Claims
- 1. A method of preparing an apatite particle for use in magnetic resonance imaging comprising the steps of:
- (a) obtaining an apatite particle having a particle size in the range from 5 nm to about 5 .mu.m for use in imaging the liver or spleen;
- (b) adsorbing a bifunctional coating agent capable of forming a chelate complex with a paramagnetic metal ion onto the apatite particle surface; and
- (c) forming a chelate complex between the bifunctional coating agent adsorbed on the apatite particle surface and the paramagnetic metal ion.
- 2. A method of preparing an apatite particle as defined in claim 1, wherein the bifunctional coating agent comprises polyphosphonate diethylenetriaminepenta(methylenephosphonic acid) having the following structure: ##STR5##
- 3. A method of preparing an apatite particle as defined in claim 1, wherein the bifunctional coating agent is a chelating agent containing one or more phosphonate groups capable of adsorption to the apatite particle surface.
- 4. A method of preparing an apatite particle as defined in claim 1, wherein bifunctional coating agent is capable of forming a chelate complex with a paramagnetic metal ion selected from a group of elements having atomic numbers of 21-25, 27-29, 42-44, and 58-70 and a valence in the range from 2+ to 3+.
- 5. A method of preparing an apatite particle as defined in claim 1, wherein the bifunctional coating agent is capable of forming a chelate complex with a paramagnetic metal ion selected from chromium(III) , manganese(II) , iron(II) , iron(III) , praseodymium(III) , neodymium(III) , samarium(III) , ytterbium(III) , gadolinium(III) , terbium(III) , dysprosium(III) , holmium(III) , and erbium (III) .
- 6. A method of preparing an apatite particle as defined in claim 1, wherein the bifunctional coating agent is capable of forming a chelate complex with a paramagnetic metal ion selected from manganese(II), iron(II), iron(III), or mixtures thereof.
- 7. A method of preparing an apatite particle for use in magnetic resonance imaging comprising the steps of:
- (a) obtaining an apatite particle having a particle size in the range from about 1 nm to about 50 nm for use in imaging the blood pool;
- (b) adsorbing a bifunctional coating agent capable of forming a chelate complex with a paramagnetic metal ion onto the apatite particle surface; and
- (c) forming a chelate complex between the bifunctional coating agent adsorbed on the apatite particle surface and the paramagnetic metal ion.
- 8. A method of preparing an apatite particle as defined in claim 7, wherein the bifunctional coating agent comprises polyphosphonate diethylenetriaminepenta-(methylenephosphonic acid) having the following structure: ##STR6##
- 9. A method of preparing an apatite particle as defined in claim 7, wherein the bifunctional coating agent is a chelating agent containing one or more phosphonate groups capable of adsorption to the apatite particle surface.
- 10. A method of preparing an apatite particle as defined in claim 7, wherein the bifunctional coating agent is capable of forming a chelate complex with a paramagnetic metal ion selected from a group of elements having atomic numbers of 21-25, 27-29, 42-44, and 58-70 and a valence in the range from 2+ to 3+.
- 11. A method of preparing an apatite particle as defined in claim 7, wherein the bifunctional coating agent is capable of forming a chelate complex with a paramagnetic metal ion selected from chromium(III) , manganese(II) , iron(II) , iron(III) , praseodymium(III) , neodymium(III) , samarium(III) , ytterbium(III) , gadolinium(III) , terbium(III) , dysprosium(III) , holmium(III) , and erbium (III) .
- 12. A method of preparing an apatite particle as defined in claim 7, wherein the bifunctional coating agent is capable of forming a chelate complex with a paramagnetic metal ion selected from manganese(II), iron(II), iron(III), or mixtures thereof.
CROSS REFERENCE TO RELATED APPLICATION
This invention is a continuation-in-part of U.S. patent application Ser. No. 07/784,325, filed Oct. 22, 1991, now abandoned titled "Treated Apatite Particles for Medical Diagnostic Imaging," which is incorporated herein by reference.
US Referenced Citations (8)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0093399 |
Nov 1983 |
EPX |
Continuation in Parts (1)
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Number |
Date |
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Parent |
784325 |
Oct 1991 |
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