Claims
- 1. A process for the preparation of compounds corresponding to the formula ##STR16## in which R.sub.1 represents C.sub.2 -C.sub.4 -alkyl, C.sub.3 -C.sub.4 -isoalkyl, CH.sub.2 -(C.sub.2 -C.sub.3 -alkenyl) or CH.sub.2 -(C.sub.3 -isoalkenyl);
- R.sub.3 represents C.sub.3 -C.sub.5 -alkyl, C.sub.3 -C.sub.5 -isoalkyl, CH.sub.2 -(C.sub.2 -C.sub.4 -alkenyl) or CH.sub.2 -(C.sub.3 -C.sub.4 -isoalkenyl);
- R.sub.8 represents H, methyl or ethyl; with the proviso that
- (1) when R.sub.8 represents H, R.sub.1 is allyl, and
- (2) R.sub.1 and R.sub.3 cannot both be butyl or allyl at the same time,
- which comprises:
- reacting a compound corresponding to the following formula ##STR17## with an alkylating agent of the formula R.sub.1 --X where R.sub.1, R.sub.3 and R.sub.8 are as defined above except that R.sub.1 and R.sub.3 are other than isopropyl and X is a halogen or monosulphate or disulphate of p-toluene sulphonate and cyclising the resulting compound.
- 2. A process as claimed in claim 1, wherein, in the compound according to formula (I) obtained by said reacting and cyclising steps, at least one of R.sub.1 and R.sub.3 is an alkenyl or isoalkenyl, as defined above, further comprising the step of hydrogenating said compound according to formula (I) to form the corresponding compound according to formula (I) wherein R.sub.1 and R.sub.3 are alkyl or isoalkyl, as defined above.
- 3. A process as claimed in claim 2, further comprising the step of converting said corresponding compound into a physiologically acceptable salt.
- 4. A process as claimed in claim 1, further comprising the step of converting said compound according to formula (I) into a physiologically acceptable salt.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3431/80 |
May 1980 |
CHX |
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Parent Case Info
This is a divisional of application Ser. No. 470,301, filed Feb. 28, 1983, now U.S. Pat. No. 4,469,698, which in turn is a continuation of application Ser. No. 255,212, filed Apr. 17, 1981, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4089959 |
Diamond |
May 1978 |
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Foreign Referenced Citations (2)
Number |
Date |
Country |
42-16315 |
Sep 1967 |
JPX |
1561005 |
Feb 1980 |
GBX |
Divisions (1)
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Number |
Date |
Country |
Parent |
470301 |
Feb 1983 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
255212 |
Apr 1981 |
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