Claims
- 1. A process for the production of a compound according to the following general formula (III): ##STR26## wherein: R.sup.4 represents cyano, ##STR27## SO.sub.2 R.sup.6, POR.sup.7 R.sup.8 ; R.sup.3 represents alkyl, alkenyl, aryl, alkynyl, or a heterocyclic group;
- R.sup.5 represents hydrogen, SR.sup.9, OR.sup.9, NR.sup.10 R.sup.11 ;
- R.sup.6 represents alkyl, alkenyl, aryl, alkynyl, or a heterocyclic group, OR.sup.9 or NR.sup.10 R.sup.11 ;
- R.sup.7 and R.sup.8 each independently represent alkyl, alkenyl, aryl, alkyloxy, aryloxy, alkylthio, arylthio, an amino group, a heterocyclic group or R.sup.7 and R.sup.8 together with the atoms to which they are attached represent the necessary atoms to form a 5- or 6- membered ring;
- R.sup.9 represents hydrogen, alkyl, alkenyl, aryl, alkynyl, or a heterocyclic group; R.sup.10 and R.sup.11 each independently represent hydrogen, alkyl, alkenyl, aryl, aralkyl, a heterocyclic group or R.sup.10 and R.sup.11 together with the atoms to which they are attached represent the necessary atoms to form a 5- or 6-membered ring, comprising reacting an iminoether according to the following formula ##STR28## wherein R.sup.3 and R.sup.4 have the same meaning as defined above or a salt of said iminoether, with a halogenating agent and thiourea.
- 2. A process according to claim 2 wherein the compound of formula III is selected from the group consisting of:
- 2-amino-4-methoxy-5-cyano-thiazole;
- 2-amino-4-ethoxy-5-cyano-thiazole;
- 2-amino-4-ethoxy-thiazole-5-yl-carboxylic acid ethyl ester;
- 2-amino-4-methoxy-thiazole-5-yl-carboxylic acid methyl ester;
- 2-amino-4-methoxy-5-formyl-thiazole;
- 2-amino-4-ethoxy-5-formyl-thiazole;
- 2-amino-4-ethoxy-thiazole-5-yl-phosphonic acid diethyl ester and
- 2-amino-4-methoxy-thiazole-5-yl-phosphonic acid dimethyl ester.
- 3. A process according to claim 2 wherein the halogenating agent is selected from the group consisting of N-chlorosuccinimide, N-bromosuccinimide and 1,3-dibromo-5,5-dimethylhydantoin.
Priority Claims (1)
Number |
Date |
Country |
Kind |
94201737.7 |
Jun 1994 |
EPX |
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Parent Case Info
This application is a divisional of U.S. patent application Ser. No. 08/428,864, filed Apr. 25, 1995, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4324899 |
Frishberg |
Apr 1982 |
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Foreign Referenced Citations (2)
Number |
Date |
Country |
0524401 |
Jan 1993 |
EPX |
0578870 |
Jan 1994 |
EPX |
Divisions (1)
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Number |
Date |
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Parent |
428864 |
Apr 1995 |
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