involved in cognitive function could prove superior to AChE inhibitors for treatment of AD and related disorders as these compounds may exhibit improved selectivity for specific mAChRs.

Efforts to create selective M₁agonists have been largely unsuccessful, in part due to the high conservation of the orthosteric ACh binding site. As a result, mAChR agonists in clinical studies induce the same adverse effects of AChE inhibitors by activation of peripheral mAChRs. To fully understand the physiological roles of individual mAChR subtypes and to further explore the therapeutic utility of mACh receptors in AD, schizophrenia and other disorders, there exists a need to develop compounds that are highly selective modulators of M₁and other individual mAChR subtypes. Accordingly, allosteric modulation may be an advantageous pathway because allosteric sites on mAChRs are less highly conserved.

Despite advances in muscarinic receptor (mAChR) research, there remains a scarcity of compounds that are potent, efficacious and selective positive allosteric modulators of the M₁mAChR that are also effective in the treatment of neurological and psychiatric disorders associated with cholinergic activity, or other neurologic diseases in which the muscarinic M₁receptor may be involved.

SUMMARY OF THE INVENTION

In one aspect, disclosed are compounds of formula (I),

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or a pharmaceutically acceptable salt thereof, wherein: X is CR^3aor N; Y is CR^3bor N; Z is S, O, or NR⁴; L is —[C(R^aR^b)]_p—, C₂-C₆-alkenylenyl, C(O), O, or S; A¹is Cyc¹or Cyc²-Q-Cyc³; R¹is hydrogen, alkyl, alkoxy, alkoxyalkyl, halogen, cyano, or haloalkyl; R²is hydrogen, alkyl or haloalkyl; M is a bond, C₂-C₆-alkenylenyl, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cyanoalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; or A²and R², together with the atoms to which they are attached, form a heterocycle; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen; R⁴is hydrogen, or alkyl; R⁵is independently, at each occurrence, hydrogen, alkyl, or —C(O)R^g; Cyc¹is aryl, heteroaryl, heterocycle or cycloalkyl; Cyc²is aryl, heteroaryl, heterocycle or cycloalkyl; Q is a bond, C₁-C₆-alkylenyl, C₂-C₆-alkenylenyl, C(O)NH, O, S, or NR⁵; Cyc³is aryl, heteroaryl, heterocycle or cycloalkyl; R^a, R^b, R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, haloalkyl, hydroxy, cyano, alkoxy, alkoxyalkyl, or halogen; p is 0, 1, 2, 3, 4, 5, or 6; t is 0, 1, 2, or 3; k is 0, 1, 2, or 3; and R^gis independently, at each occurrence, alkyl, aryl, heteroaryl, cycloalkyl or alkoxy; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, and methods of using the compounds for treatment of M₁muscarinic acetylcholine receptor related diseases and/or disorders.

DETAILED DESCRIPTION

Disclosed herein are positive allosteric modulators of the M₁muscarinic acetylcholine receptor M₁(mAChR M₁). The modulators can have the structure of formula (I). Compounds of formula (I) exhibit high affinity for mAChR M₁, and can also exhibit selectivity over other muscarinic acetylcholine receptors. Compounds of formula (I) can be used to treat or prevent diseases and disorders associated with mAChR M₁by modulating mAChR M₁activity. mAChR M₁has been implicated in a number of different diseases and disorders including, but not limited to, neurological and psychiatric disorders.

Since the orthosteric binding sites of the mAChR isoforms are highly conserved, selective modulators of the mAChRs that bind at the orthosteric site remain elusive. One strategy to selectively bind and modulate the mAChRs includes identifying allosteric sites which may be amenable to modulation by a small molecule. In particular, positive allosteric modulation of mAChR M₁can result in potentiation of the mAChR M₁receptor and provide therapeutic benefits for disorders associated with mAChR M₁dysfunction.

1. DEFINITIONS

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In case of conflict, the present document, including definitions, will control. Preferred methods and materials are described below, although methods and materials similar or equivalent to those described herein can be used in practice or testing of the present invention. All publications, patent applications, patents and other references mentioned herein are incorporated by reference in their entirety. The materials, methods, and examples disclosed herein are illustrative only and not intended to be limiting.

The terms “comprise(s),” “include(s),” “having,” “has,” “can,” “contain(s),” and variants thereof, as used herein, are intended to be open-ended transitional phrases, terms, or words that do not preclude the possibility of additional acts or structures. The singular forms “a,” “an” and “the” include plural references unless the context clearly dictates otherwise. The present disclosure also contemplates other embodiments “comprising,” “consisting of” and “consisting essentially of,” the embodiments or elements presented herein, whether explicitly set forth or not.

The modifier “about” used in connection with a quantity is inclusive of the stated value and has the meaning dictated by the context (for example, it includes at least the degree of error associated with the measurement of the particular quantity). The modifier “about” should also be considered as disclosing the range defined by the absolute values of the two endpoints. For example, the expression “from about 2 to about 4” also discloses the range “from 2 to 4.” The term “about” may refer to plus or minus 10% of the indicated number. For example, “about 10%” may indicate a range of 9% to 11%, and “about 1” may mean from 0.9-1.1. Other meanings of “about” may be apparent from the context, such as rounding off, so, for example “about 1” may also mean from 0.5 to 1.4.

Definitions of specific functional groups and chemical terms are described in more detail below. For purposes of this disclosure, the chemical elements are identified in accordance with the Periodic Table of the Elements, CAS version, Handbook of Chemistry and Physics, 75^thEd., inside cover, and specific functional groups are generally defined as described therein. Additionally, general principles of organic chemistry, as well as specific functional moieties and reactivity, are described in Organic Chemistry, Thomas Sorrell, University Science Books, Sausalito, 1999; Smith and March March's Advanced Organic Chemistry, 5^thEdition, John Wiley & Sons, Inc., New York, 2001; Larock, Comprehensive Organic Transformations, VCH Publishers, Inc., New York, 1989; Carruthers, Some Modern Methods of Organic Synthesis, 3^rdEdition, Cambridge University Press, Cambridge, 1987; the entire contents of each of which are incorporated herein by reference.

The term “alkoxy,” as used herein, refers to an alkyl group, as defined herein, appended to the parent molecular moiety through an oxygen atom. Representative examples of alkoxy include, but are not limited to, methoxy, ethoxy, propoxy, 2-propoxy, butoxy and tert-butoxy.

The term “alkyl,” as used herein, means a straight or branched, saturated hydrocarbon chain containing from 1 to 10 carbon atoms. The term “lower alkyl” or “C₁-C₆-alkyl” means a straight or branched chain hydrocarbon containing from 1 to 6 carbon atoms. The term “C₁-C₃-alkyl” means a straight or branched chain hydrocarbon containing from 1 to 3 carbon atoms. Representative examples of alkyl include, but are not limited to, methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl, 3-methylhexyl, 2,2-dimethylpentyl, 2,3-dimethylpentyl, n-heptyl, n-octyl, n-nonyl, and n-decyl.

The term “alkenyl,” as used herein, means a straight or branched, hydrocarbon chain containing at least one carbon-carbon double bond and from 1 to 10 carbon atoms.

The term “alkoxyalkyl,” as used herein, refers to an alkoxy group, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein.

The term “alkoxyfluoroalkyl,” as used herein, refers to an alkoxy group, as defined herein, appended to the parent molecular moiety through a fluoroalkyl group, as defined herein.

The term “alkylene,” as used herein, refers to a divalent group derived from a straight or branched chain hydrocarbon of 1 to 10 carbon atoms, for example, of 2 to 5 carbon atoms. Representative examples of alkylene include, but are not limited to, —CH₂CH₂—, —CH₂CH₂CH₂—, —CH₂CH₂CH₂CH₂—, and —CH₂CH₂CH₂CH₂CH₂—.

The term “alkenylenyl,” as used herein, refers to a divalent group derived from a straight or branched chain hydrocarbon of 1 to 10 carbon atoms, wherein at least one carbon-carbon bond is a double bond.

The term “alkylamino,” as used herein, means at least one alkyl group, as defined herein, is appended to the parent molecular moiety through an amino group, as defined herein.

The term “amide,” as used herein, means —C(O)NR— or —NRC(O)—, wherein R may be hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, heterocycle, alkenyl, or heteroalkyl.

The term “aminoalkyl,” as used herein, means at least one amino group, as defined herein, is appended to the parent molecular moiety through an alkylene group, as defined herein.

The term “amino,” as used herein, means —NR_xR_y, wherein R_xand R_ymay be hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, heterocycle, alkenyl, or heteroalkyl. In the case of an aminoalkyl group or any other moiety where amino appends together two other moieties, amino may be —NR_x—, wherein R_xmay be hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, heterocycle, alkenyl, or heteroalkyl.

The term “aryl,” as used herein, refers to a phenyl group, or a bicyclic fused ring system. Bicyclic fused ring systems are exemplified by a phenyl group appended to the parent molecular moiety and fused to a cycloalkyl group, as defined herein, a phenyl group, a heteroaryl group, as defined herein, or a heterocycle, as defined herein. Representative examples of aryl include, but are not limited to, indolyl, naphthyl, phenyl, quinolinyl and tetrahydroquinolinyl.

The term “cyanoalkyl,” as used herein, means at least one —CN group, is appended to the parent molecular moiety through an alkylene group, as defined herein.

The term “cyanofluoroalkyl,” as used herein, means at least one —CN group, is appended to the parent molecular moiety through a fluoroalkyl group, as defined herein.

The term “cycloalkyl,” as used herein, refers to a carbocyclic ring system containing three to ten carbon atoms, zero heteroatoms and zero double bonds. Representative examples of cycloalkyl include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, adamantyl, and bicyclo[1.1.1]pentanyl. “Cycloalkyl” also includes carbocyclic ring systems in which a cycloalkyl group is appended to the parent molecular moiety and is fused to a phenyl group, a heteroaryl group as defined herein, or a heterocycle as defined herein. Representative examples of such cycloalkyl groups include, but are not limited to, 2,3-dihydro-1H-indenyl (e.g., 2,3-dihydro-1H-inden-1-yl and 2,3-dihydro-1H-inden-2-yl), 6,7-dihydro-5H-cyclopenta[b]pyridinyl (e.g., 6,7-dihydro-5H-cyclopenta[b]pyridin-6-yl), oxaspiro[3.3]heptanyl (e.g., 2-oxaspiro[3.3]heptan-6-yl), and 5,6,7,8-tetrahydroquinolinyl (e.g., 5,6,7,8-tetrahydroquinolin-5-yl).

The term “cycloalkenyl,” as used herein, means a non-aromatic monocyclic or multicyclic ring system containing at least one carbon-carbon double bond and preferably having from 5-10 carbon atoms per ring. Exemplary monocyclic cycloalkenyl rings include cyclopentenyl, cyclohexenyl or cycloheptenyl.

The term “fluoroalkyl,” as used herein, means an alkyl group, as defined herein, in which one, two, three, four, five, six, seven or eight hydrogen atoms are replaced by fluorine. Representative examples of fluoroalkyl include, but are not limited to, 2-fluoroethyl, 2,2,2-trifluoroethyl, trifluoromethyl, difluoromethyl, pentafluoroethyl, and trifluoropropyl such as 3,3,3-trifluoropropyl.

The term “fluoroalkoxy,” as used herein, means at least one fluoroalkyl group, as defined herein, is appended to the parent molecular moiety through an oxygen atom. Representative examples of fluoroalkoxy include, but are not limited to, difluoromethoxy, trifluoromethoxy and 2,2,2-trifluoroethoxy.

The term “halogen” or “halo,” as used herein, means Cl, Br, I, or F.

The term “haloalkyl,” as used herein, means an alkyl group, as defined herein, in which one, two, three, four, five, six, seven or eight hydrogen atoms are replaced by a halogen.

The term “haloalkoxy,” as used herein, means at least one haloalkyl group, as defined herein, is appended to the parent molecular moiety through an oxygen atom.

The term “halocycloalkyl,” as used herein, means a cycloalkyl group, as defined herein, in which one or more hydrogen atoms are replaced by a halogen.

The term “heteroalkyl,” as used herein, means an alkyl group, as defined herein, in which one or more of the carbon atoms has been replaced by a heteroatom selected from S, O, P and N. Representative examples of heteroalkyls include, but are not limited to, alkyl ethers, secondary and tertiary alkyl amines, amides, and alkyl sulfides.

The term “heteroaryl,” as used herein, refers to an aromatic monocyclic ring or an aromatic bicyclic ring system. The aromatic monocyclic rings are five or six membered rings containing at least one heteroatom independently selected from the group consisting of N, O and S (e.g. 1, 2, 3, or 4 heteroatoms independently selected from O, S, and N). The five membered aromatic monocyclic rings have two double bonds and the six membered six membered aromatic monocyclic rings have three double bonds. The bicyclic heteroaryl groups are exemplified by a monocyclic heteroaryl ring appended to the parent molecular moiety and fused to a monocyclic cycloalkyl group, as defined herein, a monocyclic aryl group, as defined herein, a monocyclic heteroaryl group, as defined herein, or a monocyclic heterocycle, as defined herein. Representative examples of heteroaryl include, but are not limited to, indolyl, pyridinyl (including pyridin-2-yl, pyridin-3-yl, pyridin-4-yl), pyrimidinyl, pyrazinyl, pyridazinyl, pyrazolyl, pyrrolyl, benzopyrazolyl, 1,2,3-triazolyl, 1,3,4-thiadiazolyl, 1,2,4-thiadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-oxadiazolyl, imidazolyl, thiazolyl, isothiazolyl, thienyl, benzimidazolyl, benzothiazolyl, benzoxazolyl, benzoxadiazolyl, benzothienyl, benzofuranyl, isobenzofuranyl, furanyl, oxazolyl, isoxazolyl, purinyl, isoindolyl, quinoxalinyl, indazolyl, quinazolinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, isoquinolinyl, quinolinyl, 6,7-dihydro-1,3-benzothiazolyl, imidazo[1,2-a]pyridinyl, naphthyridinyl, pyridoimidazolyl, thiazolo[5,4-b]pyridin-2-yl, thiazolo[5,4-d]pyrimidin-2-yl.

The term “heterocycle” or “heterocyclic,” as used herein, means a monocyclic heterocycle, a bicyclic heterocycle, or a tricyclic heterocycle. The monocyclic heterocycle is a three-, four-, five-, six-, seven-, or eight-membered ring containing at least one heteroatom independently selected from the group consisting of O, N, and S. The three- or four-membered ring contains zero or one double bond, and one heteroatom selected from the group consisting of O, N, and S. The five-membered ring contains zero or one double bond and one, two or three heteroatoms selected from the group consisting of O, N and S. The six-membered ring contains zero, one or two double bonds and one, two, or three heteroatoms selected from the group consisting of O, N, and S. The seven- and eight-membered rings contains zero, one, two, or three double bonds and one, two, or three heteroatoms selected from the group consisting of O, N, and S. Representative examples of monocyclic heterocycles include, but are not limited to, azetidinyl, azepanyl, aziridinyl, diazepanyl, 1,3-dioxanyl, 1,3-dioxolanyl, 1,3-dithiolanyl, 1,3-dithianyl, imidazolinyl, imidazolidinyl, isothiazolinyl, isothiazolidinyl, isoxazolinyl, isoxazolidinyl, morpholinyl, 2-oxo-3-piperidinyl, 2-oxoazepan-3-yl, oxadiazolinyl, oxadiazolidinyl, oxazolinyl, oxazolidinyl, oxetanyl, oxepanyl, oxocanyl, piperazinyl, piperidinyl, pyranyl, pyrazolinyl, pyrazolidinyl, pyrrolinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydropyridinyl, tetrahydrothienyl, thiadiazolinyl, thiadiazolidinyl, 1,2-thiazinanyl, 1,3-thiazinanyl, thiazolinyl, thiazolidinyl, thiomorpholinyl, 1,1-dioxidothiomorpholinyl (thiomorpholine sulfone), thiopyranyl, and trithianyl. The bicyclic heterocycle is a monocyclic heterocycle fused to a phenyl group, or a monocyclic heterocycle fused to a monocyclic cycloalkyl, or a monocyclic heterocycle fused to a monocyclic cycloalkenyl, or a monocyclic heterocycle fused to a monocyclic heterocycle, or a spiro heterocycle group, or a bridged monocyclic heterocycle ring system in which two non-adjacent atoms of the ring are linked by an alkylene bridge of 1, 2, 3, or 4 carbon atoms, or an alkenylene bridge of two, three, or four carbon atoms. Representative examples of bicyclic heterocycles include, but are not limited to, benzopyranyl, benzothiopyranyl, chromanyl, 2,3-dihydrobenzofuranyl, 2,3-dihydrobenzothienyl, 2,3-dihydroisoquinoline, 2-azaspiro[3.3]heptan-2-yl, 2-oxa-6-azaspiro[3.3]heptan-6-yl, azabicyclo[2.2.1]heptyl (including 2-azabicyclo[2.2.1]hept-2-yl), azabicyclo[3.1.0]hexanyl (including 3-azabicyclo[3.1.0]hexan-3-yl), 2,3-dihydro-1H-indolyl, isoindolinyl, octahydrocyclopenta[c]pyrrolyl, octahydropyrrolopyridinyl, and tetrahydroisoquinolinyl. Tricyclic heterocycles are exemplified by a bicyclic heterocycle fused to a phenyl group, or a bicyclic heterocycle fused to a monocyclic cycloalkyl, or a bicyclic heterocycle fused to a monocyclic cycloalkenyl, or a bicyclic heterocycle fused to a monocyclic heterocycle, or a bicyclic heterocycle in which two non-adjacent atoms of the bicyclic ring are linked by an alkylene bridge of 1, 2, 3, or 4 carbon atoms, or an alkenylene bridge of two, three, or four carbon atoms. Examples of tricyclic heterocycles include, but are not limited to, octahydro-2,5-epoxypentalene, hexahydro-2H-2,5-methanocyclopenta[b]furan, hexahydro-1H-1,4-methanocyclopenta[c]furan, aza-adamantane (1-azatricyclo[3.3.1.1^3,7]decane), and oxa-adamantane (2-oxatricyclo[3.3.1.1^3,7]decane). The monocyclic, bicyclic, and tricyclic heterocycles are connected to the parent molecular moiety through any carbon atom or any nitrogen atom contained within the rings, and can be unsubstituted or substituted.

The term “hydroxyl” or “hydroxy,” as used herein, means an —OH group.

The term “hydroxyalkyl,” as used herein, means at least one —OH group, is appended to the parent molecular moiety through an alkylene group, as defined herein.

The term “hydroxyfluoroalkyl,” as used herein, means at least one —OH group, is appended to the parent molecular moiety through a fluoroalkyl group, as defined herein.

In some instances, the number of carbon atoms in a hydrocarbyl substituent (e.g., alkyl or cycloalkyl) is indicated by the prefix “C_x-C_y-,” wherein x is the minimum and y is the maximum number of carbon atoms in the substituent. Thus, for example, “C₁-C₃-alkyl” refers to an alkyl substituent containing from 1 to 3 carbon atoms.

The term “sulfonamide,” as used herein, means —S(O)₂NR^d— or —NR^dS(O)—, wherein R^dmay be hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, heterocycle, alkenyl, or heteroalkyl.

The term “substituents” refers to a group “substituted” on an aryl, heteroaryl, phenyl or pyridinyl group at any atom of that group. Any atom can be substituted.

The term “substituted” refers to a group that may be further substituted with one or more non-hydrogen substituent groups. Substituent groups include, but are not limited to, halogen, ═O (oxo), ═S (thioxo), cyano, nitro, fluoroalkyl, alkoxyfluoroalkyl, fluoroalkoxy, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, heteroalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocycle, cycloalkylalkyl, heteroarylalkyl, arylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkylene, aryloxy, phenoxy, benzyloxy, amino, alkylamino, acylamino, aminoalkyl, arylamino, sulfonylamino, sulfinylamino, sulfonyl, alkyl sulfonyl, aryl sulfonyl, aminosulfonyl, sulfinyl, —COOH, ketone, amide, carbamate, and acyl. For example, if a group is described as being “optionally substituted” (such as an alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heteroalkyl, heterocycle or other group such as an R group), it may have 0, 1, 2, 3, 4 or 5 substituents independently selected from halogen, ═O (oxo), ═S (thioxo), cyano, nitro, fluoroalkyl, alkoxyfluoroalkyl, fluoroalkoxy, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, heteroalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocycle, cycloalkylalkyl, heteroarylalkyl, arylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkylene, aryloxy, phenoxy, benzyloxy, amino, alkylamino, acylamino, aminoalkyl, arylamino, sulfonylamino, sulfinylamino, sulfonyl, alkyl sulfonyl, aryl sulfonyl, aminosulfonyl, sulfinyl, —COOH, ketone, amide, carbamate, and acyl.

For compounds described herein, groups and substituents thereof may be selected in accordance with permitted valence of the atoms and the substituents, such that the selections and substitutions result in a stable compound, e.g., which does not spontaneously undergo transformation such as by rearrangement, cyclization, elimination, etc.

For the recitation of numeric ranges herein, each intervening number there between with the same degree of precision is explicitly contemplated. For example, for the range of 6-9, the numbers 7 and 8 are contemplated in addition to 6 and 9, and for the range 6.0-7.0, the number 6.0, 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9, and 7.0 are explicitly contemplated.

2. COMPOUNDS

In one aspect, disclosed is a compound of formula (I):

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In certain embodiments, X is CR^3aor N; Y is CR^3bor N; Z is S, O, or NR⁴; L is —[C(R^aR^b)]_p—, C₂-C₆-alkenylenyl, C(O), O, or S; A¹is Cyc¹or Cyc²-Q-Cyc³; R¹is hydrogen, alkyl, alkoxy, alkoxyalkyl, halogen, cyano, or haloalkyl; R²is hydrogen, alkyl or haloalkyl; M is a bond, C₂-C₆-alkenylenyl, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cyanoalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; or A²and R², together with the atoms to which they are attached, form a heterocycle; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen; R⁴is hydrogen, or alkyl; R⁵is independently, at each occurrence, hydrogen, alkyl, or —C(O)R^g; Cyc¹is aryl, heteroaryl, heterocycle or cycloalkyl; Cyc²is aryl, heteroaryl, heterocycle or cycloalkyl; Q is a bond, C₁-C₆-alkylenyl, C₂-C₆-alkenylenyl, C(O)NH, O, S, or NR⁵; Cyc³is aryl, heteroaryl, heterocycle or cycloalkyl; R^a, R^b, R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, haloalkyl, hydroxy, cyano, alkoxy, alkoxyalkyl, or halogen; p is 0, 1, 2, 3, 4, 5, or 6; t is 0, 1, 2, or 3; k is 0, 1, 2, or 3; and R^gis independently, at each occurrence, alkyl, aryl, heteroaryl, cycloalkyl or alkoxy; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted with 1, 2, 3, 4, 5, 6, or 7 functional groups independently selected from the group consisting of halogen, ═O, ═S, cyano, cyanoalkyl, cyanofluoroalkyl, nitro, fluoroalkyl, alkoxyfluoroalkyl, fluoroalkoxy, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, heteroalkyl, cycloalkyl, halocycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocycle, cycloalkylalkyl, heteroarylalkyl, arylalkyl, hydroxy, hydroxyalkyl, hydroxyfluoroalkyl, alkoxy, alkoxyalkyl, alkylene, aryloxy, phenoxy, benzyloxy, amino, alkylamino, acylamino, aminoalkyl, arylamino, sulfonylamino, sulfinylamino, sulfonyl, alkyl sulfonyl, aryl sulfonyl, aminosulfonyl, sulfinyl, —COOH, ketone, amide, carbamate, and acyl.

In certain embodiments, X is CR^3a; Y is CR^3bor N; Z is S, O, or NR⁴; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen; and R⁴is hydrogen, or alkyl.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S, O, or NR⁴; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen; and R⁴is hydrogen, or alkyl.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S, or O; and R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is NR⁴; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen; and R⁴is hydrogen, or alkyl. In certain embodiments, X is CR^3a; Y is CR^3b; Z is NR⁴; R^3ais hydrogen, or alkyl; R^3bis hydrogen, or alkyl; and R⁴is hydrogen, or alkyl. In certain embodiments, X is CR^3a; Y is CR^3b; Z is NR⁴; R^3ais hydrogen; R^3bis hydrogen; and R⁴is hydrogen, or alkyl. In certain embodiments, X is CR^3a; Y is CR^3b; Z is NR⁴; R^3ais hydrogen; R^3bis hydrogen; and R⁴is hydrogen. In certain embodiments, X is CR^3a; Y is CR^3b; Z is NR⁴; R^3ais hydrogen; R^3bis hydrogen; and R⁴is alkyl.

In certain embodiments, X is CR^3a; Y is N; Z is NR⁴; R^3ais hydrogen, or alkyl; and R⁴is hydrogen, or alkyl. In certain embodiments, X is CR^3a; Y is N; Z is NR⁴; R^3ais hydrogen; and R⁴is hydrogen. In certain embodiments, X is CR^3a; Y is N; Z is NR⁴; R^3ais hydrogen; and R⁴is alkyl.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is O; and R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen. In certain embodiments, X is CR^3a; Y is CR^3b; Z is O; and R^3aand R^3bare each independently selected from hydrogen and alkyl. In certain embodiments, X is CR^3a; Y is CR^3b; Z is O; R^3ais hydrogen; and R^3bis hydrogen.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S; and R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen. In certain embodiments, X is CR^3a; Y is CR^3b; Z is S; and R^3aand R^3bare each independently selected from hydrogen and alkyl. In certain embodiments, X is CR^3a; Y is CR^3b; Z is S; R^3ais hydrogen; and R^3bis hydrogen.

In certain embodiments, L is —[C(R^aR^b)]_p—, C(O), or O; R^aand R^bare each independently hydrogen, alkyl, or halogen; and p is 0, 1, 2, or 3.

In certain embodiments, L is O.

In certain embodiments, L is C(O).

In certain embodiments, L is —[C(R^aR^b)]_p—; R^aand R^bare each independently hydrogen, alkyl, alkoxy, or halogen; and p is 0, 1, 2, or 3.

In certain embodiments, L is —[C(R^aR^b)]_p—; R^aand R^bare each independently hydrogen, alkoxy, or halogen; and p is 1, 2, or 3. In certain embodiments, L is —[C(R^aR^b)]_p—; R^aand R^bare each independently hydrogen, alkoxy, or halogen; and p is 1. In certain embodiments, L is —[C(R^aR^b)]_p—; R^aand R^bare each independently hydrogen, ethoxy, or fluorine; and p is 1, 2, or 3. In certain embodiments, L is —[C(R^aR^b)]_p—; R^aand R^bare each independently hydrogen, ethoxy, or fluorine; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; R^aand R^bare each hydrogen; and p is 1, 2, or 3. In certain embodiments, L is —[C(R^aR^b)]_p—; R^aand R^bare each hydrogen; and p is 1.

In certain embodiments, A¹is Cyc¹or Cyc²-Q-Cyc³; Cyc¹is aryl, or heteroaryl; Cyc²is aryl, or heteroaryl; Q is a bond or C(O)NH; and Cyc³is aryl, heteroaryl, cyclyl, or heterocyclyl.

In certain embodiments, A¹is Cyc¹or Cyc²-Q-Cyc³; Cyc¹is aryl, or heteroaryl; Cyc²is aryl, or heteroaryl; Q is a bond; and Cyc³is aryl, or heteroaryl.

In certain embodiments, A¹is Cyc¹or Cyc²-Q-Cyc³; Cyc¹is heteroaryl; Cyc²is aryl, or heteroaryl; Q is a bond; and Cyc³is heteroaryl.

In certain embodiments, A¹is Cyc¹or Cyc²-Q-Cyc³; Cyc¹is heteroaryl; Cyc²is aryl; Q is a bond; and Cyc³is heteroaryl.

In certain embodiments, A¹is Cyc¹or Cyc²-Q-Cyc³; Cyc¹is heteroaryl; Cyc²is heteroaryl; Q is a bond; and Cyc³is heteroaryl.

In certain embodiments, A¹is Cyc¹; and Cyc¹is heteroaryl. In certain embodiments, A¹is Cyc¹; and Cyc¹is pyridyl, thiazolyl or pyrimidinyl. In certain embodiments, A¹is Cyc¹; and Cyc¹is pyridyl, thiazolyl or pyrimidinyl substituted with at least one alkyl or haloalkyl. In certain embodiments, A¹is Cyc¹; and Cyc¹is pyridyl, thiazolyl or pyrimidinyl substituted with one or two substituents independently selected from methyl and trifluoromethyl.

In certain embodiments, A¹is Cyc¹; and Cyc¹is pyridyl. In certain embodiments, A¹is Cyc¹; and Cyc¹is pyridyl substituted with at least one alkyl. In certain embodiments, A¹is Cyc¹; and Cyc¹is pyridyl substituted with one or two methyl groups.

In certain embodiments, A¹is Cyc¹; and Cyc¹is thiazolyl. In certain embodiments, A¹is Cyc¹; and Cyc¹is thiazolyl substituted with at least one alkyl. In certain embodiments, A¹is Cyc¹; and Cyc¹is thiazolyl substituted with one methyl group.

In certain embodiments, A¹is Cyc¹; and Cyc¹is pyrimidinyl. In certain embodiments, A¹is Cyc¹; and Cyc¹is pyrimidinyl substituted with at least one alkyl. In certain embodiments, A¹is Cyc¹; and Cyc¹is pyrimidinyl substituted with one methyl group.

In certain embodiments, A¹is Cyc²-Q-Cyc³; Cyc²is aryl, or heteroaryl; Q is a bond; and Cyc³is heteroaryl. In certain embodiments, A¹is Cyc²-Q-Cyc³; Cyc²is phenyl or pyridyl; Q is a bond; and Cyc³is pyrazolyl, thiazolyl, oxazolyl, triazolyl, or benzopyrazolyl. In certain embodiments, A¹is Cyc²-Q-Cyc³; Cyc²is phenyl that is unsubstituted or substituted with one or two halogens, or pyridyl; Q is a bond; and Cyc³is pyrazolyl, thiazolyl, oxazolyl, triazolyl, or benzopyrazolyl, each of which may be unsubstituted or substituted with 1, 2 or 3 alkyl groups (e.g., methyl).

In certain embodiments, A¹is Cyc²-Q-Cyc³; Cyc²is aryl; Q is a bond; and Cyc³is heteroaryl. In certain embodiments, A¹is Cyc²-Q-Cyc³; Cyc²is phenyl; Q is a bond; and Cyc³is pyrazolyl, or benzopyrazolyl. In certain embodiments, A¹is Cyc²-Q-Cyc³; Cyc²is phenyl; Q is a bond; and Cyc³is pyrazolyl, or benzopyrazolyl. In certain embodiments, A¹is Cyc²-Q-Cyc³; Cyc²is phenyl substituted with at least one halogen; Q is a bond; and Cyc³is pyrazolyl substituted with at least one alkyl, or benzopyrazolyl substituted with at least one alkyl.

In certain embodiments, Cyc¹is a monocyclic aryl. In certain embodiments, Cyc¹is a bicyclic aryl. In certain embodiments, Cyc¹is a monocyclic heteroaryl. In certain embodiments, Cyc¹is a bicyclic heteroaryl. In certain embodiments, Cyc¹is a monocyclic heterocycle. In certain embodiments, Cyc¹is bicyclic heterocycle. In certain embodiments, Cyc¹is a monocyclic heterocycle fused to a phenyl group. In certain embodiments, Cyc¹is a monocyclic heterocycle fused to a monocyclic cycloalkenyl. In certain embodiments, Cyc¹is a monocyclic heterocycle fused to a monocyclic heterocycle. In certain embodiments, Cyc¹is a spiro heterocycle. In certain embodiments, Cyc¹is a bridged monocyclic heterocycle ring system. In certain embodiments, Cyc¹is a tricyclic heterocycle. In certain embodiments, Cyc¹is a bicyclic heterocycle fused to a phenyl group. In certain embodiments, Cyc¹is a bicyclic heterocycle fused to a monocyclic cycloalkyl. In certain embodiments, Cyc¹is a bicyclic heterocycle fused to a monocyclic cycloalkenyl. In certain embodiments, Cyc¹is a bicyclic heterocycle fused to a monocyclic heterocycle. In certain embodiments, Cyc¹is a bicyclic heterocycle in which two non-adjacent atoms of the bicyclic ring are linked by an alkylene bridge. In certain embodiments, Cyc¹is an aromatic monocyclic ring. In certain embodiments, Cyc¹is an aromatic bicyclic ring system. In certain embodiments, Cyc¹is a cycloalkyl. In certain embodiments, Cyc¹is a C₃-C₈cycloalkyl. In certain embodiments, Cyc¹is unsubstituted. In certain embodiments, Cyc¹is substituted with 1, 2, 3, 4, 5, 6, or 7 functional groups independently selected from the group consisting of halogen, ═O, ═S, cyano, nitro, fluoroalkyl, alkoxyfluoroalkyl, fluoroalkoxy, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, heteroalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocycle, cycloalkylalkyl, heteroarylalkyl, arylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkylene, aryloxy, phenoxy, benzyloxy, amino, alkylamino, acylamino, aminoalkyl, arylamino, sulfonylamino, sulfinylamino, sulfonyl, alkyl sulfonyl, aryl sulfonyl, aminosulfonyl, sulfinyl, —COOH, ketone, amide, carbamate, and acyl.

In certain embodiments, Cyc²is a monocyclic aryl. In certain embodiments, Cyc²is a bicyclic aryl. In certain embodiments, Cyc²is a monocyclic heteroaryl. In certain embodiments, Cyc²is a bicyclic heteroaryl. In certain embodiments, Cyc²is a monocyclic heterocycle. In certain embodiments, Cyc²is bicyclic heterocycle. In certain embodiments, Cyc²is a monocyclic heterocycle fused to a phenyl group. In certain embodiments, Cyc²is a monocyclic heterocycle fused to a monocyclic cycloalkenyl. In certain embodiments, Cyc²is a monocyclic heterocycle fused to a monocyclic heterocycle. In certain embodiments, Cyc²is a spiro heterocycle. In certain embodiments, Cyc²is a bridged monocyclic heterocycle ring system. In certain embodiments, Cyc²is a tricyclic heterocycle. In certain embodiments, Cyc²is a bicyclic heterocycle fused to a phenyl group. In certain embodiments, Cyc²is a bicyclic heterocycle fused to a monocyclic cycloalkyl. In certain embodiments, Cyc²is a bicyclic heterocycle fused to a monocyclic cycloalkenyl. In certain embodiments, Cyc²is a bicyclic heterocycle fused to a monocyclic heterocycle. In certain embodiments, Cyc²is a bicyclic heterocycle in which two non-adjacent atoms of the bicyclic ring are linked by an alkylene bridge. In certain embodiments, Cyc²is an aromatic monocyclic ring. In certain embodiments, Cyc²is an aromatic bicyclic ring system. In certain embodiments, Cyc²is a cycloalkyl. In certain embodiments, Cyc²is a C₃-C₈cycloalkyl. In certain embodiments, Cyc²is unsubstituted. In certain embodiments, Cyc²is substituted with 1, 2, 3, 4, 5, 6, or 7 functional groups independently selected from the group consisting of halogen, ═O, ═S, cyano, nitro, fluoroalkyl, alkoxyfluoroalkyl, fluoroalkoxy, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, heteroalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocycle, cycloalkylalkyl, heteroarylalkyl, arylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkylene, aryloxy, phenoxy, benzyloxy, amino, alkylamino, acylamino, aminoalkyl, arylamino, sulfonylamino, sulfinylamino, sulfonyl, alkyl sulfonyl, aryl sulfonyl, aminosulfonyl, sulfinyl, —COOH, ketone, amide, carbamate, and acyl.

In certain embodiments, Cyc³is a monocyclic aryl. In certain embodiments, Cyc³is a bicyclic aryl. In certain embodiments, Cyc³is a monocyclic heteroaryl. In certain embodiments, Cyc³is a bicyclic heteroaryl. In certain embodiments, Cyc³is a monocyclic heterocycle. In certain embodiments, Cyc³is bicyclic heterocycle. In certain embodiments, Cyc³is a monocyclic heterocycle fused to a phenyl group. In certain embodiments, Cyc³is a monocyclic heterocycle fused to a monocyclic cycloalkenyl. In certain embodiments, Cyc³is a monocyclic heterocycle fused to a monocyclic heterocycle. In certain embodiments, Cyc³is a spiro heterocycle. In certain embodiments, Cyc³is a bridged monocyclic heterocycle ring system. In certain embodiments, Cyc³is a tricyclic heterocycle. In certain embodiments, Cyc³is a bicyclic heterocycle fused to a phenyl group. In certain embodiments, Cyc³is a bicyclic heterocycle fused to a monocyclic cycloalkyl. In certain embodiments, Cyc³is a bicyclic heterocycle fused to a monocyclic cycloalkenyl. In certain embodiments, Cyc³is a bicyclic heterocycle fused to a monocyclic heterocycle. In certain embodiments, Cyc³is a bicyclic heterocycle in which two non-adjacent atoms of the bicyclic ring are linked by an alkylene bridge. In certain embodiments, Cyc³is an aromatic monocyclic ring. In certain embodiments, Cyc³is an aromatic bicyclic ring system. In certain embodiments, Cyc³is a cycloalkyl. In certain embodiments, Cyc³is a C₃-C₈cycloalkyl. In certain embodiments, Cyc³is unsubstituted. In certain embodiments, Cyc³is substituted with 1, 2, 3, 4, 5, 6, or 7 functional groups independently selected from the group consisting of halogen, ═O, ═S, cyano, nitro, fluoroalkyl, alkoxyfluoroalkyl, fluoroalkoxy, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, heteroalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocycle, cycloalkylalkyl, heteroarylalkyl, arylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkylene, aryloxy, phenoxy, benzyloxy, amino, alkylamino, acylamino, aminoalkyl, arylamino, sulfonylamino, sulfinylamino, sulfonyl, alkyl sulfonyl, aryl sulfonyl, aminosulfonyl, sulfinyl, —COOH, ketone, amide, carbamate, and acyl.

In certain embodiments, R¹is hydrogen.

In certain embodiments, R²is hydrogen, or alkyl; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0, 1, or 2; and k is 0, 1, or 2.

In certain embodiments, R²is hydrogen; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0, 1, or 2; and k is 0, 1, or 2.

In certain embodiments, R²is hydrogen, or methyl; and M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; R^c, R^d, R^e, and R^fare each independently hydrogen or alkyl; t is 0, or 1; and k is 0, or 1.

In certain embodiments, R²is hydrogen, or methyl; and M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; R^c, R^d, R^e, and R^fare each independently hydrogen or alkyl; t is 0, or 1; and k is 0.

In certain embodiments, R²is hydrogen; and M is a bond.

In certain embodiments, A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cyanoalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl.

In certain embodiments, A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl.

In certain embodiments, A²is a monocyclic aryl. In certain embodiments, A²is a bicyclic aryl. In certain embodiments, A²is a monocyclic heteroaryl. In certain embodiments, A²is a bicyclic heteroaryl. In certain embodiments, A²is a monocyclic heterocycle. In certain embodiments, A²is bicyclic heterocycle. In certain embodiments, A²is a monocyclic heterocycle fused to a phenyl group. In certain embodiments, A²is a monocyclic heterocycle fused to a monocyclic cycloalkenyl. In certain embodiments, A²is a monocyclic heterocycle fused to a monocyclic heterocycle. In certain embodiments, A²is a spiro heterocycle. In certain embodiments, A²is a bridged monocyclic heterocycle ring system. In certain embodiments, A²is a tricyclic heterocycle. In certain embodiments, A²is a bicyclic heterocycle fused to a phenyl group. In certain embodiments, A²is a bicyclic heterocycle fused to a monocyclic cycloalkyl. In certain embodiments, A²is a bicyclic heterocycle fused to a monocyclic cycloalkenyl. In certain embodiments, A²is a bicyclic heterocycle fused to a monocyclic heterocycle. In certain embodiments, A²is a bicyclic heterocycle in which two non-adjacent atoms of the bicyclic ring are linked by an alkylene bridge. In certain embodiments, A²is an aromatic monocyclic ring. In certain embodiments, A²is an aromatic bicyclic ring system. In certain embodiments, A²is a cycloalkyl. In certain embodiments, A²is a C₃-C₈cycloalkyl. In certain embodiments, A²is unsubstituted. In certain embodiments, A²is substituted with 1, 2, 3, 4, 5, 6, or 7 functional groups independently selected from the group consisting of halogen, ═O, ═S, cyano, nitro, fluoroalkyl, alkoxyfluoroalkyl, fluoroalkoxy, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, heteroalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocycle, cycloalkylalkyl, heteroarylalkyl, arylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkylene, aryloxy, phenoxy, benzyloxy, amino, alkylamino, acylamino, aminoalkyl, arylamino, sulfonylamino, sulfinylamino, sulfonyl, alkyl sulfonyl, aryl sulfonyl, aminosulfonyl, sulfinyl, —COOH, ketone, amide, carbamate, and acyl.

In certain embodiments, A²is cycloalkyl, or heterocycle. In certain embodiments, A²is a C₃-C₈cycloalkyl, or a C₄-C₈heterocycle comprising 1 nitrogen or oxygen atom.

In certain embodiments, A²is a C₃-C₁₀cycloalkyl. In certain embodiments, A²is a C₃-C₈cycloalkyl. In certain embodiments, A²is cyclopropyl. In certain embodiments, A²is cyclobutyl. In certain embodiments, A²is cyclopentyl. In certain embodiments, A²is cyclohexyl. In certain embodiments, A²is cycloheptyl. In certain embodiments, A²is cyclooctyl. In certain embodiments, A²is adamantyl. In certain embodiments, A²is bicyclo[1.1.1]pentanyl. In certain embodiments, A²is 2-oxaspiro[3.3]heptanyl. In certain embodiments, A²is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, adamantyl, bicyclo[1.1.1]pentanyl, and 2-oxaspiro[3.3]heptanyl. In certain embodiments, the C₃-C₁₀cycloalkyl or C₃-C₈cycloalkyl (e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, bicyclo[1.1.1]pentanyl, or 2-oxaspiro[3.3]heptanyl) is substituted with at least 1 substituent selected from hydroxy, alkoxy, alkyl, halo, oxo and cyano, or a combination thereof. In certain embodiments, the C₃-C₁₀cycloalkyl or C₃-C₈cycloalkyl (e.g. cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, bicyclo[1.1.1]pentanyl, or 2-oxaspiro[3.3]heptanyl) is unsubstituted or substituted with 1 or 2 substituents independently selected from hydroxy, alkoxy, alkyl, halo, oxo and cyano. In certain embodiments, the C₃-C₁₀cycloalkyl or C₃-C₈cycloalkyl (e.g. cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, bicyclo[1.1.1]pentanyl, or 2-oxaspiro[3.3]heptanyl) is unsubstituted or substituted with 1 or 2 substituents independently selected from hydroxy, methoxy, methyl, fluoro, oxo and cyano.

In certain embodiments, A²is heterocycle. In certain embodiments, A²is a C₄-C₈heterocycle comprising 1 heteroatom selected from oxygen, nitrogen and sulfur.

In certain embodiments, A²is a C₄-C₈heterocycle comprising 1 oxygen atom. In certain embodiments, A²is oxetane. In certain embodiments, A²is tetrahydrofuran. In certain embodiments, A²is tetrahydropyran. In certain embodiments, A²is oxepane. In certain embodiments, A²is oxocane. In certain embodiments, A²is selected from the group consisting of oxetane, tetrahydrofuran, and tetrahydropyran. In certain embodiments, the C₄-C₈heterocycle comprising 1 oxygen atom (e.g. oxetane, tetrahydrofuran, tetrahydropyran, oxepane, oxocane) is substituted with at least 1 substituent selected from hydroxy, alkyl and alkoxy, or a combination thereof. In certain embodiments, the C₄-C₈heterocycle comprising 1 oxygen atom (e.g. oxetane, tetrahydrofuran, tetrahydropyran, oxepane, oxocane) is unsubstituted or substituted with 1 or 2 substituents independently selected from hydroxy, alkyl and alkoxy. In certain embodiments, the C₄-C₈heterocycle comprising 1 oxygen atom (e.g. oxetane, tetrahydrofuran, tetrahydropyran, oxepane, oxocane) is substituted with 1 or 2 substituents independently selected from hydroxy, methyl and methoxy.

In certain embodiments, A²is a C₄-C₈heterocycle comprising 1 nitrogen atom. In certain embodiments, A²is azetidine. In certain embodiments, A²is pyrrolidine. In certain embodiments, A²is piperidine. In certain embodiments, A²is azepane. In certain embodiments, A²is hexahydro-1H-pyrrolizine. In certain embodiments, A²is selected from the group consisting of azetidine, pyrrolidine, piperidine, azepane, and hexahydro-1H-pyrrolizine. In certain embodiments, the C₄-C₈heterocycle comprising 1 nitrogen atom is unsubstituted or substituted with at least 1 substituent selected from alkyl, haloalkyl, oxo, and heterocyclyl. In certain embodiments, the C₄-C₈heterocycle comprising 1 nitrogen atom is unsubstituted or substituted with 1 or 2 substituents independently selected from alkyl, haloalkyl, oxo, and heterocyclyl. In certain embodiments, the C₄-C₈heterocycle comprising 1 nitrogen atom is unsubstituted or substituted with 1 or 2 substituents independently selected from methyl, ethyl, t-butyl, oxo, trifluoromethyl, and oxetane.

In certain embodiments, A²is alkoxyalkyl or cyanoalkyl. In some embodiments, A²is selected from 2-methoxyethyl, 3-methoxypropyl, 2-methoxy-1-methylethyl, and 1-cyano-1-methylethyl.

In certain embodiments, A²is heteroaryl. In certain embodiments, A²is monocyclic heteroaryl or bicyclic heteroaryl. In certain embodiments, A²is selected from indazole, pyrazole and imidazole. In certain embodiments, the heteroaryl is unsubstituted or substituted with 1 alkyl group (e.g., methyl).

In certain embodiments, A²and R², together with the atoms to which they are attached, form a heterocycle. In certain embodiments, the heterocycle is selected from the group consisting of azabicyclo[2.2.1]heptane, piperidine, piperazine, and azabicyclo[3.2.1]octane. In certain embodiments, the heterocycle is unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of oxo, hydroxy, alkyl, and hydroxyalkyl. In certain embodiments, the heterocycle is unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of oxo, hydroxy, methyl, and hydroxyethyl.

In certain embodiments, R²is hydrogen, or alkyl; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0, 1, or 2; and k is 0, 1, or 2.

In certain embodiments, R²is hydrogen; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0, 1, or 2; and k is 0, 1, or 2.

In certain embodiments, R²is hydrogen; M is a bond; and A²is cycloalkyl, or heterocycle.

In certain embodiments, R²is hydrogen; M is a bond; and A²is cycloalkyl, or heterocycle. In certain embodiments, A²is a C₃-C₈cycloalkyl, or a C₄-C₈heterocycle comprising 1 oxygen atom.

In certain embodiments, R²is hydrogen; M is a bond; and A²is a C₃-C₈cycloalkyl. In certain embodiments, R²is hydrogen; M is a bond; and A²is cyclopropyl. In certain embodiments, R²is hydrogen; M is a bond; and A²is cyclobutyl. In certain embodiments, R²is hydrogen; M is a bond; and A²is cyclopentyl. In certain embodiments, R²is hydrogen; M is a bond; and A²is cyclohexyl. In certain embodiments, R²is hydrogen; M is a bond; and A²is cycloheptyl. In certain embodiments, R²is hydrogen; M is a bond; and A²is cyclooctyl. In certain embodiments, the C₃-C₈cycloalkyl (e.g. cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, or cyclooctyl) is substituted with at least 1 substituent selected from hydroxy and alkoxy, or a combination thereof.

In certain embodiments, R²is hydrogen; M is a bond; and A²is a C₄-C₈heterocycle comprising 1 oxygen atom. In certain embodiments, R²is hydrogen; M is a bond; and A²is oxetane. In certain embodiments, R²is hydrogen; M is a bond; and A²is tetrahydrofuran. In certain embodiments, R²is hydrogen; M is a bond; and A²is tetrahydropyran. In certain embodiments, R²is hydrogen; M is a bond; and A²is oxepane. In certain embodiments, R²is hydrogen; M is a bond; and A²is oxocane. In certain embodiments, the C₄-C₈heterocycle comprising 1 oxygen atom (e.g. oxetane, tetrahydrofuran, tetrahydropyran, oxepane, or oxocane) is substituted with at least 1 substituent selected from hydroxy and alkoxy, or a combination thereof.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S, or O; L is —[C(R^aR^b)]_p—, C₂-C₆-alkenylenyl, O, S, or NR⁵; A¹is Cyc¹or Cyc²-Q-Cyc³; R¹is hydrogen, alkyl, alkoxy, alkoxyalkyl, halogen, cyano, or haloalkyl; R²is hydrogen, alkyl or haloalkyl; M is a bond, C₂-C₆-alkenylenyl, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, or halogen; R⁵is independently, at each occurrence, hydrogen, alkyl, or —C(O)R^g; Cyc¹is aryl, heteroaryl, heterocycle or cycloalkyl; Cyc²is aryl, heteroaryl, heterocycle or cycloalkyl; Q is a bond, C₁-C₆-alkylenyl, C₂-C₆-alkenylenyl, O, S, or NR⁵; Cyc³is aryl, heteroaryl, heterocycle or cycloalkyl; R^a, R^b, R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, haloalkyl, hydroxy, cyano, alkoxy, alkoxyalkyl, or halogen; p is 0, 1, 2, 3, 4, 5, or 6; t is 0, 1, 2, or 3; k is 0, 1, 2, or 3; and R^gis independently, at each occurrence, alkyl, aryl, heteroaryl, cycloalkyl or alkoxy; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S, or O; L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹or Cyc²-Q-Cyc³; R^aand R^bare each independently hydrogen, alkyl, or halogen; p is 0, 1, 2, or 3; Cyc¹is aryl, or heteroaryl; Cyc²is aryl, or heteroaryl; Q is a bond; Cyc³is aryl, or heteroaryl; R¹is hydrogen, alkyl, alkoxy, alkoxyalkyl, halogen, cyano, or haloalkyl; R²is hydrogen, alkyl or haloalkyl; M is a bond, C₂-C₆-alkenylenyl, or —[C(C^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, or halogen; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, haloalkyl, hydroxy, cyano, alkoxy, alkoxyalkyl, or halogen; t is 0, 1, 2, or 3; and k is 0, 1, 2, or 3; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S, or O; L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹or Cyc²-Q-Cyc³; R^aand R^bare each independently hydrogen, alkyl, or halogen; p is 0, 1, 2, or 3; Cyc¹is aryl, or heteroaryl; Cyc²is aryl, or heteroaryl; Q is a bond; Cyc³is aryl, or heteroaryl; R¹is hydrogen; R²is hydrogen, alkyl or haloalkyl; M is a bond, C₂-C₆-alkenylenyl, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, haloalkyl, hydroxy, cyano, alkoxy, alkoxyalkyl, or halogen; t is 0, 1, 2, or 3; and k is 0, 1, 2, or 3; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S, or O; L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹or Cyc²-Q-Cyc³; R^aand R^bare each independently hydrogen, alkyl, or halogen; p is 0, 1, 2, or 3; Cyc¹is aryl, or heteroaryl; Cyc²is aryl, or heteroaryl; Q is a bond; Cyc³is aryl, or heteroaryl; R¹is hydrogen; R²is hydrogen, or alkyl; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0, 1, 2, or 3; and k is 0, 1, 2, or 3; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S, or O; L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹or Cyc²-Q-Cyc³; R^aand R^bare each independently hydrogen, alkyl, or halogen; p is 0, 1, 2, or 3; Cyc¹is aryl, or heteroaryl; Cyc²is aryl, or heteroaryl; Q is a bond; Cyc³is aryl, or heteroaryl; R¹is hydrogen; R²is hydrogen, or alkyl; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^3aand R^3bare each independently selected from hydrogen and alkyl; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0, 1, 2, or 3; and k is 0, 1, 2, or 3; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S; L is —[C(R^aR^b)]_p—, C₂-C₆-alkenylenyl, O, S, or NR⁵; A¹is Cyc¹or Cyc²-Q-Cyc³; R¹is hydrogen, alkyl, alkoxy, alkoxyalkyl, halogen, cyano, or haloalkyl; R²is hydrogen, alkyl or haloalkyl; M is a bond, C₂-C₆-alkenylenyl, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen; R⁵is independently, at each occurrence, hydrogen, alkyl, or —C(O)R^g; Cyc¹is aryl, heteroaryl, heterocycle or cycloalkyl; Cyc²is aryl, heteroaryl, heterocycle or cycloalkyl; Q is a bond, C₁-C₆-alkylenyl, C₂-C₆-alkenylenyl, O, S, or NR⁵; Cyc³is aryl, heteroaryl, heterocycle or cycloalkyl; R^a, R^b, R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, haloalkyl, hydroxy, cyano, alkoxy, alkoxyalkyl, or halogen; p is 0, 1, 2, 3, 4, 5, or 6; t is 0, 1, 2, or 3; k is 0, 1, 2, or 3; and R^gis independently, at each occurrence, alkyl, aryl, heteroaryl, cycloalkyl or alkoxy; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S; L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹or Cyc²-Q-Cyc³; R^aand R^bare each independently hydrogen, alkyl, or halogen; p is 0, 1, 2, or 3; Cyc¹is aryl, or heteroaryl; Cyc²is aryl, or heteroaryl; Q is a bond; Cyc³is aryl, or heteroaryl; R¹is hydrogen, alkyl, alkoxy, alkoxyalkyl, halogen, cyano, or haloalkyl; R²is hydrogen, alkyl or haloalkyl; M is a bond, C₂-C₆-alkenylenyl, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, haloalkyl, hydroxy, cyano, alkoxy, alkoxyalkyl, or halogen; t is 0, 1, 2, or 3; and k is 0, 1, 2, or 3; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S; L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹or Cyc²-Q-Cyc³; R^aand R^bare each independently hydrogen, alkyl, or halogen; p is 0, 1, 2, or 3; Cyc¹is aryl, or heteroaryl; Cyc²is aryl, or heteroaryl; Q is a bond; Cyc³is aryl, or heteroaryl; R¹is hydrogen; R²is hydrogen, alkyl or haloalkyl; M is a bond, C₂-C₆-alkenylenyl, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, haloalkyl, hydroxy, cyano, alkoxy, alkoxyalkyl, or halogen; t is 0, 1, 2, or 3; and k is 0, 1, 2, or 3; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S; L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹or Cyc²-Q-Cyc³; R^aand R^bare each independently hydrogen, alkyl, or halogen; p is 0, 1, 2, or 3; Cyc¹is aryl, or heteroaryl; Cyc²is aryl, or heteroaryl; Q is a bond; Cyc³is aryl, or heteroaryl; R¹is hydrogen; R²is hydrogen, or alkyl; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^3aand R^3bare each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0, 1, 2, or 3; and k is 0, 1, 2, or 3; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, X is CR^3a; Y is CR^3b; Z is S; L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹or Cyc²-Q-Cyc³; R^aand R^bare each independently hydrogen, alkyl, or halogen; p is 0, 1, 2, or 3; Cyc¹is aryl, or heteroaryl; Cyc²is aryl, or heteroaryl; Q is a bond; Cyc³is aryl, or heteroaryl; R¹is hydrogen; R²is hydrogen, or alkyl; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; R^3aand R^3bare each independently selected from hydrogen and alkyl; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0, 1, 2, or 3; and k is 0, 1, 2, or 3; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In another aspect, the compound of formula (I) is a compound of formula (I-a):

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wherein L is —[C(R^aR^b)]_p—, C(O), or O; A¹is Cyc¹, or Cyc²-Q-Cyc³; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cyanoalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; Cyc¹is heteroaryl; Cyc²is aryl or heteroaryl; Q is a bond; Cyc³is heteroaryl; R^aand R^bare each alkyl, halogen, or hydrogen; R^c, R^d, R^e, and R^fare each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; p is 1; t is 0 or 1; and k is 0 or 1; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹, or Cyc²-Q-Cyc³; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; Cyc²is aryl; Q is a bond; Cyc³is heteroaryl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen, or fluorine; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen, or fluorine; and p is 1.

In certain embodiments, L is O; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; and Cyc¹is heteroaryl.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹, or Cyc²-Q-Cyc³; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; Cyc²is phenyl; Q is a bond; Cyc³is pyrazolyl, or benzopyrazolyl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen, or fluorine; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen, or fluorine; and p is 1.

In certain embodiments, L is O; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; and Cyc¹is pyridyl.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; M is a bond; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen; and p is 1.

In certain embodiments, A²is a C₃-C₈cycloalkyl, or a C₄-C₈heterocycle comprising 1 oxygen atom.

In certain embodiments, A²is a C₃-C₈cycloalkyl. In certain embodiments, A²is cyclopropyl. In certain embodiments, A²is cyclobutyl. In certain embodiments, A²is cyclopentyl. In certain embodiments, A²is cyclohexyl. In certain embodiments, A²is cycloheptyl. In certain embodiments, A²is cyclooctyl. In certain embodiments, the C₃-C₈cycloalkyl (e.g. cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl) is substituted with at least 1 substituent selected from hydroxy and alkoxy, or a combination thereof.

In another aspect, the compound of formula (I) is a compound of formula (I-b):

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wherein L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹, or Cyc²-Q-Cyc³; A²is cycloalkyl, heterocycle, heteroaryl, or aryl; Cyc¹is heteroaryl; Cyc²is aryl; Q is a bond; Cyc³is heteroaryl; R^aand R^bare each alkyl, halogen, or hydrogen; p is 1; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹, or Cyc²-Q-Cyc³; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; Cyc²is aryl; Q is a bond; Cyc³is heteroaryl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen, or fluorine; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen, or fluorine; and p is 1.

In certain embodiments, L is O; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; and Cyc¹is heteroaryl.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is heteroaryl; R^aand R^bare each hydrogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹, or Cyc²-Q-Cyc³; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; Cyc²is phenyl; Q is a bond; Cyc³is pyrazolyl, or benzopyrazolyl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen, or halogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen, or fluorine; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen, or fluorine; and p is 1.

In certain embodiments, L is O; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; and Cyc¹is pyridyl.

In certain embodiments, L is —[C(R^aR^b)]_p—, or O; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen; and p is 1.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc¹; A²is cycloalkyl, or heterocycle; Cyc¹is pyridyl; R^aand R^bare each hydrogen; and p is 1.

In certain embodiments, A²is a C₃-C₈cycloalkyl, or a C₄-C₈heterocycle comprising 1 oxygen atom.

In certain embodiments, the compound of formula (I-b) may be in the form of specific diastereomers represented by the structures below, wherein * denotes a defined stereocenter (R or S):

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In certain embodiments, the stereocenters may be in the (R) configuration. In certain embodiments, the stereocenters may be in the (S) configuration. In certain embodiments, the compound of formula (I-b) may have one stereocenter in the (R) configuration and one stereocenter in the (S) configuration. In certain embodiments, the compound of formula (I-b) may have both stereocenters in the (S) configuration. In certain embodiments, the compound of formula (I-b) may have both stereocenters in the (R) configuration. In certain embodiments, the compound of formula (I-b) may have one stereocenter that is racemic and one that is in the (S) configuration. In certain embodiments, the compound of formula (I-b) may have one stereocenter that is racemic and one that is in the (R) configuration. In certain embodiments, both stereocenters may be racemic. In certain embodiments A²may be a moiety in which the substituents have no chirality, for example, when A²is an unsaturated ring.

In another aspect, the compound of formula (I) is a compound of formula (I-c) or (I-d):

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wherein A¹is Cyc¹, or Cyc²-Q-Cyc³; A²is cycloalkyl or heterocycle; Cyc¹is aryl or heteroaryl; Cyc²is aryl or heteroaryl; Q is a bond; Cyc³is aryl or heteroaryl; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In another aspect, the compound of formula (I) is a compound of formula (I-e) or (I-f):

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wherein A²is cycloalkyl or heterocycle; X¹is CR⁶or N; X²is CR⁷or N; X³is CR⁸or N; X⁴is CR⁹or N; X⁵is CR¹⁰or N; provided that only one of X¹, X², X³, X⁴, and X⁵is N; R⁶, R⁷, R⁸, R⁹, and R¹⁰are each independently selected from the group consisting of hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, halogen, aryl, and heteroaryl; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, A²is C₄-C₇-cycloalkyl or a four-, five-, or six-membered monocyclic heterocycle containing at least one heteroatom independently selected from the group consisting of O, N, and S; X¹is CR⁶; X²is CR⁷; X³is CR⁸; X⁴is CR⁹; and X⁵is CR¹⁰; R⁶, R⁷, R⁸, R⁹, and R¹⁰are each independently selected from the group consisting of hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, halogen, aryl, and heteroaryl; wherein said cycloalkyl and heterocycle, at each occurrence, are independently substituted or unsubstituted. In certain embodiments, A²is C₄-C₇-cycloalkyl or a four-, five-, or six-membered monocyclic heterocycle containing at least one heteroatom independently selected from the group consisting of O, N, and S; X¹is CR⁶; X²is CR⁷; X³is CR⁸; X⁴is CR⁹; X⁵is CR¹⁰; R⁶is H; R⁷is H; R⁸is aryl or heteroaryl; R⁹is H; and R¹⁰is H or F; wherein said cycloalkyl and heterocycle, at each occurrence, are independently substituted or unsubstituted. In certain embodiments, A²is C₄-C₇-cycloalkyl or a four-, five-, or six-membered monocyclic heterocycle containing at least one heteroatom independently selected from the group consisting of O, N, and S; X¹is CR⁶; X²is CR⁷; X³is CR⁸; X⁴is N; X⁵is C¹⁰; R⁶is H; R⁷is H; R⁸is C₁-C₆-alkyl; and R¹⁰is H; wherein said cycloalkyl and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In another aspect, the compound of formula (I) is a compound of formula (I-g):

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In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc²-Q-Cyc³; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is cycloalkyl, or heterocycle; Cyc²is aryl or heteroaryl; Q is a bond; Cyc³is heteroaryl; R^aand R^bare each alkyl, halogen, or hydrogen; R^c, R^d, R^e, and R^fare each hydrogen; p is 1; t is 0 or 1; and k is 0 or 1; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc²-Q-Cyc³; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is cycloalkyl, or heterocycle; Cyc²is phenyl or pyridyl; Q is a bond; Cyc³is a five-membered heteroaryl comprising 1 or 2 heteroatoms selected from O, N and S, which may be unsubstituted or substituted with one alkyl substituent; R^aand R^bare each hydrogen; R^c, R^d, R^e, and R^fare each hydrogen; p is 1; t is 1; and k is 0.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc²-Q-Cyc³; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is cycloalkyl, or heterocycle; Cyc²is phenyl or pyridyl; Q is a bond; Cyc³is a selected from thiazole and pyrazole, each of which may be unsubstituted or substituted with one alkyl substituent; R^aand R^bare each hydrogen; R^c, R^d, R^e, and R^fare each hydrogen; p is 1; t is 1; and k is 0.

In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc²-Q-Cyc³; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is C₃-C₈cycloalkyl, or a C₄-C₈heterocycle comprising 1 oxygen atom; Cyc²is phenyl or pyridyl; Q is a bond; Cyc³is a selected from thiazole and pyrazole, each of which may be unsubstituted or substituted with one alkyl substituent; R^aand R^bare each hydrogen; R^c, R^d, R^e, and R^fare each hydrogen; p is 1; t is 1; and k is 0.

In certain embodiments, R⁴is alkyl. In certain embodiments, R⁴is methyl.

In certain embodiments, A²is a C₃-C₈cycloalkyl, or a C₄-C₈heterocycle comprising 1 oxygen atom.

In certain embodiments, A²is a C₃-C₈cycloalkyl. In certain embodiments, A²is a C₄-C₇cycloalkyl. In certain embodiments, A²is cyclopropyl. In certain embodiments, A²is cyclobutyl. In certain embodiments, A²is cyclopentyl. In certain embodiments, A²is cyclohexyl. In certain embodiments, A²is cycloheptyl. In certain embodiments, A²is cyclooctyl. In certain embodiments, A²is 2-oxaspiro[3.3]heptane. In certain embodiments, A²is selected from the group consisting of cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and 2-oxaspiro[3.3]heptane, each of which may be unsubstituted or substituted with 1 or 2 substituents independently selected from alkyl, hydroxy and halo. In certain embodiments, A²is selected from the group consisting of cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and 2-oxaspiro[3.3]heptane, each of which may be unsubstituted or substituted with 1 or 2 substituents independently selected from methyl, hydroxy and fluoro.

In another aspect, the compound of formula (I) is a compound of formula (I-h):

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In certain embodiments, L is —[C(R^aR^b)]_p—; A¹is Cyc²-Q-Cyc³; M is a bond, or —[C(R^cR^d)]_t—[C(R^eR^f)]_k—; A²is cycloalkyl, or heterocycle; Cyc²is phenyl or pyridyl; Q is a bond; Cyc³is a selected from thiazole and pyrazole, each of which may be unsubstituted or substituted with one alkyl substituent; R^aand R^bare each hydrogen; R^c, R^d, R^e, and R^fare each hydrogen; p is 1;t is 1; and k is 0.

In certain embodiments, R⁴is alkyl. In certain embodiments, R⁴is methyl.

In certain embodiments, A²is a C₃-C₈cycloalkyl, or a C₄-C₈heterocycle comprising 1 oxygen atom.

Representative compounds of formula (I) include, but are not limited to:

N-((1S,2S)-2-hydroxycyclohexyl)-7-((6-methylpyridin-3-yl)methyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-methoxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(2R)-2-hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycycloheptyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(1R,2R)-2-hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycycloheptyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclobutyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-cyclohexyl-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)oxy]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-methoxycyclohexyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycycloheptyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-[(2,5-dimethylphenyl)methyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-hydroxy-1-phenyl-ethyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-hydroxy-1,1-dimethyl-ethyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)oxy]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;

N-(1-cyclopropyl-2-hydroxy-ethyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)oxy]-N-(3,3,3-trifluoro-2-hydroxy-propyl)thieno[3,2-b]pyridine-5-carboxamide;

N-(2-hydroxy-2-methyl-propyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-methoxyethyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-hydroxy-1,2,2-trimethyl-propyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)oxy]-N-(tetrahydrofuran-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)oxy]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)oxy]-N-(2-pyridylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)oxy]-N-(1H-pyrrol-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(5-methyl-1H-indol-2-yl)methyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

N-(1H-indazol-3-yl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;

7-[[2,6-difluoro-4-(2-methylindazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-cyclohexyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclobutyl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycycloheptyl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-methoxycyclohexyl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-hydroxycyclohexyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycycloheptyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1R,2R)-2-hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycycloheptyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-hydroxy-1-adamantyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S)-5-hydroxy-2-adamantyl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1H-indazol-3-yl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxoindolin-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methyl-1H-pyrazol-5-yl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1H-imidazol-4-yl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclopentyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-cyclohexyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclohexyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-methoxycyclohexyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycycloheptyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxo-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxoazepan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

[(1S,5R)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;

[(3R)-3-hydroxy-1-piperidyl]-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;

(4-hydroxy-4-methyl-1-piperidyl)-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;

piperazin-1-yl-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;

[4-(2-hydroxyethyl)piperazin-1-yl]-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;

7-[fluoro-(6-methyl-3-pyridyl)methyl]-N-[(1R,2R)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[ethoxy-(6-methyl-3-pyridyl)methyl]-N-[(1R,2R)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclobutyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-tetrahydropyran-4-yl-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclohexyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-methoxycyclohexyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycycloheptyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-hydroxy-1-adamantyl)-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S)-5-hydroxy-2-adamantyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxo-3-piperidyl)-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxoazepan-3-yl)-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclobutyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclopentyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-cyclohexyl-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[(6-methyl-3-pyridyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclohexyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-methoxycyclohexyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycycloheptyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-hydroxy-1-adamantyl)-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S)-5-hydroxy-2-adamantyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-N-(1-methyl-4-piperidyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclobutyl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclopentyl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclohexyl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-methoxycyclohexyl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycycloheptyl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N,3-dimethyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-N-(2-oxo-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-N-(2-oxoazepan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-N-(1-methyl-4-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclopentyl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(2-methylpyrimidin-5-yl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclohexyl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-methoxycyclohexyl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycycloheptyl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclobutyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclopentyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-cyclohexyl-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(2-methylthiazol-5-yl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclohexyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-methoxycyclohexyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycycloheptyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-hydroxy-1-adamantyl)-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S)-5-hydroxy-2-adamantyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(2-methylthiazol-5-yl)methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[(2-methylthiazol-5-yl)methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclohexyl]-7-(6-methylpyridine-3-carbonyl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclobutyl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclobutyl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-tetrahydropyran-3-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclohexyl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-methoxycyclohexyl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycycloheptyl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

N-cyclohexyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(1-methyl-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(1-methyl-4-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;

N-methyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclohexyl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-methoxycyclohexyl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycycloheptyl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

[(3R)-3-hydroxy-1-piperidyl]-[7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridin-5-yl]methanone;

(4-hydroxy-4-methyl-1-piperidyl)-[7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridin-5-yl]methanone;

7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methyloxetan-3-yl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-(1-tert-butylazetidin-3-yl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methoxycyclobutyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

N-cyclohexyl-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-methyl-3-piperidyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-methyl-4-piperidyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

N-methyl-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-methoxycyclohexyl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycycloheptyl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(hexahydro-1H-pyrrolizin-1-yl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclobutyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-bicyclo[1.1.1]pentanyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(oxetan-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-tert-butylazetidin-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methoxycyclobutyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-cyclohexyl-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-methyl-3-piperidyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-methyl-4-piperidyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-methyl-N-tetrahydropyran-4-yl-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-methoxycyclohexyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycycloheptyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(hexahydro-1H-pyrrolizin-1-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxo-3-piperidyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxoazepan-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycycloheptyl]-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclobutyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-tetrahydropyran-4-yl-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(S)-fluoro-(6-methyl-3-pyridyl)methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(R)-fluoro-(6-methyl-3-pyridyl)methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-hydroxy-2-methyl-cycloheptyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-2-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-2-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-2-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

2-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[4-(1,3,5-trimethylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxaspiro[3.3]heptan-6-yl)-7-[[4-(1,3,5-trimethylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-7-[[4-(1,3,5-trimethylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-tetrahydropyran-4-yl-7-[[4-(1,3,5-trimethylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-(1-tert-butylazetidin-3-yl)-7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-(3-methoxycyclobutyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-cyanocyclopropyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3,3-difluorocyclobutyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-(4-pyrazol-1-ylbenzoyl)-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)methyl]-N-[(3R)-3-piperidyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(6-methyl-3-pyridyl)methyl]-N-[(3S)-3-piperidyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;

7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-[(1R,2R)-2-hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methyloxetan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

N-(oxetan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3,3-difluorocyclobutyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-cyanocyclopropyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-cyano-1-methyl-ethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(oxetan-2-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydrofuran-3-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2S)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(4-pyrazol-1-ylphenyl)methyl]-N[[(2R)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-4-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S)-3-piperidyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methyl-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(azetidin-2-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-tetrahydropyran-4-yl-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclobutyl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3,3-difluorocyclobutyl)-3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(oxetan-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(tetrahydrofuran-3-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-4-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-N-(oxetan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydrofuran-3-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2R)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2S)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-N-(oxetan-2-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclobutyl]-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

3-methyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-3-methyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[fluoro-(4-thiazol-4-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(tetrahydropyran-4-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(oxetan-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[[(2R)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(tetrahydropyran-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-(2-methoxyethyl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3,3-difluorocyclobutyl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(tetrahydrofuran-3-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[[(2S)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(oxetan-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(tetrahydrofuran-3-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(3S)-tetrahydrofuran-3-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(tetrahydropyran-4-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(tetrahydropyran-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;

N-(azetidin-2-ylmethyl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[(3R)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3,3-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-methoxy-1-methyl-ethyl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[1-(oxetan-3-yl)azetidin-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

N-(oxetan-3-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-tetrahydropyran-3-yl-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methyltetrahydropyran-4-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methoxypropyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-methoxyethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(tetrahydrofuran-3-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(tetrahydropyran-2-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3,3-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3,3-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(oxetan-2-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3,3-difluorocyclobutyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(tetrahydrofuran-2-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(4,4-difluorocyclohexyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,6-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[[(2S)-tetrahydrofuran-2-yl]methyl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3,3-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,6-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S,4S)-3-methyltetrahydropyran-4-yl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-methyltetrahydropyran-4-yl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-tetrahydropyran-4-yl-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(tetrahydrofuran-3-ylmethyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(oxetan-3-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-methoxyethyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methoxypropyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclobutyl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-methoxy-1-methyl-ethyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-tetrahydropyran-4-yl-7-[[4-(tetrahydropyran-4-ylcarbamoyl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3,3-difluorocyclobutyl)-7-[[4-[(3,3-difluorocyclobutyl)carbamoyl]phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-[(2,2-dimethyltetrahydropyran-4-yl)carbamoyl]phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycycloheptyl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2R)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2S)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;

N-(2-methoxyethyl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3,3-difluorocyclobutyl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(azetidin-2-ylmethyl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3R)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-methoxy-1-methyl-ethyl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[1-(oxetan-3-yl)azetidin-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2S)-pyrrolidin-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2R)-pyrrolidin-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-methoxyethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methoxypropyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methoxycyclobutyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(4-pyrazol-1-ylphenyl)methyl]-N-[1-(2,2,2-trifluoroethyl)azetidin-3-yl]thieno[3,2-b]pyridine-5-carboxamide;

N-[1-(oxetan-3-yl)azetidin-3-yl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-tert-butylazetidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-methylazetidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-cyclobutyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(2-oxocyclopentyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-methyl-5-oxo-pyrrolidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1,1-dioxothiolan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydrofuran-3-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-(5-oxopyrrolidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-methyl-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(1-methyl-4-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

N-(3-methyltetrahydropyran-4-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

2-oxa-5-azabicyclo[2.2.1]heptan-5-yl-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;

7-[(4-pyrazol-1-ylphenyl)methyl]-N-(1-tetrahydrofuran-2-ylethyl)thieno[3,2-b]pyridine-5-carboxamide;

7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-3-yl-thieno[3,2-b]pyridine-5-carboxamide;

N-(1H-pyrazol-3-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;

1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-tetrahydropyran-4-yl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycycloheptyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclobutyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(2S,6R)-2,6-dimethyltetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-[(3S)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-[(3R)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-(oxetan-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-tetrahydropyran-4-yl-pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(tetrahydropyran-4-ylmethyl)pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(3,3-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-tetrahydropyran-4-yl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclobutyl]-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(3,3-dimethyltetrahydropyran-4-yl)-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(3,3-difluorocyclobutyl)-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclobutyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

1-methyl-N-(oxetan-2-ylmethyl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

1-methyl-N-[[(2R)-tetrahydrofuran-2-yl]methyl]-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

N-[(1R,2R)-2-hydroxycyclobutyl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

1-methyl-N-(oxetan-2-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2R)-tetrahydrofuran-2-yl]methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;

1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-tetrahydropyran-4-yl-pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(3,3-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(2,6-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(tetrahydropyran-4-ylmethyl)pyrrolo[3,2-b]pyridine-5-carboxamide;

1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(tetrahydrofuran-3-ylmethyl)pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(3-fluorocyclobutyl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-(3,3-difluorocyclobutyl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide; and

N-[(1S,2S)-2-hydroxycyclobutyl]-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide,

or a pharmaceutically acceptable salt thereof.

Compound names are assigned by using the Struct=Name naming algorithm as part of CHEMDRAW® ULTRA v. 12.0.

The compound may exist as a stereoisomer wherein asymmetric or chiral centers are present. The stereoisomer is “R” or “S” depending on the configuration of substituents around the chiral carbon atom. The terms “R” and “S” used herein are configurations as defined in IUPAC 1974 Recommendations for Section E, Fundamental Stereochemistry, in Pure Appl. Chem., 1976, 45: 13-30. The disclosure contemplates various stereoisomers and mixtures thereof and these are specifically included within the scope of this invention. Stereoisomers include enantiomers and diastereomers, and mixtures of enantiomers or diastereomers. Individual stereoisomers of the compounds may be prepared synthetically from commercially available starting materials, which contain asymmetric or chiral centers or by preparation of racemic mixtures followed by methods of resolution well-known to those of ordinary skill in the art. These methods of resolution are exemplified by (1) attachment of a mixture of enantiomers to a chiral auxiliary, separation of the resulting mixture of diastereomers by recrystallization or chromatography and optional liberation of the optically pure product from the auxiliary as described in Furniss, Hannaford, Smith, and Tatchell, “Vogel's Textbook of Practical Organic Chemistry,” 5th edition (1989), Longman Scientific & Technical, Essex CM20 2JE, England, or (2) direct separation of the mixture of optical enantiomers on chiral chromatographic columns, or (3) fractional recrystallization methods.

It should be understood that the compound may possess tautomeric forms, as well as geometric isomers, and that these also constitute embodiments of the disclosure.

The present disclosure also includes an isotopically-labeled compound, which is identical to those recited in formula (I), but for the fact that one or more atoms are replaced by an atom having an atomic mass or mass number different from the atomic mass or mass number usually found in nature. Examples of isotopes suitable for inclusion in the compounds of the invention are hydrogen, carbon, nitrogen, oxygen, phosphorus, sulfur, fluorine, and chlorine, such as, but not limited to ²H, ³H, ¹³C, ¹⁴C, ¹⁵N, ¹⁸O, ¹⁷O, ³¹P, ³²P, ³⁵S, ¹⁸F, and ³⁶Cl, respectively. Substitution with heavier isotopes such as deuterium, i.e. ²H, can afford certain therapeutic advantages resulting from greater metabolic stability, for example increased in vivo half-life or reduced dosage requirements and, hence, may be preferred in some circumstances. The compound may incorporate positron-emitting isotopes for medical imaging and positron-emitting tomography (PET) studies for determining the distribution of receptors. Suitable positron-emitting isotopes that can be incorporated in compounds of formula (I) are ¹¹C, ¹³N, ¹⁵O, and ¹⁸F. Isotopically-labeled compounds of formula (I) can generally be prepared by conventional techniques known to those skilled in the art or by processes analogous to those described in the accompanying Examples using appropriate isotopically-labeled reagent in place of non-isotopically-labeled reagent.

a. Allosteric Modulation of mAChR M₁

The disclosed compounds are positive allosteric modulators of mAChR M₁. Thus, by positive allosteric modulation, the compounds indirectly activate the muscarinic receptor subtype M₁. In one aspect, the disclosed compounds potentiate the agonist response (e.g., acetylcholine) of mAChR M₁. In a further aspect, the disclosed compounds increase mAChR M₁response to non-maximal concentrations of agonist in the presence of compound compared to the response to agonist in the absence of compound. The potentiation of mAChR M₁activity can be demonstrated by methodology known in the art. For example, activation of mAChR M₁activity can be determined by measurement of calcium flux in response to agonist, e.g. acetylcholine, in cells loaded with a Ca²⁺-sensitive fluorescent dye (e.g., Fluo-4). In a further aspect, the calcium flux was measured as an increase in fluorescent static ratio. In a yet further aspect, positive allosteric modulator activity was analyzed as a concentration-dependent increase in the EC₂₀acetylcholine response (i.e. the response of mAChR M₁at a concentration of acetylcholine that yields 20% of the maximal response).

In an embodiment, the disclosed compounds may activate mAChR M₁response as an increase in calcium fluorescence in mAChR M₁-transfected CHO-K1 cells in the presence of the compound, compared to the response of equivalent CHO-K1 cells in the absence of the compound. For example, a disclosed compound may have an EC₅₀of less than or equal to 10 μM, less than or equal to 5 μM, less than or equal to 2.5 μM, less than or equal to 1 μM, less than or equal to 500 nM, less than or equal to 250 nM, less than or equal to 100 nM, or less than or equal to 50 nM. In an embodiment, the mAChR M₁-transfected CHO-K1 cells are transfected with human mAChR M₁. In another embodiment, the mAChR M₁-transfected CHO-K1 cells are transfected with rat mAChR M₁.

In an embodiment, the disclosed compounds exhibit potentiation of mAChR M₁response to acetylcholine as an increase in response to non-maximal concentrations of acetylcholine in CHO-K1 cells transfected with a mammalian mAChR M₁in the presence of the compound, compared to the response to acetylcholine in the absence of the compound. For example, CHO-K1 cells can be transfected with human mAChR M₁. For example, CHO-K1 cells can be transfected with rat mAChR M₁. For example, a compound can exhibit positive allosteric modulation of mAChR M₁with an EC₅₀of less than or equal to 10,000 nM, less than or equal to 5,000 nM, less than or equal to 2,500 nM, less than or equal to 1,000 nM, less than or equal to 500 nM, less than or equal to 250 nM, or less than or equal to 100 nM. Alternatively, the disclosed compounds exhibit potentiation of mAChR M₁response to acetylcholine as an increase in response to non-maximal concentrations of acetylcholine in CHO-K1 cells transfected with human mAChR M₁in the presence of the compound, compared to the response to acetylcholine in the absence of the compound. For example, a compound can exhibit positive allosteric modulation of mAChR M₁with an EC₅₀of less than or equal to 10,000 nM, less than or equal to 5,000 nM, less than or equal to 2,500 nM, less than or equal to 1,000 nM, less than or equal to 500 nM, less than or equal to 250 nM, less than or equal to 100 nM, or less than or equal to 50 nM.

In an embodiment, the disclosed compounds exhibit positive allosteric modulation of mAChR M₁response to acetylcholine as an increase in response to non-maximal concentrations of acetylcholine in CHO-K1 cells transfected with a mAChR M₁in the presence of the compound, compared to the response to acetylcholine in the absence of the compound. For example, the disclosed compounds may exhibit positive allosteric modulation of the mAChR M₁response to acetylcholine with an EC₅₀of less than or equal to 10,000 nM, less than or equal to 5,000 nM, less than or equal to 2,500 nM, less than or equal to 1,000 nM, less than or equal to 500 nM, less than or equal to 250 nM, or less than or equal to 100 nM. In an embodiment, the EC₅₀for positive allosteric modulation is determined in CHO-K1 cells are transfected with a mAChR M₁. In another embodiment, the CHO-K1 cells are transfected with a human mAChR M₁. In another embodiment, the CHO-K1 cells are transfected with a rat mAChR M₁.

In an embodiment, the compounds activate mAChR M₁response in mAChR M₁-transfected CHO-K1 cells with an EC₅₀less than the EC₅₀for one or more of mAChR M₂, mAChR M₃, mAChR M₄, or mAChR M₅response in mAChR M₂, M₃, M₄or M₅-transfected CHO-K1 cells. That is, the disclosed compounds can have selectivity for the mAChR M₁receptor vis-à-vis one or more of the mAChR M₂, M₃, M₄or M₅receptors. For example, the disclosed compounds can activate mAChR M₁response with an EC₅₀of at least 5-fold less than that for mAChR M₂, at least 10-fold less than that for mAChR M₂, at least 20-fold less than that for mAChR M₂, at least 30-fold less than that for mAChR M₂, at least 50-fold less than that for mAChR M₂, or at least 100-fold less than that for mAChR M₂. In another embodiment, the disclosed compounds can activate mAChR M₁response with an EC₅₀of at least 5-fold less than that for mAChR M₃, at least 10-fold less than that for mAChR M₃, at least 20-fold less than that for M₃, at least 30-fold less than that for mAChR M₃, at least 50-fold less than that for mAChR M₃, or at least 100-fold less than that for mAChR M₃. In another embodiment, the disclosed compounds can activate mAChR M₁response with an EC₅₀of at least 5-fold less than that for mAChR M₄, at least 10-fold less than that for mAChR M₄, at least 20-fold less than that for M₄, at least 30-fold less than that for mAChR M₄, at least 50-fold less than that for mAChR M₄, or at least 100-fold less than that for mAChR M₄. In another embodiment, the disclosed compounds can activate mAChR M₁response with an EC₅₀of at least 5-fold less than that for mAChR M₅, at least 10-fold less than that for mAChR M₅, at least 20-fold less than that for mAChR M₅, at least 30-fold less than that for mAChR M₅, at least 50-fold less than that for mAChR M₅, or at least 100-fold less than that for mAChR M₅. In another embodiment, the disclosed compounds can activate mAChR M₁response with an EC₅₀of at least 5-fold less than that for the mAChR M₂, M₃, M₄or M₅receptors, at least 10-fold less than that for the mAChR M₂, M₃, M₄or M₅receptors, at least 20-fold less than that for the mAChR M₂, M₃, M₄or M₅receptors, at least 30-fold less than that for the mAChR M₂, M₃, M₄or M₅receptors, at least 50-fold less than that for the mAChR M₂, M₃, M₄or M₅receptors, or at least 100-fold less than that for the mAChR M₂, M₃, M₄or M₅receptors. In another embodiment, the compound activates mAChR M₁response in mAChR M₁-transfected CHO-K1 cells and is inactive for one or more of mAChR M₁, mAChR M₃, mAChR M₄, or mAChR M₅response in mAChR M₂, M₃, M₄or M₅-transfected CHO-K1 cells.

In an embodiment, the compounds activate mAChR M₁response in M₁-transfected CHO-K1 cells with an EC₅₀of less than or equal to 10 μM and exhibits a selectivity for the M₁receptor vis-à-vis one or more of the mAChR M₂, M₃, M₄or M₅receptors. For example, the compounds can have an EC₅₀of less than or equal to 10 μM, less than or equal to 5 μM, less than or equal to 2.5 μM, less than or equal to 1 μM, less than or equal to 500 nM, less than or equal to 250 nM, less than or equal to 100 nM, or less than or equal to 50 nM; and the compounds can also activate mAChR M₁response with an EC₅₀of at least 5-fold less than that for mAChR M₂, at least 10-fold less than that for mAChR M₂, at least 20-fold less than that for mAChR M₂, at least 30-fold less than that for mAChR M₂, or at least 50-fold less than that for mAChR M₂. In another embodiment, the compounds can have an EC₅₀of less than or equal to 10 μM, less than or equal to 5 μM, less than or equal to 2.5 μM, less than or equal to 1 μM, less than or equal to 500 nM, less than or equal to 250 nM, less than or equal to 100 nM, or less than or equal to 50 nM; and the compounds can also activate mAChR M₁response with an EC₅₀of at least 5-fold less than that for mAChR M₃, at least 10-fold less than that for mAChR M₃, at least 20-fold less than that for mAChR M₃, at least 30-fold less than that for mAChR M₃, or at least 50-fold less than that for mAChR M₃. In another embodiment, the compounds can have an EC₅₀of less than or equal to 10 μM, less than or equal to 5 μM, less than or equal to 2.5 μM, less than or equal to 1 μM, less than or equal to 500 nM, less than or equal to 250 nM, less than or equal to 100 nM, or less than or equal to 50 nM; and the compounds can also activate mAChR M₁response with an EC₅₀of at least 5-fold less than that for mAChR M₄, of at least 10-fold less than that for mAChR M₄, of at least 20-fold less than that for mAChR M₄, of at least 30-fold less than that for mAChR M₄, or at least 50-fold less than that for mAChR M₄. In another embodiment, the compound can have an EC₅₀of less than or equal to 10 μM, less than or equal to 5 μM, less than or equal to 2.5 μM, less than or equal to 1 μM, less than or equal to 500 nM, less than or equal to 250 nM, less than or equal to 100 nM, or less than or equal to 50 nM; and the compounds can also activate mAChR M₁response with an EC₅₀of at least 5-fold less than that for mAChR M₅, of at least 10-fold less than that for mAChR M₅, of at least 20-fold less than that for mAChR M₅, of at least 30-fold less than that for mAChR M₅, or at least 50-fold less than that for mAChR M₅. In another embodiment, the compounds can have an EC₅₀of less than or equal to 10 μM, less than or equal to 5 μM, less than or equal to 2.5 μM, less than or equal to 1 μM, less than or equal to 500 nM, less than or equal to 250 nM, less than or equal to 100 nM, or less than or equal to 50 nM; and the compounds can also activate mAChR M₁response with an EC₅₀of at least 5-fold less than that for the mAChR M₂, M₃, M₄or M₅receptors, at least 10-fold less than that for the mAChR M₂, M₃, M₄or M₅receptors, at least 20-fold less than that for the mAChR M₂, M₃, M₄or M₅receptors, at least 30-fold less than that for the mAChR M₂, M₃, M₄or M₅receptors, or at least 50-fold less than that for the mAChR M₂, M₃, M₄or M₅receptors.

The disclosed compounds may exist as pharmaceutically acceptable salts. The term “pharmaceutically acceptable salt” refers to salts or zwitterions of the compounds which are water or oil-soluble or dispersible, suitable for treatment of disorders without undue toxicity, irritation, and allergic response, commensurate with a reasonable benefit/risk ratio and effective for their intended use. The salts may be prepared during the final isolation and purification of the compounds or separately by reacting an amino group of the compounds with a suitable acid. For example, a compound may be dissolved in a suitable solvent, such as but not limited to methanol and water and treated with at least one equivalent of an acid, like hydrochloric acid. The resulting salt may precipitate out and be isolated by filtration and dried under reduced pressure. Alternatively, the solvent and excess acid may be removed under reduced pressure to provide a salt. Representative salts include acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, digluconate, glycerophosphate, hemisulfate, heptanoate, hexanoate, formate, isethionate, fumarate, lactate, maleate, methanesulfonate, naphthylenesulfonate, nicotinate, oxalate, pamoate, pectinate, persulfate, 3-phenylpropionate, picrate, oxalate, maleate, pivalate, propionate, succinate, tartrate, trichloroacetate, trifluoroacetate, glutamate, para-toluenesulfonate, undecanoate, hydrochloric, hydrobromic, sulfuric, phosphoric and the like. The amino groups of the compounds may also be quaternized with alkyl chlorides, bromides and iodides such as methyl, ethyl, propyl, isopropyl, butyl, lauryl, myristyl, stearyl and the like.

Basic addition salts may be prepared during the final isolation and purification of the disclosed compounds by reaction of a carboxyl group with a suitable base such as the hydroxide, carbonate, or bicarbonate of a metal cation such as lithium, sodium, potassium, calcium, magnesium, or aluminum, or an organic primary, secondary, or tertiary amine. Quaternary amine salts can be prepared, such as those derived from methylamine, dimethylamine, trimethylamine, triethylamine, diethylamine, ethylamine, tributylamine, pyridine, N,N-dimethylaniline, N-methylpiperidine, N-methylmorpholine, dicyclohexylamine, procaine, dibenzylamine, N,N-dibenzylphenethylamine, 1-ephenamine and N,N′-dibenzylethylenediamine, ethylenediamine, ethanolamine, diethanolamine, piperidine, piperazine, and the like.

b. General Synthesis

Compounds of formula (I) may be prepared by synthetic processes or by metabolic processes. Preparation of the compounds by metabolic processes includes those occurring in the human or animal body (in vivo) or processes occurring in vitro.

Compounds of formula (I), wherein the groups X, Y, Z, L, A¹, R¹, R², M, and A²have the meanings as set forth in the Summary of the Invention unless otherwise noted, can be synthesized as shown in Schemes 1-7.

Abbreviations which have been used in the descriptions of the Schemes that follow are: mCPBA for meta-chloroperbenzoic acid; DMCC for dimethylcarbamoyl chloride; DMF for dimethylformamide; dppf for 1,1′-bis(diphenylphosphino)ferrocene; HATU for 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate.

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As shown in Scheme 1, intermediate iii can be prepared from pyridine derivative i, wherein X, Y, Z, and R¹are as defined in the Summary of the Invention. Oxidation of i, can result in formation of N-oxide ii. Installation of the nitrile can be achieved to afford intermediate iii.

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Scheme 2 illustrates the conversion of iii to intermediate vii, wherein L is O and A¹is Cyc²-Q-Cyc³. Intermediate iii can be coupled with iv, wherein Cyc²is as defined in the Summary of the Invention, to form intermediate v. Intermediate v can then participate in a Suzuki coupling with vi, wherein Cyc³is as defined in the Summary of the Invention and Q is a bond, to provide intermediate vii.

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Scheme 3 depicts the preparation of intermediate ix, wherein L is O. Intermediate iii can be coupled with viii, wherein A¹is as defined in the Summary of the Invention, to provide intermediate ix.

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Scheme 4 demonstrates the conversion of iii to intermediate xii. Intermediate iii can be reacted with bis(pinacoloto)diboron to provide boronic ester x. Boronic ester x can be coupled with xi, wherein L and A¹are as defined in the Summary of the Invention, to give intermediate xii.

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Scheme 5 demonstrates the conversion of xii to intermediate xiv. The nitrile-containing intermediate xii can be treated with strong base to yield primary amide xiii. Amide xiii can be hydrolyzed in the presence of concentrated hydrochloric acid to provide intermediate xiv.

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Scheme 6 shows an alternative conversion of xii to intermediate xiv. Conversion can be achieved in one step in the presence of strong base and elevated temperatures to afford intermediate xiv.

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Scheme 7 illustrates preparation of the compound of formula (I) from intermediate xiv. Intermediate xiv can be coupled with amine xv, wherein R², M, and A²are as defined in the Summary of the Invention, to afford the compound of formula (I).

The compounds and intermediates may be isolated and purified by methods well-known to those skilled in the art of organic synthesis. Examples of conventional methods for isolating and purifying compounds can include, but are not limited to, chromatography on solid supports such as silica gel, alumina, or silica derivatized with alkylsilane groups, by recrystallization at high or low temperature with an optional pretreatment with activated carbon, thin-layer chromatography, distillation at various pressures, sublimation under vacuum, and trituration, as described for instance in “Vogel's Textbook of Practical Organic Chemistry,” 5th edition (1989), by Furniss, Hannaford, Smith, and Tatchell, pub. Longman Scientific & Technical, Essex CM20 2JE, England.

A disclosed compound may have at least one basic nitrogen whereby the compound can be treated with an acid to form a desired salt. For example, a compound may be reacted with an acid at or above room temperature to provide the desired salt, which is deposited, and collected by filtration after cooling. Examples of acids suitable for the reaction include, but are not limited to tartaric acid, lactic acid, succinic acid, as well as mandelic, atrolactic, methanesulfonic, ethanesulfonic, toluenesulfonic, naphthalenesulfonic, benzenesulfonic, carbonic, fumaric, maleic, gluconic, acetic, propionic, salicylic, hydrochloric, hydrobromic, phosphoric, sulfuric, citric, hydroxybutyric, camphorsulfonic, malic, phenylacetic, aspartic, or glutamic acid, and the like.

Reaction conditions and reaction times for each individual step can vary depending on the particular reactants employed and substituents present in the reactants used. Specific procedures are provided in the Examples section. Reactions can be worked up in the conventional manner, e.g. by eliminating the solvent from the residue and further purified according to methodologies generally known in the art such as, but not limited to, crystallization, distillation, extraction, trituration and chromatography. Unless otherwise described, the starting materials and reagents are either commercially available or can be prepared by one skilled in the art from commercially available materials using methods described in the chemical literature. Starting materials, if not commercially available, can be prepared by procedures selected from standard organic chemical techniques, techniques that are analogous to the synthesis of known, structurally similar compounds, or techniques that are analogous to the above described schemes or the procedures described in the synthetic examples section.

Routine experimentations, including appropriate manipulation of the reaction conditions, reagents and sequence of the synthetic route, protection of any chemical functionality that cannot be compatible with the reaction conditions, and deprotection at a suitable point in the reaction sequence of the method are included in the scope of the invention. Suitable protecting groups and the methods for protecting and deprotecting different substituents using such suitable protecting groups are well known to those skilled in the art; examples of which can be found in P G M Wuts and T W Greene, in Greene's book titled Protective Groups in Organic Synthesis (4^thed.), John Wiley & Sons, NY (2006), which is incorporated herein by reference in its entirety. Synthesis of the compounds of the invention can be accomplished by methods analogous to those described in the synthetic schemes described hereinabove and in specific examples.

When an optically active form of a disclosed compound is required, it can be obtained by carrying out one of the procedures described herein using an optically active starting material (prepared, for example, by asymmetric induction of a suitable reaction step), or by resolution of a mixture of the stereoisomers of the compound or intermediates using a standard procedure (such as chromatographic separation, recrystallization or enzymatic resolution).

Similarly, when a pure geometric isomer of a compound is required, it can be obtained by carrying out one of the above procedures using a pure geometric isomer as a starting material, or by resolution of a mixture of the geometric isomers of the compound or intermediates using a standard procedure such as chromatographic separation.

It can be appreciated that the synthetic schemes and specific examples as described are illustrative and are not to be read as limiting the scope of the invention as it is defined in the appended claims. All alternatives, modifications, and equivalents of the synthetic methods and specific examples are included within the scope of the claims.

3. PHARMACEUTICAL COMPOSITIONS

The disclosed compounds may be incorporated into pharmaceutical compositions suitable for administration to a subject (such as a patient, which may be a human or non-human). The disclosed compounds may also be provided as formulations, such as spray-dried dispersion formulations.

The pharmaceutical compositions and formulations may include a “therapeutically effective amount” or a “prophylactically effective amount” of the agent. A “therapeutically effective amount” refers to an amount effective, at dosages and for periods of time necessary, to achieve the desired therapeutic result. A therapeutically effective amount of the composition may be determined by a person skilled in the art and may vary according to factors such as the disease state, age, sex, and weight of the individual, and the ability of the composition to elicit a desired response in the individual. A therapeutically effective amount is also one in which any toxic or detrimental effects of a compound of the disclosure (e.g., a compound of formula (I)) are outweighed by the therapeutically beneficial effects. A “prophylactically effective amount” refers to an amount effective, at dosages and for periods of time necessary, to achieve the desired prophylactic result. Typically, since a prophylactic dose is used in subjects prior to or at an earlier stage of disease, the prophylactically effective amount will be less than the therapeutically effective amount.

For example, a therapeutically effective amount of a compound of formula (I), may be about 1 mg/kg to about 1000 mg/kg, about 5 mg/kg to about 950 mg/kg, about 10 mg/kg to about 900 mg/kg, about 15 mg/kg to about 850 mg/kg, about 20 mg/kg to about 800 mg/kg, about 25 mg/kg to about 750 mg/kg, about 30 mg/kg to about 700 mg/kg, about 35 mg/kg to about 650 mg/kg, about 40 mg/kg to about 600 mg/kg, about 45 mg/kg to about 550 mg/kg, about 50 mg/kg to about 500 mg/kg, about 55 mg/kg to about 450 mg/kg, about 60 mg/kg to about 400 mg/kg, about 65 mg/kg to about 350 mg/kg, about 70 mg/kg to about 300 mg/kg, about 75 mg/kg to about 250 mg/kg, about 80 mg/kg to about 200 mg/kg, about 85 mg/kg to about 150 mg/kg, and about 90 mg/kg to about 100 mg/kg.

The pharmaceutical compositions and formulations may include pharmaceutically acceptable carriers. The term “pharmaceutically acceptable carrier,” as used herein, means a non-toxic, inert solid, semi-solid or liquid filler, diluent, encapsulating material or formulation auxiliary of any type. Some examples of materials which can serve as pharmaceutically acceptable carriers are sugars such as, but not limited to, lactose, glucose and sucrose; starches such as, but not limited to, corn starch and potato starch; cellulose and its derivatives such as, but not limited to, sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt; gelatin; talc; excipients such as, but not limited to, cocoa butter and suppository waxes; oils such as, but not limited to, peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; glycols; such as propylene glycol; esters such as, but not limited to, ethyl oleate and ethyl laurate; agar; buffering agents such as, but not limited to, magnesium hydroxide and aluminum hydroxide; alginic acid; pyrogen-free water; isotonic saline; Ringer's solution; ethyl alcohol, and phosphate buffer solutions, as well as other non-toxic compatible lubricants such as, but not limited to, sodium lauryl sulfate and magnesium stearate, as well as coloring agents, releasing agents, coating agents, sweetening, flavoring and perfuming agents, preservatives and antioxidants can also be present in the composition, according to the judgment of the formulator.

Thus, the compounds and their physiologically acceptable salts and solvates may be formulated for administration by, for example, solid dosing, eye drop, in a topical oil-based formulation, injection, inhalation (either through the mouth or the nose), implants, or oral, buccal, parenteral, or rectal administration. Techniques and formulations may generally be found in “Remington's Pharmaceutical Sciences,” (Meade Publishing Co., Easton, Pa.). Therapeutic compositions must typically be sterile and stable under the conditions of manufacture and storage.

The route by which the disclosed compounds are administered and the form of the composition will dictate the type of carrier to be used. The composition may be in a variety of forms, suitable, for example, for systemic administration (e.g., oral, rectal, nasal, sublingual, buccal, implants, or parenteral) or topical administration (e.g., dermal, pulmonary, nasal, aural, ocular, liposome delivery systems, or iontophoresis).

Carriers for systemic administration typically include at least one of diluents, lubricants, binders, disintegrants, colorants, flavors, sweeteners, antioxidants, preservatives, glidants, solvents, suspending agents, wetting agents, surfactants, combinations thereof, and others. All carriers are optional in the compositions.

Suitable diluents include sugars such as glucose, lactose, dextrose, and sucrose; diols such as propylene glycol; calcium carbonate; sodium carbonate; sugar alcohols, such as glycerin; mannitol; and sorbitol. The amount of diluent(s) in a systemic or topical composition is typically about 50 to about 90%.

Suitable lubricants include silica, talc, stearic acid and its magnesium salts and calcium salts, calcium sulfate; and liquid lubricants such as polyethylene glycol and vegetable oils such as peanut oil, cottonseed oil, sesame oil, olive oil, corn oil and oil of theobroma. The amount of lubricant(s) in a systemic or topical composition is typically about 5 to about 10%.

Suitable binders include polyvinyl pyrrolidone; magnesium aluminum silicate; starches such as corn starch and potato starch; gelatin; tragacanth; and cellulose and its derivatives, such as sodium carboxymethylcellulose, ethyl cellulose, methylcellulose, microcrystalline cellulose, and sodium carboxymethylcellulose. The amount of binder(s) in a systemic composition is typically about 5 to about 50%.

Suitable disintegrants include agar, alginic acid and the sodium salt thereof, effervescent mixtures, croscarmellose, crospovidone, sodium carboxymethyl starch, sodium starch glycolate, clays, and ion exchange resins. The amount of disintegrant(s) in a systemic or topical composition is typically about 0.1 to about 10%.

Suitable colorants include a colorant such as an FD&C dye. When used, the amount of colorant in a systemic or topical composition is typically about 0.005 to about 0.1%.

Suitable flavors include menthol, peppermint, and fruit flavors. The amount of flavor(s), when used, in a systemic or topical composition is typically about 0.1 to about 1.0%.

Suitable sweeteners include aspartame and saccharin. The amount of sweetener(s) in a systemic or topical composition is typically about 0.001 to about 1%.

Suitable antioxidants include butylated hydroxyanisole (“BHA”), butylated hydroxytoluene (“BHT”), and vitamin E. The amount of antioxidant(s) in a systemic or topical composition is typically about 0.1 to about 5%.

Suitable preservatives include benzalkonium chloride, methyl paraben and sodium benzoate. The amount of preservative(s) in a systemic or topical composition is typically about 0.01 to about 5%.

Suitable glidants include silicon dioxide. The amount of glidant(s) in a systemic or topical composition is typically about 1 to about 5%.

Suitable solvents include water, isotonic saline, ethyl oleate, glycerine, hydroxylated castor oils, alcohols such as ethanol, and phosphate buffer solutions. The amount of solvent(s) in a systemic or topical composition is typically from about 0 to about 100%.

Suitable suspending agents include AVICEL RC-591 (from FMC Corporation of Philadelphia, Pa.) and sodium alginate. The amount of suspending agent(s) in a systemic or topical composition is typically about 1 to about 8%.

Suitable surfactants include lecithin, Polysorbate 80, and sodium lauryl sulfate, and the TWEENS from Atlas Powder Company of Wilmington, Del. Suitable surfactants include those disclosed in the C.T.F.A. Cosmetic Ingredient Handbook, 1992, pp.587-592; Remington's Pharmaceutical Sciences, 15th Ed. 1975, pp. 335-337; and McCutcheon's Volume 1, Emulsifiers & Detergents, 1994, North American Edition, pp. 236-239. The amount of surfactant(s) in the systemic or topical composition is typically about 0.1% to about 5%.

Although the amounts of components in the systemic compositions may vary depending on the type of systemic composition prepared, in general, systemic compositions include 0.01% to 50% of an active compound (e.g., a compound of formula (I)) and 50% to 99.99% of one or more carriers. Compositions for parenteral administration typically include 0.1% to 10% of actives and 90% to 99.9% of a carrier including a diluent and a solvent.

Compositions for oral administration can have various dosage forms. For example, solid forms include tablets, capsules, granules, and bulk powders. These oral dosage forms include a safe and effective amount, usually at least about 5%, and more particularly from about 25% to about 50% of actives. The oral dosage compositions include about 50% to about 95% of carriers, and more particularly, from about 50% to about 75%.

Tablets can be compressed, tablet triturates, enteric-coated, sugar-coated, film-coated, or multiple-compressed. Tablets typically include an active component, and a carrier comprising ingredients selected from diluents, lubricants, binders, disintegrants, colorants, flavors, sweeteners, glidants, and combinations thereof. Specific diluents include calcium carbonate, sodium carbonate, mannitol, lactose and cellulose. Specific binders include starch, gelatin, and sucrose. Specific disintegrants include alginic acid and croscarmellose. Specific lubricants include magnesium stearate, stearic acid, and talc. Specific colorants are the FD&C dyes, which can be added for appearance. Chewable tablets preferably contain sweeteners such as aspartame and saccharin, or flavors such as menthol, peppermint, fruit flavors, or a combination thereof.

Capsules (including implants, time release and sustained release formulations) typically include an active compound (e.g., a compound of formula (I)), and a carrier including one or more diluents disclosed above in a capsule comprising gelatin. Granules typically comprise a disclosed compound, and preferably glidants such as silicon dioxide to improve flow characteristics. Implants can be of the biodegradable or the non-biodegradable type.

The selection of ingredients in the carrier for oral compositions depends on secondary considerations like taste, cost, and shelf stability, which are not critical for the purposes of this invention.

Solid compositions may be coated by conventional methods, typically with pH or time-dependent coatings, such that a disclosed compound is released in the gastrointestinal tract in the vicinity of the desired application, or at various points and times to extend the desired action. The coatings typically include one or more components selected from the group consisting of cellulose acetate phthalate, polyvinyl acetate phthalate, hydroxypropyl methyl cellulose phthalate, ethyl cellulose, EUDRAGIT® coatings (available from Evonik Industries of Essen, Germany), waxes and shellac.

Compositions for oral administration can have liquid forms. For example, suitable liquid forms include aqueous solutions, emulsions, suspensions, solutions reconstituted from non-effervescent granules, suspensions reconstituted from non-effervescent granules, effervescent preparations reconstituted from effervescent granules, elixirs, tinctures, syrups, and the like. Liquid orally administered compositions typically include a disclosed compound and a carrier, namely, a carrier selected from diluents, colorants, flavors, sweeteners, preservatives, solvents, suspending agents, and surfactants. Peroral liquid compositions preferably include one or more ingredients selected from colorants, flavors, and sweeteners.

Other compositions useful for attaining systemic delivery of the subject compounds include sublingual, buccal and nasal dosage forms. Such compositions typically include one or more of soluble filler substances such as diluents including sucrose, sorbitol and mannitol; and binders such as acacia, microcrystalline cellulose, carboxymethyl cellulose, and hydroxypropyl methylcellulose. Such compositions may further include lubricants, colorants, flavors, sweeteners, antioxidants, and glidants.

The disclosed compounds can be topically administered. Topical compositions that can be applied locally to the skin may be in any form including solids, solutions, oils, creams, ointments, gels, lotions, shampoos, leave-on and rinse-out hair conditioners, milks, cleansers, moisturizers, sprays, skin patches, and the like. Topical compositions include: a disclosed compound (e.g., a compound of formula (I)), and a carrier. The carrier of the topical composition preferably aids penetration of the compounds into the skin. The carrier may further include one or more optional components.

The amount of the carrier employed in conjunction with a disclosed compound is sufficient to provide a practical quantity of composition for administration per unit dose of the compound. Techniques and compositions for making dosage forms useful in the methods of this invention are described in the following references: Modern Pharmaceutics, Chapters 9 and 10, Banker & Rhodes, eds. (1979); Lieberman et al., Pharmaceutical Dosage Forms: Tablets (1981); and Ansel, Introduction to Pharmaceutical Dosage Forms, 2nd Ed., (1976).

A carrier may include a single ingredient or a combination of two or more ingredients. In the topical compositions, the carrier includes a topical carrier. Suitable topical carriers include one or more ingredients selected from phosphate buffered saline, isotonic water, deionized water, monofunctional alcohols, symmetrical alcohols, aloe vera gel, allantoin, glycerin, vitamin A and E oils, mineral oil, propylene glycol, PPG-2 myristyl propionate, dimethyl isosorbide, castor oil, combinations thereof, and the like. More particularly, carriers for skin applications include propylene glycol, dimethyl isosorbide, and water, and even more particularly, phosphate buffered saline, isotonic water, deionized water, monofunctional alcohols, and symmetrical alcohols.

The carrier of a topical composition may further include one or more ingredients selected from emollients, propellants, solvents, humectants, thickeners, powders, fragrances, pigments, and preservatives, all of which are optional.

Suitable emollients include stearyl alcohol, glyceryl monoricinoleate, glyceryl monostearate, propane-1,2-diol, butane-1,3-diol, mink oil, cetyl alcohol, isopropyl isostearate, stearic acid, isobutyl palmitate, isocetyl stearate, oleyl alcohol, isopropyl laurate, hexyl laurate, decyl oleate, octadecan-2-ol, isocetyl alcohol, cetyl palmitate, di-n-butyl sebacate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, butyl stearate, polyethylene glycol, triethylene glycol, lanolin, sesame oil, coconut oil, arachis oil, castor oil, acetylated lanolin alcohols, petroleum, mineral oil, butyl myristate, isostearic acid, palmitic acid, isopropyl linoleate, lauryl lactate, myristyl lactate, decyl oleate, myristyl myristate, and combinations thereof. Specific emollients for skin include stearyl alcohol and polydimethylsiloxane. The amount of emollient(s) in a skin-based topical composition is typically about 5% to about 95%.

Suitable propellants include propane, butane, isobutane, dimethyl ether, carbon dioxide, nitrous oxide, and combinations thereof. The amount of propellant(s) in a topical composition is typically about 0% to about 95%.

Suitable solvents include water, ethyl alcohol, methylene chloride, isopropanol, castor oil, ethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, dimethylsulfoxide, dimethyl formamide, tetrahydrofuran, and combinations thereof. Specific solvents include ethyl alcohol and homotopic alcohols. The amount of solvent(s) in a topical composition is typically about 0% to about 95%.

Suitable humectants include glycerin, sorbitol, sodium 2-pyrrolidone-5-carboxylate, soluble collagen, dibutyl phthalate, gelatin, and combinations thereof. Specific humectants include glycerin. The amount of humectant(s) in a topical composition is typically 0% to 95%.

The amount of thickener(s) in a topical composition is typically about 0% to about 95%.

Suitable powders include beta-cyclodextrins, hydroxypropyl cyclodextrins, chalk, talc, fullers earth, kaolin, starch, gums, colloidal silicon dioxide, sodium polyacrylate, tetra alkyl ammonium smectites, trialkyl aryl ammonium smectites, chemically-modified magnesium aluminum silicate, organically-modified montmorillonite clay, hydrated aluminum silicate, fumed silica, carboxyvinyl polymer, sodium carboxymethyl cellulose, ethylene glycol monostearate, and combinations thereof. The amount of powder(s) in a topical composition is typically 0% to 95%.

The amount of fragrance in a topical composition is typically about 0% to about 0.5%, particularly, about 0.001% to about 0.1%.

Suitable pH adjusting additives include HCl or NaOH in amounts sufficient to adjust the pH of a topical pharmaceutical composition.

a. Spray-Dried Dispersion Formulations

The disclosed compounds may be formulated as a spray-dried dispersion (SDD). An SDD is a single-phase, amorphous molecular dispersion of a drug in a polymer matrix. It is a solid solution with the compound molecularly “dissolved” in a solid matrix. SDDs are obtained by dissolving drug and a polymer in an organic solvent and then spray-drying the solution. The use of spray drying for pharmaceutical applications can result in amorphous dispersions with increased solubility of Biopharmaceutics Classification System (BCS) class II (high permeability, low solubility) and class IV (low permeability, low solubility) drugs. Formulation and process conditions are selected so that the solvent quickly evaporates from the droplets, thus allowing insufficient time for phase separation or crystallization. SDDs have demonstrated long-term stability and manufacturability. For example, shelf lives of more than 2 years have been demonstrated with SDDs. Advantages of SDDs include, but are not limited to, enhanced oral bioavailability of poorly water-soluble compounds, delivery using traditional solid dosage forms (e.g., tablets and capsules), a reproducible, controllable and scalable manufacturing process and broad applicability to structurally diverse insoluble compounds with a wide range of physical properties.

Thus, in one embodiment, the disclosure may provide a spray-dried dispersion formulation comprising a compound of formula (I).

4. METHODS OF TREATMENT

The disclosed compounds may be used in methods for treatment of mAChR M₁related medical disorders and/or diseases. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of the compound of formula (I).

The compounds can be administered to a subject in need thereof to modulate mAChR M₁, for a variety of diverse biological processes. The present disclosure is directed to methods for administering the composition to potentiate mAChR M₁, a GPCR whose dysfunction is associated with neurological and psychiatric disorders, for example.

The compounds may be useful for treating and preventing certain diseases and disorders in humans and animals related to mAChR M₁dysfunction. Treatment or prevention of such diseases and disorders can be effected by modulating mAChR M₁in a subject, by administering a compound or composition of the disclosure, either alone or in combination with another active agent as part of a therapeutic regimen to a subject in need thereof.

In combination therapy, the other drug(s) can be administered by a route and in an amount commonly used therefore, contemporaneously or sequentially with a disclosed compound. When a disclosed compound is used contemporaneously with one or more other drugs, a pharmaceutical composition in unit dosage form containing such drugs and the disclosed compound is preferred. However, the combination therapy can also be administered on overlapping schedules. It is also envisioned that the combination of one or more active ingredients and a disclosed compound can be more efficacious than either as a single agent.

In an embodiment, the compounds can be coadministered with anti-Alzheimer's agents, beta-secretase inhibitors, gamma-secretase inhibitors, orthosteric muscarinic agonists, muscarinic potentiators, cholinesterase inhibitors, HMG-CoA reductase inhibitors, NSAIDs and anti-amyloid antibodies. In a further aspect, the compounds can be administered in combination with sedatives, hypnotics, anxiolytics, antipsychotics (typical and atypical), selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), 5-HT2 antagonists, GlyT1 inhibitors and the like such as, but not limited to: risperidone, clozapine, haloperidol, fluoxetine, prazepam, xanomeline, lithium, phenobarbitol, and salts thereof and combinations thereof.

The compounds may be useful for treating a disease or disorder associated with dysfunction of mAChR M₁, wherein the disease or disorder is selected from at least one of Alzheimer's disease, a sleep disorder, a pain disorder, a cognitive disorder, psychosis, schizophrenia, conduct disorder, disruptive behavior disorder, bipolar disorder, psychotic episodes of anxiety, anxiety associated with psychosis, psychotic mood disorders, severe major depressive disorder, mood disorders associated with psychotic disorders, acute mania, depression associated with bipolar disorder, mood disorders associated with schizophrenia, behavioral manifestations of mental retardation, conduct disorder, autistic disorder, movement disorders, Tourette's syndrome, akinetic-rigid syndrome, movement disorders associated with Parkinson's disease, tardive dyskinesia, drug induced and neurodegeneration based dyskinesias, attention deficit hyperactivity disorder, cognitive disorders, dementias, and memory disorders.

The compounds may be useful for treating a pain disorder, wherein the pain disorder is neuropathic pain, central pain syndrome, postsurgical pain syndrome, bone and joint pain, repetitive motion pain, dental pain, cancer pain, myofascial pain, perioperative pain, chronic pain, dysmennorhea, inflammatory pain, headache, migraine headache, cluster headache, headache, primary hyperalgesia, secondary hyperalgesis, primary allodynia, secondary allodynia, or a combination thereof.

The compounds disclosed herein are useful for treating, preventing, ameliorating, controlling or reducing the risk of a variety of disorders wherein the patient or subject would benefit from selective positive allosteric modulation of the M₁receptor. In one aspect, a treatment can include selective M₁receptor modulation to an extent effective to affect cholinergic activity. Thus, a disorder can be associated with cholinergic activity, for example cholinergic hypofunction. In one aspect, provided is a method of treating or preventing a disorder in a subject comprising the step of administering to the subject at least one disclosed compound; at least one disclosed pharmaceutical composition; and/or at least one disclosed product in a dosage and amount effective to treat the disorder in the subject.

Also provided is a method for the treatment of one or more disorders, for which muscarinic receptor activation is predicted to be beneficial, in a subject comprising the step of administering to the subject at least one disclosed compound; at least one disclosed pharmaceutical composition; and/or at least one disclosed product in a dosage and amount effective to treat the disorder in the subject.

The disclosure is directed to the use of described chemical compositions to treat diseases or disorders in patients (preferably human) wherein muscarinic receptor activation would be predicted to have a therapeutic effect, such as Alzheimer's disease (both palliative cognitive and disease-modifying), cognitive impairment, schizophrenia, pain disorders (including acute pain, neuropathic pain and inflammatory pain), and sleep disorders, by administering one or more disclosed compounds or products.

Also provided is a method for the treatment of a disorder in a mammal comprising the step of administering to the mammal at least one disclosed compound, composition, or medicament.

a. Neurological and Psychiatric Disorders

The disclosed compounds have utility in treating a variety of neurological and psychiatric disorders, including one or more of the following conditions or diseases: schizophrenia or psychosis including schizophrenia (paranoid, disorganized, catatonic or undifferentiated), schizophreniform disorder, schizoaffective disorder, delusional disorder, brief psychotic disorder, shared psychotic disorder, psychotic disorder due to a general medical condition and substance-induced or drug-induced (phencyclidine, ketamine and other dissociative anesthetics, amphetamine and other psychostimulants and cocaine) psychosis psychotic disorder, psychosis associated with affective disorders, brief reactive psychosis, schizoaffective psychosis, “schizophrenia-spectrum” disorders such as schizoid or schizotypal personality disorders, or illness associated with psychosis (such as major depression, manic depressive (bipolar) disorder, Alzheimer's disease and post-traumatic stress syndrome), including both the positive and the negative symptoms of schizophrenia and other psychoses; cognitive disorders including dementia (associated with Alzheimer's disease, ischemia, multi-infarct dementia, trauma, vascular problems or stroke, HIV disease, Parkinson's disease, Huntington's disease, Pick's disease, Creutzfeldt-Jacob disease, perinatal hypoxia, other general medical conditions or substance abuse); delirium, amnestic disorders or age-related cognitive decline; anxiety disorders including acute stress disorder, agoraphobia, generalized anxiety disorder, obsessive-compulsive disorder, panic attack, panic disorder, post-traumatic stress disorder, separation anxiety disorder, social phobia, specific phobia, substance-induced anxiety disorder and anxiety due to a general medical condition; substance-related disorders and addictive behaviors (including substance-induced delirium, persisting dementia, persisting amnestic disorder, psychotic disorder or anxiety disorder; tolerance, dependence or withdrawal from substances including alcohol, amphetamines, cannabis, cocaine, hallucinogens, inhalants, nicotine, opioids, phencyclidine, sedatives, hypnotics or anxiolytics); obesity, bulimia nervosa and compulsive eating disorders; bipolar disorders, mood disorders including depressive disorders; depression including unipolar depression, seasonal depression and post-partum depression, premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PDD), mood disorders due to a general medical condition, and substance-induced mood disorders; learning disorders, pervasive developmental disorder including autistic disorder, attention disorders including attention-deficit hyperactivity disorder (ADHD) and conduct disorder; NMDA receptor-related disorders such as autism, depression, benign forgetfulness, childhood learning disorders and closed head injury; movement disorders, including akinesias and akinetic-rigid syndromes (including Parkinson's disease, drug-induced parkinsonism, post-encephalitic parkinsonism, progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, parkinsonism-ALS dementia complex and basal ganglia calcification), medication-induced parkinsonism (such as neuroleptic-induced parkinsonism, neuroleptic malignant syndrome, neuroleptic-induced acute dystonia, neuroleptic-induced acute akathisia, neuroleptic-induced tardive dyskinesia and medication-induced postural tremor), Gilles de La Tourette's syndrome, epilepsy, muscular spasms and disorders associated with muscular spasticity or weakness including tremors; dyskinesias including tremor (such as rest tremor, postural tremor and intention tremor), chorea (such as Sydenham's chorea, Huntington's disease, benign hereditary chorea, neuroacanthocytosis, symptomatic chorea, drug-induced chorea and hemiballism), myoclonus (including generalized myoclonus and focal myoclonus), tics (including simple tics, complex tics and symptomatic tics),and dystonia (including generalized dystonia such as idiopathic dystonia, drug-induced dystonia, symptomatic dystonia and paroxysmal dystonia, and focal dystonia such as blepharospasm, oromandibular dystonia, spasmodic dysphonia, spasmodic torticollis, axial dystonia, dystonic writer's cramp and hemiplegic dystonia)]; urinary incontinence; neuronal damage including ocular damage, retinopathy or macular degeneration of the eye, tinnitus, hearing impairment and loss, and brain edema; emesis; and sleep disorders including insomnia and narcolepsy.

1. Cognitive Disorders

The present disclosure provides a method for treating cognitive disorders, comprising: administering to a patient in need thereof an effective amount of a compound of the present disclosure. Particular cognitive disorders are dementia, delirium, amnestic disorders and age-related cognitive decline. The text revision of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) (2000, American Psychiatric Association, Washington D.C.) provides a diagnostic tool that includes cognitive disorders including dementia, delirium, amnestic disorders and age-related cognitive decline. As used herein, the term “cognitive disorders” includes treatment of those mental disorders as described in DSM-IV-TR. The skilled artisan will recognize that there are alternative nomenclatures, nosologies and classification systems for mental disorders, and that these systems evolve with medical and scientific progress. Thus the term “cognitive disorders” is intended to include like disorders that are described in other diagnostic sources.

2. Anxiety Disorders

The present disclosure provides a method for treating anxiety disorders, comprising: administering to a patient in need thereof an effective amount of a compound of the present disclosure. Particular anxiety disorders are generalized anxiety disorder, obsessive-compulsive disorder and panic attack. The text revision of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) (2000, American Psychiatric Association, Washington D.C.) provides a diagnostic tool that includes anxiety disorders are generalized anxiety disorder, panic disorder with or without agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, obsessive-compulsive disorder, post-traumatic stress disorder, acute stress disorder, generalized anxiety disorder, anxiety disorder due to a general medical condition, substance-induced anxiety disorder and anxiety disorder not otherwise specified. As used herein, the term “anxiety disorders” includes treatment of those mental disorders as described in DSM-IV-TR. The skilled artisan will recognize that there are alternative nomenclatures, nosologies and classification systems for mental disorders, and that these systems evolve with medical and scientific progress. Thus the term “anxiety disorders” is intended to include like disorders that are described in other diagnostic sources.

3. Alzheimer's Disease

Alzheimer's disease (AD) is a neurodegenerative disease affecting the elderly, which results in progressive impairment of memory, language skills and severe behavioral deficits. Hallmarks of the disease include degeneration of cholinergic neurons in the cerebral cortex, hippocampus, basal forebrain and other regions of the brain important for memory and cognition. Other hallmarks of AD include neurofibrillary tangles composed of hyperphosphorylated tau and accumulation of amyloid peptide (Aβ). Aβ is a 39-43 amino acid peptide produced in the brain by proteolytic processing of β-amyloid precursor protein (APP) by the β-amyloid cleaving enzyme (BACE) and gamma secretase which leads to accumulation of Aβ in the brain, where Aβ 1-40 and 1-42 are the principal aggregate-forming species of Aβ.

Activation of various muscarinic receptors, particularly the M₁subtype, has been proposed as a mechanism to enhance cognition in disorders such as AD. Thus, without wishing to be bound by theory, it is believed that selective positive allosteric modulators of mAChR subtypes that regulate processes involved in cognitive function could prove superior to AChE inhibitors for treatment of AD and related disorders as it is postulated that these compounds would exhibit improved selectivity for specific mAChRs.

Phase III clinical trials have shown that orthosteric mAChR activators can have efficacy in improving cognitive performance in AD patients. Moreover, data indicate that administration of M₁activators decreases behavioral disturbances, including delusions, hallucinations, outbursts, and other symptoms in patients suffering from neurodegenerative diseases such as Alzheimer's disease. However, dose limiting adverse effects that may be due to lack of mAChR M₁selectivity led to failed launches of previous M₁agonists. In some cases, evidence suggests that mAChR activation also has the potential to be disease-modifying in that these agents may lower Aβ in AD patients. The M₁-selective allosteric agonist TBPB was found to display effects on the processing of APP toward the non-amyloidogenic pathway and decrease Aβ1-40 and 1-42 production in vitro. These data suggest that selective activation of M₁may provide a novel approach for both symptomatic and disease modifying the treatment of Alzheimer's disease.

4. Schizophrenia

Schizophrenia is a debilitating psychiatric disorder characterized by a combination of negative (blunted affect, withdrawal, anhedonia) and positive (paranoia, hallucinations, delusions) symptoms as well as marked cognitive deficits. While schizophrenia remains an idiopathic disorder, it appears to be produced by a complex interaction of biological, environmental, and genetic factors. Over 40 years ago it was found that phencyclidine (PCP) induces a psychotic state in humans that is very similar to that observed in schizophrenic patients. The finding that the main mode of action of PCP is that of a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptor stimulated a series of studies that have led to the development of the NMDA receptor hypofunction model of schizophrenia.

The present disclosure provides a method for treating schizophrenia or psychosis comprising: administering to a patient in need thereof an effective amount of a compound of the present disclosure. Particular schizophrenia or psychosis pathologies are paranoid, disorganized, catatonic or undifferentiated schizophrenia and substance-induced psychotic disorder. The text revision of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) (2000, American Psychiatric Association, Washington D.C.) provides a diagnostic tool that includes paranoid, disorganized, catatonic or undifferentiated schizophrenia and substance-induced psychotic disorder.

NMDA receptor function can be modulated by activation of G Protein-Coupled Receptors (GPCRs) that are known to physically and/or functionally interact with the NMDA receptor. The NMDA receptor hypofunction hypothesis is a proposal to explain the underlying cause of schizophrenia. According to this hypothesis, any agent that can potentiate NMDA receptor currents, either directly by action on modulatory sites on the NMDA receptor (e.g., the glycine co-agonist binding site) or indirectly by activation of GPCRs known to potentiate NMDA receptor function (e.g. the mAChR M₁), has the potential to ameliorate the symptoms of schizophrenia. In both preclinical and in clinical studies, xanomeline, an M₁/M₄preferring orthosteric agonist has proved efficacious with regard to positive, negative and cognitive symptoms, indicating that M₁activation is a reasonable approach to the treatment of schizophrenia. More recently, the selective M₁allosteric agonist TBPB demonstrated efficacy in multiple preclinical models of schizophrenia.

As used herein, the term “schizophrenia or psychosis” includes treatment of those mental disorders as described in DSM-W-TR. The skilled artisan will recognize that there are alternative nomenclatures, nosologies and classification systems for mental disorders, and that these systems evolve with medical and scientific progress. Thus the term “schizophrenia or psychosis” is intended to include like disorders that are described in other diagnostic sources.

5. Substance-Related Disorders and Addictive Behaviors

The present disclosure provides a method for treating substance-related disorders and addictive behaviors, comprising: administering to a patient in need thereof an effective amount of a compound of the present disclosure. Particular substance-related disorders and addictive behaviors are persisting dementia, persisting amnestic disorder, psychotic disorder or anxiety disorder induced by substance abuse; and tolerance of, dependence on or withdrawal from substances of abuse. The text revision of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) (2000, American Psychiatric Association, Washington D.C.) provides a diagnostic tool that includes persisting dementia, persisting amnestic disorder, psychotic disorder or anxiety disorder induced by substance abuse; and tolerance of, dependence on or withdrawal from substances of abuse. As used herein, the term “substance-related disorders and addictive behaviors” includes treatment of those mental disorders as described in DSM-IV-TR. The skilled artisan will recognize that there are alternative nomenclatures, nosologies and classification systems for mental disorders, and that these systems evolve with medical and scientific progress. Thus the term “substance-related disorders and addictive behaviors” is intended to include like disorders that are described in other diagnostic sources.

6. Pain

In another aspect, the present disclosure provides a method for treating pain, comprising: administering to a patient in need thereof an effective amount of a compound of the present disclosure. Particular pain embodiments are bone and joint pain (osteoarthritis), repetitive motion pain, dental pain, cancer pain, myofascial pain (muscular injury, fibromyalgia), perioperative pain (general surgery, gynecological), chronic pain and neuropathic pain.

7. Obesity and Eating Disorders

The present disclosure provides a method for treating obesity or eating disorders associated with excessive food intake and complications associated therewith, comprising: administering to a patient in need thereof an effective amount of a compound of the present disclosure. Obesity is included in the tenth edition of the International Classification of Diseases and Related Health Problems (ICD-10) (1992 World Health Organization) as a general medical condition. The text revision of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) (2000, American Psychiatric Association, Washington D.C.) provides a diagnostic tool that includes obesity in the presence of psychological factors affecting medical condition. As used herein, the term “obesity or eating disorders associated with excessive food intake” includes treatment of those medical conditions and disorders described in ICD-10 and DSM-W-TR. The skilled artisan will recognize that there are alternative nomenclatures, nosologies and classification systems for general medical conditions, and that these systems evolve with medical and scientific progress. Thus, the term “obesity or eating disorders associated with excessive food intake” is intended to include like conditions and disorders that are described in other diagnostic sources.

The compounds are further useful in a method for the prevention, treatment, control, amelioration, or reduction of risk of the diseases, disorders and conditions noted herein. The compounds are further useful in a method for the prevention, treatment, control, amelioration, or reduction of risk of the aforementioned diseases, disorders and conditions in combination with other agents.

The present disclosure is further directed to administration of a selective M₁receptor modulator for improving treatment outcomes in the context of cognitive or behavioral therapy. That is, in one aspect, the disclosure relates to a cotherapeutic method comprising the step of administering to a mammal an effective amount and dosage of at least one compound of the disclosure in connection with cognitive or behavioral therapy.

In another aspect, administration improves treatment outcomes in the context of cognitive or behavioral therapy. Administration in connection with cognitive or behavioral therapy can be continuous or intermittent. Administration need not be simultaneous with therapy and can be before, during, and/or after therapy. For example, cognitive or behavioral therapy can be provided within 1, 2, 3, 4, 5, 6, 7 days before or after administration of the compound. As a further example, cognitive or behavioral therapy can be provided within 1, 2, 3, or 4 weeks before or after administration of the compound. As another example, cognitive or behavioral therapy can be provided before or after administration within a period of time of 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 half-lives of the administered compound.

b. Modes of Administration

Methods of treatment may include any number of modes of administering a disclosed composition. Modes of administration may include tablets, pills, dragees, hard and soft gel capsules, granules, pellets, aqueous, lipid, oily or other solutions, emulsions such as oil-in-water emulsions, liposomes, aqueous or oily suspensions, syrups, elixirs, solid emulsions, solid dispersions or dispersible powders. For the preparation of pharmaceutical compositions for oral administration, the agent may be admixed with commonly known and used adjuvants and excipients such as for example, gum arabic, talcum, starch, sugars (such as, e.g., mannitose, methyl cellulose, lactose), gelatin, surface-active agents, magnesium stearate, aqueous or non-aqueous solvents, paraffin derivatives, cross-linking agents, dispersants, emulsifiers, lubricants, conserving agents, flavoring agents (e.g., ethereal oils), solubility enhancers (e.g., benzyl benzoate or benzyl alcohol) or bioavailability enhancers (e.g. Gelucire™). In the pharmaceutical composition, the agent may also be dispersed in a microparticle, e.g. a nanoparticulate composition.

For parenteral administration, the agent can be dissolved or suspended in a physiologically acceptable diluent, such as, e.g., water, buffer, oils with or without solubilizers, surface-active agents, dispersants or emulsifiers. As oils for example and without limitation, olive oil, peanut oil, cottonseed oil, soybean oil, castor oil and sesame oil may be used. More generally spoken, for parenteral administration, the agent can be in the form of an aqueous, lipid, oily or other kind of solution or suspension or even administered in the form of liposomes or nano-suspensions.

The term “parenterally,” as used herein, refers to modes of administration which include intravenous, intramuscular, intraperitoneal, intrasternal, subcutaneous and intraarticular injection and infusion.

c. Combination Therapies

In one aspect, the disclosed compounds can be used in combination with one or more other drugs in the treatment, prevention, control, amelioration, or reduction of risk of diseases or conditions for which disclosed compounds or the other drugs can have utility, where the combination of the drugs together are safer or more effective than either drug alone. Such other drug(s) can be administered, by a route and in an amount commonly used therefor, contemporaneously or sequentially with a compound of the present disclosure. When a compound of the present disclosure is used contemporaneously with one or more other drugs, a pharmaceutical composition in unit dosage form containing such other drugs and a disclosed compound is preferred. However, the combination therapy can also include therapies in which a disclosed compound and one or more other drugs are administered on different overlapping schedules. It is also contemplated that when used in combination with one or more other active ingredients, the disclosed compounds and the other active ingredients can be used in lower doses than when each is used singly.

Accordingly, the pharmaceutical compositions include those that contain one or more other active ingredients, in addition to a compound of the present disclosure.

The above combinations include combinations of a disclosed compound not only with one other active compound, but also with two or more other active compounds. Likewise, disclosed compounds can be used in combination with other drugs that are used in the prevention, treatment, control, amelioration, or reduction of risk of the diseases or conditions for which disclosed compounds are useful. Such other drugs can be administered, by a route and in an amount commonly used therefor, contemporaneously or sequentially with a compound of the present disclosure. When a compound of the present disclosure is used contemporaneously with one or more other drugs, a pharmaceutical composition containing such other drugs in addition to a disclosed compound is preferred. Accordingly, the pharmaceutical compositions include those that also contain one or more other active ingredients, in addition to a compound of the present disclosure.

The weight ratio of a disclosed compound to the second active ingredient can be varied and will depend upon the effective dose of each ingredient. Generally, an effective dose of each will be used. Thus, for example, when a compound of the present disclosure is combined with another agent, the weight ratio of a disclosed compound to the other agent will generally range from about 1000:1 to about 1:1000, preferably about 200:1 to about 1:200. Combinations of a compound of the present disclosure and other active ingredients will generally also be within the aforementioned range, but in each case, an effective dose of each active ingredient should be used.

In such combinations disclosed compounds and other active agents can be administered separately or in conjunction. In addition, the administration of one element can be prior to, concurrent to, or subsequent to the administration of other agent(s).

Accordingly, the disclosed compounds can be used alone or in combination with other agents which are known to be beneficial in the subject indications or other drugs that affect receptors or enzymes that either increase the efficacy, safety, convenience, or reduce unwanted side effects or toxicity of the disclosed compounds. The subject compound and the other agent can be coadministered, either in concomitant therapy or in a fixed combination.

In an embodiment, the disclosed compounds can be employed in combination with anti-Alzheimer's agents, beta-secretase inhibitors, gamma-secretase inhibitors, HMG-CoA reductase inhibitors, NSAID's including ibuprofen, vitamin E, and anti-amyloid antibodies. In another embodiment, the subject compound can be employed in combination with sedatives, hypnotics, anxiolytics, antipsychotics, antianxiety agents, cyclopyrrolones, imidazopyridines, pyrazolopyrimidines, minor tranquilizers, melatonin agonists and antagonists, melatonergic agents, benzodiazepines, barbiturates, 5HT-2 antagonists, and the like, such as: adinazolam, allobarbital, alonimid, alprazolam, amisulpride, amitriptyline, amobarbital, amoxapine, aripiprazole, bentazepam, benzoctamine, brotizolam, bupropion, buspirone, butabarbital, butalbital, capuride, carbocloral, chloral betaine, chloral hydrate, clomipramine, clonazepam, cloperidone, clorazepate, chlordiazepoxide, clorethate, chlorpromazine, clozapine, cyprazepam, desipramine, dexclamol, diazepam, dichloralphenazone, divalproex, diphenhydramine, doxepin, estazolam, ethchlorvynol, etomidate, fenobam, flunitrazepam, flupentixol, fluphenazine, flurazepam, fluvoxamine, fluoxetine, fosazepam, glutethimide, halazepam, haloperidol, hydroxyzine, imipramine, lithium, lorazepam, lormetazepam, maprotiline, mecloqualone, melatonin, mephobarbital, meprobamate, methaqualone, midaflur, midazolam, nefazodone, nisobamate, nitrazepam, nortriptyline, olanzapine, oxazepam, paraldehyde, paroxetine, pentobarbital, perlapine, perphenazine, phenelzine, phenobarbital, prazepam, promethazine, propofol, protriptyline, quazepam, quetiapine, reclazepam, risperidone, roletamide, secobarbital, sertraline, suproclone, temazepam, thioridazine, thiothixene, tracazolate, tranylcypromaine, trazodone, triazolam, trepipam, tricetamide, triclofos, trifluoperazine, trimetozine, trimipramine, uldazepam, venlafaxine, zaleplon, ziprasidone, zolazepam, Zolpidem, and salts thereof, and combinations thereof, and the like, or the subject compound can be administered in conjunction with the use of physical methods such as with light therapy or electrical stimulation.

In an embodiment, the disclosed compounds can be employed in combination with levodopa (with or without a selective extracerebral decarboxylase inhibitor such as carbidopa or benserazide), anticholinergics such as biperiden (optionally as its hydrochloride or lactate salt) and trihexyphenidyl (benzhexol) hydrochloride, COMT inhibitors such as entacapone, MOA-B inhibitors, antioxidants, A2a adenosine receptor antagonists, cholinergic agonists, NMDA receptor antagonists, serotonin receptor antagonists and dopamine receptor agonists such as alentemol, bromocriptine, fenoldopam, lisuride, naxagolide, pergolide and pramipexole. It will be appreciated that the dopamine agonist can be in the form of a pharmaceutically acceptable salt, for example, alentemol hydrobromide, bromocriptine mesylate, fenoldopam mesylate, naxagolide hydrochloride and pergolide mesylate. Lisuride and pramipexol are commonly used in a non-salt form.

In an embodiment, the disclosed compounds can be employed in combination with a compound from the phenothiazine, thioxanthene, heterocyclic dibenzazepine, butyrophenone, diphenylbutylpiperidine and indolone classes of neuroleptic agent. Suitable examples of phenothiazines include chlorpromazine, mesoridazine, thioridazine, acetophenazine, fluphenazine, perphenazine and trifluoperazine. Suitable examples of thioxanthenes include chlorprothixene and thiothixene. An example of a dibenzazepine is clozapine. An example of a butyrophenone is haloperidol. An example of a diphenylbutylpiperidine is pimozide. An example of an indolone is molindolone. Other neuroleptic agents include loxapine, sulpiride and risperidone. It will be appreciated that the neuroleptic agents when used in combination with the subject compound can be in the form of a pharmaceutically acceptable salt, for example, chlorpromazine hydrochloride, mesoridazine besylate, thioridazine hydrochloride, acetophenazine maleate, fluphenazine hydrochloride, flurphenazine enathate, fluphenazine decanoate, trifluoperazine hydrochloride, thiothixene hydrochloride, haloperidol decanoate, loxapine succinate and molindone hydrochloride. Perphenazine, chlorprothixene, clozapine, haloperidol, pimozide and risperidone are commonly used in a non-salt form. Thus, the subject compound can be employed in combination with acetophenazine, alentemol, aripiprazole, amisulpride, benzhexol, bromocriptine, biperiden, chlorpromazine, chlorprothixene, clozapine, diazepam, fenoldopam, fluphenazine, haloperidol, levodopa, levodopa with benserazide, levodopa with carbidopa, lisuride, loxapine, mesoridazine, molindolone, naxagolide, olanzapine, pergolide, perphenazine, pimozide, pramipexole, quetiapine, risperidone, sulpiride, tetrabenazine, trihexyphenidyl, thioridazine, thiothixene, trifluoperazine or ziprasidone.

In an embodiment, the disclosed compounds can be employed in combination with an anti-depressant or anti-anxiety agent, including norepinephrine reuptake inhibitors (including tertiary amine tricyclics and secondary amine tricyclics), selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), reversible inhibitors of monoamine oxidase (RIMAs), serotonin and noradrenaline reuptake inhibitors (SNRIs), corticotropin releasing factor (CRF) antagonists, α-adrenoreceptor antagonists, neurokinin-1 receptor antagonists, atypical anti-depressants, benzodiazepines, 5-HT1A agonists or antagonists, especially 5-HT1A partial agonists, and corticotropin releasing factor (CRF) antagonists. Specific agents include: amitriptyline, clomipramine, doxepin, imipramine and trimipramine; amoxapine, desipramine, maprotiline, nortriptyline and protriptyline; fluoxetine, fluvoxamine, paroxetine and sertraline; isocarboxazid, phenelzine, tranylcypromine and selegiline; moclobemide: venlafaxine; duloxetine; aprepitant; bupropion, lithium, nefazodone, trazodone and viloxazine; alprazolam, chlordiazepoxide, clonazepam, chlorazepate, diazepam, halazepam, lorazepam, oxazepam and prazepam; buspirone, flesinoxan, gepirone and ipsapirone, and pharmaceutically acceptable salts. thereof.

The compounds and processes of the invention will be better understood by reference to the following examples, which are intended as an illustration of and not a limitation upon the scope of the invention.

5. KITS

In one aspect, the disclosure provides kits comprising at least one disclosed compound or a pharmaceutically acceptable salt thereof, and one or more of:

- (a) at least one agent known to increase mAChR M₁activity;
- (b) at least one agent known to decrease mAChR M₁activity;
- (c) at least one agent known to treat a disorder associated with cholinergic activity;
- (d) instructions for treating a disorder associated with cholinergic activity;
- (e) instructions for treating a disorder associated with M₁receptor activity; or
- (f) instructions for administering the compound in connection with cognitive or behavioral therapy.

In some embodiments, the at least one disclosed compound and the at least one agent are co-formulated. In some embodiments, the at least one disclosed compound and the at least one agent are co-packaged. The kits can also comprise compounds and/or products co-packaged, co-formulated, and/or co-delivered with other components. For example, a drug manufacturer, a drug reseller, a physician, a compounding shop, or a pharmacist can provide a kit comprising a disclosed compound and/or product and another component for delivery to a patient.

That the disclosed kits can be employed in connection with disclosed methods of use.

The kits may f information, instructions, or both that use of the kit will provide treatment for medical conditions in mammals (particularly humans). The information and instructions may be in the form of words, pictures, or both, and the like. In addition or in the alternative, the kit may include the compound, a composition, or both; and information, instructions, or both, regarding methods of application of compound, or of composition, preferably with the benefit of treating or preventing medical conditions in mammals (e.g., humans).

6. EXAMPLES

Examples 1-7 below give representative experimental procedures for the syntheses of intermediates useful for the syntheses of compounds of formula (I). Example 8 provides a representative experimental procedure for completion of the syntheses of the disclosed compounds. Example 9 reports the biological activity of the disclosed compounds.

All NMR spectra were recorded on a 400 MHz AMX Bruker NMR spectrometer. ¹H chemical shifts are reported in δ values in ppm downfield with the deuterated solvent as the internal standard. Data are reported as follows: chemical shift, multiplicity (s=singlet, bs=broad singlet, d=doublet, t=triplet, q=quartet, dd=doublet of doublets, m=multiplet, ABq=AB quartet), coupling constant, integration. Reversed-phase LCMS analysis was performed using an Agilent 1200 system comprised of a binary pump with degasser, high-performance autosampler, thermostatted column compartment, C18 column, diode-array detector (DAD) and an Agilent 6150 MSD with the following parameters. The gradient conditions were 5% to 95% acetonitrile with the aqueous phase 0.1% TFA in water over 1.4 minutes. Samples were separated on a Waters Acquity UPLC BEH C18 column (1.7 μm, 1.0×50 mm) at 0.5 mL/min, with column and solvent temperatures maintained at 55° C. The DAD was set to scan from 190 to 300 nm, and the signals used were 220 nm and 254 nm (both with a band width of 4 nm). The MS detector was configured with an electrospray ionization source, and the low-resolution mass spectra were acquired by scanning from 140 to 700 AMU with a step size of 0.2 AMU at 0.13 cycles/second, and peak width of 0.008 minutes. The drying gas flow was set to 13 liters per minute at 300° C. and the nebulizer pressure was set to 30 psi. The capillary needle voltage was set at 3000 V, and the fragmentor voltage was set at 100V. Data acquisition was performed with Agilent Chemstation and Analytical Studio Reviewer software.

Example 1. 4-(4-(Bromomethyl)-3-fluorophenyl)-2-methyl-2H-indazole (C)

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4-(4-(Bromomethyl)-3-fluorophenyl)-2-methyl-2H-indazole (C): 4-bromo-2-fluorobenzyl bromide A (1 g, 3.73 mmol, 1 eq.), 1M sodium carbonate solution (10 mL, 10 mmol, 2.7 eq.), 2-methyl-2h-indazole-4-boronic acid pinacol ester (B) (1.06 g, 4.12 mmol, 1.1 eq.), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (273 mg, 0.37 mmol, 0.1 eq.) and dimethoxyethane (20 mL) were added to a microwave vial. The vial was capped and heated to 50° C. After one hour, the reaction was filtered over Celite®, washed with DCM and concentrated in vacuo. Purification by flash chromatography on silica gel using 0-60% ethyl acetate/hexanes afforded 1.1 g (92%) of the title compound. ES-MS [M+1]⁺: 319.2.

Example 2. 7-Chlorothieno[3,2-b]pyridine-5-carbonitrile (F)

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7-Chlorothieno[3,2-b]pyridine 4-oxide (E): To a solution of 7-chlorothieno[3,2-b]pyridine (4.2 g, 24.76 mmol, 1 eq.) in dichloromethane (140 mL) was added 3-chloroperoxybenzoic acid (16 g, 71.39 mmol, 2.9 eq.) in two gram quantities over 15 minutes. After 18 hours, the reaction was quenched with 10% NaS₂O₃solution and washed with 10% K₂CO₃. The aqueous layer was back extracted (3×) with 3:1 CHCl₃/IPA solution. The organic layers were combined, dried (MgSO₄), filtered and concentrated in vacuo. Purification by flash chromatography on silica gel afforded 4.1 g (89%) of the title compound. ¹H NMR (400 MHz, DMSO-d₆) δ 8.38 (d, J=6.8 Hz, 1H), 8.19 (d, J=5.7 Hz, 1H), 7.76 (d, J=5.7 Hz, 1H), 7.58 (d, J=6.8 Hz, 1H); ES-MS [M+1]⁺: 186.3.

7-Chlorothieno[3,2-b]pyridine-5-carbonitrile (F): To a solution of E (1.8 g, 9.7 mmol, 1 eq.) in dichloromethane (48.5 mL) was added trimethylsilylcyanide (2.43 mL, 19.4 mmol, 2 eq.). After 15 minutes, dimethylcarbamoyl chloride (1.78 mL, 19.4 mmol, 2 eq.) was added over a 15 minute period. The reaction stirred for four hours before an additional amount of trimethylsilylcyanide (2.43 mL, 19.4 mmol, 2 eq.) and dimethylcarbamoyl chloride (1.78 mL, 19.4 mmol, 2 eq.) were added. After 18 hours, reaction was quenched with 10% K₂CO₃, washed with water and back extracted twice with dichloromethane. The organic layers were combined, dried (MgSO₄), filtered and concentrated in vacuo. Purification by flash chromatography on silica gel using 0-10% ethyl acetate/hexanes afforded 1.47 g (78%) of the title compound. ¹H NMR (400 MHz, DMSO-d₆) δ 8.49 (d, J=5.5 Hz, 1H), 8.33 (s, 1H), 7.80 (d, J=5.5 Hz, 1H); ES-MS [M+1]⁺: 195.2.

Example 3. 7-(2-Fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenoxy)thieno[3,2-b]pyridine-5-carbonitrile (J)

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7-(4-Bromo-2-fluorophenoxy)thieno[3,2-b]pyridine-5-carbonitrile (H): F (515 mg, 2.65 mmol, 1 eq.), 4-bromo-2-fluorophenol (G) (348 μL, 3.18 mmol, 1.2 eq.), potassium carbonate (768 mg, 5.56 mmol, 2.1 eq.) and DMF (13.2 mL) were added to a microwave vial. The vial was capped and set in the microwave reactor at 150° C. for 15 minutes. The reaction was diluted with water and brine then extracted with ethyl acetate. The organic layer was washed with water, brine and the aqueous layer was back extracted with ethyl acetate. All organic layers were combined, dried (MgSO₄), filtered and concentrated. Purification by flash chromatography on silica gel using 0-20% ethyl acetate/hexanes afforded 850 mg (92%) of the title compound. ES-MS [M+1]⁺: 349.2.

7-(2-Fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenoxy)thieno[3,2-b]pyridine-5-carbonitrile (J): Intermediate H (100 mg, 0.29 mmol, 1 eq.), 1M sodium carbonate solution (716 μL, 0.72 mmol, 2.5 eq.), 1-methyl-1h-pyrazol-4-boronic acid (I) (54 mg, 0.43 mmol, 1.5 eq.), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (21 mg, 0.03 mmol, 0.1 eq.) and dimethoxyethane (1.42 mL) were added to a microwave vial. The vial was capped and set in the microwave reactor at 150° C. for 15 minutes. The reaction was filtered over Celite®, washed with DCM and concentrated in vacuo. Purification by flash chromatography on silica gel using 0-70% ethyl acetate/hexanes afforded 82 mg (82%) of the title compound. ES-MS [M+1]⁺: 351.2.

Example 4. 7-((6-Methylpyridin-3-yl)oxy)thieno[3,2-b]pyridine-5-carbonitrile (L)

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7-((6-Methylpyridin-3-yl)oxy)thieno[3,2-b]pyridine-5-carbonitrile (L): Intermediate F (300 mg, 1.54 mmol, 1 eq.), 3-hydroxy-6-methylpyridine (K) (202 mg, 1.85 mmol, 1.2 eq.), potassium carbonate (447 mg, 3.24 mmol, 2.1 eq.) and DMF (7.7 mL) were added to a microwave vial. The vial was capped and set in the microwave reactor at 150° C. for 15 minutes. The reaction was diluted with water and brine then extracted with ethyl acetate. The aqueous layer was back extracted with ethyl acetate (2×). The combined organic layers were dried (MgSO₄), filtered and concentrated in vacuo. Purification by flash chromatography on silica gel using 0-40% ethyl acetate/hexanes afforded 410 mg (99.5%) of the title compound. ES-MS [M+1]⁺: 268.2.

Example 5. 7-((6-Methylpyridin-3-yl)methyl)thieno[3,2-b]pyridine-5-carbonitrile (P)

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7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thieno[3,2-b]pyridine-5-carbonitrile (N): Intermediate F (1.1 g, 5.65 mmol, 1 eq.), bis(pinacolato)diboron (M) (2.87 g, 11.3 mmol, 2 eq.), potassium acetate (2.77 g, 28.3 mmol, 5 eq.), trans-dichlorobis(triphenylphosphine)palladium(II) (199 mg, 0.28 mmol, 0.05 eq.) and 1,4-dioxane (30 mL) were added to a microwave vial. The reaction stirred overnight at 80° C. After LCMS showed an incomplete reaction, the reaction was heated overnight at 100° C. The reaction was filtered over Celite®, washed with DCM and concentrated in vacuo to afford 1.6 g (99%) of the title compound which was used without further purification. ES-MS [M+1]⁺: 205.3.

7-((6-Methylpyridin-3-yl)methyl)thieno[3,2-b]pyridine-5-carbonitrile (P): Intermediate N (590 mg, 2.06 mmol, 1 eq.), cesium carbonate (2.02 g, 6.19 mmol, 3 eq.), 5-(bromomethyl)-2-methyl-pyridine (O) (384 mg, 2.06 mmol, 1 eq.), THF (7 mL) and water (1 mL) were added to a microwave vial. Nitrogen gas was bubbled through the mixture for five minutes before the addition of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (227 mg, 0.31 mmol, 0.15 eq.). The vial was capped and the reaction heated to 100° C. The reaction was filtered over Celite®, washed well with DCM and concentrated in vacuo. Purification by flash chromatography on silica gel using 0-90% ethyl acetate/hexanes afforded 380 mg (69%) of the title compound. ¹H NMR (400 MHz, DMSO-d₆) δ 8.49 (s, 1H), 8.35 (d, J=5.6 Hz, 1H), 7.92 (s, 1H), 7.69 (d, J=5.6 Hz, 1H), 7.60 (d, J=8.0 Hz, 1H), 7.19 (d, J=8.0 Hz, 1H), 4.33 (s, 2H), 2.43 (s, 3H); ES-MS [M+1]⁺: 266.2.

Example 6. 7-((6-Methylpyridin-3-yl)oxy)thieno[3,2-b]pyridine-5-carboxylic acid (R)

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7-((6-Methylpyridin-3-yl)oxy)thieno[3,2-b]pyridine-5-carboxamide (Q): To a solution of L (410 mg, 1.53 mmol, 1 eq.) in 1,4-dioxane (7.7 mL) was added 2N NaOH (2.3 mL, 4.60 mmol, 3 eq.). After stirring at 80° C. for three hours, the reaction was concentrated in vacuo to afford 440 mg (100%) of the title compound which was used without further purification. ES-MS [M+1]⁺: 286.4.

7-((6-Methylpyridin-3-yl)oxy)thieno[3,2-b]pyridine-5-carboxylic acid (R): Intermediate Q (440 mg, 1.54 mmol, 1 eq.) was allowed to reflux for two hours in conc. HCl (5 mL). The reaction was allowed to cool to room temperature before neutralization using 6 M NaOH. The water and solvent were removed in vacuo and the crude material was dissolved in 10% MeOH/DCM. The undissolved salt was filtered off and the solvents were concentrated in vacuo to afford 440 mg (100%) of the title compound which was used without further purification. ES-MS [M+1]⁺: 287.2.

Example 7. 7-((6-Methylpyridin-3-yl)methyl)thieno[3,2-b]pyridine-5-carboxylic acid (S)

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7-((6-Methylpyridin-3-yl)methyl)thieno[3,2-b]pyridine-5-carboxylic acid (S): Intermediate P (200 mg, 0.75 mmol, 1 eq.) was dissolved in ethanol (3.8 mL). After the addition of 2N NaOH solution (1.9 mL, 3.77 mmol, 5 eq.), the reaction was heated to 100° C. for 18 hours. The water and solvent were removed in vacuo and the crude material was dissolved in 10% MeOH/DCM. The undissolved salt was filtered off and the solvents were concentrated in vacuo to afford 215 mg (100%) of the title compound which was used without further purification. ES-MS [M+1]⁺: 285.4.

Example 8. N-((1S,2S)-2-Hydroxycyclohexyl)-7-((6-methylpyridin-3-yl)methyl)thieno[3,2-b]pyridine-5-carboxamide (1)

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N-((1S,2S)-2-Hydroxycyclohexyl)-7-((6-methylpyridin-3-yl)methyl)thieno[3,2-b]pyridine-5-carboxamide (1): To a solution of 7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxylic acid S (17 mg, 0.06 mmol, 1 eq.) in DMF (2 mL) was added N,N-diisopropylethylamine (52 μL, 0.30 mmol, 5 eq.). After five minutes HATU (27 mg, 0.07 mmol, 1.2 eq.) was added. After another five minutes, (1S,2S)-2-aminocyclohexanol T (8.3 mg, 0.07 mmol, 1.2 eq.) was added. Upon completion, the reaction was diluted with water and extracted twice with DCM. Organic layers were combined, passed through a phase separator, and concentrated. Purification by reverse phase HPLC afforded 7.8 mg (34%) of the title compound. ¹H NMR (400 MHz, DMSO-d₆) δ 8.47 (s, 1H), 8.39 (d, J=8.3 Hz, 1H), 8.25 (d, J=5.7 Hz, 1H), 7.90 (s, 1H), 7.68 (d, J=5.3 Hz, 1H), 7.57 (d, J=7.9 Hz, 1H), 7.20 (d, J=7.9 Hz, 1H), 4.71 (d, J=5.3 Hz, 1H), 4.35 (s, 2H), 3.64-3.57 (m, 1H), 3.49-3.47 (m, 1H), 2.44 (s, 3H), 1.94-1.92 (m, 2H), 1.67-1.62 (m, 2H), 1.34-1.25 (m, 3H), 1.15-1.08 (m, 1H); ES-MS [M+1]⁺: 382.2.

The following compounds were prepared in an analogous manner by first preparing the appropriate synthetic intermediate by use of the synthetic procedures (or analogous procedures) indicated next to each compound:

Example used

to prepare

intermediate
ES-MS

No.
Name
compound
[M + 1]⁺

2
7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-
2, 3, 6
467.3

hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide

3
7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-
2, 3, 6
481.3

methoxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide

4
7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-
2, 3, 6
453,2

tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide

5
7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(2R)-2-
2, 3, 6
439.2

hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide

6
7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-
2, 3, 6
453.2

hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide

7
7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(3R,4S)-
2, 3, 6
469.2

3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-

carboxamide

8
7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(3S,4S)-4-
2, 3, 6
469.2

hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-

carboxamide

9
7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-
2, 3, 6
481.2

hydroxycycloheptyl]thieno[3,2-b]pyridine-5-carboxamide

10
7-[2-fluoro-4-(1-methylindazol-4-yl)phenoxy]-N-[(1R,2R)-
2, 3, 6
489.3

2-hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide

11
7-[2-fluoro-4-(1-methylindazol-4-yl)phenoxy]-N-[(1S,2S)-2-
2, 3, 6
503.3

hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide

12
7-[2-fluoro-4-(1-methylindazol-4-yl)phenoxy]-N-[(1S,2S)-2-
2, 3, 6
517.4

hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide

13
7-[2-fluoro-4-(1-methylindazol-4-yl)phenoxy]-N-[(3R,4S)-
2, 3, 6
519.3

3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-

carboxamide

14
7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(3S,4S)-4-
2, 3, 6
519.2

hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-

carboxamide

15
7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(1S,2S)-2-
2, 3, 6
531.3

hydroxycycloheptyl]thieno[3,2-b]pyridine-5-carboxamide

16
N-[(1R,2R)-2-hydroxycyclobutyl]-7-[(6-methyl-3-
2, 4, 6
356.3

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

17
N-(3-fluorocyclobutyl)-7-[(6-methyl-3-
2, 4, 6
358.4

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

18
N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(6-methyl-3-
2, 4, 6
370.4

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

19
N-cyclohexyl-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-
2, 4, 6
368.3

b]pyridine-5-carboxamide

20
7-[(6-methyl-3-pyridyl)oxy]-N-tetrahydropyran-4-yl-
2, 4, 6
370.4

thieno[3,2-b]pyridine-5-carboxamide

21
N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(6-methyl-3-
2, 4, 6
384.3

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

22
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(6-methyl-3-
2, 4, 6
386.3

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

23
N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(6-methyl-3-
2, 4, 6
386.4

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

24
N-[(1S,2S)-2-methoxycyclohexyl]-7-[(6-methyl-3-
2, 4, 6
398.4

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

25
N-[(1S,2S)-2-hydroxycycloheptyl]-7-[(6-methyl-3-
2, 4, 6
398.3

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

26
N-[(2,5-dimethylphenyl)methyl]-7-[(6-methyl-3-
2, 4, 6
404.3

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

27
N-(2-hydroxy-1-phenyl-ethyl)-7-[(6-methyl-3-
2, 4, 6
406.3

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

28
N-(2-hydroxy-1,1-dimethyl-ethyl)-7-[(6-methyl-3-
2, 4, 6
358.3

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

29
7-[(6-methyl-3-pyridyl)oxy]-N-(2-oxo-3-
2, 4, 6
383.4

piperidyl)thieno[3,2-b]pyridine-5-carboxamide

30
N-(1-cyclopropyl-2-hydroxy-ethyl)-7-[(6-methyl-3-
2, 4, 6
370.2

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

31
7-[(6-methyl-3-pyridyl)oxy]-N-(3,3,3-trifluoro-2-hydroxy-
2, 4, 6
398.3

propyl)thieno[3,2-b]pyridine-5-carboxamide

32
N-(2-hydroxy-2-methyl-propyl)-7-[(6-methyl-3-
2, 4, 6
358.3

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

33
N-(2-methoxyethyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-
2, 4, 6
344.3

b]pyridine-5-carboxamide

34
N-(3-hydroxy-1,2,2-trimethyl-propyl)-7-[(6-methyl-3-
2, 4, 6
386.3

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

35
7-[(6-methyl-3-pyridyl)oxy]-N-(tetrahydrofuran-2-
2, 4, 6
370.3

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

36
7-[(6-methyl-3-pyridyl)oxy]-N-(2-oxoazepan-3-
2, 4, 6
397.4

yl)thieno[3,2-b]pyridine-5-carboxamide

37
7-[(6-methyl-3-pyridyl)oxy]-N-(2-pyridylmethyl)thieno[3,2-
2, 4, 6
377.4

b]pyridine-5-carboxamide

38
7-[(6-methyl-3-pyridyl)oxy]-N-(1H-pyrrol-2-
2, 4, 6
365.3

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

39
N-[(5-methyl-1H-indol-2-yl)methyl]-7-[(6-methyl-3-
2, 4, 6
429.3

pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide

40
N-(1H-indazol-3-yl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-
2, 4, 6
402.3

b]pyridine-5-carboxamide

41
7-[[2,6-difluoro-4-(2-methylindazol-4-yl)phenyl]methyl]-N-
1, 2, 5, 6
533.3

[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-

carboxamide

42
N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(6-methyl-3-
2, 5, 6
368.2

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

43
N-cyclohexyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-
2, 5, 6
366.3

b]pyridine-5-carboxamide

44
N-[(1R,2R)-2-hydroxycyclobutyl]-7-[(6-methyl-3-
2, 5, 6
354.2

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

45
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(6-methyl-3-
2, 5, 6
384.3

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

46
N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(6-methyl-3-
2, 5, 6
384.3

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

47
N-[(1S,2S)-2-hydroxycycloheptyl]-7-[(6-methyl-3-
2, 5, 6
396.3

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

48
N-[(1S,2S)-2-methoxycyclohexyl]-7-[(6-methyl-3-
2, 5, 6
396.3

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

49
N-(3-hydroxycyclohexyl)-7-[(6-methyl-3-
2, 5, 6
382.3

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

50
7-[(6-methyl-3-pyridyl)methyl]-N-tetrahydropyran-4-yl-
2, 5, 6
368.3

thieno[3,2-b]pyridine-5-carboxamide

The following compounds were prepared in an analogous manner using the same or similar routes as described above.

ES-MS

No.
Name
[M + 1]⁺

51
7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-
465.4

hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide

52
7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3R,4S)-3-
467.3

hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide

53
7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3S,4S)-4-
467.3

hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide

54
7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-
479.3

hydroxycycloheptyl]thieno[3,2-b)]pyridine-5-carboxamide

55
7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-
437.3

hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide

56
7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-
451.3

hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide

57
7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-
483.2

hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide

58
7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-
469.3

hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide

59
7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3S,4S)-3-
485.4

hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide

60
7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3S,4S)-4-
485.2

hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide

61
7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-
497.2

hydroxycycloheptyl]thieno[3,2-b]pyridine-5-carboxamide

62
N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[[6-(1-methylpyrazol-4-yl)-3-
450.4

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

63
N-(3-hydroxy-1-adamantyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-
434.4

b]pyridine-5-carboxamide

64
N-[(1S)-5-hydroxy-2-adamantyl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-
434.5

b]pyridine-5-carboxamide

65
N-(1H-mdazol-3-yl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-
400.3

carboxamide

66
7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-
381.4

carboxamide

67
7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-
395.3

carboxamide

68
7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxoindolin-3-yl)thieno[3,2-b]pyridine-5-
415.3

carboxamide

69
N-(3-methyl-1H-pyrazol-5-yl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-
364.3

b]pyridine-5-carboxamide

70
N-(1H-imidazol-4-yl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-
350.3

carboxamide

71
N-[(1R,2R)-2-hydroxycyclopentyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
419.2

6]pyridine-5-carboxamide

72
N-cyclohexyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
417.2

carboxamide

73
N-[(1R,2R)-2-hydroxycyclohexyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
433.2

b]pyridine-5-carboxamide

74
N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[(4-pyrazol-1-
435.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

75
N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[(4-pyrazol-1-
435.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

76
N-[(1R,2R)-2-methoxycyclohexyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
447.2

b]pyridine-5-carboxamide

77
N-[(1R,2R)-2-hydroxycycloheptyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
447.3

b]pyridine-5-carboxamide

78
N-(2-oxo-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
432.3

carboxamide

79
N-(2-oxoazepan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
446.3

carboxamide

80
[(1S,5R)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]-[7-[(4-pyrazol-1-
445.2

ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone

81
[(3R)-3-hydroxy-1-piperidyl]-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
419.3

b]pyridin-5-yl]methanone

82
(4-hydroxy-4-methyl-1-piperidyl)-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
433.2

b]pyridin-5-yl]methanone

83
piperazin-1-yl-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-
404.3

yl]methanone

84
[4-(2-hydroxyethyl)piperazin-1-yl]-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
448.3

b]pyridin-5-yl]methanone

85
7-[fluoro-(6-methyl-3-pyridyl)methyl]-N-[(1R,2R)-2-
400.2

hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide

86
7-[ethoxy-(6-methyl-3-pyridyl)methyl]-N-[(1R,2R)-2-
426.3

hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide

87
N-[(1S,2S)-2-hydroxycyclobutyl]-7-[[6-(trifluoromethyl)-3-
408.4

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

88
N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[6-(trifluoromethyl)-3-
422.4

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

89
N-tetrahydropyran-4-yl-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-
422.3

b]pyridine-5-carboxamide

90
N-[(1R,2R)-2-hydroxycyclohexyl]-7-[[6-(trifluoromethyl)-3-
436.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

91
N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[[6-(trifluoromethyl)-3-
438.4

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

92
N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[6-(trifluoromethyl)-3-
438.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

93
N-[(1R,2R)-2-methoxycyclohexyl]-7-[[6-(trifluoromethyl)-3-
450.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

94
N-[(1R,2R)-2-hydroxycycloheptyl]-7-[[6-(trifluoromethyl)-3-
450.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

95
N-(3-hydroxy-1-adamantyl)-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-
488.4

b]pyridine-5-carboxamide

96
N-[(1S)-5-hydroxy-2-adamantyl]-7-[[6-(trifluoromethyl)-3-
488.2

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

97
N-(2-oxo-3-piperidyl)-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-
435.2

b]pyridine-5-carboxamide

98
N-(2-oxoazepan-3-yl)-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-
449.2

b]pyridine-5-carboxamide

99
N-[(1S,2S)-2-hydroxycyclobutyl]-3-methyl-7-[(6-methyl-3-
368.3

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

100
N-[(1R,2R)-2-hydroxycyclopentyl]-3-methyl-7-[(6-methyl-3-
382.3

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

101
N-cyclohexyl-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-
380.3

carboxamide

102
3-methyl-7-[(6-methyl-3-pyridyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-
382.4

b]pyridine-5-carboxamide

103
N-[(1R,2R)-2-hydroxycyclohexyl]-3-methyl-7-[(6-methyl-3-
396.4

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

104
N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[(6-methyl-3-
398.4

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

105
N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-3-methyl-7-[(6-methyl-3-
398.3

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

106
N-[(1R,2R)-2-methoxycyclohexyl]-3-methyl-7-[(6-methyl-3-
410.3

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

107
N-[(1R,2R)-2-hydroxycycloheptyl]-3-methyl-7-[(6-methyl-3-
410.4

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

108
N-(3-hydroxy-1-adamantyl)-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-
448.4

b]pyridine-5-carboxamide

109
N-[(1S)-5-hydroxy-2-adamantyl]-3-methyl-7-[(6-methyl-3-
448.3

pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

110
3-methyl-7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-
395.3

b]pyridine-5-carboxamide

111
3-methyl-7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-
409.3

b]pyridine-5-carboxamide

112
3-methyl-N-(1-methyl-4-piperidyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-
395.4

b]pyridine-5-carboxamide

113
N-[(1S,2S)-2-hydroxycyclobutyl]-3-methyl-7-[(4-pyrazol-1-
419.3

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

114
N-[(1R,2R)-2-hydroxycyclopentyl]-3-methyl-7-[(4-pyrazol-1-
433.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

115
3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-
433.4

b]pyridine-5-carboxamide

116
N-[(1R,2R)-2-hydroxycyclohexyl]-3-methyl-7-[(4-pyrazol-1-
447.4

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

117
N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[(4-pyrazol-1-
449.4

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

118
N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-3-methyl-7-[(4-pyrazol-1-
449.3

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

119
N-[(1R,2R)-2-methoxycyclohexyl]-3-methyl-7-[(4-pyrazol-1-
461.4

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

120
N-[(1R,2R)-2-hydroxycycloheptyl]-3-methyl-7-[(4-pyrazol-1-
461.3

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

121
N,3-dimethyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-
447.3

tnieno[3,2-b]pyridine-5-carboxamide

122
3-methyl-N-(2-oxo-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
446.3

b]pyridine-5-carboxamide

123
3-methyl-N-(2-oxoazepan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
460.4

b]pyridine-5-carboxamide

124
3-methyl-N-(1-methyl-4-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
446.4

b]pyridine-5-carboxamide

125
N-[(1R,2R)-2-hydroxycyclopentyl]-7-[(2-methylpyrimidin-5-
369.4

yl)methyl]thieno[3,2-b]pyridine-5-carboxamide

126
7-[(2-methylpyrimidin-5-yl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-
369.2

b]pyridine-5-carboxamide

127
N-[(1R,2R)-2-hydroxycyclohexyl]-7-[(2-methylpyrimidin-5-
383.2

yl)methyl]thieno[3,2-b]pyridine-5-carboxamide

128
N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[(2-methylpyrimidin-5-
385.2

yl)methyl]thieno[3,2-b]pyridine-5-carboxamide

129
N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[(2-methylpyrimidin-5-
385.3

yl)methyl]thieno[3,2-b]pyridine-5-carboxamide

130
N-[(1R,2R)-2-methoxycyclohexyl]-7-[(2-methylpyrimidin-5-
397.2

yl)methyl]thieno[3,2-b]pyridine-5-carboxamide

131
N-[(1R,2R)-2-hydroxycycloheptyl]-7-[(2-methylpyrimidin-5-
397.4

yl)methyl]thieno[3,2-b]pyridine-5-carboxamide

132
N-[(1S,2S)-2-hydroxycyclobutyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-
360.2

b]pyridine-5-carboxamide

133
N-[(1R,2R)-2-hydroxycyclopentyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-
374.2

b]pyridine-5-carboxamide

134
N-cyclohexyl-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-
372.2

carboxamide

135
7-[(2-methylthiazol-5-yl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-
374.2

5-carboxamide

136
N-[(1R,2R)-2-hydroxycyclohexyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-
388.2

b]pyridine-5-carboxamide

137
N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[(2-methylthiazol-5-
390.2

yl)methyl]thieno[3,2-b]pyridine-5-carboxamide

138
N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[(2-methylthiazol-5-
390.2

yl)methyl]thieno[3,2-b]pyridine-5-carboxamide

139
N-[(1R,2R)-2-methoxycyclohexyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-
402.3

b]pyridine-5-carboxamide

140
N-[(1R,2R)-2-hydroxycycloheptyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-
402.2

b]pyridine-5-carboxamide

141
N-(3-hydroxy-1-adamantyl)-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-
440.2

b]pyridine-5-carboxamide

142
N-[(1S)-5-hydroxy-2-adamantyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-
440.2

b]pyridine-5-carboxamide

143
7-[(2-methylthiazol-5-yl)methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-
387.2

carboxamide

144
7-[(2-methylthiazol-5-yl)methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-
401.3

carboxamide

145
N-[(1R,2R)-2-hydroxycyclohexyl]-7-(6-methylpyridine-3-carbonyl)thieno[3,2-
396.3

b]pyridine-5-carboxamide

146
N-[(1S,2S)-2-hydroxycyclobutyl]-7-[[4-(2-methyloxazol-4-
420.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

147
7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(oxctan-3-yl)thieno[3,2-
406.3

b]pyridine-5-carboxamide

148
N-[(1S,2S)-2-hydroxycyclobutyl]-7-[[4-(1-methyltriazol-4-
420.4

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

149
N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[4-(1-methyltriazol-4-
434.4

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

150
7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-3-
420.3

yl]thieno[3,2-b]pyridine-5-carboxamide

151
7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-3-
420.4

yl]thieno[3,2-b]pyridine-5-carboxamide

152
7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-tetrahydropyran-3-yl-thieno[3,2-
434.3

b]pyridine-5-carboxamide

153
N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(1-methyltriazol-4-
450.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

154
N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[4-(1-methyltriazol-4-
450.4

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

155
N-[(1R,2R)-2-hydroxycyclohexyl]-7-[[4-(1-methyltriazol-4-
448.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

156
N-[(1R,2R)-2-methoxycyclohexyl]-7-[[4-(1-methyltriazol-4-
462.4

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

157
N-[(1R,2R)-2-hydroxycycloheptyl]-7-[[4-(1-methyltriazol-4-
462.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

158
7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-
446.2

yl)thieno[3,2-b]pyridine-5-carboxamide

159
N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[4-(2-methyloxazol-4-
434.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

160
7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-3-
420.2

yl]thieno[3,2-b]pyridine-5-carboxamide

161
7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-3-
420.2

yl]thieno[3,2-b]pyridine-5-carboxamide

162
N-cyclohexyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-
432.2

5-carboxamide

163
7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(1-methyl-3-piperidyl)thieno[3,2-
447.3

b]pyridine-5-carboxamide

164
7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(1-methyl-4-piperidyl)thieno[3,2-
447.3

b]pyridine-5-carboxamide

165
N-methyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-
448.3

thieno[3,2-b]pyridine-5-carboxamide

166
N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(2-methyloxazol-4-
450.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

167
N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[4-(2-methyloxazol-4-
450.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

168
N-[(1R,2R)-2-hydroxycyclohexyl]-7-[[4-(2-methyloxazol-4-
448.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

169
N-[(1R,2R)-2-methoxycyclohexyl]-7-[[4-(2-methyloxazol-4-
462.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

170
N-[(1R,2R)-2-hydroxycycloheptyl]-7-[[4-(2-methyloxazol-4-
462.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

171
7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-
447.2

b]pyridine-5-carboxamide

172
7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-
461.2

b]pyridine-5-carboxamide

173
[(3R)-3-hydroxy-1-piperidyl]-[7-[[4-(2-methyloxazol-4-
434.2

yl)phenyl]methyl]thieno[3,2-b]pyridin-5-yl]methanone

174
(4-hydroxy-4-methyl-1-piperidyl)-[7-[[4-(2-methyloxazol-4-
448.3

yl)phenyl]methyl]thieno[3,2-b]pyridin-5-yl]methanone

175
7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-
446.2

yl)thieno[3,2-b]pyridine-5-carboxamide

176
N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[4-(2-methylthiazol-4-
436.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

177
N-(3-methyloxetan-3-yl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-
436.2

b]pyridine-5-carboxamide

178
7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-
462.2

yl)thieno[3,2-b]pyridine-5-carboxamide

179
N-(1-tert-butylazetidin-3-yl)-7-[[4-(2-methylthiazol-4-
477.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

180
N-(3-methoxycyclobutyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-
450.2

b]pyridine-5-carboxamide

181
N-(3-fluorocyclobutyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-
438.2

b]pyridine-5-carboxamide

182
N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[4-(2-methylthiazol-4-
450.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

183
7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-3-
436.2

yl]thieno[3,2-b]pyridine-5-carboxamide

184
7-[[4-(2-methNlthiazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-3-
436.2

yl]thieno[3,2-b]pyridine-5-carboxamide

185
N-cyclohexyl-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-
448.3

5-carboxamide

186
N-(1-methyl-3-piperidyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-
463.2

b]pyridine-5-carboxamide

187
N-(1-methyl-4-piperidyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-
463.2

b]pyridine-5-carboxamide

188
7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydropyran-3-
450.2

yl]thieno[3,2-b]pyridine-5-carboxamide

189
7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydropyran-3-
450.2

yl]thieno[3,2-b]pyridine-5-carboxamide

190
N-methyl-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-
464.2

thieno[3,2-b]pyridine-5-carboxamide

191
7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-
450.2

b]pyridine-5-carboxamide

192
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(2-methylthiazol-4-
466.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

193
N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[[4-(2-methylthiazol-4-
466.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

194
N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[4-(2-methylthiazol-4-
464.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

195
N-[(1S,2S)-2-methoxycyclohexyl]-7-[[4-(2-methylthiazol-4-
478.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

196
N-[(1S,2S)-2-hydroxycycloheptyl]-7-[[4-(2-methylthiazol-4-
478.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

197
N-(hexahydro-1H-pyrrolizin-1-yl)-7-[[4-(2-methylthiazol-4-
475.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

198
7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-
463.2

b]pyridine-5-carboxamide

199
7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-
477.2

b]pyridine-5-carboxamide

200
N-[(1R,2R)-2-hydroxycyclobutyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
422.3

b]pyridine-5-carboxamide

201
N-(3-bicyclo[1.1.1]pentanyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
418.3

b]pyridine-5-carboxamide

202
N-(oxctan-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
408.3

carboxamide

203
N-(1-tert-butylazetidin-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
463.4

b]pyridine-5-carboxamide

204
N-(3-methoxycyclobutyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
436.2

b]pyridine-5-carboxamide

205
N-(3-fluorocyclobutyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
424.2

carboxamide

206
N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
436.2

b]pyridine-5-carboxamide

207
N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
422.3

b]pyridine-5-carboxamide

208
N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
422.4

b]pyridine-5-carboxamide

209
N-cyclohexyl-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
434.3

carboxamide

210
N-(1-methyl-3-piperidyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-
449.4

5-carboxamide

211
N-(1-methyl-4-piperidyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-
449.4

5-carboxamide

212
N-[(3R)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
436.2

b]pyridine-5-carboxamide

213
N-[(3S)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
436.2

b]pyridine-5-carboxamide

214
N-methyl-N-tetrahydropyran-4-yl-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
450.2

b]pyridine-5-carboxamide

215
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(4-thiazol-4-
452.3

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

216
N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(4-thiazol-4-
452.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

217
N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
450.3

b]pyridine-5-carboxamide

218
N-[(1S,2S)-2-methoxycyclohexyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
464.3

b]pyridine-5-carboxamide

219
N-[(1S,2S)-2-hydroxycycloheptyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
464.3

b]pyridine-5-carboxamide

220
N-(hexahydro-1H-pyrrolizin-1-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
461.3

b]pyridine-5-carboxamide

221
N-(2-oxo-3-piperidyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
449.3

carboxamide

222
N-(2-oxoazepan-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
463.3

carboxamide

223
N-[(1S,25)-2-hydroxycyclopentyl]-7-[[6-(1-methylpyrazol-4-yl)-3-
434.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

224
N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[6-(1-methylpyrazol-4-yl)-3-
448.4

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

225
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[6-(1-methylpyrazol-4-yl)-3-
450.2

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

226
N-1(1S,2S)-2-hydroxycycloheptyl]-7-[[6-(1-methylpyrazol-4-yl)-3-
462.4

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

227
N-1(1R,2R)-2-hydroxycyclobutyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
405.4

b]pyridine-5-carboxamide

228
7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-
419.3

5-carboxamide

229
7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-
434.4

b]pyridine-5-carboxamide

230
7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-
434.4

b]pyridine-5-carboxamide

231
N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-
448.2

b]pyridine-5-carboxamide

232
N-tetrahydropyran-4-yl-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
436.3

carboxamide

233
7-[(S)-fluoro-(6-methyl-3-pyridyl)methyl]-N-[(1S,2S)-2-
400.2

hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide

234
7-[(R)-fluoro-(6-methyl-3-pyridyl)methyl]-N-[(1S,2S)-2-
400.3

hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide

235
N-(2-hydroxy-2-methyl-cycloheptyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-
410.3

b]pyridine-5-carboxamide

236
(1S,2S)-2-hydroxycyclopentyl]-2-methyl-7-[(4-pyrazol-1-
433.4

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

237
N-[(1S,2S)-2-hydroxycyclohexyl]-2-methyl-7-[(4-pyrazol-1-
447.3

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

238
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-2-methyl-7-[(4-pyrazol-1-
449.4

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

239
2-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-
433.3

b]pyridine-5-carboxamide

240
N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[4-(1,3,5-trimethylpyrazol-4-
447.4

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

241
N-(2-oxaspiro[3.3]heptan-6-yl)-7-[[4-(1,3,5-trimethylpyrazol-4-
473.4

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

242
N-[(1S,2S)-2-hydroxycyclopentyl]-7-[[4-(1,3,5-trimethylpyrazol-4-
461.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

243
N-tetrahydropyran-4-yl-7-[[4-(1,3,5-trimethylpyrazol-4-
461.5

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

244
7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-(oxctan-3-yl)thieno[3,2-
419.4

b]pyridine-5-carboxamide

245
N-(1-tert-butylazetidin-3-yl)-7-[[4-(1,3-dimethylpyrazol-4-
474.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

246
7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-(3-
447.2

methoxycyclobutyl)thieno[3,2-b]pyridine-5-carboxamide

247
7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-
447.3

hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide

248
7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(3R,4S)-3-
463.3

hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide

249
7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(3S,4S)-4-
463.3

hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide

250
7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-
461.4

hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide

251
N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[4-(1-methylpyrazol-3-
419.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

252
7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-
445.2

yl)thieno[3,2-b]pyridine-5-carboxamide

253
N-[(1S,2S)-2-hydroxycyclopentyl]-7-[[4-(1-methylpyrazol-3-
433.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

254
7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-
433.3

b]pyridine-5-carboxamide

255
N-1(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(1-methylpyrazol-3-
449.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

256
N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[4-(1-methylpyrazol-3-
447.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

257
N-(1-cyanocyclopropyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-
349.3

carboxamide

258
7-[(6-methyl-3-pyridyl)methyl]-N-(oxctan-3-yl)thieno[3,2-b]pyridine-5-
340.3

carboxamide

259
N-(3-fluorocyclobutyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-
356.2

carboxamide

260
N-(3,3-difluorocyclobutyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-
374.4

5-carboxamide

261
7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-
380.3

b]pyridine-5-carboxamide

262
7-[(6-methyl-3-pyridyl)methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-
354.3

b]pyridine-5-carboxamide

263
7-[(6-methyl-3-pyridyl)methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-
354.4

b]pyridine-5-carboxamide

264
7-(4-pyrazol-1-y1Renzoyl)-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-
433.3

carboxamide

265
7-[(6-methyl-3-pyridyl)methyl]-N-[(3R)-3-piperidyl]thieno[3,2-b]pyridine-5-
367.3

carboxamide

266
7-[(6-methyl-3-pyridyl)methyl]-N-[(3S)-3-piperidyl]thieno[3,2-b]pyridine-5-
367.3

carboxamide

267
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(1-methylpyrazol-4-
449.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

268
7-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-
433.4

b]pyridine-5-carboxamide

269
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[(4-pyrazol-1-
449.3

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

270
7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-[(3R,4S)-3-
488.2

hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide

271
7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-tetrahydropyran-4-yl-
472.2

thieno[3,2-b]pyridine-5-carboxamide

272
7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-(2-oxaspiro[3.3]heptan-6-
484.2

yl)thieno[3,2-b]pyridine-5-carboxamide

273
7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-[(1S,2S)-2-
486.2

hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide

274
7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-[(1R,2R)-2-
458.3

hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide

275
N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
431.4

b]pyridine-5-carboxamidc

276
N-(3-methyloxetan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-
405

5-carboxamide

277
7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-
405.3

b]pyridine-5-carboxamidc

278
7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-
405.4

b]pyridine-5-carboxamidc

279
N-(oxetan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
391.4

carboxamide

280
N-(3-fluorocyclobutyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-
407.3

5-carboxamide

281
N-(3,3-difluorocyclobutyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
425.3

b]pyridine-5-carboxamide

282
N-(1-cyanocyclopropyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-
400.3

5-carboxamide

283
N-(1-cyano-1-methyl-ethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
402.4

b]pyridine-5-carboxainidc

284
N-(oxctan-2-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
405.4

carboxamide

285
7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydrofuran-3-ylmethyl]thieno[3,2-
419.3

b]pyridine-5-carboxamide

286
7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2S)-tetrahydrofuran-2-
419.3

yl]methyl]thieno[3,2-b]pyridine-5-carboxamide

287
7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2R)-tetrahydrofuran-2-
419.2

yl]methyl]thieno[3,2-b]pyridine-5-carboxamide

288
7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-4-ylmethyl]thieno[3,2-
433.3

b]pyridine-5-carboxamide

289
7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-2-ylmethyl]thieno[3,2-
433.4

b]pyridine-5-carboxamide

290
N-[(3S)-3-piperidyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
418.3

carboxamide

291
N-(3-methyl-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
432.4

b]pyridine-5-carboxamide

292
N-(azetidin-2-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-
404.3

5-carboxamide

293
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(4-pyrazol-1-
435.3

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

294
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(4-thiazol-2-
452.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

295
N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
450.2

b]pyridine-5-carboxamide

296
N-tetrahydropyran-4-yl-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
436.2

carboxamide

297
N-[(1S,2S)-2-hydroxycyclobutyl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
422.2

b]pyridine-5-carboxamide

298
N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
450.2

b]pyridine-5-carboxamide

299
N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[4-(2-methyloxazol-4-
462.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

300
N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-(2-methyloxazol-4-
462.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

301
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl)methyl]-N-tetrahydropyran-4-yl-
464.2

thieno[3,2-b]pyridine-5-carboxamide

302
3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-
447.4

thieno[3,2-b]pyridine-5-carboxamide

303
N-[(1S,2S)-2-hydroxycyclopentyl]-3-methyl-7-[[4-(1-methylpyrazol-3-
447.4

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

304
3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-
459.2

6-yl)thieno[3,2-b]pyridine-5-carboxamide

305
3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-
433.3

3-yl]thieno[3,2-b]pyridine-5-carboxamide

306
3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-
433.3

3-yl]thieno[3,2-b]pyridine-5-carboxamide

307
3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(oxetan-9-
419.2

yl)thieno[3,2-b]pyridine-5-carboxamide

308
N-(3-fluorocyclobutyl)-3-methyl-7-[[4-(1-methylpyrazol-3-
435.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

309
N-(3,3-difluorocyclobutyl)-3-methyl-7-[[4-(1-methylpyrazol-3-
453.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

310
3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(oxctan-2-
433.3

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

311
3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(tetrahydrofuran-3-
447.2

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

312
N-[(1S,2S)-2-hydroxycyclohexyl]-3-methyl-7-[[4-(1-methylpyrazol-3-
461.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

313
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[[4-(1-methylpyrazol-3-
463.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

314
N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
436.2

b]pyridine-5-carboxamide

315
3-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-
445.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

316
3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3R)-tetrahydrofuran-3-
419.3

yl]thieno[3,2-b]pyridine-5-carboxamide

317
3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3S)-tetrahydrofuran-3-
419.3

yl]thieno[3,2-b]pyridine-5-carboxamide

318
3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-4-
447.3

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

319
3-methyl-N-(oxctan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
405.3

b]pyridine-5-carboxamide

320
3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-2-
447.2

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

321
3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydrofuran-3-
433.3

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

322
3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2R)-tetrahydrofuran-2-
433.3

yl]methyl]thieno[3,2-b]pyridine-5-carboxamide

323
3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2S)-tetrahydrofuran-2-
433.2

yl]methyl]thieno[3,2-b]pyridine-5-carboxamide

324
3-methyl-N-(oxctan-2-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
419.2

b]pyridine-5-carboxamide

325
N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-3-
461.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

326
N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-3-
461.4

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

327
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-
446.3

yl)thieno[3,2-b]pyridine-5-carboxamide

328
N-[(1S,2S)-2-hydroxycyclobutyl]-7-[[6-(1-methylpyrazol-4-yl)-3-
420.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

329
3-methyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-
448.3

thieno[3,2-b]pyridine-5-carboxamide

330
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[[4-(2-methyloxazol-4-
464.2

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

331
N-[(1S,2S)-2-hydroxycyclopentyl]-3-methyl-7-[[4-(2-methyloxazol-4-
448.4

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

332
7-[fluoro-(4-thiazol-4-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-
454.3

b]pyridine-5-carboxamide

333
N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
448.3

b]pyridine-5-carboxamide

334
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl)methyl]-N-(tetrahydropyran-4-
448.3

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

335
N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-4-yl)-3-
462.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

336
N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-4-yl)-3-
462.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

337
N-(2,2-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-2-
464.3

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

338
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(oxetan-2-
420.3

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

339
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[[(2R)-tetrahydrofuran-2-
434.2

yl]methyl]thieno[3,2-b]pyridine-5-carboxamide

340
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(tetrahydropyran-2-
448.3

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

341
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl)methyl]-N-(oxetan-3-yl]thieno[3,2-
406.3

b]pyridine-5-carboxamide

342
N-(2-methoxyethyl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-
408.3

b]pyridine-5-carboxamide

343
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydrofuran-3-
420.4

yl]thieno[3,2-b]pyridine-5-carboxamide

344
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[(3R)-tetrahydrofuran-3-
420.3

yl]thieno[3,2-b]pyridine-5-carboxamide

345
N-(3,3-difluorocyclobutyl)-7-[[6-(1-methylpyrazol-4-yl)-3-
440.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

346
N-(3-fluorocyclobutyl)-7-[[6-(1-methylpyrazol-4-yl)-3-
422.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

347
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydropyran-3-
434.3

yl]thieno[3,2-b]pyridine-5-carboxamide

348
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(tetrahydrofuran-3-
434.3

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

349
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[[(2S)-tetrahydrofuran-2-
434.3

yl]methyl]thieno[3,2-b]pyridine-5-carboxamide

350
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-tetrahydropyran-4-yl-
434.4

thieno[3,2-b]pyridine-5-carboxamide

351
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-
446.2

yl)thieno[3,2-b]pyridine-5-carboxamide

352
N-[(1S,2S)-2-hydroxycyclopentyl]-7-[[6-(1-methylpyrazol-3-yl)-3-
434.4

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

353
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[6-(1-methylpyrazol-3-yl)-3-
450.2

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

354
N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[6-(1-methylpyrazol-3-yl)-3-
448.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

355
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl)methyl]-N-(oxetan-2-
420.3

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

356
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl)methyl]-N-(tetrahydrofuran-3-
434.3

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

357
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(3S)-tetrahydrofuran-3-
434.4

yl]methyl]thieno[3,2-b]pyridine-5-carboxamide

358
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl)methyl]-N-(tetrahydropyran-4-
448.2

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

359
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl)methyl]-N-(tetrahydropyran-2-
448.4

ylmethyl)thieno[3,2-b]pyridine-5-carboxamide

360
N-(azetidin-2-ylmethyl)-7-[[6-(1-methylpyrazol-4-yl)-3-
419.2

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

361
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl)methyl]-N-[(3R)-tetrahydropyran-3-
434.2

yl]thieno[3,2-b]pyridine-5-carboxamide

362
N-(3,3-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-4-yl)-3-
462.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

363
N-(2-methoxy-1-methyl-ethyl)-7-[[6-(1-methylpyrazol-4-yl)-3-
422.2

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

364
7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[1-(oxetan-3-yl)azetidin-3-
461.3

yl]thieno[3,2-b]pyridine-5-carboxamide

365
N-(oxctan-3-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
408.3

carboxamide

366
N-tetrahydropyran-3-yl-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
436.4

carboxamide

367
N-(3-fluorocyclobutyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
424.2

carboxamide

368
N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
422.3

b]pyridine-5-carboxamide

369
N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
422.2

b]pyridine-5-carboxamide

370
N-(3-methyltetrahydropyran-4-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
450.4

b]pyridine-5-carboxamide

371
N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(4-thiazol-2-
452.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

372
N-(3-methoxypropyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
424.3

carboxamide

373
N-(2-methoxyethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
410.3

carboxamide

374
N-(tetrahydrofuran-3-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
436.2

b]pyridine-5-carboxamide

375
N-(tetrahydropyran-2-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
450.3

b]pyridine-5-carboxamide

376
N-(3,3-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-3-yl)-3-
462.2

pyridyl]methyl]thieno[3,2-b)]pyridine-5-carboxamide

377
N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-3-yl)-3-
462.2

pyridyl]methyl]thieno[3,2-b)]pyridine-5-carboxamide

378
N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-3-yl)-3-
462.2

pyridyl]methyl]thieno[3,2-b)]pyridine-5-carboxamide

379
N-(3,3-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-4-
461.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

380
N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-4-
461.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

381
N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-4-
461.3

yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

382
N-(oxctan-2-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
422.2

carboxamide

383
N-(3,3-difluorocyclobutyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
442.2

b]pyridine-5-carboxamide

384
N-(tetrahydrofuran-2-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
436.2

b]pyridine-5-carboxamide

385
N-(4,4-difluorocyclohexyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-
470.2

b]pyridine-5-carboxamide

386
N-(2,6-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-2-
464.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

387
N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-
450.2

b]pyridine-5-carboxamide

388
N-(2,2-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-5-
464.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

389
N-[[(2S)-tetrahydrofuran-2-yl]methyl]-7-[(4-thiazol-2-
436.3

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

390
N-(3,3-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-5-
464.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

391
N-(2,6-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-5-
464.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

392
N-[(3S,4S)-3-methyltetrahydropyran-4-yl]-7-[(4-thiazol-5-
450.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

393
N-[(3R,4S)-3-methyltetrahydropyran-4-yl]-7-[(4-thiazol-5-
450.2

ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide

394
N-tetrahydropyran-4-yl-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
436.2

carboxamide

395
N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-
450.2

b]pyridine-5-carboxamide

396
N-(tetrahydrofuran-3-ylmethyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-
436

b]pyridine-5-carboxamide

397
N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-
436

b]pyridine-5-carboxamidc

398
N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-
448.2

b]pyridine-5-carboxamidc

399
N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-
422.2

b]pyridine-5-carboxamide

400
N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-
422.2

b]pyridine-5-carboxamide

401
N-(3-fluorocyclobutyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
424

carboxamide

402
N-(oxctan-3-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
408

carboxamide

403
N-(2-methoxyethyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
410.2

carboxamide

404
N-(3-methoxypropyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
424

carboxamide

405
N-[(1S,2S)-2-hydroxycyclobutyl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-
422.2

b]pyridine-5-carboxamide

406
N-(2-methoxy-1-methyl-ethyl)-7-[(4-thiazol-5-yIphenyl)methyl]thieno[3,2-
424.2

b]pyridine-5-carboxamide

407
N-tetrahydropyran-4-yl-7-[[4-(tetrahydropyran-4-
480.3

ylcarbamoyl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

408
N-(3,3-difluoracyclobutyl)-7-[[4-[(3,3-
492.2

difluorocyclobutyl)carbamoyl]phenyl]methyl]thieno[3,2-b]pyridine-5-

carboxamide

409
N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-[(2,2-dimethyltetrahydropyran-4-
536.3

yl)carbamoyl]phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

410
N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[6-(1-methylpyrazol-3-yl)-3-
450.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

411
N-[(1S,2S)-2-hydroxycycloheptyl]-7-[[6-(1-methylpyrazol-3-yl)-3-
462.4

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

412
N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[6-(1-methylpyrazol-3-yl)-3-
420.2

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

413
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2R)-tetrahydrofuran-2-
434.4

yl]methyl]thieno[3,2-b]pyridine-5-carboxamide

414
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2S)-tetrahydrofuran-2-
434.3

yl]methyl]thieno[3,2-b]pyridine-5-carboxamide

415
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(oxctan-3-yl)thieno[3,2-
406.4

b]pyridine-5-carboxamide

416
N-(2-methoxyethyl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-
408.4

b]pyridine-5-carboxamide

417
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydrofuran-3-
420.3

yl]thieno[3,2-b]pyridine-5-carboxamide

418
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3R)-tetrahydrofuran-3-
420.4

yl]thieno[3,2-b]pyridine-5-carboxamide

419
N-(3-fluorocyclobutyl)-7-[[6-(1-methylpyrazol-3-yl)-3-
422.4

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

420
N-(3,3-difluorocyclobutyl)-7-[[6-(1-methylpyrazol-3-yl)-3-
440.2

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

421
N-(azctidin-2-ylmethyl)-7-[[6-(1-methylpyrazol-3-yl)-3-
419.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

422
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydropyran-3-
434.3

yl]thieno[3,2-b]pyridine-5-carboxamide

423
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3R)-tetrahydropyran-3-
434.3

yl]thieno[3,2-b]pyridine-5-carboxamide

424
N-(2-methoxy-1-methyl-ethyl)-7-[[6-(1-methylpyrazol-3-yl)-3-
422.4

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

425
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[1-(oxetan-3-yl)azetidin-3-
461.4

yl]thieno[3,2-b]pyridine-5-carboxamide

426
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2S)-pyrrolidin-2-
433.4

yl]methyl]thieno[3,2-b]pyridine-5-carboxamide

427
7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2R)-pyrrolidin-2-
433.2

yl]methyl]thieno[3,2-b]pyridine-5-carboxamide

428
N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-7-[[6-(1-methylpyrazol-3-yl)-3-
461.3

pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide

429
N-(2-methoxyethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
393.3

carboxamide

430
N-(3-methoxypropyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
407.3

carboxamide

431
N-(3-methoxycyclobutyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
419.2

b]pyridine-5-carboxamide

432
7-[(4-pyrazol-1-ylphenyl)methyl]-N-[1-(2,2,2-trifluoroethyl)azetidin-3-
472.3

yl]thieno[3,2-b]pyridine-5-carboxamide

433
N-[1-(oxetan-3-yl)azetidin-3-yl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
446.2

b]pyridine-5-carboxamide

434
N-(1-tert-butylazetidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
446.4

b]pyridine-5-carboxamide

435
N-(1-methylazetidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
404.3

b]pyridine-5-carboxamide

436
N-cyclobutyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
389.4

carboxamide

437
N-(2-oxocyclopentyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-
417.4

carboxamide

438
N-(1-methyl-5-oxo-pyrrolidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
432.2

b]pyridine-5-carboxamide

439
N-(1,1-dioxothiolan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
453.3

b]pyridine-5-carboxamide

440
7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydrofuran-3-yl-thieno[3,2-b]pyridine-
405.3

5-carboxamide

441
N-(5-oxopyrrolidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
418.3

b]pyridine-5-carboxamide

442
N-(1-methyl-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
432.5

b]pyridine-5-carboxamide

443
N-(1-methyl-4-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
432.2

b]pyridine-5-carboxamide

444
N-(3-methyltetrahydropyran-4-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
433.3

b]pyridine-5-carboxamide

445
2-oxa-5-azabicyclo[2.2.1]heptan-5-yl-[7-[(4-pyrazol-1-
417.3

ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone

446
7-[(4-pyrazol-1-ylphenyl)methyl]-N-(1-tetrahydrofuran-2-ylethyl]thieno[3,2-
433.3

b]pyridine-5-carboxamide

447
7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-3-yl-thieno[3,2-b]pyridine-
419.2

5-carboxamide

448
N-(1H-pyrazol-3-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-
415.3

b]pyridine-5-carboxamide

Example 9. 7-Chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile (T)

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7-chloro-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile was prepared using the procedure from Storz, Thomas et al., Synthesis, 2008, 2, 201-214. ¹H NMR (400 MHz, DMSO-d₆) δ 8.02 (d, J=3.2 Hz, 1H), 8.00 (s, 1H), 6.84 (d, J=3.1 Hz, 1H); ES-MS [M+1]⁺: 178.2.

To a solution of 7-chloro-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile (635 mg, 3.57 mmol, 1.0 eq.) in DMF (18 mL, 0.2 M) at 0° C., NaH (60% dispersion in mineral oil, 215 mg, 5.36 mmol, 1.5 eq.) was added. The suspension was stirred for 15 min and iodomethane (334 uL, 5.36 mmol, 1.5 eq.) was added. The reaction mixture was stirred at 0° C. for 30 min. Water (˜5 mL) was added slowly. The mixture was extracted with EtOAc (3×). The combined extracts were washed with brine, dried (Na₂SO₄) filtered and concentrated in vacuo. Purification by flash chromatography on silica gel (0-50% EtOAc/hexanes) afforded 447 mg (90%) of the title compound. ¹H NMR (400 MHz, DMSO-d₆) δ 7.97 (d, J=3.2 Hz, 1H), 7.95 (s, 1H), 6.80 (d, J=3.2 Hz, 1H), 4.15 (s, 3H); ES-MS [M+1]⁺: 192.2.

Example 10. 1-Methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carbonitrile (V)

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Compound T (465 mg, 2.43 mmol, 1 eq.), bis(pinacolato)diboron (1.23 g, 4.85 mmol, 2 eq.), potassium acetate (715 mg, 7.28 mmol, 3 eq.), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II) (178 mg, 0.24 mmol, 0.1 eq.) and 1,4-dioxane (16 mL, 0.15 M) were charged into a microwave vial. The reaction mixture was stirred at 100° C. overnight. Upon completion by LCMS, the reaction mixture was filtered over a Celite® pad which was rinsed with DCM/EtOAc (1:1). The filtrate was concentrated in vacuo. Purification by flash chromatography on silica gel (0-60% EtOAc/DCM) to provide 1-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[3,2-b]pyridine-5-carbonitrile (U) (680 mg, 99% -contaminated with some boronic ester). ¹H NMR (400 MHz, DMSO-d₆) δ 7.93 (d, J=3.3 Hz, 1H), 7.75 (s, 1H), 6.76 (d, J=3.3 Hz, 1H), 3.99 (s, 3H), 1.39 (s, 12H); ES-MS [M+1]⁺: 202.3 (boronic acid).

Compound U (190 mg, 0.67 mmol, 1 eq.), cesium carbonate (328 mg, 1.0 mmol, 1.5 eq.), 1-[4-(chloromethyl)phenyl]-1H-pyrazole (162 mg, 0.84 mmol, 1.25 eq.), THF (3.9 mL) and water (0.56 mL) were charged into a microwave vial. Nitrogen gas was bubbled through the mixture for five minutes. [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (78 mg, 0.1 mmol, 0.15 eq.) was added. The vial was capped and the reaction stirred at 100° C. overnight. Upon completion by LCMS, the reaction mixture was filtered over a Celite® pad which was washed DCM/EtOAc (1:1). The filtrated was concentrated in vacuo. Purification using reverse phase HPLC to provide the title compound (V) as a TFA salt (80 mg, 28%). ¹H NMR (400 MHz, DMSO-d₆) δ 8.47 (s, 1H), 7.82-7.80 (m, 3H), 7.73 (s, 1H), 7.42 (s, 1H), 7.27 (d, J=8.0 Hz, 2H), 6.71 (d, J=3.1 Hz, 1H), 6.53 (s, 1H), 4.63 (s, 2H), 3.96 (s, 3H); ES-MS [M+1]⁺: 314.4.

Example 11. 1-Methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxylic acid

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A mixture of compound V (70 mg, 0.16 mmol, 1 eq.) and concentrated hydrochloric acid solution (37%, 1.0 mL) was stirred at 100° C. After 2 h, the mixture was concentrated under reduced pressure to provide the title compound as an HCl salt (60 mg, 99%) which was used without further purification. ES-MS [M+1]⁺: 333.2.

Example 12. 1-Methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide (449)

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To a solution of carboxylic acid W (9.2 mg, 0.025 mmol, 1 eq.) in DMF (1 mL) was added N,N-diisopropylethylamine (22 μL, 0.125 mmol, 5 eq.) and 6-amino-2-oxa-spiro[3.3]heptane hydrochloride (7.9 mg, 0.053 mmol, 2.1 eq.). The mixture was stirred for 5 min and HATU (20 mg, 0.053 mmol, 2.1 eq.) was added. The reaction mixture was stirred for 20 min at rt. Purification by reverse phase HPLC afforded 5.3 mg (50%) of the title compound: ¹H NMR (400 MHz, DMSO-d₆) δ 8.82 (d, J=8.4 Hz, 1H), 8.52 (s, 1H), 7.86 (d, J=8.0 Hz, 2H), 7.78 (s, 1H), 7.73 (d, J=3.0 Hz, 1H), 7.60 (s, 1H), 7.31 (d, J=7.7 Hz, 2H), 6.70 (d, J=3.0 Hz, 1H), 6.60 (s, 1H), 4.69 (s, 4H), 4.56 (s, 2H), 4.35-4.28 (m, 1H), 4.04 (s, 3H), 2.41-2.39 (m, 4H); ES-MS [M+1]⁺: 428.2.

The following compounds were prepared in an analogous manner using the same or similar routes as described above.

ES-MS

No.
Name
[M + 1]⁺

450
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-4-
449.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

451
1-methyl-N-tetrahydropyran-4-yl-7-[(4-thiazol-4-
433.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

452
1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-4-
445.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

453
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-pyrazol-1-
432.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

454
N-[(1S,2S)-2-hydroxycycloliexyl]-1-methyl-7-[(4-pyrazol-1-
430.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

455
1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-
416.2

pyrrolo[3,2-b]pyridine-5-caiboxamide

456
N-[(1S,2S)-2-hydroxycycloheptyl]-1-methyl-7-[(4-thiazol-4-
461.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

457
N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-thiazol-4-
447.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

458
N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-thiazol-4-
433.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

459
N-[(1S,2S)-2-hydroxycyclobutyl]-1-methyl-7-[(4-thiazol-4-
419.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

460
N-[(2S,6R)-2,6-dimethyltetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-
461.2

4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-caiboxamide

461
N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[(4-thiazo1-4-
461.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

462
1-methyl-N-[(3S)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-
433.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

463
1-methyl-N-[(3R)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-
433.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

464
1-methyl-N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-
419.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

465
1-methyl-N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-
419.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

466
1-methyl-N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-4-
447.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

467
1-methyl-N-(oxctan-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-
405.2

b]pyridine-5-carboxamide

468
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[[6-(1-
447.4

methylpyrazol-4-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-

carboxamide

469
N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[[6-(1-methylpyrazol-4-
445.4

yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

470
1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-
431.3

tetrahydropyran-4-yl-pyrrolo[3,2-b]pyridine-5-carboxamide

471
1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(2-
443.3

oxaspiro[3.3]heptan-6-yl)pyrrolo[3,2-b]pyridine-5-carboxamide

472
N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-
459.4

methylpyrazol-4-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-

carboxamide

473
1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-
430.2

tetrahydropyran-4-yl-pyrrolo[3,2-b]pyridine-5-carboxamide

474
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[[4-(1-
446.4

methylpyrazol-3-yl)phenyl]methyl]pyrrolo[3,2-b]pyridine-5-

carboxamide

475
1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(2-
442.4

oxaspiro[3.3]heptan-6-yl)pyrrolo[3,2-b]pyridine-5-carboxamide

476
1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-
444.5

(tetrahydropyran-4-ylmethyl)pyrrolo[3,2-b]pyridine-5-carboxamide

477
N-(3,3-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[4-(1-
458.4

methylpyrazol-3-yl)phenyl]methyl]pyrrolo[3,2-b]pyridine-5-

carboxamide

478
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-2-
449.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

479
N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-thiazol-2-
447.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

480
1-methyl-N-tetrahydropyran-4-yl-7-[(4-thiazol-2-
433.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

481
1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-2-
445.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

482
N-[(1S,2S)-2-hydroxycyclobutyl]-1-methyl-7-[(4-thiazol-2-
419.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

483
N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-thiazol-2-
433.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

484
N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[(4-thiazol-2-
461.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

485
N-(3,3-dimethyltetrahydropyran-4-yl)-1-methyl-7-[(4-thiazol-2-
461.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

486
1-methyl-N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-2-
447.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

487
N-(3,3-difluorocyclobutyl)-1-methyl-7-[(4-thiazol-2-
439.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

488
N-(3-fluorocyclobutyl)-1-methyl-7-[(4-thiazol-2-
421.2

ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide

503
1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-
431.2

tetrahydropyran-4-yl-pyrrolo[3,2-b]pyridine-5-carboxamide;

504
N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-
459.2

methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-

carboxamide;

505
N-(3,3-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-
459.3

methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pxridine-5-

carboxamide;

506
N-(2,6-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-
459.2

methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-

carboxamide;

507
1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(2-
443.2

oxaspiro[3.3]heptan-6-yl)pyrrolo[3,2-b]pyridine-5-carboxamide;

508
1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-
445.2

(tetrahydropyran-4-ylmethyl)pyrrolo[3,2-b]pyridine-5-

carboxamide;

509
1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-
431.2

(tetrahydrofuran-3-ylmethyl)pyrrolo[3,2-b]pyridine-5-carboxamide;

510
N-(3-fluorocyclobutyl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-
419.2

pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

511
N-(3,3-difluorocyclobutyl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-
437.2

3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;

512
N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[[6-(1-
445.2

methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-

carboxamide; and

513
N-[(1S,2S)-2-hydroxycyclobutyl]-1-methyl-7-[[6-(1-
417.2

methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-

carboxamide

Example 13. 7-chloro-1H-pyrazolo[4,3-b]pyridine (X)

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To a solution of 7-chloro-1H-pyrazolo[4,3-b]pyridine (1000 mg, 6.51 mmol, 1.0 eq.) in THF (33 mL, 0.2 M) at 0° C., NaH (60% dispersion in mineral oil, 547 mg, 13.68 mmol, 2.1 eq.) was added. The suspension was stirred for 15 min and iodomethane (405 uL, 6.51 mmol, 1.0 eq.) was added dropwise. The reaction mixture was stirred at 0° C. for 1 h and the ice bath was removed. After 16 h at rt, NH₄Cl (aq) (˜5 mL) was added slowly. The mixture was extracted with EtOAc (3×). The combined extracts were washed with brine, dried (Na₂SO₄) filtered and concentrated in vacuo to afford 1100 mg of the title compound. Material was taken forward without further purification. ES-MS [M+1]⁺: 168.4.

Example 14. 7-Chloro-1-methyl-1H-pyrazolo[4,3-b]pyridine-5-carbonitrile (Z)

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To a solution compound X (0.800 g, 4.77 mmol, 1 eq.) in dichloromethane (47.6 mL, 0.10 M) was added 3-chloroperoxybenzoic acid (3.21 g, 14.32 mmol, 3.0 eq.) in small portions over 15 minutes. After 16 h, the mixture was quenched with 10% NaS₂O₃solution and washed with 10% K₂CO₃. The aqueous layer was extracted with CHCl₃/iPA solution (3:1, 4×). The organic layers were combined, dried (Na₂SO₄), filtered and concentrated in vacuo. Purification by flash chromatography on silica gel (0-100% 89/10/1 DCM/MeOH/NH₄OH with DCM) afforded 455 mg (52%) of 7-chloro-1-methyl-1H-pyrazolo[4,3-b]pyridine 4-oxide (Y). ES-MS [M+1]⁺: 184.2.

To a solution of compound Y (455 mg, 2.48 mmol, 1 eq.) in dichloromethane (12.4 mL, 0.2 M) was added trimethylsilylcyanide (0.62 mL, 4.96 mmol, 2 eq.). After 15 minutes, dimethylcarbamoylchloride (0.45 mL, 4.96 mmol, 2 eq.) was added over a 15 minute period. The reaction stirred for four hours before an additional amount of trimethylsilylcyanide (0.62 mL, 4.96 mmol, 2 eq.) and dimethylcarbamoylchloride (0.45 mL, 4.96 mmol, 2.0 eq.) were added in a similar manner as above. After 18 hours, reaction was quenched with 10% K₂CO₃, washed with water and back extracted twice with dichloromethane. The organic layers were combined, dried (Na₂SO₄), filtered and concentrated in vacuo. Purification by flash chromatography on silica gel (0-40% EtOAc/hexanes) afforded 280 mg (59%) of the title compound Z. ES-MS [M+1]⁺: 193.3.

Example 15. 1-methyl-7-(4-(thiazol-4-yl)benzyl)-1H-pyrazolo[4,3-b]pyridine-5-carbonitrile (BB)

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Compound Z (275 mg, 1.43 mmol, 1 eq.), bis(pinacolato)diboron (725 mg, 2.86 mmol, 2 eq.), potassium acetate (700 mg, 7.14 mmol, 5 eq.), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II) (50 mg, 0.07 mmol, 0.05 eq.) and 1,4-dioxane (7.1 mL, 0.20 M) were charged into a microwave vial. The reaction mixture was heated to 100° C. After 16 h and LCMS confirmed complete conversion, the reaction mixture was filtered over a Celite® pad which was rinsed with DCM/EtOAc (1:1). The filtrate was concentrated in vacuo to afford 1-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[4,3-b]pyridine-5-carbonitrile (AA) (400 mg, 98%). Material was taken forward without further purification. ES-MS [M+1]⁺: 203.3 (boronic acid).

Compound AA (200 mg, 0.70 mmol, 1 eq.), cesium carbonate (688 mg, 2.1 mmol, 3.0 eq.), 4-[4-(chloromethyl)phenyl]thiazole hydrochloride (173 mg, 0.70 mmol, 1.0 eq.), THF (7.0 mL) and water (1.0 mL) were charged into a microwave vial. Nitrogen gas was bubbled through the mixture for five minutes. [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (77 mg, 0.106 mmol, 0.15 eq.). The vial was capped and the reaction stirred at 100° C. overnight. Upon completion by LCMS, the reaction mixture was filtered over a Celite® pad which was washed EtOAc. The filtrated was concentrated in vacuo. Purification using normal phase on silica gel (0-100% EtOAc/hexanes) to provide the title compound BB (230 mg, 99%, ˜85% pure @ 254 nm). ES-MS [M+1]⁺: 332.2.

Example 16. 1-methyl-7-(4-(thiazol-4-yl)benzyl)-1H-pyrazolo[4,3-b]pyridine-5-carboxylic acid (CC)

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A mixture of compound BB (230 mg, 0.69 mmol, 1 eq.) and concentrated hydrochloric acid solution (37%, 4.0 mL) was stirred at 100° C. After 1 h, LCMS confirms complete conversion. The mixture was concentrated under reduced pressure. Crude residue was taken through without further purification. ES-MS [M+1]⁺: 351.2.

Example 17. 1-Methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide (489)

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To a solution of carboxylic acid (CC) (10 mg, 0.029 mmol, 1 eq.) in DMF (1.0 mL) was added N,N-diisopropylethylamine (25 μL, 0.143 mmol, 5.0 eq.) and 2-oxaspiro[3.3]heptan-6-amine hydrochloride (5.1 mg, 0.034 mmol, 1.2 eq.). The mixture was stirred for 5 min and HATU (13.0 mg, 0.034 mmol, 1.2 eq.) was added. The reaction mixture was stirred for 20 min at rt. Purification by reverse phase HPLC (30-60% acetonitrile:water w/0.1% TFA) afforded 7.6 mg (60%) of the title compound. ES-MS [M+1]⁺: 446.3.

The following compounds were prepared in an analogous manner using the same or similar routes as described above.

ES-MS

No.
Name
[M + 1]⁺

490
N-[(1R,2R)-2-hydroxycyclobutyl]-1-methyl-7-[(4-thiazol-4-
420.3

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

491
N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-thiazol-4-
434.3

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

492
N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-thiazol-4-
448.4

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

493
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-4-
4S0.3

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

494
1-methyl-N-(oxetan-2-ylmethyl)-7-[(4-thiazol-4-
420.3

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

495
1-methyl-N-[[(2R)-tetrahydrofuran-2-yl]methyl]-7-[(4-thiazol-4-
434.4

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

496
N-[(1R,2R)-2-hydroxycyclobutyl]-1-methyl-7-[(4-pyrazol-1-
403.3

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

497
N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-pyrazol-1-
417.4

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

498
N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-pyrazol-1-
431.4

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

499
N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-pyrazol-1-
433.3

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

500
1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-
429.4

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

501
1-methyl-N-(oxctan-2-ylmethyl)-7-[(4-pyrazol-1-
403.4

ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

502
1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2R)-tetrahydrofuran-
417.4

2-yl]methyl]pyrazolo[4,3-b]pyridine-5-carboxamide

Example 18. Biological Activity

a. Cell Lines Expressing Muscarinic Acetylcholine Receptors

Chinese hamster ovary (CHO-K1) cells stably expressing rat (r)M₁were purchased from the American Type Culture Collection and cultured according to their indicated protocol. CHO cells stably expressing human (h)M₂, hM₃, and hM₅were described previously (Levey, et al., 1991); hM₁and hM₄cDNAs were purchased from Missouri S&T cDNA Resource; rM₄cDNA was provided by T. I. Bonner (National Institutes of Health, Bethesda, Md.). rM₂and rM₃were cloned from a rat brain cDNA library and sequence verified. hM₁, rM₂, rM₃, hM₄, and rM₄cDNAs were used to stably transfect CHO-K1 cells purchased from the American Type Culture Collection using Lipofectamine2000. To make stable rM₂, hM₂, rM3, hM₄, and rM₄cell lines for use in calcium mobilization assays, these cells also were stably transfected with a chimeric G-protein (G_qi5) (provided by B. R. Conklin, University of California, San Francisco) using Lipofectamine 2000. rM₁, hM₁, rM₃, hM₃, rM₅, and hM₅cells were grown in Ham's F-12 medium containing 10% heat-inactivated fetal bovine serum (FBS), 20 mM HEPES, and 50 μg/mL G418 sulfate. rM2-G_qi5, hM₂-G_qi5, and hM₄-G_qi5cells were grown in the same medium also containing 500 μg/mL Hygromycin B. Stable rM₄-G_qi5cells were grown in DMEM containing 10% heat-inactivated FBS, 20 mM HEPES, 400 μg/mL G418 sulfate, and 500 μg/mL Hygromycin B.

b. Cell-Based Functional Assay of Muscarinic Acetylcholine Receptor Activity

For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated in growth medium lacking G418 and hygromycin at 15,000 cells/20 μL/well in Greiner 384-well black-walled, tissue culture (TC)-treated, clear-bottom plates (VWR). Cells were incubated overnight at 37° C. and 5% CO₂. The next day, cells were washed using an ELX 405 (BioTek) with four washes (80 μL) of assay buffer then aspirated to 20 μL. Next, 20 μL of 16 μM Fluo-4/acetoxymethyl ester (Invitrogen, Carlsbad, Calif.) prepared as a 2.3 mM stock in DMSO and mixed in a 1:1 ratio with 10% (w/v) Pluronic F-127 and diluted in assay buffer was added to the wells and the cell plates were incubated for 50 min at 37° C. and 5% CO₂. Dye was removed by washing with the ELX 405 (four 80 μL washes of assay buffer) then aspirated to 20 μL. Compound master plates were formatted in an 11 point CRC format (1:3 dilutions) in 100% DMSO with a starting concentration of 10 mM using the BRAVO liquid handler (Agilent). Test compound CRCs were then transferred to daughter plates (240 nL) using the Echo acoustic plate reformatter (Labcyte, Sunnyvale, Calif.) and then diluted into assay buffer (40 μL) to a 2× stock using a Thermo Fisher Combi (Thermo Fisher Scientific, Waltham, Mass.).

Calcium flux was measured using the Functional Drug Screening System (FDSS) 6000 (Hamamatsu Corporation, Tokyo, Japan) as an increase in the fluorescent static ratio. Compounds were applied to cells (20 μL, 2×) using the automated system of the FDSS 6000 at 4 s into the 300 s protocol and the data were collected at 1 Hz. At 144 s into the 300 s protocol, 10 μL of an EC₂₀concentration of the muscarinic receptor agonist acetylcholine was added (5×), followed by the addition of 12 μL an EC₈₀concentration of acetylcholine at the 230 s time point (5×). Agonist activity was analyzed as a concentration-dependent increase in calcium mobilization upon compound addition. Positive allosteric modulator activity was analyzed as a concentration-dependent increase in the EC₂₀acetylcholine response. Antagonist activity was analyzed as a concentration-dependent decrease in the EC₈₀acetylcholine response. Concentration-response curves were generated using a four-parameter logistical equation in XLfit curve fitting software (IDBS, Bridgewater, N.J.) for Excel (Microsoft, Redmond, Wash.) or Prism (GraphPad Software, Inc., San Diego, Calif.).

The above described assay was also operated in a second mode where an appropriate fixed concentration of the present compounds were added to the cells after establishment of a fluorescence baseline for about 3 seconds, and the response in cells was measured. 140 s later the appropriate concentration of agonist was added and readings taken for an additional 106 s. Data were reduced as described above and the EC₅₀values for the agonist in the presence of test compound were determined by nonlinear curve fitting. A decrease in the EC₅₀value of the agonist with increasing concentrations of the present compounds (a leftward shift of the agonist concentration-response curve) is an indication of the degree of muscarinic positive allosteric modulation at a given concentration of the present compound. An increase in the EC₅₀value of the agonist with increasing concentrations of the present compounds (a rightward shift of the agonist concentration response curve) is an indication of the degree of muscarinic antagonism at a given concentration of the present compound. The second mode also indicates whether the present compounds also affect the maximum response of the muscarinic receptor to agonists.

c. Results and Discussion of Biological Activity Data

Activity (EC₅₀) was determined in the mAChR M₁cell-based functional assay as described above and the data are shown in Table 1. The data in Table 1 demonstrates that the disclosed compounds are positive allosteric modulators of mAChR M₁and show high affinity for the mAChR M₁receptor(s). Moreover, compounds in Table 1 are at least 10-fold selective versus M₂-M₅.

TABLE 1

Compound

No.
EC₅₀(μM)

1
0.087

2
2.15

3
—

4
4.985

5
>10

6
>10

7
3.255

8
7.788

9
>10

10
—

11
—

12
—

13
4.124

14
4.253

15
—

16
>10

17
>10

18
>10

19
>10

20
>10

21
1.140

22
1.789

23
>10

24
>10

25
0.750

26
—

27
>10

28
—

29
>10

30
>10

31
>10

32
>10

33
>10

34
>10

35
>10

36
>10

37
—

38
—

39
—

40
—

41
3.641

42
0.360

43
1.987

44
3.766

45
0.080

46
0.029

47
0.117

48
5.766

49
>10

50
4.960

Data for additional compounds are provided in Table 2.

TABLE 2

Compound
Human M₁

No.
EC₅₀(μM)
E_max(%)

51
3.61
76.92

52
1.96
76.04

53
3.07
79.02

54
>10 μM
53.06

55
5.7
31.08

56
3.26
50.99

57
2.64
80.09

58
6.03
50.2

59
2.84
88.5

60
5.6
71.62

61
>10 μM
64.81

62
>10 μM
41.24

63
3.99
87.02

64
0.962
70.71

65
1.72
37.28

66
7.41
92.97

67
2.78
92.7

68
9.7
22.75

69
6.82
80.32

70
>10 μM
62.39

71
0.0803
92.73

72
>10 μM
84.47

73
0.0501
87.88

74
0.0122
84.94

75
0.0221
90.07

76
0.739
67.62

77
0.136
84.83

78
0.31
87.24

79
0.397
70.48

80
>10 μM
65.92

81
>10 μM
33.03

82
>10 μM
70.42

83
>10 μM
52.87

84
>10 μM
24.37

85
0.0801
87.87

86
0.255
87.7

87
3.13
84.89

88
0.503
90.46

89
1.73
71.84

90
0.154
90.66

91
0.0738
87.89

92
>10 μM
66.77

93
6.72
70.34

94
1.25
84.58

95
3.13
34.21

96
>10 μM
43.58

97
>10 μM
75.15

98
6
66.62

99
7.3
77.7

100
0.654
87.55

101
4.96
75.66

102
2.7
82.52

103
0.233
89.27

104
0.164
86.85

105
0.825
87.69

106
2.2
82.14

107
0.474
88.47

108
5.27
48.36

109
3.25
54.6

110
5.06
71

111
2.4
72.46

112
5.82
36.67

113
0.985
83.82

114
0.562
84.54

115
1.05
86.25

116
0.32
78.67

117
0.0833
76.61

118
0.134
83.65

119
2.28
83.31

120
1.32
75.32

121
6.76
54.85

122
0.869
80.43

123
0.435
28.83

124
2.46
64.38

125
>10 μM
59.06

126
>10 μM
27.39

127
>10 μM
79.22

128
>10 μM
74.96

129
>10 μM
51.45

130
>10 μM
20.05

131
4.65
83.39

132
>10 μM
54.86

133
3.62
77.86

134
3.21
37.6

135
>10 μM
60.93

136
0.359
80.96

137
0.548
80.27

138
>10 μM
74.29

139
>10 μM
51.11

140
0.306
82.79

141
>10 μM
36.89

142
4.95
23.86

143
>10 μM
50.46

144
>10 μM
50.66

145
>10 μM
41.57

146
0.336
90.73

147
>10 μM
33.95

148
0.0331
85.47

149
0.00984
85.01

150
0.722
88.55

151
0.595
88.37

152
0.272
92.28

153
0.00474
59.77

154
0.0062
83.91

155
0.0127
68.65

156
0.26
89.15

157
0.0242
70.03

158
0.343
89.65

159
0.141
80.54

160
3.93
77.54

161
3.51
78.75

162
5.04
73.98

163
2.53
75.36

164
2.55
74.57

165
>10 μM
70.83

166
0.0168
81.62

167
0.0253
90.39

168
0.0842
82.56

169
1.36
84.13

170
0.15
82.9

171
0.373
93.02

172
0.685
88.76

173
>10 μM
37.04

174
>10 μM
45.14

175
0.0177
84.29

176
0.362
93.15

177
>10 μM
39.68

178
0.652
85.99

179
3.8
65.21

180
3.3
72.06

181
3.82
63.96

182
0.183
83.95

183
2.53
67.35

184
3.61
68.49

185
4.23
52.12

186
3.29
74.23

187
3.2
72.06

188
1.79
83.18

189
6.27
72.03

190
6.14
75.45

191
0.247
86.86

192
0.0153
78.68

193
0.0311
85.67

194
0.0596
80.68

195
2.39
81.75

196
0.234
81.27

197
1.38
80.8

198
0.484
89.95

199
1.42
88.09

200
0.116
89.39

201
>10 μM
38.46

202
1.37
63.67

203
2.2
75.31

204
0.897
83.55

205
1.72
77.95

206
0.0388
86.96

207
2.97
77.02

208
1.88
80.3

209
3.89
69.69

210
2.34
82.25

211
1.78
82.64

212
0.858
73.26

213
1.12
61.23

214
5.95
81.07

215
0.0101
72.68

216
0.022
81.25

217
0.0454
74.83

218
>10 μM
52.22

219
0.144
72.99

220
1.28
80.64

221
0.595
86.93

222
0.317
80.3

223
0.0294
79.92

224
0.0134
71.22

225
0.00731
63.59

226
0.00936
66.22

227
0.125
79.83

228
0.16
81.82

229
0.0271
78.57

230
0.175
77.69

231
0.0687
88.47

232
0.134
75.66

233
0.161
67.8

234
1.37
64.6

235
1.01
71.14

236
2.68
78.19

237
0.455
85.16

238
0.108
84.65

239
3.08
81.48

240
>10 μM
19.9

241
>10 μM
18.81

242
>10 μM
17.83

243
>10 μM
17.87

244
0.187
15.03

245
>10 μM
16.23

246
>10 μM
16.02

247
4.06
30.64

248
4.88
71.3

249
>10 μM
42.09

250
>10 μM
48.08

251
0.234
70.27

252
0.258
78.38

253
0.144
74.45

254
0.142
71.61

255
0.00576
46.95

256
0.0576
50.01

257
>10 μM
26.42

258
>10 μM
27.49

259
>10 μM
56.22

260
5.37
58.41

261
>10 μM
52.84

262
>10 μM
24.36

263
>10 μM
29.33

264
>10 μM
72.68

265
>10 μM
56.36

266
>10 μM
59.3

267
0.00341
50.9

268
0.0595
70.06

269
0.0234
77.56

270
0.0397
78.51

271
0.312
45.55

272
0.434
35.87

273
0.272
73.57

274
>10 μM
46.82

275
0.043
69.87

276
5.5
64.52

277
0.627
67.93

278
0.485
73.41

279
1.05
68.72

280
0.297
71.76

281
0.256
55.01

282
0.601
40.02

283
>10 μM
43.07

284
0.0677
66.88

285
0.0953
64.33

286
0.203
69.33

287
0.0494
64.92

288
0.0974
74.38

289
1.16
80.68

290
5.34
65.28

291
1.12
64.33

292
0.225
81.79

293
0.006
61.64

294
0.0157
71.08

295
0.0525
72.42

296
0.273
79.9

297
0.225
76.42

298
0.368
45.53

299
0.702
75.01

300
0.225
75.26

301
0.0423
71.87

302
0.405
69.87

303
0.366
70.72

304
0.568
72.27

305
2.85
76.33

306
2.92
79.3

307
3.44
67.22

308
5.36
62.14

309
4.93
57.34

310
0.471
78.09

311
0.714
77.06

312
0.109
65.49

313
0.0227
63.88

314
0.203
84.1

315
0.475
82.29

316
1.09
56.48

317
1.68
43.15

318
1.41
72.2

319
1.81
56.08

320
3.98
60.68

321
0.805
79.16

322
0.62
75.09

323
0.689
76.81

324
1.05
78.86

325
0.907
83.27

326
2.84
83.87

327
0.166
79.21

328
0.197
80.5

329
0.458
73.51

330
0.0228
62.77

331
0.368
69.67

332
0.0569
69.03

333
0.446
84.74

334
0.103
83.05

335
0.158
83.61

336
0.0643
58.36

337
0.852
84.16

338
0.0849
93.29

339
0.131
87.38

340
0.225
88.31

341
1.69
78.77

342
0.289
89.5

343
0.975
80.78

344
0.798
85.55

345
0.203
74.46

346
0.266
89.4

347
0.499
82.2

348
0.128
85.56

349
0.0254
89.75

350
0.0805
70.48

351
0.143
89.87

352
0.0327
90.7

353
0.00505
62.06

354
0.0148
64.22

355
0.355
86.61

356
0.39
84.81

357
0.458
86.52

358
0.201
84.34

359
0.573
83.42

360
0.0385
88.14

361
0.114
86.9

362
0.0849
72.37

363
0.321
85.17

364
0.832
83.83

365
1.35
57.88

366
1.87
83.72

367
>10 μM
71.86

368
2.3
65.61

369
2.29
59.48

370
0.4
77.72

371
0.0221
81.49

372
1.88
75.26

373
1.42
79.59

374
0.556
73.1

375
>10 μM
77.37

376
0.17
60.72

377
0.412
58.66

378
0.167
58.93

379
0.15
53.87

380
0.287
64.46

381
0.0981
60.43

382
0.386
56.62

383
>10 μM
30.37

384
1.37
65.25

385
>10 μM
41.11

386
1.91
66.14

387
0.583
69.46

388
0.846
67.84

389
0.345
64.91

390
0.926
66.28

391
1.8
73.38

392
0.199
65.44

393
1.34
68.69

394
0.233
65.49

395
0.0185
60.12

396
1.06
63.03

397
0.111
59.59

398
0.438
60.92

399
4.31
45.13

400
4.21
51.41

401
4.57
40.54

402
>10 μM
41.68

403
6.98
60.8

404
3.57
56.74

405
0.428
73.46

406
5.05
59.11

407
0.368
69.86

408
0.397
44.96

409
0.725
68.81

410
0.0562
63.37

411
0.077
57.58

412
0.222
69.08

413
0.191
72.51

414
0.703
71.54

415
8.35
62.96

416
1.29
71.42

417
4.65
66.62

418
5.13
66.98

419
0.76
70.1

420
0.4
64.22

421
0.422
66.92

422
1.62
71.62

423
0.637
70.61

424
8.47
68.61

425
5.14
65.75

426
0.29
62.73

427
0.316
64.56

428
1.89
70.24

429
0.597
72.71

430
1.08
72.89

431
1.48
69.35

432
3.42
47.52

433
1.77
65.42

434
1.46
66.23

435
2.29
76.93

436
1.5
69.09

437
0.201
69.97

438
2.21
63.11

439
0.4
68.08

440
1.97
69.34

441
1.48
63.69

442
1.49
71.83

443
1.48
66.59

444
0.263
70.95

445
>10 μM
50.74

446
0.922
72.8

447
1.1
73.94

448
0.795
67.85

449
0.157
73.14

450
0.00689
71

451
0.184
71.66

452
0.339
71.94

453
0.00677
63.09

454
0.0139
69.29

455
0.136
75.13

456
0.129
67.89

457
0.0348
64.79

458
0.129
73.39

459
0.108
73.52

460
0.379
70.34

461
0.41
70.83

462
2.05
67.89

463
1.01
71.89

464
1.87
71.2

465
1.87
72.04

466
0.364
72.15

467
2.97
61.18

468
0.0118
70.04

469
0.0298
72.28

470
0.223
85.95

471
0.39
85.42

472
0.422
85.57

473
0.106
85.75

474
0.00643
70.38

475
0.183
83.52

476
0.28
83.47

477
0.2
86.38

478
0.00624
53.2

479
0.041
52.5

480
0.36
57.2

481
0.386
57

482
0.171
61.2

483
0.065
58.6

484
0.704
47.2

485
0.662
61.6

486
0.483
37.5

487
0.819
25.5

488
1.15
37.5

489
2.75
52.02

490
>10 μM
61.88

491
1.71
72.93

492
0.504
73.26

493
0.176
65.53

494
5.02
52.23

495
3.91
65.12

496
>10 μM
65.66

497
1.18
68.11

498
0.428
67.26

499
0.267
65.29

500
>10 μM
63.14

501
>10 μM
57.37

502
4.14
67.22

503
1.56
66.62

504
1.35
79.48

505
0.752
79.36

506
7.12
78.23

507
0.985
77.63

508
2.31
79.87

509
4.32
75.4

510
4.28
76.78

511
1.77
66.13

512
0.0913
70.76

513
0.712
77.77

It is understood that the foregoing detailed description and accompanying examples are merely illustrative and are not to be taken as limitations upon the scope of the invention, which is defined solely by the appended claims and their equivalents.

Various changes and modifications to the disclosed embodiments will be apparent to those skilled in the art. Such changes and modifications, including without limitation those relating to the chemical structures, substituents, derivatives, intermediates, syntheses, compositions, formulations, or methods of use of the invention, may be made without departing from the spirit and scope thereof.

Claims

1. A compound of formula (I),
2. The compound of claim 1, wherein X is CR3a;Y is CR3b; andZ is S or O.
3. The compound of claim 1 or claim 2, wherein L is —[C(RaRb)]p—, or O;A1 is Cyc1 or Cyc2-Q-Cyc3; Ra and Rb are each independently hydrogen, alkyl, or halogen;p is 0, 1, 2, or 3;Cyc1 is aryl, or heteroaryl;Cyc2 is aryl, or heteroaryl;Q is a bond; andCyc3 is aryl, or heteroaryl.
4. The compound of any one of claims 1-3, wherein R1 is hydrogen.
5. The compound of any one of claims 1-4, wherein R2 is hydrogen, or alkyl;M is a bond, or —[C(RcRd)]t—[C(ReRf)]k—;A2 is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cyanoalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; Rc, Rd, Re, and Rf are each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy;t is 0, 1, or 2; andk is 0, 1, or 2.
6. The compound of any one of claims 1-5, wherein the compound is a compound of formula (I-a),
7. The compound of any one of claims 1-6, wherein L is —[C(RaRb)]p—, or O;A1 is Cyc1, or Cyc2-Q-Cyc3;M is a bond, or —[C(RcRd)]t—[C(ReRf)]k—;A2 is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cyanoalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; Cyc1 is heteroaryl;Cyc2 is aryl or heteroaryl;Q is a bond or CONH;Cyc3 is heteroaryl;Ra and Rb are each hydrogen;Rc, Rd, Re, and Rf are each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy;p is 1;t is 0 or 1; andk is 0 or 1.
8. The compound of any one of claims 1-7, wherein L is —[C(RaRb)]p—, or O;A1 is Cyc1, or Cyc2-Q-Cyc3;M is a bond;A2 is cycloalkyl, or heterocycle; Cyc1 is heteroaryl;Cyc2 is aryl;Q is a bond;Cyc3 is heteroaryl;Ra and Rb are each hydrogen; andp is 1.
9. The compound of any one of claims 1-8, wherein L is —[C(RaRb)]p—, or O;A1 is Cyc1;M is a bond;A2 is cycloalkyl, or heterocycle; Cyc1 is heteroaryl;Ra and Rb are each hydrogen; andp is 1.
10. The compound of any one of claims 1-9, wherein L is —[C(RaRb)]p—;A1 is Cyc1;M is a bond;A2 is cycloalkyl, or heterocycle; Cyc1 is heteroaryl;Ra and Rb are each hydrogen; andp is 1.
11. The compound of any one of claims 1-10, wherein A2 is a C3-C8 cycloalkyl, or a C4-C8 heterocycle comprising 1 oxygen atom.
12. The compound of any one of claims 1-11, wherein the compound is a compound of formula (I-b),
13. The compound of claim 1, wherein X is CR3a;Y is N; andZ is NR4.
14. The compound of claim 1, wherein X is CR3a;Y is CR3b; andZ is NR4.
15. The compound of claim 13 or claim 14, wherein L is —[C(RaRb)]p—;A1 is Cyc2-Q-Cyc3; Ra and Rb are each independently hydrogen, alkyl, or halogen;p is 0, 1, or 2;Cyc2 is aryl, or heteroaryl;Q is a bond; andCyc3 is aryl, heteroaryl.
16. The compound of any one of claims 13-15, wherein R1 is hydrogen.
17. The compound of any one of claims 13-16, wherein R2 is hydrogen, or alkyl;M is a bond, or —[C(RcRd)]t—[C(ReRf)]k—;A2 is cycloalkyl, heterocycle, heteroaryl, or aryl; Rc, Rd, Re, and Rf are each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy;t is 0, 1, or 2; andk is 0, 1, or 2.
18. The compound of claim 1, wherein the compound is a compound of formula (I-g)
19. The compound of claim 1, wherein the compound is a compound of formula (I-h):
20. The compound of claim 18 or claim 19, wherein R4 is methyl.
21. The compound of any one of claims 18-20, wherein L is —[C(RaRb)]p—;A1 is Cyc2-Q-Cyc3; Ra and Rb are each independently hydrogen or alkyl;p is 0 or 1;Cyc2 is aryl, or heteroaryl;Q is a bond; andCyc3 is heteroaryl.
22. The compound of any one of claims 18-21, wherein M is a bond, or —[C(RcRd)]t—[C(ReRf)]k—;A2 is cycloalkyl, or heterocycle; Rc, Rd, Re, and Rf are each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy;t is 0 or 1; andk is 0 or 1.
23. The compound of claim 1, wherein the compound is selected from: N-((1S,2S)-2-hydroxycyclohexyl)-7-((6-methylpyridin-3-yl)methyl)thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-methoxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(2R)-2-hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(1-methylpyrazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycycloheptyl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(1R,2R)-2-hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[2-fluoro-4-(2-methylindazol-4-yl)phenoxy]-N-[(1S,2S)-2-hydroxycycloheptyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclobutyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-cyclohexyl-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)oxy]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-methoxycyclohexyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycycloheptyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-[(2,5-dimethylphenyl)methyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-(2-hydroxy-1-phenyl-ethyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-(2-hydroxy-1,1-dimethyl-ethyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)oxy]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;N-(1-cyclopropyl-2-hydroxy-ethyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)oxy]-N-(3,3,3-trifluoro-2-hydroxy-propyl)thieno[3,2-b]pyridine-5-carboxamide;N-(2-hydroxy-2-methyl-propyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-(2-methoxyethyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-(3-hydroxy-1,2,2-trimethyl-propyl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)oxy]-N-(tetrahydrofuran-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)oxy]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)oxy]-N-(2-pyridylmethyl)thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)oxy]-N-(1H-pyrrol-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;N-[(5-methyl-1H-indol-2-yl)methyl]-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;N-(1H-indazol-3-yl)-7-[(6-methyl-3-pyridyl)oxy]thieno[3,2-b]pyridine-5-carboxamide;7-[[2,6-difluoro-4-(2-methylindazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-cyclohexyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclobutyl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycycloheptyl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-methoxycyclohexyl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-hydroxycyclohexyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycycloheptyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1R,2R)-2-hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[2,6-difluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycycloheptyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-hydroxy-1-adamantyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S)-5-hydroxy-2-adamantyl]-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1H-indazol-3-yl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxoindolin-3-yl)thieno[3,2-b]pyridine-5-carboxamide;N-(3-methyl-1H-pyrazol-5-yl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1H-imidazol-4-yl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclopentyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-cyclohexyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclohexyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-methoxycyclohexyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycycloheptyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxo-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxoazepan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;[(1S,5R)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;[(3R)-3-hydroxy-1-piperidyl]-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;(4-hydroxy-4-methyl-1-piperidyl)-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;piperazin-1-yl-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;[4-(2-hydroxyethyl)piperazin-1-yl]-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;7-[fluoro-(6-methyl-3-pyridyl)methyl]-N-[(1R,2R)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;7-[ethoxy-(6-methyl-3-pyridyl)methyl]-N-[(1R,2R)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclobutyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-tetrahydropyran-4-yl-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclohexyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-methoxycyclohexyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycycloheptyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-hydroxy-1-adamantyl)-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S)-5-hydroxy-2-adamantyl]-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxo-3-piperidyl)-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxoazepan-3-yl)-7-[[6-(trifluoromethyl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclobutyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclopentyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-cyclohexyl-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[(6-methyl-3-pyridyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclohexyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-methoxycyclohexyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycycloheptyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-hydroxy-1-adamantyl)-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S)-5-hydroxy-2-adamantyl]-3-methyl-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;3-methyl-N-(1-methyl-4-piperidyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclobutyl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclopentyl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclohexyl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-methoxycyclohexyl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycycloheptyl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N,3-dimethyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;3-methyl-N-(2-oxo-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-N-(2-oxoazepan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-N-(1-methyl-4-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclopentyl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(2-methylpyrimidin-5-yl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclohexyl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-methoxycyclohexyl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycycloheptyl]-7-[(2-methylpyrimidin-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclobutyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclopentyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-cyclohexyl-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(2-methylthiazol-5-yl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclohexyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-methoxycyclohexyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycycloheptyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-hydroxy-1-adamantyl)-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S)-5-hydroxy-2-adamantyl]-7-[(2-methylthiazol-5-yl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(2-methylthiazol-5-yl)methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;7-[(2-methylthiazol-5-yl)methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclohexyl]-7-(6-methylpyridine-3-carbonyl)thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclobutyl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclobutyl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-tetrahydropyran-3-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclohexyl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-methoxycyclohexyl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycycloheptyl]-7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;N-cyclohexyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(1-methyl-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(1-methyl-4-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;N-methyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4R)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclohexyl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-methoxycyclohexyl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycycloheptyl]-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;[(3R)-3-hydroxy-1-piperidyl]-[7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridin-5-yl]methanone;(4-hydroxy-4-methyl-1-piperidyl)-[7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridin-5-yl]methanone;7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-methyloxetan-3-yl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;N-(1-tert-butylazetidin-3-yl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-methoxycyclobutyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclopentyl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;N-cyclohexyl-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-methyl-3-piperidyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-methyl-4-piperidyl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-[(3R)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-[(3S)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;N-methyl-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-methoxycyclohexyl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycycloheptyl]-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(hexahydro-1H-pyrrolizin-1-yl)-7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-(2-oxo-3-piperidyl)thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methylthiazol-4-yl)phenyl]methyl]-N-(2-oxoazepan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclobutyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-bicyclo[1.1.1]pentanyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(oxetan-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-tert-butylazetidin-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-methoxycyclobutyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-cyclohexyl-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-methyl-3-piperidyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-methyl-4-piperidyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-methyl-N-tetrahydropyran-4-yl-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-methoxycyclohexyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycycloheptyl]-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(hexahydro-1H-pyrrolizin-1-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxo-3-piperidyl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxoazepan-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycycloheptyl]-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclobutyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1-methyltriazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-tetrahydropyran-4-yl-7-[(4-thiazol-4-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(S)-fluoro-(6-methyl-3-pyridyl)methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(R)-fluoro-(6-methyl-3-pyridyl)methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-hydroxy-2-methyl-cycloheptyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-2-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-2-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-2-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;2-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[4-(1,3,5-trimethylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxaspiro[3.3]heptan-6-yl)-7-[[4-(1,3,5-trimethylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-7-[[4-(1,3,5-trimethylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-tetrahydropyran-4-yl-7-[[4-(1,3,5-trimethylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;N-(1-tert-butylazetidin-3-yl)-7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-(3-methoxycyclobutyl)thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclopentyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1,3-dimethylpyrazol-4-yl)phenyl]methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-cyanocyclopropyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3,3-difluorocyclobutyl)-7-[(6-methyl-3-pyridyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-(4-pyrazol-1-ylbenzoyl)-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)methyl]-N-[(3R)-3-piperidyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(6-methyl-3-pyridyl)methyl]-N-[(3S)-3-piperidyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-[(1S,2S)-2-hydroxycyclohexyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(2,6-difluoro-4-thiazol-4-yl-phenyl)methyl]-N-[(1R,2R)-2-hydroxycyclobutyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-methyloxetan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;N-(oxetan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3,3-difluorocyclobutyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-cyanocyclopropyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-cyano-1-methyl-ethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(oxetan-2-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydrofuran-3-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2S)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2R)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-4-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;N-[(3S)-3-piperidyl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-methyl-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(azetidin-2-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-tetrahydropyran-4-yl-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclobutyl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3,3-difluorocyclobutyl)-3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(oxetan-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(tetrahydrofuran-3-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-4-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;3-methyl-N-(oxetan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydropyran-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-(tetrahydrofuran-3-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2R)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2S)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-N-(oxetan-2-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclobutyl]-7[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;3-methyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-3-methyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-3-methyl-7-[[4-(2-methyloxazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[fluoro-(4-thiazol-4-ylphenyl)methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(tetrahydropyran-4-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(oxetan-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[[(2R)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(tetrahydropyran-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;N-(2-methoxyethyl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;N-(3,3-difluorocyclobutyl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(tetrahydrofuran-3-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[[(2S)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-tetrahydropyran-4-yl-thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(oxetan-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(tetrahydrofuran-3-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(3S)-tetrahydrofuran-3-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(tetrahydropyran-4-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(tetrahydropyran-2-ylmethyl)thieno[3,2-b]pyridine-5-carboxamide;N-(azetidin-2-ylmethyl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[(3R)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;N-(3,3-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-methoxy-1-methyl-ethyl)-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-[1-(oxetan-3-yl)azetidin-3-yl]thieno[3,2-b]pyridine-5-carboxamide;N-(oxetan-3-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-tetrahydropyran-3-yl-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-methyltetrahydropyran-4-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-methoxypropyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-methoxyethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(tetrahydrofuran-3-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(tetrahydropyran-2-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3,3-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3,3-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,6-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(oxetan-2-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3,3-difluorocyclobutyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(tetrahydrofuran-2-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(4,4-difluorocyclohexyl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,6-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[[(2S)-tetrahydrofuran-2-yl]methyl]-7-[(4-thiazol-2-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3,3-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,6-dimethyltetrahydropyran-4-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S,4S)-3-methyltetrahydropyran-4-yl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-methyltetrahydropyran-4-yl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-tetrahydropyran-4-yl-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(tetrahydrofuran-3-ylmethyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(oxetan-3-yl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-methoxyethyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-methoxypropyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclobutyl]-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-methoxy-1-methyl-ethyl)-7-[(4-thiazol-5-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-tetrahydropyran-4-yl-7-[[4-(tetrahydropyran-4-ylcarbamoyl)phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3,3-difluorocyclobutyl)-7-[[4-[(3,3-difluorocyclobutyl)carbamoyl]phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-7-[[4-[(2,2-dimethyltetrahydropyran-4-yl)carbamoyl]phenyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(3R,4R)-4-hydroxytetrahydropyran-3-yl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycycloheptyl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclobutyl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2R)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2S)-tetrahydrofuran-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(oxetan-3-yl)thieno[3,2-b]pyridine-5-carboxamide;N-(2-methoxyethyl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3R)-tetrahydrofuran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3,3-difluorocyclobutyl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(azetidin-2-ylmethyl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3S)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[(3R)-tetrahydropyran-3-yl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-methoxy-1-methyl-ethyl)-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[1-(oxetan-3-yl)azetidin-3-yl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2S)-pyrrolidin-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-[[(2R)-pyrrolidin-2-yl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-methoxyethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-methoxypropyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-methoxycyclobutyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(4-pyrazol-1-ylphenyl)methyl]-N-[1-(2,2,2-trifluoroethyl)azetidin-3-yl]thieno[3,2-b]pyridine-5-carboxamide;N-[1-(oxetan-3-yl)azetidin-3-yl]-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-tert-butylazetidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-methylazetidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-cyclobutyl-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(2-oxocyclopentyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-methyl-5-oxo-pyrrolidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1,1-dioxothiolan-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydrofuran-3-yl-thieno[3,2-b]pyridine-5-carboxamide;N-(5-oxopyrrolidin-3-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-methyl-3-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(1-methyl-4-piperidyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;N-(3-methyltetrahydropyran-4-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;2-oxa-5-azabicyclo[2.2.1]heptan-5-yl-[7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridin-5-yl]methanone;7-[(4-pyrazol-1-ylphenyl)methyl]-N-(1-tetrahydrofuran-2-ylethyl)thieno[3,2-b]pyridine-5-carboxamide;7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-3-yl-thieno[3,2-b]pyridine-5-carboxamide;N-(1H-pyrazol-3-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]thieno[3,2-b]pyridine-5-carboxamide;1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-tetrahydropyran-4-yl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-tetrahydropyran-4-yl-pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycycloheptyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclobutyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(2S,6R)-2,6-dimethyltetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-[(3S)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-[(3R)-tetrahydropyran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-[(3S)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-[(3R)-tetrahydrofuran-3-yl]-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-(oxetan-3-yl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-tetrahydropyran-4-yl-pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)pyrrolo[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-tetrahydropyran-4-yl-pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-N-(tetrahydropyran-4-ylmethyl)pyrrolo[3,2-b]pyridine-5-carboxamide;N-(3,3-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-tetrahydropyran-4-yl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclobutyl]-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-(3,3-dimethyltetrahydropyran-4-yl)-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-(tetrahydropyran-4-ylmethyl)-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-(3,3-difluorocyclobutyl)-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-1-methyl-7-[(4-thiazol-2-ylphenyl)methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclobutyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;1-methyl-N-(oxetan-2-ylmethyl)-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;1-methyl-N-[[(2R)-tetrahydrofuran-2-yl]methyl]-7-[(4-thiazol-4-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;N-[(1R,2R)-2-hydroxycyclobutyl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclopentyl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;N-[(3R,4S)-3-hydroxytetrahydropyran-4-yl]-1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;1-methyl-N-(2-oxaspiro[3.3]heptan-6-yl)-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;1-methyl-N-(oxetan-2-ylmethyl)-7-[(4-pyrazol-1-ylphenyl)methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;1-methyl-7-[(4-pyrazol-1-ylphenyl)methyl]-N-[[(2R)-tetrahydrofuran-2-yl]methyl]pyrazolo[4,3-b]pyridine-5-carboxamide;1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-tetrahydropyran-4-yl-pyrrolo[3,2-b]pyridine-5-carboxamide;N-(2,2-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-(3,3-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-(2,6-dimethyltetrahydropyran-4-yl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(2-oxaspiro[3.3]heptan-6-yl)pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(tetrahydropyran-4-ylmethyl)pyrrolo[3,2-b]pyridine-5-carboxamide;1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]-N-(tetrahydrofuran-3-ylmethyl)pyrrolo[3,2-b]pyridine-5-carboxamide;N-(3-fluorocyclobutyl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-(3,3-difluorocyclobutyl)-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide;N-[(1S,2S)-2-hydroxycyclohexyl]-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide; andN-[(1S,2S)-2-hydroxycyclobutyl]-1-methyl-7-[[6-(1-methylpyrazol-3-yl)-3-pyridyl]methyl]pyrrolo[3,2-b]pyridine-5-carboxamide,or a pharmaceutically acceptable salt thereof.
24. A pharmaceutical composition comprising a therapeutically effective amount of at least one compound of any one of claims 1-23, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
25. A method for the treatment of a disorder associated with muscarinic acetylcholine receptor activity in a mammal, comprising administering to the mammal an effective amount of a compound of any one of claims 1-23, or a pharmaceutically acceptable salt thereof.
26. The method of claim 25, wherein the mammal is human.
27. The method of claim 25, wherein the muscarinic acetylcholine receptor is mAChR M1.
28. The method of claim 25, wherein the mammal has been diagnosed with a need for treatment of the disorder prior to the administering step.
29. The method of claim 25, further comprising the step of identifying a mammal in need of treatment of the disorder.
30. The method of claim 25, wherein the disorder is a neurological disorder or psychiatric disorder, or a combination thereof.
31. The method of claim 25, wherein the disorder is psychosis, schizophrenia, conduct disorder, disruptive behavior disorder, bipolar disorder, psychotic episodes of anxiety, anxiety associated with psychosis, psychotic mood disorders, severe major depressive disorder, mood disorders associated with psychotic disorders, acute mania, depression associated with bipolar disorder, mood disorders associated with schizophrenia, behavioral manifestations of mental retardation, conduct disorder, autistic disorder, movement disorders, Tourette's syndrome, akinetic-rigid syndrome, movement disorders associated with Parkinson's disease, tardive dyskinesia, drug induced and neurodegeneration based dyskinesias, attention deficit hyperactivity disorder, cognitive disorders, dementias, or memory disorders, or a combination thereof.
32. The method of claim 25, wherein the disorder is Alzheimer's disease, schizophrenia, a sleep disorder, a pain disorder, or a cognitive disorder, or a combination thereof.
33. The method of claim 32, wherein the pain disorder is neuropathic pain, central pain syndrome, postsurgical pain syndrome, bone and joint pain, repetitive motion pain, dental pain, cancer pain, myofascial pain, perioperative pain, chronic pain, dysmennorhea, inflammatory pain, headache, migraine headache, cluster headache, headache, primary hyperalgesia, secondary hyperalgesis, primary allodynia, secondary allodynia, or a combination thereof.

CROSS-REFERENCE TO RELATED APPLICATIONS

This patent application claims the benefit of priority to U.S. Provisional Application No. 62/296,012, filed on Feb. 16, 2016, and to U.S. Provisional Application No. 62/402,438, filed on Sep. 30, 2016, the entire contents of each of which are hereby incorporated by reference. Priority to each application is hereby claimed.

STATEMENT OF GOVERNMENT INTEREST

This invention was made with government support under Grant number 1U19MH106839-01 awarded by the National Institute of Mental Health (NIMH). The government has certain rights in the invention.

PCT Information

Filing Document	Filing Date	Country	Kind
PCT/US2017/018140	2/16/2017	WO	00

Provisional Applications (2)

	Number	Date	Country
	62296012	Feb 2016	US
	62402438	Sep 2016	US

POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1

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CROSS-REFERENCE TO RELATED APPLICATIONS

STATEMENT OF GOVERNMENT INTEREST

PCT Information

Provisional Applications (2)