PRECURSORS FOR THE CONTROLLED RELEASE OF A,B-UNSATURATED ALDEHYDES OR KETONES AND OTHER HIGH IMPACT FRAGRANCE SUBSTANCES

Abstract

The present invention primarily relates to compounds of formula (I) as defined herein. It also relates to fragrance substance mixtures as defined herein and methods for producing the same and to perfumed products as defined herein and methods for producing the same. The present invention further relates to the use of a compound of formula (I) as defined herein as a precursor for the release of two or more different pleasantly smelling fragrance substances, to methods for the release of two or more different pleasantly smelling fragrance substances and to thiols as defined herein.

Description

The present invention primarily relates to compounds of formula (I) as defined herein. It also relates to fragrance substance mixtures as defined herein and methods for producing the same and to perfumed products as defined herein and methods for producing the same. The present invention further relates to the use of a compound of formula (I) as defined herein as a precursor for the release of two or more different pleasantly smelling fragrance substances, to methods for the release of two or more different pleasantly smelling fragrance substances and to thiols as defined herein.

Further aspects and preferred embodiments of the present invention are apparent from the following description, the attached examples and, in particular, the attached patent claims.

On the part of the perfume industry, there is a particular interest in a controlled and long-lasting release of certain fragrances. This applies in particular to fragrances with a high volatility or low substantivity. The washing of textiles, for example, is an area where there is a great desire to be able to perceive the pleasant odours of the fragrance substances or perfume oils used in detergents or fabric softeners on the laundry for a long period of time after washing and drying of the textiles.

Precursors are known in the perfume industry and are formed, for example, from α,β-unsaturated carbonyl compounds and thiols by way of Michael additions. They usually release a pleasantly smelling α,β-unsaturated carbonyl compound, such as an α,β-unsaturated aldehyde or ketone. This release takes place in a controlled manner and thus enables a sensorial perception of highly volatile fragrance substances that would not be achievable if the aldehyde or ketone compounds were used directly in a perfume oil.

There is a great demand in the perfume industry for precursors that are capable of releasing several fragrance substances simultaneously or over time. This would allow an expansion of the perfumery palette. There is also a particularly high demand for fragrance substances that have a strong olfactory effect even at low dosages (i.e. a low odorant threshold), so-called “high impact” fragrance substances.

The known precursors are limited to the release of fragrant α,β-unsaturated carbonyl compounds. Due to the unpleasant odour impression of common, especially short-chain, thiol compounds, the prior art teaches the use of thiol compounds that are as odourless as possible for the formation of precursors. In patent application WO 2004/105713 A1, for example, 3-mercaptopropyltriethoxysilanes and 3-mercaptopropyltrimethoxysilanes are reacted with α,β-unsaturated carbonyl compounds to form precursors. Only the released α,β-unsaturated carbonyl compounds serve as fragrance substances in the teaching described therein.

In patent application WO 2015/032885 A1, short-chain thiol compounds are used as thiol compounds to form the precursors. Also in this publication, only the α,β-unsaturated carbonyl compounds released from the precursors serve as fragrance substances. It is described that the unpleasant odour of the short-chain thiol compounds, which are also released from the precursors, surprisingly does not affect the positive olfactory effect of the α,β-unsaturated carbonyl compounds too negatively, so that overall, unexpectedly, the positive olfactory impression of the released α,β-unsaturated carbonyl compounds dominates.

The primary task was to provide improved precursors that meet the above requirements, i.e. are capable of releasing pleasantly smelling, high impact fragrances in a controlled manner and over a long period of time. This release should preferably be possible from surfaces treated with the precursors, especially from textiles.

Surprisingly, this task is solved by a compound of formula (I)

• • (i) wherein R is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₉, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and
    • wherein R′ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and
    • wherein R¹ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₉, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and
    • wherein R² is selected from the group consisting of C₄ to C₁₅, preferably C₄ to C₁₂, more preferably C₅ to C₁₂, more preferably C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, preferably additionally comprising one, two or more functional groups selected from the group consisting of ether, alcohol, and ketone, more preferably additionally comprising one ether group or two ether groups or one alcohol group or one ketone group, and
    • wherein R³ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another),
  • or
  • (ii) wherein R¹, R² and R³ are independently selected from the groups as defined in (i), respectively, and R and R¹ are bonded together to form a saturated or unsaturated ring system comprising 5 to 10 carbon atoms, preferably 6 to 8 carbon atoms, most preferably 6 carbon atoms, preferably wherein the ring system additionally carries one, two, three, four or more C₁ to C₅ linear, branched or cyclic alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another),
  • or
  • (iii) wherein R¹, R¹ and R² are independently selected from the groups as defined in (i), respectively, and R and R³ are bonded together to form a saturated or unsaturated, mono or bicyclic, ring system comprising 5 to 10 carbon atoms and optionally 1 or 2 ether functional groups, preferably comprising 6 to 8 carbon atoms and optionally 1 ether functional group, most preferably comprising 6 carbon atoms, preferably wherein the ring system additionally carries one, two, three, four or more C₁ to C₈ linear, branched or cyclic alkyl, alkenyl or alkadienyl substituents, preferably one, two or more methyl groups.

The ring system as defined in (ii) above includes the carbon atoms to which R and R¹ are bonded and the ring system as defined in (iii) above includes the carbon atoms to which R and R³ are bonded.

The compound of formula (I) (i.e. the precursor) may be in the form of a pure diastereomer or stereoisomer or in the form of any mixture of said isomers.

The compounds of formula (I) as defined herein have not been previously known in the perfume industry. The suitability of the compounds of formula (I) as precursors for the release of fragrance substances was therefore unexpected. In the course of the studies underlying this application, and contrary to the teaching in the prior art with respect to the negative olfactory influence of the released thiol compound, it was surprisingly found that the compounds of formula (I) according to the present invention release both a pleasantly smelling (high impact) α,β-unsaturated aldehyde or ketone and a pleasantly smelling (high impact) thiol compound. Said release of the two (or more) different fragrance substances, and thus their sensorial perception, advantageously occurs in a controlled way, preferably at different points in time, which was particularly surprising. The sensory odour impression of the released thiol compound (e.g. sulphurous-fruity notes), for instance, is very intensely perceptible on damp laundry, especially directly after washing, while the released α,β-unsaturated aldehyde or ketone provides a long-lasting, fresh odour impression on dried laundry (e.g. fresh, green and/or flowery notes).

Further advantages of the present invention are:

• • Due to the controlled release of two different pleasantly smelling, high impact fragrance substances with low odorant thresholds (α,β-unsaturated aldehyde or ketone compound, thiol compound), a distinct odour perception occurs when even small amounts of compounds of formula (I) according to the present invention are used.
  • A higher atomic economy is achieved compared to the precursors of the prior art, since, unexpectedly, both compounds released by the compounds of formula (I) according to the present invention (α,β-unsaturated aldehyde or ketone compound, thiol compound) contribute to a pleasant odour profile.
  • A positive effect of the compounds of formula (I) according to the present invention on the odour impression is surprisingly achieved both on wet laundry (thiol compound) as well as on dried laundry (α,β-unsaturated aldehyde or ketone compound), as the different fragrance substances are preferably released from the compounds of formula (I) according to the present invention and/or sensorially perceived at different points in time.
  • The thiol compound released by the compounds of formula (I) according to the present invention not only improves the substantivity and/or deposition of the compounds of formula (I) according to the present invention on e.g. textiles, hair or skin, but it also serves as a pleasantly smelling fragrance substance itself.

According to a preferred embodiment of the compound of formula (I) according to the invention,

• • R is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl or alkenyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and
  • R′ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl or alkenyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and
  • R¹ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl or alkenyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and
  • R² is selected from the group consisting of C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, preferably additionally comprising one, two or more functional groups selected from the group consisting of ether, alcohol, and ketone, more preferably additionally comprising one ether group or two ether groups or one alcohol group or one ketone group, and
  • R³ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl or alkenyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another).

According to another preferred embodiment of the compound of formula (I) according to the invention, R is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl or alkenyl residues, preferably wherein the residues additionally carry one, two, three or more substituents selected from the group consisting of methyl and ethenyl (and wherein the substituents can be the same or different from one another), and

• • R′ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl or alkenyl residues, preferably wherein the residues additionally carry one, two, three or more substituents selected from the group consisting of methyl and ethenyl (and wherein the substituents can be the same or different from one another), and
  • R¹ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl or alkenyl residues, preferably wherein the residues additionally carry one, two, three or more substituents selected from the group consisting of methyl and ethenyl (and wherein the substituents can be the same or different from one another), and
  • R² is selected from the group consisting of C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, preferably additionally comprising one, two or more functional groups selected from the group consisting of ether, alcohol, and ketone, more preferably additionally comprising one ether group or two ether groups or one alcohol group or ketone group, and
  • R³ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl or alkenyl residues, preferably wherein the residues additionally carry one, two, three or more substituents selected from the group consisting of methyl and ethenyl (and wherein the substituents can be the same or different from one another).

According to another preferred embodiment of the compound of formula (I) according to the invention, R is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl or alkenyl residues, preferably wherein the residues additionally carry one, two, three or more substituents selected from the group consisting of methyl and ethenyl (and wherein the substituents can be the same or different from one another), and

• • R¹ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl or alkenyl residues, preferably wherein the residues additionally carry one, two, three or more substituents selected from the group consisting of methyl and ethenyl (and wherein the substituents can be the same or different from one another), and

R¹ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl or alkenyl residues, preferably wherein the residues additionally carry one, two, three or more substituents selected from the group consisting of methyl and ethenyl (and wherein the substituents can be the same or different from one another), and

• • R² is selected from the group consisting of C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, preferably additionally comprising one, two or more functional groups selected from the group consisting of ether, alcohol, and ketone, more preferably additionally comprising one ether group or two ether groups or one alcohol group or one ketone group, and
  • R³ is hydrogen.

Residue R² of the compounds of formula (I) according to the invention does not comprise any Si atoms.

According to another preferred embodiment of the compound of formula (I) according to the invention, R² is not an n-butyl, n-pentyl, or n-hexyl (or 2-propyl) residue.

According to another preferred embodiment of the compound of formula (I) according to the invention, R² is not a residue of the following formula (4-hydroxybutyl):

According to an alternative preferred embodiment of the compound of formula (I) according to the invention, R² is selected from the group consisting of C₄ to C₁₅, preferably C₄ to C₁₂, more preferably C₅ to C₁₂, more preferably C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, additionally comprising one, two or more ether functional groups.

According to an alternative preferred embodiment of the compound of formula (I) according to the invention, R² is selected from the group consisting of C₄ to C₁₅, preferably C₄ to C₁₂, more preferably C₅ to C₁₂, more preferably C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, additionally comprising one ether functional group.

According to an alternative preferred embodiment of the compound of formula (I) according to the invention, R² is selected from the group consisting of C₄ to C₁₅, preferably C₄ to C₁₂, more preferably C₅ to C₁₂, more preferably C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, additionally comprising two ether functional groups.

According to an alternative preferred embodiment of the compound of formula (I) according to the invention, R² is selected from the group consisting of C₄ to C₁₅, preferably C₄ to C₁₂, more preferably C₅ to C₁₂, more preferably C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, additionally comprising one, two or more alcohol functional groups.

According to an alternative preferred embodiment of the compound of formula (I) according to the invention, R² is selected from the group consisting of C₄ to C₁₅, preferably C₄ to C₁₂, more preferably C₅ to C₁₂, more preferably C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, additionally comprising one alcohol functional group.

According to an alternative preferred embodiment of the compound of formula (I) according to the invention, R² is selected from the group consisting of C₄ to C₁₅, preferably C₄ to C₁₂, more preferably C₅ to C₁₂, more preferably C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, additionally comprising two alcohol functional groups.

According to an alternative preferred embodiment of the compound of formula (I) according to the invention, R² is selected from the group consisting of C₄ to C₁₅, preferably C₄ to C₁₂, more preferably C₅ to C₁₂, more preferably C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, additionally comprising one, two or more ketone functional groups.

According to an alternative preferred embodiment of the compound of formula (I) according to the invention, R² is selected from the group consisting of C₄ to C₁₅, preferably C₄ to C₁₂, more preferably C₅ to C₁₂, more preferably C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, additionally comprising one ketone functional group.

According to an alternative preferred embodiment of the compound of formula (I) according to the invention, R² is selected from the group consisting of C₄ to C₁₅, preferably C₄ to C₁₂, more preferably C₅ to C₁₂, more preferably C₆ to C₁₂, more preferably C₇ to C₁₂, most preferably C₈ to C₁₂, linear, cyclic or branched alkyl residues, additionally comprising two ketone functional groups.

According to a preferred embodiment of the compound of formula (I) according to the invention, R is selected from the group consisting of

According to another preferred embodiment of the compound of formula (I) according to the invention, R′ is selected from the group consisting of

According to another preferred embodiment of the compound of formula (I) according to the invention, R¹ is selected from the group consisting of

According to another preferred embodiment of the compound of formula (I) according to invention, R² is selected from the group consisting of

According to another preferred embodiment of the compound of formula (I) according to invention, R² is selected from the group consisting of

According to another preferred embodiment of the compound of formula (I) according to the invention, R is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and

R′ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and

• • R¹ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and R² is selected from the group consisting of

• • and
  • R³ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another).

According to a particularly preferred embodiment of the compound of formula (I) according to the invention,

• • R is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and
  • R′ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and
  • R¹ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another), and
  • R² is selected from the group consisting of

• • and
  • R³ is selected from the group consisting of hydrogen and C₁ to C₁₀, preferably C₁ to C₉, more preferably C₁ to C₈, more preferably C₁ to C₇, more preferably C₁ to C₆, most preferably C₁ to C₅, linear or cyclic alkyl, alkenyl or alkadienyl residues, preferably wherein the residues additionally carry one, two, three, four or more C₁ to C₄ linear, cyclic or branched alkyl, alkenyl or alkadienyl substituents (and wherein the substituents can be the same or different from one another).

According to another particularly preferred embodiment of the compound of formula (I) according to the invention, residue

of the compound of formula (I) is selected from the group consisting of

and/or, preferably and, residue R² of the compound of formula (I) is selected from the group consisting of

According to a preferred embodiment, the compound of formula (I) according to the invention is obtained or obtainable by a [1,4]-addition reaction between:

• • an α,β-unsaturated aldehyde or ketone (Michael acceptor, electrophile) selected from the group consisting of (group of compounds as shown below in the column entitled “Structure” of Table 1)

TABLE 1
CAS
Number(s)	Name	Structure
102322-83-8	Filbertone
39872-57-6	Isodamascone
23726-91-2	beta-Damascone
24720-09-0	alpha-Damascone
57378-68-4	delta-Damascone
57350-34-2	epsilon- Damascone
35076-56-3	gamma- Damascone
79-76-5	gamma-Ionone
79-77-6	beta-Ionone
127-41-3	alpha-Ionone
127-42-4	Methyliridone
56973-84-3	beta-Dynascone
56973-85-4	alpha-Dynascone
23911-56-0	Nerolione
1646-26-0	Coumarone
13215-88-8, 163440-97-9 (mixture of isomers)	Tabanone
505-57-7	2-Hexenal
2463-63-0	2-Heptenal
2363-89-5	2-Octenal
2463-53-8	2-Nonenal
3913-71-1	2-Decenal
2463-77-6	2-Undecenal
4826-62-4	2-Dodecenal
7774-82-5	2-Tridecenal
106-26-3	Neral
141-27-5	Geranial
5392-40-5 (mixture of isomers)	Citral
	2- Pentylcyclopent- 2-en-1-one
	(Z)-3-Methyl-2- (pent-2-en-1- yl)cyclopent-2- en-1-one
	3-Methyl-2- pentylcyclopent- 2-en-1-one

and

• • a thiol (Michael donor, nucleophile) selected from the group consisting of (group of compounds as shown below in the column entitled “Structure” of Table 2)

TABLE 2
Chemical Name	Odour Description	Structure
4-Methoxy-2-methyl-butane-2- thiol	—
1-Methoxyhexane-3-thiol	—
2-Methyl-2-sulfanyl-pentan-1- ol	Grapefruit, cassis, onion
2-Methyl-1-(4- methyltetrahydropyran-2- yl)propane-1-thiol	Very powerful, more fruity, better quality, exotic fruit, guava
1-Isopentyloxy-3-methyl- butane-2-thiol	breath of smoker
8-Methoxy-2,6-dimethyl- octane-3-thiol	Sulphur, grapefruit- sulphuric side, more fruity, cassis, plastic, green, rose oxide, green pepper
3-(4-Methyl-1,3-dioxan-2- yl)butane-2-thiol	Liver sausage, burnt plastic, buchu (Asian chives) note, cassis, gasoline
1-Methoxy-3-methyl-butane-2- thiol	Strong, more fruity, juicy, natural, cat grass, meat broth (“Fleischbrühe”), onion
7-Methoxy-3,7-dimethyl- octane-1-thiol	Cheesy, camembert, cheese in the fridge
1-(1,3-Dioxan-2-yl)-2-methyl- propane-1-thiol	Fresh, strong, hot rubber, petrol
3-Methoxyoctane-1-thiol	Rose oxide, violet
Methoxytricyclo[5.2.1.02,6] decane-3-thiol	Blackcurrant, catnip, natural, fruity, zestral aspect, anisic
3-(2-Methoxy-1-methyl- ethoxy)propane-1-thiol	Minty green, catnip grass, mushroom, soup, leek
7-Methoxy-2,4-dimethyl- octane-3-thiol	Sulphur and something well known behind, agrumen, fruity, grapefruit but with natural aspect, odour direction: grapfruit natural
7-Methoxy-2,4,7-trimethyl- octane-3-thiol	Peach, cassis, meat, sulphur
4-Isopropyl-1-methyl-7- oxabicyclo[2.2.1]heptane-2- thiol	—
8-Ethoxy- tricyclo[5.2.1.02,6]decane-4- thiol	Cassis, sulphur
3-Ethyl-2-(2-methoxyethyl)- 4,4-dimethyl-cyclohexanethiol	Grapefruit, pine, meat, natural
1-Methoxypropane-2-thiol	Mango, meat
7-Methoxy-2,6-dimethyl- heptane-3-thiol	Sulphur, durian, jackfruit, artichoke
6-(Methoxymethyl)-2,3- dimethyl-cyclohexanethiol	Cassis, blackcurrant
6-Methoxy-2-methyl-heptane- 3-thiol	Sulphur
3-(1-Methoxyethyl)-2,6- dimethyl-cyclohexanethiol	Sulphur
6-Methoxy-2,6-dimethyl- heptane-3-thiol	Grapefruit, fruity, apricot, peach
2-(2-Mercaptopropan-2-yl)-5- methylcyclohexan-1-one	Buchu

According to a preferred embodiment, Citral—i.e. a mixture of Neral and Geranial as shown above in Table 1—is used as (a mixture of) α,β-unsaturated aldehyde(s) for the formation of a compound of formula (I).

The compounds of formula (I) according to the invention

release a (pleasantly smelling, high impact) thiol, which is preferably selected from the group consisting of compounds as shown above in the column entitled “Structure” of Table 2, and a (pleasantly smelling, high impact) α,β-unsaturated aldehyde or ketone, which is preferably selected from the group consisting of compounds as shown above in the column entitled “Structure” of Table 1, via the following decomposition reaction:

Preferably, said release is triggered by certain pH values and/or temperatures, UV light, water, and/or oxygen.

According to a particularly preferred embodiment, the compound of formula (I) according to the invention is selected from the group consisting of (group of compounds as shown below in the column entitled “Structure” of Table 3):

TABLE 3
Chemical name Structure
3-[2-Methyl-1-(4- methyltetrahydropyran-2- yl)propyl]sulfanyl-1-(2,6,6- trimethylcyclohex-3-en-1-yl)butan-1- one
3-[2-Methyl-1-(4- methyltetrahydropyran-2- yl)propyl]sulfanyldecanal
2-[1-(Methoxymethyl)-2-methyl- propyl]sulfanyl-5-methyl-heptan-4-one
2-(3-Methoxyoctylsulfanyl)-5-methyl- heptan-4-one
2-[(8-Ethoxy-4- tricyclo[5.2.1.02,6]decanyl)sulfanyl]-5- methyl-heptan-4-one
2-(2-Methoxy-1-methyl-ethyl)sulfanyl- 5-methyl-heptan-4-one
3-(3-Methoxy-1,1-dimethyl- propyl)sulfanyl-1-(2,6,6- trimethylcyclohex-3-en-1-yl)butan-1- one
3-[1-(2-Methoxyethyl)butylsulfanyl]-1- (2,6,6-trimethylcyclohex-3-en-1- yl)butan-1-one
3-[1-(Hydroxymethyl)-1-methyl- butyl]sulfanyl-1-(2,6,6- trimethylcyclohex-3-en-1-yl)butan-1- one
3-(1-Isopropyl-6-methoxy-4-methyl- hexyl)sulfanyl-1-(2,6,6- trimethylcyclohex-3-en-1-yl)butan-1- one
3-[1-(Methoxymethyl)-2-methyl- propyl]sulfanyl-1-(2,6,6- trimethylcyclohex-3-en-1-yl)butan-1- one
3-(3-Methoxyoctylsulfanyl)-1-(2,6,6- trimethylcyclohex-3-en-1-yl)butan-1- one
3-[(8-Ethoxy-4- tricyclo[5.2.1.02,6]decanyl)sulfanyl]-1- (2,6,6-trimethylcyclohex-3-en-1- yl)butan-1-one
3-(2-Methoxy-1-methyl-ethyl)sulfanyl- 1-(2,6,6-trimethylcyclohex-3-en-1- yl)butan-1-one
3-(1-Isopropyl-4-methoxy-4-methyl- pentyl)sulfanyl-1-(2,6,6- trimethylcyclohex-3-en-1-yl)butan-1- one
3-[1-(Methoxymethyl)-2-methyl- propyl]sulfanyl-1-(2,4,4- trimethylcyclohex-2-en-1-yl)butan-1- one
3-[(8-Ethoxy-4- tricyclo[5.2.1.02,6]decanyl)sulfanyl]-1- (2,4,4-trimethylcyclohex-2-en-1- yl)butan-1-one
3-(2-Methoxy-1-methyl-ethyl)sulfanyl- 1-(2,4,4-trimethylcyclohex-2-en-1- yl)butan-1-one
1-[2-[(8-Ethoxy-4- tricyclo[5.2.1.02,6]decanyl)sulfanyl]- 3,3-dimethyl-cyclohexyl]pent-4-en-1- one
1-[2-(1-Isopropyl-6-methoxy-4-methyl- hexyl)sulfanyl-3,3-dimethyl- cyclohexyl]pent-4-en-1-one
1-[2-(2-Methoxy-1-methyl- ethyl)sulfanyl-3,3-dimethyl- cyclohexyl]pent-4-en-1-one
1-[2-(3-Methoxyoctylsulfanyl)-3,3- dimethyl-cyclohexyl]pent-4-en-1-one
1-[2-(3-Methoxy-1,1-dimethyl- propyl)sulfanyl-5,5-dimethyl- cyclohexyl]pentan-1-one
1-[2-[1-(2-Methoxyethyl)butylsulfanyl]- 5,5-dimethyl-cyclohexyl]pentan-1-one
1-[2-[1-(Hydroxymethyl)-1-methyl- butyl]sulfanyl-5,5-dimethyl- cyclohexyl]pentan-1-one
1-[2-(1-Isopropyl-4-methoxy-4-methyl- pentyl)sulfanyl-5,5-dimethyl- cyclohexyl]pentan-1-one
1-[3-(2-Methoxy-1-methyl- ethyl)sulfanyl-2,3-dihydrobenzofuran- 2-yl]ethanone
1-[3-[(8-Ethoxy-4- tricyclo[5.2.1.02,6]decanyl)sulfanyl]- 2,3-dihydrobenzofuran-2-yl]ethanone
1-[3-[1-(Methoxymethyl)-2-methyl- propyl]sulfanyl-2,3- dihydrobenzofuran-2-yl]ethanone
1-[3-[1-(Hydroxymethyl)-1-methyl- butyl]sulfanyl-2,3-dihydrobenzofuran- 2-yl]ethanone
1-[3-(3-Methoxy-1,1-dimethyl- propyl)sulfanyl-2,3- dihydrobenzofuran-2-yl]ethanone
3-[1-(2- Methoxyethyl)butylsulfanyl]hexanal
3-(1-Isopropyl-6-methoxy-4-methyl- hexyl)sulfanylhexanal
3-(3-Methoxyoctylsulfanyl)hexanal
3-(2-Methoxy-1-methyl- ethyl)sulfanylhexanal
3-(1-Isopropyl-4-methoxy-4-methyl- pentyl)sulfanylundecanal
3-[(8-Ethoxy-4- tricyclo[5.2.1.02,6]decanyl)sulfanyl] undecanal
3-(3-Methoxyoctylsulfanyl)undecanal
3-(1-Isopropyl-6-methoxy-4-methyl- hexyl)sulfanylundecanal
3-(3-Methoxy-1,1-dimethyl- propyl)sulfanylundecanal
3-[1-(Hydroxymethyl)-1-methyl- butyl]sulfanyltridecanal
3-(3-Methoxyoctylsulfanyl)tridecanal
3-(3-Methoxyoctylsulfanyl)-3,7- dimethyl-oct-6-enal
3-[1-(Methoxymethyl)-2-methyl- propyl]sulfanyl-3,7-dimethyl-oct-6-enal
3-[(8-Ethoxy-4- tricyclo[5.2.1.02,6]decanyl)sulfanyl]- 3,7-dimethyl-oct-6-enal
3-[1-(2-Methoxyethyl)butylsulfanyl]- 3,7-dimethyl-oct-6-enal
3-((2-Methyl-1-(4-methyltetrahydro- 2H-pyran-2-yl)propyl)thio)-2- pentylcyclopentan-1-one
5-Methyl-2-(2-((3-oxo-2- pentylcyclopentyl)thio)propan-2- yl)cyclohexan-1-one
5-Methyl-2-[1-methyl-1-[1-methyl-3- oxo-3-(2,6,6-trimethylcyclohex-3-en-1- yl)propyl]sulfanyl-ethyl]cyclohexanone

According to a particularly preferred embodiment, the compound of formula (I) according to the invention is not

Another aspect of the present invention relates to a fragrance substance mixture, preferably perfume oil, comprising or consisting of the following components:

• • (i) one or more compound(s) of formula (I) as defined herein,
  • and
  • (ii) one or more further fragrance substances.

The one or more further fragrance substances are different from the compounds of formula (I) according to the invention.

Examples of further fragrance substances that can be advantageously combined with the compounds of formula (I) as defined herein within the scope of the present invention are known to the skilled person and can be found, for example, in S. Arctander, Perfume and Flavor Materials, Vol. I and II, Montclair, N. J. 1969, Eigenverlag, or K. Bauer et al., Common Fragrance and Flavor Materials, 4th Edition, Wiley-VCH, Weinheim 2001.

According to a preferred embodiment of the fragrance substance mixture according to the invention, preferably perfume oil, the proportion of the total amount of compound(s) of formula (I) as defined herein in the fragrance substance mixture is 0.1 to 3% by weight, preferably 0.5 to 2.5% by weight, particularly preferably 1 to 2% by weight, based on the total mass of the fragrance substance mixture.

Another aspect of the present invention relates to a method for producing a fragrance substance mixture, preferably a perfume oil, as defined above, comprising or consisting of the following step:

Mixing of one or more compound(s) of formula (I) as defined herein with one or more further fragrance substances.

Furthermore, fragrance substance mixtures, preferably perfume oils, according to the invention may be adsorbed on a carrier which provides both a fine distribution of the fragrance substance mixture, preferably perfume oil, in the perfumed product and a controlled release during application. Such carriers may be porous inorganic materials such as light sulphate, silica gels, zeolites, gypsums, clays, clay granules, gas concrete, etc. or organic materials such as wood, cellulose-based materials, sugar, dextrins (e.g. maltodextrin) or plastics such as PVC, polyvinyl acetates or polyurethanes. The combination of a fragrance substance mixture, preferably perfume oil, according to the invention and a carrier is also to be understood as a fragrance substance mixture, preferably perfume oil, of the invention or may be presented as a perfumed product according to the invention (as described below).

Fragrance substance mixtures, preferably perfume oils, or perfumed products of the invention (as described below) may also be microencapsulated, spray-dried, or may be provided as inclusion complexes or as extrusion products and, in the case of a fragrance substance mixture, preferably perfume oil, may be added in this form e.g. to a perfumed product to be perfumed (as described below).

If necessary, the properties of such modified mixtures or products can be further optimized by so-called “coating” with suitable materials with a view to a more targeted release of fragrance, preferably using wax-like plastics such as polyvinyl alcohol. The resulting products in turn represent products of the invention.

Microencapsulation can, for example, be achieved by the so-called coacervation method using capsule materials such as polyurethane-like substances or soft gelatin.

Spray-dried products are preferably produced by spray-drying an emulsion or dispersion containing the fragrance substance mixtures, preferably perfume oils, according to the invention, whereby modified starches, proteins, dextrin and vegetable gums can be used as carriers.

Inclusion complexes can be produced e.g. by incorporating dispersions of the fragrance substance mixtures, preferably perfume oils, according to the invention and cyclodextrins or urea derivatives into a suitable solvent, e.g. water.

Extrusion products can be obtained, e.g., by using the fragrance substance mixtures, preferably perfume oils, according to the invention with a suitable waxy substance and by extrusion followed by solidification, if necessary, in a suitable solvent, e.g. isopropanol.

Another aspect of the present invention relates to a perfumed product comprising one or more compound(s) of formula (I) as defined herein or a fragrance substance mixture, preferably a perfume oil, as defined herein, preferably in a sensorially effective amount.

Advantageously, the one or more compound(s) of formula (I) according to the invention positively impart or modify the odour of a perfumed product to which said compound(s) of formula (I) are added.

According to a preferred embodiment, the perfumed product is selected from the group consisting of perfume extracts, eau de parfums, eau de toilettes, aftershaves, eau de colognes, pre-shave products, splash colognes, perfumed refreshing cloths, acidic, alkaline and neutral detergents, textile fresheners, ironing aids, liquid detergents, powdered detergents, laundry pre-treatment agents, fabric softeners, washing soaps, washing tablets, disinfectants, surface disinfectants, air fresheners, aerosol sprays, waxes and polishes, personal care products, hand creams and lotions, foot creams and lotions, depilatory creams and lotions, aftershave creams and lotions, tanning creams and lotions, hair care products, deodorants and antiperspirants, decorative cosmetic products, candles, lamp oils, incense sticks, insecticides, repellents, and fuels, most preferably is a fabric softener.

According to a preferred embodiment of the perfumed product according to the invention, the proportion of the total amount of fragrance substance mixture as defined herein, preferably perfume oil, in the perfumed product is 0.1 to 3% by weight, preferably 0.5 to 2.5% by weight, particularly preferably 1 to 2% by weight, based on the total mass of the perfumed product.

Another aspect of the present invention relates to a method for producing a perfumed product, preferably a perfumed product as defined herein, comprising or consisting of the following steps:

• • (i) Providing one or more compound(s) of formula (I) as defined herein or a fragrance substance mixture, preferably a perfume oil, as defined herein,
  • (ii) providing one or more further components of the perfumed product to be produced,and
  • (iii) contacting or mixing the further components provided in step (ii) with a sensorially effective amount of the components provided in step (i).

Another aspect of the present invention relates to the use of a compound of formula (I) as defined herein as a precursor for the (controlled) release of one, two, three or more different pleasantly smelling fragrance substances, preferably wherein the two or more different fragrance substances are released and/or sensorially perceived at the same or different, preferably different, point(s) in time (if two or more different fragrance substances are released).

Another aspect of the present invention relates to the use of a compound of formula (I) as defined herein as a precursor for the (controlled) release of a pleasantly smelling thiol and of a pleasantly smelling α,β-unsaturated aldehyde or ketone, preferably wherein the thiol and the α,β-unsaturated aldehyde or ketone are released and/or sensorially perceived at the same or different, preferably different, point(s) in time.

Another aspect of the present invention relates to the use of a compound of formula (I) as defined herein as a precursor for the (controlled) release of a (pleasantly smelling) thiol selected from the group consisting of

and/or, preferably and, of a (pleasantly smelling) α,β-unsaturated aldehyde or ketone selected from the group consisting of

preferably wherein the thiol and the α,β-unsaturated aldehyde or ketone are released and/or sensorially perceived at the same or different, preferably different, point(s) in time.

Another aspect of the present invention relates to the use of a compound of formula (I), wherein residue

of the compound of formula (I) is selected from the group consisting of

and/or, preferably and, wherein residue R² of the compound of formula (I) is selected from the group consisting of

as a precursor for the (controlled) release of a (pleasantly smelling) thiol selected from the group consisting of

and/or, preferably and, of a (pleasantly smelling) α,β-unsaturated aldehyde or ketone selected from the group consisting of

preferably wherein the thiol and the α,β-unsaturated aldehyde or ketone are released and/or sensorially perceived at the same or different, preferably different, point(s) in time.

The thiols and α,β-unsaturated aldehydes or ketones released by the compounds of formula (I) according to the invention and/or used for the formation of a compound of formula (I) according to the invention may be in the form of a pure diastereomer or stereoisomer or in the form of any mixture of said isomers.

According to a preferred embodiment of the use according to the invention, the thiol that is released from the compound of formula (I) as defined herein is released and/or sensorially perceived before the α,β-unsaturated aldehyde or ketone that is released from the (same) compound of formula (I) as defined herein.

According to an alternative embodiment of the use according to the invention, the α,β-unsaturated aldehyde or ketone that is released from the compound of formula (I) as defined herein is released and/or sensorially perceived before the thiol that is released from the (same) compound of formula (I) as defined herein.

According to a further alternative embodiment of the use according to the invention, the thiol that is released from the compound of formula (I) as defined herein and the α,β-unsaturated aldehyde or ketone that is released from the (same) compound of formula (I) as defined herein are released and/or sensorially perceived at the same time.

Preferably, a pleasantly smelling thiol has one or more odour notes selected from the group consisting of grapefruit, cassis, onion, fruity, exotic fruit, guava, breath of smoker, sulphur, (burnt) plastic, (minty) green, rose oxide, green pepper, liver sausage, buchu (Asian chives), gasoline, juicy, natural, cat grass, meat broth (“Fleischbrühe”), cheesy, camembert, cheese in the fridge, fresh, hot rubber, petrol, violet, blackcurrant, catnip (grass), zestral, anisic, mushroom, soup, leek, agrumen, peach, meat, pine, mango, durian, jackfruit, artichoke, and apricot,

more preferably a pleasantly smelling thiol has one or more odour notes selected from the group consisting of grapefruit, cassis, onion, fruity, exotic fruit, guava, sulphur, (minty) green, rose oxide, green pepper, liver sausage, buchu (Asian chives), juicy, natural, cat grass, meat broth (“Fleischbrühe”), cheesy, camembert, fresh, violet, blackcurrant, catnip (grass), zestral, anisic, mushroom, soup, leek, agrumen, peach, meat, pine, mango, durian, jackfruit, artichoke, and apricot.

Another aspect of the present invention relates to a method for the (controlled) release of one, two, three or more different pleasantly smelling fragrance substances comprising or consisting of the following steps:

• • (a) Providing a compound of formula (I) as defined herein or a fragrance substance mixture as defined herein (comprising one or more compound(s) of formula (I) as defined herein) or a perfumed product as defined herein (comprising one or more compound(s) of formula (I) as defined herein),
  • (b) optionally, applying or introducing the compound of formula (I) or the fragrance substance mixture or the perfumed product of step (a) to hair or skin or textile fibres or to a surface to be perfumed, or into ambient air to be perfumed, preferably in a sensorially effective amount, and
  • (c) releasing one, two, three or more different pleasantly smelling fragrance substances from the compound of formula (I), preferably wherein the two or more different pleasantly smelling fragrance substances are released and/or sensorially perceived at the same or different, preferably different, point(s) in time (if two or more different fragrance substances are released).

Another aspect of the present invention relates to a method for the (controlled) release of a pleasantly smelling thiol and of a pleasantly smelling α,β-unsaturated aldehyde or ketone comprising or consisting of the following steps:

• • (a) Providing a compound of formula (I) as defined herein or a fragrance substance mixture as defined herein (comprising one or more compound(s) of formula (I) as defined herein) or a perfumed product as defined herein (comprising one or more compound(s) of formula (I) as defined herein),
  • (b) optionally, applying or introducing the compound of formula (I) or the fragrance substance mixture or the perfumed product of step (a) to hair or skin or textile fibres or to a surface to be perfumed, or into ambient air to be perfumed, preferably in a sensorially effective amount,
  • (c) releasing the pleasantly smelling thiol and the pleasantly smelling α,β-unsaturated aldehyde or ketone from the compound of formula (I), preferably wherein the pleasantly smelling thiol and the pleasantly smelling α,β-unsaturated aldehyde or ketone are released and/or sensorially perceived at the same or different, preferably different, point(s) in time.

According to a preferred embodiment of the method according to the invention, the thiol that is released from the compound of formula (I) as defined herein in step (c) is released and/or sensorially perceived before the α,β-unsaturated aldehyde or ketone that is released from the (same) compound of formula (I) as defined herein in step (c).

According to an alternative embodiment of the method according to the invention, the α,β-unsaturated aldehyde or ketone that is released from the compound of formula (I) as defined herein in step (c) is released and/or sensorially perceived before the thiol that is released from the (same) compound of formula (I) as defined herein in step (c).

According to a further alternative embodiment of the method according to the invention, the thiol that is released from the compound of formula (I) as defined herein in step (c) and the α,β-unsaturated aldehyde or ketone that is released from the (same) compound of formula (I) as defined herein in step (c) are released and/or sensorially perceived at the same time.

Another aspect of the present invention relates to a method for the (controlled) release of a (pleasantly smelling) thiol selected from the group consisting of

and/or, preferably and, of a (pleasantly smelling) α,β-unsaturated aldehyde or ketone selected from the group consisting of

comprising or consisting of the following steps:

• • (a) Providing a compound of formula (I) (or a fragrance substance mixture or a perfumed product comprising a compound of formula (I) as defined above), wherein residue

of the compound of formula (I) is selected from the group consisting of

and/or, preferably and, wherein residue R² of the compound of formula (I) is selected from the group consisting of

• • (b) optionally, applying or introducing the compound of formula (I) of step (a) (or the fragrance substance mixture or the perfumed product comprising a compound of formula (I) of step (a)) to hair or skin or textile fibres or to a surface to be perfumed, or into ambient air to be perfumed, preferably in a sensorially effective amount,
  • (c) releasing the (pleasantly smelling) thiol and/or the (pleasantly smelling) α,β-unsaturated aldehyde or ketone from the compound of formula (I), preferably wherein the (pleasantly smelling) thiol and the (pleasantly smelling) α,β-unsaturated aldehyde or ketone are released and/or sensorially perceived at the same or different, preferably different, point(s) in time.

Another aspect of the present invention relates to a thiol selected from the group consisting of

During the studies underlying the present invention, it was surprisingly found that the thiols as defined above can serve as pleasantly smelling, high impact fragrances, preferably after release from a compound of formula (I) according to the invention.

The thiols according to the invention can be obtained by applying the procedures disclosed in WO 2019/037862 A1.

An odour description of the thiols according to the invention can be found in Table 2 above.

Another aspect of the present invention thus relates to the use of one or more thiol(s) according to the invention as a fragrance substance.

Another aspect of the present invention relates to a method for perfuming hair, skin, textile fibres, surfaces and/or ambient air comprising or consisting of the following steps:

• • (a) Providing
    • (i) one or more thiol(s) as defined herein and preferably also a surfactant or a surfactant mixture, or
    • (ii) one or more compound(s) of formula (I) as defined herein and preferably also a surfactant or a surfactant mixture, or
    • (iii) a fragrance substance mixture as defined herein, preferably containing a surfactant or a surfactant mixture, or
    • (iv) a perfumed product as defined herein, preferably containing a surfactant or a surfactant mixture,
    • and
  • (b) applying or introducing the (i) thiol(s) and preferably also a surfactant or a surfactant mixture or (ii) compound(s) and preferably also a surfactant or a surfactant mixture or the (ii) fragrance substance mixture or the (iii) perfumed product of step (a) to the hair or skin or textile fibres or surface to be perfumed, or into the ambient air to be perfumed, in a sensorially effective amount.

Another aspect of the present invention relates to the use of a compound of formula (I) as defined herein or of a fragrance substance mixture, preferably perfume oil, as defined herein as a perfuming ingredient.

Another aspect of the present invention relates to the use a compound of formula (I) as defined herein or of a fragrance substance mixture, preferably perfume oil, as defined herein for perfuming hair, skin, textile fibres, surfaces and/or ambient air.

Another aspect of the present invention relates to a fragrance substance mixture, preferably perfume oil, as defined herein, wherein the amount of compound(s) of formula (I) is sufficient

• • (a) to mask or to reduce the or one or several unpleasant odour impressions of another fragrance substance in the fragrance substance mixture,
  • and/or
  • (b) to enhance the or one or several pleasant odour impressions of another fragrance substance in the fragrance substance mixture.

Another aspect of the present invention relates to the use of one or more compound(s) of formula (I) as defined herein or of a fragrance substance mixture, preferably perfume oil, as defined herein

• • (a) for masking or reducing the or one or several unpleasant odour impressions of one or several unpleasantly smelling substances,
  • and/or
  • (b) for enhancing the or one or several pleasant odour impressions of one or several pleasantly smelling substances.

Another aspect of the present invention relates to a method

• • (a) for masking or reducing the or one or several unpleasant odour impressions of one or several unpleasantly smelling substances,
  • and/or
  • (b) for enhancing the or one or several pleasant odour impressions of one or several pleasantly smelling substances, comprising the following step:
  • Mixing the unpleasantly and/or pleasantly smelling substances with one or more compound(s) of formula (I) as defined herein or with a fragrance substance mixture, preferably perfume oil, as defined herein, wherein the amount of the one or more compound(s) of formula (I) as defined herein or of the fragrance substance mixture, preferably perfume oil, as defined herein is sufficient to (a) reduce or to mask the unpleasant odour impression(s) of the unpleasantly smelling substance(s) and/or (b) enhance the pleasant odour impression(s) of the pleasantly smelling substance(s).

What has been stated herein in connection with the fragrance substance mixtures, perfumed products, methods, uses and thiols according to the invention applies accordingly to preferred embodiments of the compounds of formula (I) according to the invention, and vice versa.

In the following, the invention is explained in more detail using examples.

EXAMPLES

Synthesis Procedures of Precursors According to the Invention

1. Synthesis of Precursor 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanyl-1-(2,6,6-trimethylcyclohex-3-en-1-yl) butan-1-one (Compound of Formula (I) According to the Invention)

In a 500 ml stirring apparatus with magnetic stirrer, reflux condenser, thermometer, dropping funnel and ice bath, 5.8 g of 1,1,3,3-tetramethylguanidine, 9.4 g of 2-methyl-1-(4-methyltetrahydropyran-2-yl)propanethiol and 200 ml of tetrahydrofuran were added under a nitrogen atmosphere at 0° C. At 0-5° C., 8.1 g of delta-damascone were added dropwise within 1 hour. For post-reaction, stirring was continued for 6 hours at 0-5° C. The mixture was washed twice with saturated sodium bicarbonate solution at room temperature and then the solvents were evaporated on the rotary evaporator. 16.8 g crude yield of 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanyl-1-(2,6,6-trimethyl-cyclohex-3-en-1-yl) butan-1-one, with a GC content of 90%, were obtained. For further purification, the crude yield was chromatographed over a silica gel column with hexane:diethyl ether (10:1) as eluent. 4.0 g of 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanyl-1-(2,6,6-trimethylcyclohex-3-en-1-yl) butan-1-one, with a GC content of 94%, were obtained.

Mass spectrometric analysis of product:

m/z: 99 (100), 123 (35), 81 (35), 43 (33), 69 (27), 115 (24), 55 (18), 225 (17), 41 (17), 192 (16) 2. Synthesis of precursor 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl) propyl]-sulfanyldecanal (compound of formula (I) according to the invention)

In a 500 ml stirring apparatus with magnetic stirrer, reflux condenser, thermometer, dropping funnel and ice bath, 5.8 g of 1,1,3,3-tetramethylguanidine, 9.4 g of 2-methyl-1-(4-methyltetrahydropyran-2-yl)propanethiol and 200 ml of tetrahydrofuran were placed under a nitrogen atmosphere at 0° C. At 0-5° C., 6.4 g of 2-(E)-decenal were added dropwise within 1 hour. For post-reaction, stirring was continued for 6 hours at 0-5° C. The mixture was washed twice with saturated sodium bicarbonate solution at room temperature and then the solvents were evaporated on the rotary evaporator. 14.6 g crude yield of 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanyldecanal, with a GC content of 76%, were obtained. For further purification, the crude yield was chromatographed over a silica gel column with hexane:diethyl ether (10:1) as eluent. 4.2 g of 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanyldecanal, with a GC content of 90%, were obtained.

Mass spectrometric analysis of product:

m/z: 99 (100), 43 (23), 55 (17), 81 (13), 41 (13), 69 (11), 57 (10), 98 (8), 29 (7), 100 (7)

3. Synthesis of Precursor 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanylhexanal (Compound of Formula (I) According to the Invention)

In a 500 mL stirring apparatus with magnetic stirrer, reflux condenser, thermometer, dropping funnel and ice bath, 12.4 g of 1,1,3,3-tetramethylguanidine, 20.4 g of 2-methyl-1-(4-methyltetrahydropyran-2-yl)propane-1-thiol and tetrahydrofuran (400 mL) were added under a nitrogen atmosphere at 0° C. At 0-5° C., 12.7 g of (E)-hex-2-enal were added dropwise within 1 hour. For post-reaction, stirring was continued for 6 hours at 0-5° C. The mixture was washed twice with saturated sodium bicarbonate solution at room temperature and then the solvents were evaporated on the rotary evaporator. 30.9 g crude of 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanyl-hexanal were obtained. For further purification, the crude yield was chromatographed over a silica gel column with hexane:diethyl ether (10:1) as eluent. 26.8 g of 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanylhexanal, with a GC content of 90%, were obtained.

Mass spectrometric analysis of product:

m/z: 99 (100), 43 (24), 55 (15), 41 (13), 81 (12), 69 (12), 100 (6), 57 (6), 170 (6), 29 (5), 98 (5).

4. Synthesis of Precursor 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanyl-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-butan-2-one (Compound of Formula (I) According to the Invention)

In a 50 mL stirring apparatus with magnetic stirrer, reflux condenser, thermometer, dropping funnel and ice bath, 0.02 g of 1,1,3,3-tetramethylguanidine, 14.1 g of 2-methyl-1-(4-methyltetrahydropyran-2-yl)propane-1-thiol and tetrahydrofuran (40 mL) were added under a nitrogen atmosphere at 0° C. At 0-5° C., 14.4 g of (E)-[4]-(2,6,6-trimethylcyclohex-1-en-1-yl) but-3-en-2-one were added dropwise within 1 hour. For post-reaction, stirring was continued for 6 hours at 0-5° C. The mixture was washed twice with saturated sodium bicarbonate solution at room temperature and then the solvents were evaporated on the rotary evaporator. 28.5 g crude of 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanyl-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-butan-2-one were obtained. For further purification, the crude yield was chromatographed over a silica gel column with hexane:diethyl ether (10:1) as eluent. 18.9 g of 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanyl-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-butan-2-one, with a GC content of 90%, were obtained.

Mass spectrometric analysis of product:

m/z: 43 (100), 99 (78), 177 (35), 175 (33), 133 (29), 41 (29), 135 (27), 55 (24), 81 (19), 69 (18), 193 (15), 149 (15), 192 (12), 93 (12), 29 (11), 91 (11), 79 (10).

5. Synthesis of Precursor 8-ethoxytricyclo [5.2.1.02,6]decane-4-sulfanyl-1-(2,6,6-trimethylcyclohex-3-en-1-yl) butan-1-one (Compound of Formula (I) According to the Invention)

In a 50 mL stirring apparatus with magnetic stirrer, reflux condenser, thermometer, dropping funnel and ice bath, 0.02 g of 1,1,3,3-tetramethylguanidine, 16.4 g of 8-ethoxytricyclo [5.2.1.02,6]decane-4-thiol and tetrahydrofuran (40 mL) were added under a nitrogen atmosphere at 0° C. At 0-5° C., 14.4 g of (E)-[1]-(2,6,6-trimethylcyclohex-3-en-1-yl) but-2-en-1-one were added dropwise within 1 hours. For post-reaction, stirring was continued for 6 hours at 0-5° C. The mixture was washed twice with saturated sodium bicarbonate solution at room temperature and then the solvents were evaporated on the rotary evaporator. 30.4 g crude of 8-ethoxytricyclo [5.2.1.02,6]decane-4-sulfanyl-1-(2,6,6-trimethylcyclohex-3-en-1-yl) butan-1-one were obtained.

Mass spectrometric analysis of product:

m/z: 133 (100), 67 (58), 123 (51), 91 (48), 81 (45), 239 (41), 79 (41), 107 (41), 41 (37), 69 (37), 29 (35), 105 (24), 103 (21), 55 (20), 43 (18), 122 (17), 77 (17).

Synthesis Procedures of Thiols According to the Invention

1. 2-Methyl-1-[4-methyltetrahydropyran-2-yl]propane-1-thiol

2-Methyl-1-[4-methyltetrahydropyran-2-yl]propane-1-thiol was prepared in accordance to WO 2019/037862 A1:

To 463 g 4-methyl-2-(2-methyl-prop-1-enyl)tetrahydropyran and 228 g thioacetic acid was added 2.46 g 2,2-azobis-(2-methyl-propionitril, AIBN) at 5-10° C. and stirred at room temperature for 30 min.

Afterwards, the mixture is slowly heated to 60° C. and stirred for 10 h at 60° C. until complete conversion. After cooling to room temperature, the product is obtained by distillation (2.0 mbar, 104-110° C.) to yield 527.69 g (76%) of 2-methyl-(1-4-methyltetrahdyropyran-2-yl) propyl-ethanethioate as a mixture of isomers.

EI-MS m/z (%): 231 (1, [M]⁺), 215 (1), 187 (1), 173 (1), 154 (4), 139 (4), 99 (100), 81 (15), 69 (12), 55 (12), 43 (42), 29 (4).

A solution of 501 g 2-methyl-(1-4-methyltetrahdyropyran-2-yl) propyl-ethanethioate in dry methanol (3.3 L) was treated with 300 g potassium carbonate und nitrogen and stirred over night until complete conversion. Afterwards, the mixture is acidified by 2 M hydrochloric acid (1 L) and 1 L H₂O and 1.5 L Et₂O are added. The organic phase is separated and the aqueous phase is extracted with 500 ml Et₂O. The combined organic phases are washed with brine (500 mL), dried over sodium sulfate and reduced in vacuum. The crude product is purified by distillation (3.6 mbar, 99-102° C.) to obtain 372 g (91%) 2-methyl-1-[4-methyltetrahydropyran-2-yl]propane-1-thiol as a mixture of isomers.

EI-MS m/z (%): 188 (1, [M]⁺), 170 (1), 139 (1), 111 (1), 99 (100), 81 (19), 69 (12), 55 (19), 43 (22), 29 (5).

2. 8-Ethoxytricyclo [5.2.1.02,6]decane-4-thiol

To 583 g 8-methoxytricyclo [5.2.1.02,6]dec-3-ene and 279 g thioacetic acid was added 2.91 g 2,2-azobis-(2-methyl-propionitril, AIBN) at 5-10° C. and stirred at room temperature for 30 min. Afterwards, the mixture is slowly heated to 60° C. and stirred for 10 h at 60° C. until complete conversion. After cooling to room temperature, the product is obtained by distillation (2.0 mbar, 104-110° C.) to yield 773 g (91%) of (8-methoxytricyclo-4-[5.2.1.02,6]decanyl) ethanethioate as a mixture of isomers.

A solution of 538 g (8-methoxytricyclo-4-[5.2.1.02,6]decanyl) ethanethioate in dry methanol (3.3 L) was treated with 300 g potassium carbonate und nitrogen and stirred over night until complete conversion. The solvent is evaporated under reduced pressure and 400 mL MTBE is added. The organic phase is separated and the aqueous phase is extracted with 200 mL MTBE. The combined organic phases are washed with saturated sodium hydrogencarbonate solution, sodium sulfite solution and brine, dried over sodium sulfate and reduced under reduced pressure. The crude product is purified by distillation (3.6 mbar, 99-102° C.) to obtain 376 g (90%) 8-ethoxytricyclo [5.2.1.02,6]decane-4-thiol as a mixture of isomers.

Mass spectrometric analysis of product:

m/z: 166 (100), 91 (75), 92 (75), 133 (72), 79 (57), 132 (48), 105 (47), 117 (45), 93 (44), 67 (37), 106 (35), 212 (28), 77 (26), 29 (25), 41 (25), 66 (24), 137 (24).

Products According to the Invention

1. Fabric Softener

TABLE 4
Fabric softener formulation according to the invention
		INCI Name /
Ingredients	Supplier	description	(w/w)
Water, demin.		Aqua	86.60
Rewoquat WE 18	Evonik	Di-(tallow	12.00
		carboxyethyl)
		hydroxyethyl
		methylammonium
		methosulfate
Parmetol N 20	Hoesch		0.10
	Julius
Calcium Chloride 25%		Calcium Chloride	0.40
solution
3-[2-methyl-1-(4-			0.02
methyltetrahydropyran-
2-yl)propyl]sulfanyl-1-
(2,6,6-
trimethylcyclohex-3-
en-1-yl)butan-1-one
Dipropylengylcol	Symrise	Dipropylengylcol,	0.88
		mixture of isomers

2. Deodorant

TABLE 5
Deodorant formulation according to the invention
Ingredients	Supplier	INCI Name/description	(w/w)
Propylenglycol 1-2	Symrise	Propan-1,2-diol	7.00
Ethanol 96%	Symrise	Ethanol	50.00
Klucel HF	Uniqema	Hydrocxlpropyl cellulose	0.80
Water, demin	Symrise	Aqua	39.65
Deolite	Symrise		0.50
Trilon B Liquid	BTC Europe	Na4-EDTA	0.05
	GmbH
Solubilizer	Symrise	PEG-40 hydrogenated	1.00
		Castor oil, Trideceth-9,
		Propyleneglycol, Water
3-[2-methyl-1-(4-			0.02
methyltetrahydropyran-
2-yl)propyl]sulfanyl-1-
(2,6,6-
trimethylcyclohex-3-
en-1-yl)butan-1-one
Dipropylengylcol	Symrise	Dipropylengylcol,	0.98
		mixture of isomers

3. Shampoo

TABLE 6
Shampoo formulation according to the invention
		INCI
Ingredients	Supplier	Name/description	(w/w)
Water, demin		Aqua	76.84
Plantacare PS 10	Kraemer &	Sodium Lauryl	20.00
		Sulphate, Lauryl
	Martin	glucoside
	GmbH
Sodium Chloride	Symrise	Sodium Chloride	2.00
Citric Acid E 330	Symrise	Citric Acid	0.164
Preservative Complex	Symrise		0.50
3-[2-methyl-1-(4-			0.08
methyltetrahydropyran-
2-yl)propyl]sulfanyl-1-
(2,6,6-
trimethylcyclohex-3-en-
1-yl)butan-1-one
Dipropylengylcol	Symrise	Dipropylengylcol,	0.416
		mixture of isomers

Sensorial Analyses

1. Headspace Gas Chromatographic/Mass Spectrometric Analysis

Application of Precursor in Fabric Softener (Hand Wash):

1.0 g of a solution containing 1.0% compound of formula (I) according to the present invention in fabric softener (cf. Table 7 below for composition of the fabric softener) was added to 1 l H₂O in a 2 l beaker and mixed for a short period of time to form a homogeneous solution.

TABLE 7
Composition of the used fabric softener
Ingredients	Supplier	INCI Name / description	(w/w)
Water, demin.		Aqua	87.50
Rewoquat WE 18	Evonik	Di-(tallow carboxyethyl)	12.00
		hydroxyethyl
		methylammonium
		methosulfate
Parmetol N 20	Hoesch	Mixture of Bronopol and 2-	0.10
	Julius	octyl-2H-isothiazol-3-one
Calcium Chloride 25		Calcium Chloride	0.40
% solution

Five pieces of cotton fabric (16×17 cm, 25 g each) were added and stirred using a magnetic stirrer for 30 min at room temperature. Afterwards, the pieces of cotton fabric were individually wrung (approx. 60 g each) and dried on a laundry rack in a self-made closed drying chamber (143 l) at a constant air exchange and temperature of 25° C. At defined points in time, volatiles were adsorbed on a Tenax® cartridge for 2 min at a continuous flow of 500 ml/min by means of a Gerstel gas sampling system.

Additional measurements were carried out in a self-made glass tube using two pieces of fabric after 1 hour of drying in the drying chamber. Two pieces of fabric were taken from the laundry rack and introduced into the glass tube (0.44 l) at room temperature. The volatiles were adsorbed at a continuous flow of air (500 ml/min) using a Gerstel gas sampling system, initially for 58 min on a waste Tenax® cartridge and then for 2 min on a fresh Tenax® cartridge. Sampling on a waste Tenax® cartridge was then continued until, at defined points in time, samplings on fresh Tenax® cartridges were carried out for 2 mins each after 1 h, 2 h, 3 h, 4 h, 5 h, 6 h, 7 h, 8 h, 24 h, 48 h, 72 h. These cartridges were then desorbed on a Gerstel Thermal Desorption Unit at 260° C. The volatiles were injected into an Agilent 6890 gas chromatograph with a DB-1 MS column (30 m, 0.25 mm, 0.25 μm) coupled to an Agilent mass spectrometer 5973 N. The volatiles were eluted with a flow of He at 1.4 ml/min using a temperature gradient moving from 50° C. (for 4 min) to 260° C. at 8° C./min.

Headspace concentrations were calculated by external standard calibrations using different concentrations of the corresponding fragrance materials (0.1, 0.25, 0.5, 1.0, 2.5, 5.0 ng/l) in EtOH. The corresponding fragrance materials are the fragrance materials that are released from a specific precursor/compound of formula (I), i.e. the corresponding α,β-unsaturated carbonyl compounds and thiol compounds. Each calibration solution (1 μl) was injected onto a clean, empty cartridge which was desorbed and analyzed using the same conditions as described above.

FIG. 1: Fragrance release curve for precursor 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanyldecanal (obtained according to procedure 2 as described above under synthesis procedures of precursors) as determined by procedure 1 as described above under sensorial analyses.

FIG. 2: Fragrance release curve for precursor 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]sulfanyl-1-(2,6,6-trimethylcyclohex-3-en-1-yl) butan-1-one (obtained according to procedure 1 as described above under synthesis procedures of precursors) as determined by procedure 1 as described above under sensorial analyses.

FIGS. 1 and 2 show the release of 2-methyl-1-(4-methyltetrahydropyran-2-yl)propanethiol and the respective α,β-unsaturated carbonyl compound from the compounds of formula (I) obtained according to procedures 1 and 2 as described above under synthesis procedures of precursors. The x axis of the Figures shows the period of time over which the measurement was conducted. On the y axis, the headspace concentrations (determined according to procedure 1 as described above under sensorial analyses) of the two components released from the compound of formula (I) are shown, respectively. From the Figures it can be seen that on the freshly washed/wet laundry a strong release of the thiol compound occurs, which is also sensory perceptible. On the other hand, a noticeable release of the α,β-unsaturated carbonyl compound occurs with a time delay on dried laundry after several hours (2-decenal: 2-48 h, delta-damascone: 24-72 h). These analytical results demonstrate the (controlled) decomposition of the compounds of formula (I) according to the invention with simultaneous release of the α,β-unsaturated aldehyde or ketone over time and are in line with the sensory evaluation of the washing tests (cf. below). The controlled decomposition of the compound of formula (I) advantageously leads to a long-lasting perception of the α,β-unsaturated aldehyde or ketone on the dried laundry. Additionally, the high impact thiol compound improves the overall scent of the freshly washed laundry without unwanted or unpleasant off notes.

For comparison, the experiment was repeated, however instead of using the compounds of formula (I) according to the invention, 1.0 g of a mixture of α,β-unsaturated carbonyl compound (hexenal) and thiol (2-methyl-1-(4-methyltetrahydropyran-2-yl)propane-1-thiol) was employed.

TABLE 8
Fragrance release for precursor 3-[2-methyl-1-(4-methyltetrahydropyran-
2-yl)propyl]sulfanylhexanal (compound of formula (I) according
to the invention) and a mixture of 34% hexenal and 66% 2-methyl-
1-(4-methyltetrahydropyran-2-yl)propane-1-thiol.
	c(Thiol) from
	c(Hexenal) from		compound of
	compound of	c(Hexenal)	formula (I)	c(Thiol)
Time	formula (I) [ng/L]	[ng/L]	[ng/L]	[ng/L]
0	h	10.7	285.0	12.1	215.7
0.5	h	12.6	0.5	19.1	7.5
1	h	46.0	5.3	5.0	3.5
2	h	67.1	13.5	3.2	2.2
3	h	58.9	11.9	3.1	2.6
4	h	69.5	11.4	3.3	2.1
5	h	75.6	11.1	3.4	2.1
6	h	70.2	11.7	3.6	2.1
7	h	74.8	10.0	3.3	2.1
8	h	62.1	10.2	3.1	2.1
24	h	43.9	1	2.1	2.1
48	h	13.9	—	2.2	—
72	h	3.9	0.3	2.1	2.1

It can be seen that the fragrance release from the compound of formula (I) according to the invention is substantially different to the release from the mixture of α,β-unsaturated carbonyl compound and thiol, underlying that released fragrance materials are delivered from the partial degradation of the compound of formula (I) according to the invention over time. Unexpectedly, it is observed that the peak of thiol release is between 0-1 h, while the peak of release of hexenal is reached at 4-7 h, surprisingly revealing that the compounds of formula (I) according to the invention can deliver two pleasantly smelling fragrance materials at different points in time.

2. Washing Tests

A sensory evaluation of the compounds of formula (I) according to the invention (obtained according to procedures 1 and 2 as described above under synthesis procedures of precursors) after a washing application was carried out as described below and delivered the test results as shown in Table 9 below.

• • Application of the respective compound of formula (I) according to the invention in perfume oil in a realistic in-use test
  • Perfume oil dosage: 1% by weight in fabric softener (cf. Table 7 above for composition of the fabric softener)
  • Precursor dosage in perfume oil: 2% by weight
  • Cotton fabric cloths were washed at 30° C. in a washing machine using the short cycle program
  • The sensory evaluation was carried out by a panel of 5 persons. The intensities given in Table 9 on a scale of 0 (no odour) to 9 (very strong odour) are an average of three evaluations by three panelists, respectively. The odour descriptions given in Table 9 are an average of five evaluations by five panelists, respectively.

	TABLE 9
			Perfume oil with 2%
			3-[2-methyl-1-(4-
		Perfume oil with 2%	methyltetrahydropyran-
		3-[2-methyl-1-(4-	2-yl)propyl]sulfanyl-1-
		methyltetrahydropyran-	(2,6,6-trimethylcyclohex-
	Benchmark:	2-yl)propyl]-	3-en-1-yl)butan-1-one
	Perfume oil with	sulfanyldecanal	(releases delta-
	2% dipropylene	(releases 2-decenal as	damascone as carbonyl
	glycol	carbonyl compound)	compound)
Wet fabric -	Floral, transparent,	Strongest effect,	Pleasant, soft,
fresh	slight musky 5	strong sulfuric-fruity	slight sulfuric-fruity
			odour 7-8	note 5-6
4	h	3	Same odour profile	Same odour profile
			as benchmark 3	as benchmark 3
24	h	2	Intense decenal	Intense damascone
			(for 24-48 h)	(for 24-120 h)
			4	4-5
48	h	2	3	5
120	h	2	2	4

3. Fabric Softener

Perfumed fabric softener samples were prepared by mixing the appropriate amount of compound of formula (I) and dipropylene glycol (DPG) to the perfume oil and adding 1% of the resulting fragrance mixture to unperfumed fabric softener.

2 kg of cotton towels were washed in a European washing machine (Express 20 program, 20° C., 800 rpm) using 30 g of perfumed fabric softener (cf. Table 7 for composition of the fabric softener). The fabrics were lined dried over night and put on a table for evaluation after 24 h, 48 h, and 72 h. The fabrics were evaluated by 12 trained panelists. Perfume intensities are evaluated on a scale from no odor (0) to strongest imaginable (10). Panelists were also asked to choose which sample is perceived in higher intensity.

It is concluded that the fragrance perception is significantly stronger using compound of formula (I) in comparison to an equivalent amount of delta-damascone. To underline this, one piece of cotton towel was analyzed by headspace GC/MS according to procedure 1 as described above under sensorial analyses, revealing a significantly higher headspace concentration of delta-damascone of the cotton towel washed with perfume oil including compound of formula (I).

TABLE 10
Mean intensities
		Perfume oil with 2% 3-[2-
		methyl-1-(4-
		methyltetrahydropyran-2-
		yl)propyl]sulfanyl-1- (2,6,6-
	Perfume oil containing 1%	yl)butan-1-one (releases delta-
	delta-damascone and 1%	damascone as carbonyl
	DPG	compound)
24	h	2.14	2.94
48	h	1.46	2.53
72	h	1.03	2.37
168	h	1.04	1.51

TABLE 11
Probability of strongest sample
		Perfume oil with 2% 3-[2-
		methyl-1-(4-
		methyltetrahydropyran-2-
		yl)propyl]sulfanyl-1- (2,6,6-
		trimethylcyclohex-3-en-1-
	Perfume oil containing 1%	yl)butan-1-one (releases delta-
	delta-damascone and 1%	damascone as carbonyl
	DPG	compound)
24 h	0.31	0.62
48 h	0.08	0.92
72 h	0.15	0.85
168 h	0.36	0.64

TABLE 12
Composition of used perfume oil
AGRUMEX LC                       40
ALDEHYD C14 SOG                  5
ALLYLCYCLOHEXYLPROPIONAT         5
ALLYLHEPTYLAT                    5
AMBROXIDE                        5
CITRONELLOL 950                  10
CYCLAMENALDEHYD                  10
CYCLOGALBANAT ®                  1
DECALACTON GAMMA                 3
DIHYDROMYRCENOL                  300
DIMETHYLBENZYLCARBINYLACETAT     10
DYNASCONE 10% DPG                5
ETHYLENBRASSYLAT                 45
ETHYLVANILLIN 10% DPG            5
FLORAZON                         1
FLOWERPOOL 0.1% DPG              5
FREESIOL / CORPS 119             50
GLOBALIDE ®                      60
HERBAFLORAT                      40
HERBYLPROPIONAT                  25
HEXENOL CIS-3 10% DPG            35
HEXYLZIMTALDEHYD ALPHA           140
KRAUSEMINZOEL 65% AMERIK.        5
MANZANATE 10% DPG                5
MELONAL                          15
NEROLIN YARA YARA KRIST.         10
ORANGENOEL TERPENE               40
PHENIRAT ®                       20
STYROLYLACETAT                   5
TERPINEOL ALPHA                  10
TIMBEROL ®                       10
VANILLE EXTRAKT BOURBON 10X FAIR 15
10% DPG
VELOUTONE 10% DPG                15
VERTOCITRAL                      5
YSAMBER ® K                      20

Fragrance Release for Compound of Formula (I) 3-[2-methyl-1-(4-methyltetrahydropyran-2-yl)propyl]-sulfanyl-1-(2,6,6-trimethylcyclohex-3-en-1-yl)butan-1-one and a Mixture of 50% delta-damascone and 50% DPG

TABLE 13
	c(damascone) from
	compound of formula (I)	c(damascone)
Time	[ng/L]	[ng/L]
24 h	1.2	0.2
48 h	4.8	0.2
72 h	6.7	0.2
168 h	0.3	0.2

4. Deodorant

An artificial skin model was prepared using synthetic skin (Vitro-Skin®, approx. 2.5 cm radius), fat, cellulose, and agar.

Perfumed deo samples were prepared by mixing the appropriate amount of compound of formula (I) and DPG to the perfume oil and adding 1% of the resulting fragrance mixture to unperfumed deo base.

100 mg of perfumed deo is added on artificial skin and evenly distributed for 15 s. Afterwards, the model is placed on a heating plate (43° C.) and evaluated after 0 h, 4 h, 24 h, and 48 h by 6 trained panelists. Perfume intensities are evaluated on a scale from no odor (0) to strongest imaginable (9).

It is concluded that the intensity of the fragrance is significantly stronger when applying a perfume oil including a compound of formula (I). Unexpectedly, it is revealed the perception of the individual precursor components (thiol, α,β-unsaturated carbonyl) occurs non-simultaneously, as the thiol component is perceived at 0 h, giving a richer fruity profile, while delta-damascone is perceived after 4-48 h without any perception of thiol notes.

TABLE 14
Mean intensities
		Perfume oil with 0.5%	Perfume oil with 1%	Perfume oil with 2%
		3-[2-methyl-1-(4-	3-[2-methyl-1-(4-	3-[2-methyl-1-(4-
		methyltetrahydropyran-2-	methyltetrahydropyran-2-	methyltetrahydropyran-2-
		yl)propyl]sulfanyl-1-	yl)propyl]sulfanyl-1-	yl)propyl]sulfanyl-1-
		(2,6,6-	(2,6,6-	(2,6,6-
		trimethylcyclohex-	trimethylcyclohex-3-	trimethylcyclohex-
	Perfume	3-en-1-yl)butan-1-	en-1-yl)butan-1-one	3-en-1-yl)butan-1-
	oil	one (releases delta-	(releases delta-	one (releases delta-
	containing	damascone as	damascone as	damascone as
	2% DPG	carbonyl compound)	carbonyl compound)	carbonyl compound)
0 h	4.2	4.9	4.8	4.8
4 h	3.2	4.3	4.6	4.7
24 h	1.5	2.5	3.3	4
48 h	1.6	2	3	3.3

Panelists were asked to describe the hedonic differences between the different samples.

TABLE 15
Sensory descriptions by panelists
		Perfume oil with 0.5%	Perfume oil with 1%	Perfume oil with 2%
		3-[2-methyl-1-(4-	3-[2-methyl-1-(4-	3-[2-methyl-1-(4-
		methyltetrahydropyran-2-	methyltetrahydropyran-2-	methyltetrahydropyran-2-
		yl)propyl]sulfanyl-1-	yl)propyl]sulfanyl-1-	yl)propyl]sulfanyl-1-
	Perfume	(2,6,6-trimethylcyclohex-	(2,6,6-trimethylcyclohex-	(2,6,6-trimethylcyclohex-
	oil	3-en-1-yl)butan-1-one	3-en-1-yl)butan-1-one	3-en-1-yl)butan-1-one
	containing	(releases delta-damascone	(releases delta-damascone	(releases delta-damascone
	2% DPG	as carbonyl compound)	as carbonyl compound)	as carbonyl compound)
0 h		More floral-creamy,	More floral, fruity,	More floral, fruity,
		slight thiol note	slight thiol note	slight thiol note
		(not unpleasant)	(not unpleasant	(not unpleasant
4 h		Stronger, more	Stronger, more	Stronger, more
		floral, apple,	floral, apple,	floral, apple,
		fruitier,	fruitier,	fruitier,
		damascone	damascone	damascone
24 h		Fruity, apple,	Fruity, apple,	Fruity, apple,
		damascone	damascone	damascone
48 h		Slight damascone,	Damascone, fruity,	Damascone, fruity,
		slight plum	plum	dried plum

TABLE 16
Composition of the used perfume oil
AGRUMEX LC                    20
ALDEHYD C 8                   1.5
ALDEHYD C11 UNDECYLENIC       2
10% DPG
ALDEHYD C12 LAURIN            1
ALDEHYD C18 SOG.              3
ALLYLCYCLOHEXYLPROPIONAT      4
AMAROCIT ®                    10
BENZYLACETAT                  8
BENZYLSALICYLAT               15
CITRAL 95                     4
CITRONELLOL 950               20
CUMARIN                       3
DECALACTON GAMMA              13
DIHYDROMYRCENYLACETAT         23
DIMETHYLBENZYLCARBINYLACETAT  2
DIPROPYLENGLYCOL              183
ETHYLENBRASSYLAT              40
ETHYLLINALOOL                 8
EVERNYL 10% DPG               5
Ecomusk R                     10
FLOROPAL                      3
FLOROSA BM/PYRANOL            22
GERANIOL SUPRA                15
GERANYLACETAT PUR             5
GLOBALIDE ®                   15
GRAPEFRUITOEL TERPENE         80
HELIONAL                      8
HELIOTROPIN/PIPERONAL         3
HEXENOL CIS-3                 0.5
HEXENYLACETAT CIS-3           1
HEXENYLSALICYLAT CIS-3        4
HEXYLSALICYLAT                25
HEXYLZIMTALDEHYD ALPHA        45
INDOFLOR ® KRIST. 10% DPG     2
IONON ALPHA                   2
ISO E SUPER                   35
ISOPROPYLMETHYLBUTYRAT-2      1
LILYBELLE ® 10% DPG           3
LINALOOL                      20
LINALYLACETAT                 15
MAJANTOL ®                    2
METHYL IONONE 70              25
ORANGENOEL ITAL. SUESS ENTF.  60
PETITGRAINOEL PARAG. BOLEADOR 1
PHENYLETHYLALKOHOL            30
PHENYLETHYLPHENYLACETAT       3
ROSAPHEN ®                    8
STYROLYLACETAT                12
SYMFRESH ® NX                 150
TERPINEOL REIN                7
THIOCINEOL 100P 1% DPG        4
VERTACETAL ® COEUR            2
VERTOCITRAL 10% DPG           6

TABLE 17
Composition of the used deodorant
Ingredients	Supplier	INCI Name/description	(w/w)
Propylenglycol 1-2	Symrise	Propan-1,2-diol	7.00
Ethanol 96%	Symrise	Ethanol	50.00
Klucel HF	Uniqema	Hydrocxlpropyl cellulose	0.80
Water, demin	Symrise	Aqua	39.65
Deolite	Symrise		0.50
Trilon B Liquid	BTC Europe	Na4-EDTA	0.05
	GmbH
Solubilizer	Symrise	PEG-40 hydrogenated	1.00
		Castor oil, Trideceth-9,
		Propyleneglycol, Water

5. Shampoo

Perfumed shampoo samples were prepared by mixing the appropriate amount of compound of formula (I) and DPG to the perfume oil and adding 1% of the resulting fragrance mixture to unperfumed shampoo base.

One slightly wet hair swatch (2 g Caucasian hair) is treated with 1 g of perfumed shampoo and carefully washed for 15 s. Afterwards, the swatch is left to stand for 30 s and rinsed with warm water (30° C.) for 15 s. Excess water is removed by passing the swatch between the fingers.

The hair swatches were lined dried and evaluated after 0 h, 4 h, and 24 h by 5 trained panelists. Perfume intensities are evaluated on a scale from no odor (0) to strongest imaginable (9).

TABLE 18
Mean intensities
		Perfume oil with 1%	Perfume oil with 2%
		3-[2-methyl-1-(4-	3-[2-methyl-1-(4-
		methyltetrahydropyran-	methyltetrahydropyran-
		2-yl)propyl]sulfanyl-1-	2-yl)propyl]sulfanyl-1-
		(2,6,6-trimethylcyclohex-	(2,6,6-trimethylcyclohex-
		3-en-1-yl)butan-1-one	3-en-1-yl)butan-1-one
	Perfume oil	(releases delta-	(releases delta-
	containing	damascone as	damascone as
	2% DPG	carbonyl compound)	carbonyl compound)
0 h	5	5	4.6
4 h	3.6	4.2	4
24 h	0.7	1.3	2

Panelists were asked to describe the hedonic differences between the different samples.

TABLE 19
Sensory descriptions by panelists
		Perfume oil with 1%	Perfume oil with 2%
		3-[2-methyl-1-(4-	3-[2-methyl-1-(4-
		methyltetrahydropyran-	methyltetrahydropyran-
		2-yl)propyl]sulfanyl-1-	2-yl)propyl]sulfanyl-1-
		(2,6,6-trimethylcyclohex-	(2,6,6-trimethylcyclohex-
		3-en-1-yl)butan-1-one	3-en-1-yl)butan-1-one
	Perfume oil	(releases delta-	(releases delta-
	containing	damascone as	damascone as
	2% DPG	carbonyl compound)	carbonyl compound)
0 h		More creamy-caring	Slightly more fougère
4 h		Fruity, apple	Fruity, damascone
24 h		Fruity, apple	Fruity, fresh,
			creamier, damascone

TABLE 20
Composition of the used perfume oil
AGRUMEX LC               100
ALLYLAMYLGLYCOLAT        10
BEIFUSSOEL               10
BRAHMANOL ®              25
DIHYDROMYRCENOL          200
DIPROPYLENGLYCOL         194
ETHYLMALTOL 10% DPG      12
EVERNYL 10% DPG          70
FICHTENNADELOEL SIB. TYP 15
FRAMBINON ® 10% DPG      10
GERANIUMOEL MADAG.       5
HEXYLSALICYLAT           119
ISOBORNYLACETAT          20
LAVANDIN ESPIEUR CENSO   60
PATCHOULIOEL ENTF.       50

TABLE 21
Composition of the used shampoo
		INCI
Ingredients	Supplier	Name/description	(w/w)
Water, demin	Symrise	Aqua	76.84
Plantacare PS 10	Kraemer &	Sodium Lauryl	20.00
	Martin GmbH	Sulphate, Lauryl
		glucoside
Sodium Chloride	Symrise	Sodium Chloride	2.00
Citric Acid E 330	Symrise	Citric Acid	1.64
Preservative	Symrise		0.50
Complex

6. Deodorant

An artificial skin model was prepared using synthetic skin (Vitro-Skin®, approx. 2.5 cm radius), fat, cellulose, and agar.

Perfumed deo samples were prepared by mixing the appropriate amount of precursor to the perfume oil and adding 1% of the resulting fragrance mixture to unperfumed deo base. 100 mg of perfumed deo is added on artificial skin and evenly distributed for 15 s. Afterwards, the model is placed on a heating plate (43° C.) and evaluated after 0 h, 4 h, 24 h, and 48 h by 12 trained panelists. Perfume intensities are evaluated on a scale from no odor (0) to strongest imaginable (9).

It is detected that the perfume oil containing compound of formula (I) according to the invention is perceived stronger compared to perfume oil containing precursor of the prior art (WO 2015/032885 A1) at all stages of evaluation, showing a clear benefit of the compounds of formula (I) according to the invention. Surprisingly, both the hedonic profile and the perceived intensity of the fragrance after 0 h are positively influenced by introduction of a pleasantly smelling thiol component, while the superior and long-lasting performance at 6-24 h is likely due to the lower evaporation profile/higher substantivity of the compound of formula (I) according to the invention.

TABLE 22
Probability of strongest sample
		Perfume oil with 1%
		3-[2-methyl-1-(4-
	Perfume oil with 0.8%	methyltetrahydropyran-
	pentanethiol damascone	2-yl)propyl]sulfanyl-1-
	(releases delta-damascone	(2,6,6-trimethylcyclohex-
	as carbonyl compound;	3-en-1-yl)butan-1-one
	cf. I-C5 of WO	(releases delta-damascone
	2015/032885 A1)	as carbonyl compound)
0 h	0.19	0.81
4 h	0.27	0.73
6 h	0.31	0.69
24 h	0.20	0.80

TABLE 23
Mean intensities
		Perfume oil with 1%
		3-[2-methyl-1-(4-
	Perfume oil with 0.8%	methyltetrahydropyran-
	pentanethiol damascone	2-yl)propyl]sulfanyl-1-
	(releases delta-damascone	(2,6,6-trimethylcyclohex-
	as carbonyl compound;	3-en-1-yl)butan-1-one
	cf. I-C5 of WO	(releases delta-damascone
	2015/032885 A1)	as carbonyl compound)
0 h	5.1	5.9
4 h	3.8	4.7
6 h	3.2	3.8
24 h	2.6	3.1

TABLE 24
Probability of strongest sample
		Perfume oil with 1%
		3-[2-methyl-1-(4-
	Perfume oil with 1%	methyltetrahydropyran-
	3-(dodecylthio)-1-(2,6,6-	2-yl)propyl]sulfanyl-1-
	trimethyl-3-cyclohexen-1-	(2,6,6-trimethylcyclohex-
	yl)-1-butanone (releases	3-en-1-yl)butan-1-one
	delta-damascone as	(releases delta-damascone
	carbonyl compound)	as carbonyl compound)
0 h	0.46	0.54
4 h	0.46	0.54
6 h	0.45	0.55
24 h	0.29	0.71
48 h	0.27	0.73

TABLE 25
Mean intensities
		Perfume oil with 1%
		3-[2-methyl-1-(4-
	Perfume oil with 1%	methyltetrahydropyran-
	3-(dodecylthio)-1-(2,6,6-	2-yl)propyl]sulfanyl-1-
	trimethyl-3-cyclohexen-1-	(2,6,6-trimethylcyclohex-
	yl)-1-butanone (releases	3-en-1-yl)butan-1-one
	delta-damascone as	(releases delta-damascone
	carbonyl compound)	as carbonyl compound)
0 h	5.2	5.3
4 h	4.1	4.2
6 h	3.5	4.0
24 h	3	3.3
48 h	2.1	2.8

TABLE 26
Composition of used perfume oil
AGRUMEX LC                    20
ALDEHYD C 8                   1.5
ALDEHYD C11 UNDECYLENIC       2
10% DPG
ALDEHYD C12 LAURIN            1
ALDEHYD C18 SOG.              3
ALLYLCYCLOHEXYLPROPIONAT      4
AMAROCIT ®                    10
BENZYLACETAT                  8
BENZYLSALICYLAT               15
CITRAL 95                     4
CITRONELLOL 950               20
CUMARIN                       3
DECALACTON GAMMA              13
DIHYDROMYRCENYLACETAT         23
DIMETHYLBENZYLCARBINYLACETAT  2
DIPROPYLENGLYCOL              183
ETHYLENBRASSYLAT              40
ETHYLLINALOOL                 8
EVERNYL 10% DPG               5
Ecomusk R                     10
FLOROPAL                      3
FLOROSA BM/PYRANOL            22
GERANIOL SUPRA                15
GERANYLACETAT PUR             5
GLOBALIDE ®                   15
GRAPEFRUITOEL TERPENE         80
HELIONAL                      8
HELIOTROPIN/PIPERONAL         3
HEXENOL CIS-3                 0.5
HEXENYLACETAT CIS-3           1
HEXENYLSALICYLAT CIS-3        4
HEXYLSALICYLAT                25
HEXYLZIMTALDEHYD ALPHA        45
INDOFLOR ® KRIST. 10% DPG     2
IONON ALPHA                   2
ISO E SUPER                   35
ISOPROPYLMETHYLBUTYRAT-2      1
LILYBELLE ® 10% DPG           3
LINALOOL                      20
LINALYLACETAT                 15
MAJANTOL ®                    2
METHYL IONONE 70              25
ORANGENOEL ITAL. SUESS ENTF.  60
PETITGRAINOEL PARAG. BOLEADOR 1
PHENYLETHYLALKOHOL            30
PHENYLETHYLPHENYLACETAT       3
ROSAPHEN ®                    8
STYROLYLACETAT                12
SYMFRESH ® NX                 150
TERPINEOL REIN                7
THIOCINEOL 100P 1% DPG        4
VERTACETAL ® COEUR            2
VERTOCITRAL 10% DPG           6

7. Fabric Softener

Perfumed fabric softener samples were prepared by mixing the appropriate amount of precursor to the perfume oil and adding 1% of the resulting fragrance mixture to unperfumed fabric softener.

2 kg of cotton towels were washed in a European washing machine (Express 20 program, 20° C., 800 rpm) using 30 g of perfumed fabric softener (cf. Table 7 for composition of the fabric softener). The fabrics were lined dried over night and put on a table for evaluation after 0 h, 24 h, 48 h, 72 h, and 144 h. The fabrics were evaluated by 15 trained panelists. Perfume intensities are evaluated on a scale from no odor (0) to strongest imaginable (10). Panelists were also asked to choose which sample is perceived in higher intensity.

It is detected that the perfume oil containing compound of formula (I) according to the invention is perceived stronger compared to precursor of the prior art (WO 2015/032885 A1) at all stages of evaluation, showing a clear benefit of the present system. Surprisingly, both the hedonic profile and the perceived intensity of the fragrance after 0 h are positively influenced by introduction of a pleasantly smelling thiol component, while the superior, long-lasting performance at 24-48 h is likely due to the lower evaporation profile/higher substantivity of the compound of formula (I) according to the invention.

TABLE 27
Probability of strongest sample
		Perfume oil with 1%
		3-[2-methyl-1-(4-
	Perfume oil with 0.8%	methyltetrahydropyran-
	pentanethiol damascone	2-yl)propyl]sulfanyl-1-
	(releases delta-damascone	(2,6,6-trimethylcyclohex-
	as carbonyl compound;	3-en-1-yl)butan-1-one
	cf. I-C5 of WO	(releases delta-damascone
	2015/032885 A1)	as carbonyl compound)
0 h	0.46	0.54
24 h	0.07	0.93
48 h	0.12	0.88
72 h	0.45	0.55
144 h	0.57	0.43

TABLE 28
Mean intensities
		Perfume oil with 1%
		3-[2-methyl-1-(4-
	Perfume oil with 0.8%	methyltetrahydropyran-
	pentanethiol damascone	2-yl)propyl]sulfanyl-1-
	(releases delta-damascone	(2,6,6-trimethylcyclohex-
	as carbonyl compound;	3-en-1-yl)butan-1-one
	cf. I-C5 of WO	(releases delta-damascone
	2015/032885 A1)	as carbonyl compound)
1 h	4.70	5.00
24 h	2.1	3.2
48 h	1.8	2.6
72 h	1.7	1.7
144 h	1.5	1.7

TABLE 29
Composition of the used perfume oil
AGRUMEX LC                   20
ALDEHYD C14 SOG.             10
ALLYLPHENOXYACETAT           40
BENZYLACETAT                 60
BERGAMOT SYNTH. AFRIC.       5
W/O MYRCENE
CITRONELLOL 950              135
CYCLAMENALDEHYD              100
DAMASCON ALPHA 10% DPG       5
DIHYDROMYRCENOL              25
DIMETHYLBENZYLCARBINYLACETAT 30
DIPROPYLENGLYCOL             10
FRAMBINON ® 10% DPG          10
HEDION                       10
HERBAFLORAT                  100
HEXYLZIMTALDEHYD ALPHA       35
ISOBORNYLACETAT              25
ISOMUSCONE ®                 25
LAVANDIN GROSSO RCO          35
LINALOOL                     40
LINALYLACETAT                10
MANZANATE                    5
MENTHANYLACETAT              40
METHYL IONONE 70             25
MUSCENONE                    40
PHENYLACETALDEHYD            5
DIMETHYLACETAL
PHENYLETHYLACETAT            5
PHENYLPROPYLALKOHOL          5
ROSACETAT                    50
TERPINEOL REIN               65
TIMBERSILK                   30

Claims

1-15. (canceled)

16. A compound of formula (I)

17. The compound of claim 16, wherein R is selected from the group consisting of

18. The compound of claim 16, wherein R′ is selected from the group consisting of

19. The compound of claim 16, wherein R1 is selected from the group consisting of

20. The compound of claim 16, wherein R2 is selected from the group consisting of

21. The compound of claim 16 obtained or obtainable by a [1,4]-addition reaction between: an α,β-unsaturated aldehyde or ketone selected from the group consisting of

22. The compound of claim 16, wherein the compound of formula (I) is selected from the group consisting of

23. A fragrance mixture comprising: (i) one or more compounds of claim 16, and(ii) one or more further fragrance substances.

24. A method for producing a fragrance substance mixture of claim 23 comprising mixing of one or more compounds of claim 1 with one or more further fragrance substances.

25. A perfumed product comprising one or more compounds of claim 16 in a sensorially effective amount.

26. The perfumed product of claim 25, wherein the product is selected from perfume extracts, eau de parfums, eau de toilettes, aftershaves, eau de colognes, pre-shave products, splash colognes, perfumed refreshing cloths, acidic, alkaline and neutral detergents, textile fresheners, ironing aids, liquid detergents, powdered detergents, laundry pre-treatment agents, fabric softeners, washing soaps, washing tablets, disinfectants, surface disinfectants, air fresheners, aerosol sprays, waxes and polishes, personal care products, hand creams and lotions, foot creams and lotions, depilatory creams and lotions, aftershave creams and lotions, tanning creams and lotions, hair care products, deodorants and antiperspirants, decorative cosmetic products, candles, lamp oils, incense sticks, insecticides, repellents, and fuels.

27. A method for producing a perfumed product of claim 25 comprising: (i) providing one or more compounds of formula (I);(ii) providing one or more further components of the perfumed product to be produced, and(iii) contacting or mixing the further components with a sensorially effective amount of the one or more compounds of formula (I).

28. A method for release of two or more different pleasant smelling fragrance substances comprising: (a) providing a compound of claim 16;(b) optionally, applying or introducing the compound to hair, skin, textile fibres, a surface to be perfumed, or into ambient air to be perfumed; and(c) releasing two or more different pleasantly smelling fragrance substances from the compound.

29. A thiol selected from the group consisting of

30. The compound of claim 16, wherein R1, R2 and R3 are independently selected from the groups as defined in (i), respectively, and R and R1 are bonded together to form a saturated or unsaturated ring system comprising 5 to 10 carbon atoms, preferably wherein the ring system additionally carries one, two or more C1 to C5 linear, branched or cyclic alkyl, alkenyl or alkadienyl substituents,

31. The compound of claim 16, wherein R1, R1 and R2 are independently selected from the groups as defined in (i), respectively, and R and R3 are bonded together to form a saturated or unsaturated, mono or bicyclic, ring system comprising 5 to 10 carbon atoms and optionally 1 or 2 ether functional groups, preferably wherein the ring system additionally carries one, two or more C1 to C5 linear, branched or cyclic alkyl, alkenyl or alkadienyl substituents.