Claims
- 1. A method for producing tetrahydrofolic acid from folic acid and isolating same, comprising the steps of:
- (a) reducing folic acid with sodium borohydride in alkaline aqueous solution employing an amount of said sodium borohydride at least equal to the weight of said folic acid to convert said folic acid to tetrahydrofolic acid;
- (b) adding acid to neutralize the reaction mixture so as to decompose any excess sodium borohydride;
- (c) dissolving ascorbic acid as an antioxidant in the reaction mixture;
- (d) acidifying the reaction mixture to a pH sufficient to precipitate said tetrahydrofolic acid; and
- (e) recovering said tetrahydrofolic acid from the reaction mixture.
Parent Case Info
This is a divisional of application Ser. No. 826,677, filed Aug. 22, 1977, U.S. Pat. No. 4,148,899.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
2741608 |
Shive |
Apr 1956 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
826677 |
Aug 1977 |
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