Claims
- 1. A pour-on formulation for simultaneous control of both internal and external parasites on a mammal by localized pour-on application of a small volume thereof to a localized surface area of the mammal; said formulation comprising;
- (A) a pyrethroid of the formula ##STR9## and wherein X.sub.1 to X.sub.4 are independently selected from halo,
- C.sub.1 -C.sub.4 alkyl, halogen-substituted C.sub.1 -C.sub.4 alkyl, and halogen-substituted phenyl;
- X.sub.5 is --H or halo;
- R.sub.1 is --H or cyano; and
- R.sub.2 is halogen-substituted phenyl
- (B) a thiazole selected from the group consisting of levamisole, tetramisole and acid addition salts and fatty acid salts thereof,
- said pyrethroid and said thiazole each being present in an amount of 0.1 to 500 mg per ml of said formulation, and a topically acceptable pour-on carrier effective to minimize run-off of the applied formulation from said localized surface area of the mammal.
- 2. A formulation according to claim 1 wherein the pyrethroid is deltamethrin.
- 3. A formulation according to claim 1 wherein the pyrethroid is cypermethrin.
- 4. A formulation according to claim 1 wherein the pyrethroid is cyhalothrin.
- 5. A formulation according to claim 1 wherein the carrier is a mixture of xylene, cyclohexanone and corn oil.
- 6. A formulation according to claim 1 wherein the carrier is xylene.
- 7. A formulation according to claim 1 wherein the carrier is selected from ethylene glycol, propylene glycol, polyethylene glycols, polypropylene glycols or ethylene glycol-propylene glycol copolymers.
- 8. A formulation according to claim 1 wherein the carrier is an alkyl ether or alkyl ether ester of general formula: ##STR10## where R.sup.1 =methyl or hydrogen
- R.sup.2 =C.sub.1 -C.sub.5 alkyl, hydrogen or --CO--R.sup.3,
- R.sup.3 =C.sub.1 -C.sub.12 alkyl
- n=1-40, and
- m=0 or 1.
- 9. A formulation according to claim 8 wherein the carrier is diethylene glycol mono-n-butyl ether.
- 10. A formulation according to claim 7 which further comprises an antioxidant selected from 2,6-ditertbutyl-4-cresol and 2-tert-butyl-4-methoxy phenol.
- 11. A formulation according to claim 1 wherein one of the pyrethroid and the thiazole or salt thereof is suspended, dispersed or emulsified in the carrier, whilst the other is dissolved.
- 12. A formulation according to claim 1 wherein the pyrethroid and the thiazole or salt thereof are separately suspended, dispersed or emulsified in the carrier.
- 13. A formulation according to claim 1 wherein one of the pyrethroid and the thiazole or salt thereof are separately encapsulated in wax beadlets.
- 14. A method of simultaneously controlling internal and external parasites on a mammal by the single localized application of a small volume of a pour-on formulation to a localized surface area of the mammal; said formulation comprising
- (A) a pyrethroid of the formula ##STR11## and wherein X.sub.1 to X.sub.4 are independently selected from halo,
- C.sub.1 -C.sub.4 alkyl, halogen-substituted C.sub.1 -C.sub.4 alkyl, and halogen-substituted phenyl;
- X.sub.5 is --H or halo;
- R.sub.1 is --H or cyano; and
- R.sub.2 is halogen-substituted phenyl
- (B) a thiazole selected from the group consisting of levamisole, tetramisole and acid addition salts and fatty acid salts thereof,
- said pyrethroid and said thiazole each being present in an amount of 0.1 to 500 mg per ml of said formulation, and a topically acceptable pour-on carrier effective to minimize run-off of the applied formulation from said localized surface area of the mammal.
- 15. A pour-on formulation suitable for localized application to a small area of an amimal comprising permethrin and levamisole, said permethrin amd said levamisole, each being present in an amount of 0.1 to 500 mg/ml of said formulation.
- 16. A method of simultameously controlling internal and external parisites on an animal which comprises applying to said animal an effective amount of a pour-on formulation comprising permethrin and levamisole, each being present in an amount of 0.1 to 500 mg/ml said formulation.
- 17. The method treating of preventing lice infestions of cattle, sheep, goats, horses and pigs which comprises topically applying to said cattle, sheep, goats, horses and pigs an effective amount of a pour-on formulation comprising permethrin and levamisole, each being present in an amount of 0.1 to 500 mg/ml of said formulation.
Priority Claims (1)
Number |
Date |
Country |
Kind |
PF3147 |
Mar 1982 |
AUX |
|
Parent Case Info
This application is a continuation of application Ser. No. 475,513 filed Mar. 15, 1983, now abandoned.
US Referenced Citations (6)
Foreign Referenced Citations (12)
Number |
Date |
Country |
0489412 |
Dec 1977 |
AUX |
0490027 |
Jan 1978 |
AUX |
0499160 |
Apr 1979 |
AUX |
0506372 |
Dec 1979 |
AUX |
0017810 |
Apr 1979 |
EPX |
1176799 |
Jan 1970 |
GBX |
2065475A |
Dec 1980 |
GBX |
1591105 |
Jun 1981 |
GBX |
1591106 |
Jun 1981 |
GBX |
2079603A |
Jul 1981 |
GBX |
2085302A |
Oct 1981 |
GBX |
2088212A |
Nov 1981 |
GBX |
Non-Patent Literature Citations (2)
Entry |
Van Der Veken, et al., Australian Patent Abstract, 71322/81. |
Evans et al--Chem. Abst., vol. 99 (1983), p. 43566a. |
Continuations (1)
|
Number |
Date |
Country |
Parent |
475513 |
Mar 1983 |
|