Claims
- 1. A process for the production of a 4-hydroxybenzaldehyde derivative of the formula: ##STR6## wherein each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is selected from the group consisting of hydrogen atoms, halogen atoms, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy,
- said process comprising the reaction of a p-cresol derivative of the formula: ##STR7## wherein each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is as defined above, with a molecular oxygen or a molecular oxygen-containing gas in an alcohol solvent, in the presence of a base selected from the group consisting of metal hydroxides, metal alkoxides and metal amides, and a catalyst selected from the group consisting of cobalt halides, organic acid salts of cobalt, inorganic acid salts of cobalt, cobalt oxides, cobalt hydroxides, cobalt chelates and metallic cobalt, wherein the molar ratio of the base to the p-cresol derivative is in the range of 1.0-10.0 and wherein the molar ratio of the cobalt compound to the p-cresol derivative is in the range of 0.0005-0.05.
- 2. The process according to claim 1, in which said p-cresol derivative is p-cresol,
- p-cresol,
- 2-bromo-p-cresol,
- 2-chloro-p-cresol,
- 2,6-dibromo-p-cresol,
- 2. 6-dichloro-p-cresol,
- 2,4-xylenol,
- 3,4-xylenol,
- mesitol,
- 2-t-butyl-p-cresol,
- 2,6-di-t-butyl-p-cresol,
- 2-methoxy-p-cresol,
- 2-ethoxy-p-cresol or
- 2,6-dimethoxy-p-cresol.
- 3. The process according to claim 1, in which said base is sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide, potassium ethoxide, potassium t-butoxide or sodium amide.
- 4. The process according to claim 1, in which said cobalt compound is cobalt hydroxide, cobalt oxides, cobalt chloride, cobalt acetate, cobalt sulfate or cobalt nitrate.
- 5. The process according to claim 1, in which said solvent is methyl alcohol, ethyl alcohol, isopropyl alcohol, t-butyl alcohol or ethylene glycol.
- 6. The process according to claim 1, in which the reaction temperature is in the range of 20.degree.-200.degree. C.
- 7. The process according to claim 1, in which said oxygen-containing gas is air or a mixture of oxygen and nitrogen.
- 8. A process as claimed in claim 1, wherein said alcohol solvent is selected from the group consisting of methanol, ethanol, isopropanol, butanol, tertiary butanol and ethylene glycol.
- 9. A process as claimed in claim 1, wherein the reaction of said p-cresol derivative with molecular oxygen or a molecular oxygen-containing gas takes place in a reaction mixture consisting essentially of said p-cresol derivative, said molecular oxygen or molecular oxygen-containing gas, said alcohol solvent, said base and said catalyst.
Priority Claims (1)
Number |
Date |
Country |
Kind |
53-155974 |
Dec 1978 |
JPX |
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Parent Case Info
This is a continuation of application Ser. No. 99,714 filed on Dec. 3, 1979, now abandoned.
US Referenced Citations (4)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2605678 |
Sep 1976 |
DEX |
Non-Patent Literature Citations (2)
Entry |
Nishinaga et al., Angew. Chem., Int, Edit, vol. 14 (1975) p. 3565. |
Nishinaga et al., J.A.C.S., vol. 100, pp. 1820-1825, (1978). |
Continuations (1)
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Number |
Date |
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Parent |
99714 |
Dec 1979 |
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