Claims
- 1. A process for preparing 4-(2-hydroxyalkyl)-2-piperazinones and their substituted derivatives which comprises: (1) reacting a compound having the formula ##STR5## wherein R.sub.3 is hydrogen or an alkyl group having from 1-4 carbon atoms, with (2) an N-hydroxyalkylalkylenediamine having the formula ##STR6## wherein R is hydrogen or an alkyl group of 1 or 2 carbon atoms, R.sub.1 is hydrogen, an alkyl group of 1 to 6 carbon atoms, an aryl or an aralkyl group having from 6 to 12 carbon atoms, R.sub.2 is hydrogen, an alkyl or hydroxyalkyl group of 1-6 carbon atoms, an aryl or an aralkyl group having from 6 to 12 carbon atoms and n is 1 or 2.
- 2. The process of claim 1 wherein R, R.sub.1 and R.sub.2 are each hydrogen.
- 3. The process of claim 2 wherein n is 1.
- 4. The process of claim 2 wherein n is 2.
- 5. The process of claim 1 wherein the ratio of the reactant amine to the [.alpha.,.beta.-dicarbonyl compound] 2,3-dihydroxy-1,4-dioxane, or its alkyl derivative, is from about 0.75/1 to about 4/1.
- 6. The process of claim 5 wherein the ratio is from about 1/1 to about 2/1.
- 7. The process of claim 1 wherein the reaction is conducted at a temperature within the range of from about 0.degree. to about 200.degree. C.
- 8. The process of claim 7 wherein the temperature is within the range of from about 80.degree. to about 100.degree. C.
- 9. The process of claim 1 wherein R and R.sub.1 each is hydrogen.
- 10. The process of claim 9 wherein R.sub.2 is alkyl.
- 11. The process of claim 10 wherein the alkyl group is methyl or ethyl.
- 12. The process of claim 9 wherein R.sub.2 is hydroxyalkyl.
- 13. The process of claim 9 wherein the hydroxyalkyl group is hydroxyethyl.
- 14. The process of claim 1 wherein R and R.sub.2 each is hydrogen.
- 15. The process of claim 14 wherein at least one R.sub.1 is alkyl.
- 16. The process of claim 15 wherein the alkyl group is methyl or ethyl.
Parent Case Info
This is a division of application Ser. No. 085,428, filed Aug. 13, 1987, now Pat. No. 4,814,443.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4767860 |
Dunmore et al. |
Aug 1988 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
85428 |
Aug 1987 |
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