Claims
- 1. A process for preparing a compound of Formula I ##STR110## comprising acylating a compound of Formula Ia ##STR111## with a haloacetylhalide or an alkyl haloacetate to form a compound of Formula Ib, ##STR112## condensing the compound of Formula Ib with hydrazine in a reaction mixture to form an alkyl-pyrazole-precursor intermediate, the reaction mixture having an organic phase and an aqueous phase, hydrazine being present in the reaction mixture in a stoichiometric excess amount relative to the compound of Formula Ib,
- heating the reaction mixture to dissolve into the organic phase any amount of precipitate which may have formed and to separate the aqueous phase from the organic phase,
- removing excess hydrazine from the reaction mixture by removing the aqueous phase from the reaction mixture,
- alkylating the intermediate with an alkylating agent under acidic conditions to form a compound of Formula Id, ##STR113## oxidizing the compound of Formula Id with with molecular oxygen in the presence of metal salt catalyst, halide salt and acetone promoter and benzoyl peroxide to form a compound of Formula Ie, ##STR114## halogenating the compound of Formula Ie with a halogenating agent to form a compound of Formula If, and ##STR115## esterifying the compound of Formula If to form a compound of Formula I, wherein R.sup.1 is C.sub.1-5 alkyl, R.sup.2 is C.sub.1-3 haloalkyl, R.sup.3, R.sup.5 and R.sup.6 are halogen and R.sup.10 is C.sub.1-5 alkyl.
- 2. The process as set forth in claim 1 wherein R.sup.1 is methyl, R.sup.2 is trifluoromethyl, R.sup.3 is bromo, R.sup.5 is fluoro, R.sup.6 is chloro and R.sup.10 is isopropyl.
- 3. The process as set forth in claim 1 wherein the compound of Formula If is esterified by
- reacting the compound of Formula If with a halogenating agent to form a corresponding benzoic acid halide, and
- reacting the benzoic acid halide with an esterification reagent, the esterification reagent being formed by mixing an alcohol and acetylchloride.
- 4. The process as set forth in claim 1 wherein the compound of Formula If is esterified by
- reacting the compound of Formula If with a trialkylorthoester of Formula F1, ##STR116## wherein: R.sup.11 is hydrogen or alkyl, and R.sup.10 is C.sub.3-5 alkyl.
- 5. A process for preparing a compound of Formula II, ##STR117## comprising acylating a compound of Formula IIa ##STR118## with trifluoroacetylhalide or ethyl trifluoroacetate to form a compound of Formula IIb, ##STR119## condensing the compound of Formula IIb with hydrazine in a reaction mixture to form an alkyl-pyrazole-precursor intermediate, the reaction mixture having an organic phase and an aqueous phase, hydrazine being present in the reaction mixture in a stoichiometric excess amount relative to the compound of Formula Ib,
- heating the reaction mixture to dissolve into the organic phase any amount of precipitate which may have formed and to separate the aqueous phase from the organic phase,
- removing excess hydrazine from the reaction mixture by removing the aqueous phase from the reaction mixture,
- alkylating the intermediate with a methylating agent under acidic conditions to form a compound of Formula IId, ##STR120## oxidizing the compound of Formula IId with with molecular oxygen in the presence of metal salt catalyst, halide salt, acetone and benzoyl peroxide to form a compound of Formula IIe, ##STR121## brominating the compound of Formula IIe with a bromide salt under oxidizing conditions to form a compound of Formula IIf, and ##STR122## esterifying the compound of Formula IIf to form a compound of Formula II.
- 6. The process as set forth in claim 5 wherein the compound of Formula IIf is esterified by
- reacting the compound of Formula IIf with a halogenating agent to form a corresponding benzoic acid halide, and
- reacting the benzoic acid halide with an esterification reagent, the esterification reagent being formed by mixing isopropyl alcohol and acetylchloride.
- 7. The process as set forth in claim 5 wherein the compound of Formula IIf is esterified by reacting the compound of Formula IIf with triisopropylorthoformate.
RELATED APPLICATION
This application is a continuation-in-part of application U.S. Ser. No. 08/189,337, filed Jan. 31, 1994, now U.S. Pat. No. 5,530,126.
US Referenced Citations (33)
Foreign Referenced Citations (1)
Number |
Date |
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0344055 |
Mar 1989 |
AUX |
Continuation in Parts (1)
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Number |
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189337 |
Jan 1994 |
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