Patent Application
20200062690
Vegetable oils (VO) and derivatives have been important industrial feedstock chemicals and intermediates. In recent years, there has been a growing interest in development of VO-based alternative thermosetting polymers, such as polyurethanes, unsaturated polyesters, and epoxies. Reactions on the double bonds and ester bonds of the unsaturated fatty chains of VOs may introduce various polymerizable functional groups and, hence, turn VO molecules into bio-based monomers for polymers with less carbon footprint. When the VO-derived monomers are used as co-monomers, the long fatty acid chains of VO provide certain flexibility and/or toughness for some brittle resin systems. However, when utilized alone as base resin monomers, VO-derived monomers tend to give the crosslinked polymer network insufficient modulus and strength. This is mainly due to the VO-based monomers being built on the triglyceride structure in which the polymerizable groups are generally linked by a long flexible fatty chain. This results in polymer materials with poor mechanical properties, which are not appropriate for applications such as composite matrix polymer and protective coatings. There are different ways to improve strength and modulus, including use of rigid co-monomers, curing with rigid hardeners, or increase the crosslink density by introducing more polymerizable groups.
The present embodiments herein generally relate to thermoset resins that are derived from vegetable oil. The vegetable oil may be obtained from fibrous plant sources, such as the hempseed plant. The utilization of plant-based oils as starting materials makes this technology a green alternative to currently available solutions. This, coupled with the novel synthetic methods that are utilized, allow the plant-based oils to be transformed into useful and durable thermoset resins. Thus, the plant-based oils are uniquely transformed to durable and resilient thermoset resins.
To easily identify the discussion of any particular element or act, the most significant digit or digits in a reference number refer to the figure number in which that element is first introduced.
Disclosed herein are biobased monomer compounds derived from fatty acids (FAs) that are the hydrolysis products of VOs. VO-based polymer materials are mostly based on the monomers obtained by derivatization of the carbon-carbon double bonds in the chains of the unsaturated fatty acids of the oil (Scheme 1a). Therefore, when the monomer is built on the triglyceride structure of the oil, the properties of the resulting thermoset is determined by the distance between the two polymerizable groups from one fatty acid to another fatty acid on the same oil structure. This distance is the same as that from a double bond of one unsaturated fatty acid to the double bond of another unsaturated fatty acid and is at least 21 single chemical bonds, making the cured thermosets soft. When the monomer is directly built on the structure of an unsaturated FA derived from hydrolysis of oil, one polymerizable group is introduced through the carboxyl end group of the FA, in addition to the ones derived from the double bonds, as shown in Scheme 1b. In this way, the distance between two polymerizable groups is reduced (it is 16 in Scheme 1 b). As a result, thermosetting polymers based on the FA-derived monomers tend to give higher crosslink density, resulting in improved strength and modulus. The FAs that may be utilized may be obtained from a variety of resources, including hempseed oil, cottonseed oil, soybean oil, castor oil, tung oil, and linseed oil. Three types of FA-derived monomers are presented by way of example: acrylate monomers, thiol-containing monomers, and silane-containing monomers. These monomers may be polymerized or co-polymerized via either thermal initiation or photo initiation to form crosslinked network structures.
In one embodiment, a sodium hydroxide (16 g) solution in 140 mL ethanol-H2O (1:1, V/V) is charged into a 1-L three-necked round-bottom flask equipped with reflux condenser, magnetic stirrer, and thermometer. After the solution is heated to 70° C., hempseed oil (100 g) is dropwise added to the reaction system using a dropping funnel. The reaction is continued at 70° C. for 2 hours. After that, the reaction mixture is adjusted to pH 2-3 using 1 M hydrochloric acid, and then the reaction is continued at 70° C. for another hour. After the reaction is cooled down, the mixture is extracted with ethyl ether and is washed with de-ionized (DI) water three times. The ethyl ether solution is dried over magnesium sulfate. Finally, the ethyl ether is removed by vacuum distillation, resulting in a viscous mixture of hydrolyzed hempseed oil fatty acids (HFA, yield 90%). The composition of fatty acids in hydrolyzed hempseed oil is determined by Gas Chromatography-Flame Ionization Detector (GC-FID) using a standard fatty acid methyl esters (FAME) procedure.
The HFA is directly acrylated in the presence of BF3.Et2O, as shown in Scheme 2. Representative reaction conditions are as follows: the mixture of HFA, acrylic acid (AA) and BF3.Et2O in the molar ratios of 1:27.4:1.37 are reacted under stirring at 80° C. for 4 hours. Depending on the size of reaction, two different work-up procedures may be employed. For the small size reactions, the excess AA and catalyst are removed by NaHCO3 aq. washing directly. For the large size reactions, the excess AA and catalyst are recovered by distillation at 35-45° C. under reduced pressure, and the recovered AA and catalyst are reused. The yellow liquid acrylate hempseed oil fatty acid (AHFA) is obtained (yield 90%).
A 100-mL round-bottom flask equipped with a magnetic stirrer is charged with 0.10 mol AHFA, 0.002 mol (2 mol % on fatty acid) of benzyl trimethyl ammonium bromide (BTMAB), and 1 wt % hydroquinone. The mixture is allowed to warm under argon atmosphere for about 15 minutes in an oil bath preheated to 120° C. Glycidyl methacrylate (GMA, 0.11 mol) is subsequently added dropwise using a dropping funnel. The reaction progress is monitored over 6 hours by thin layer chromatograph (TLC) using methylene chloride and ethyl acetate (7:3). Due to the competing side reactions, further addition of up to 0.1 molar equivalent of GMA and additional reaction time may be utilized to react all of the AHFA. Two major oxirane ring-opening products are observed as the reaction proceeded to completion within a total of 8-10 hours. To produce a purified sample for characterizations, the dark-colored reaction mixture is allowed to cool to room temperature and then passed through a short silica (200 mesh) column using 20% ethyl acetate in methylene chloride to remove the catalyst and dark brown particulates. A yellowish brown liquid AHFA-GMA (mixture of 1a & 1b, yield 75-86%) is obtained.
Synthesis of castor oil fatty acid methacrylates (2a & 2b)
In another embodiment, the synthesis of the compound depicted in Scheme 3 is achieved in a two-step process. A 100-mL round-bottom flask equipped with a magnetic stirrer is charged with 29.85 g (0.10 mol) ricinoleic acid (RA, from castor oil), 0.46 g (0.002 mol, 2 mol % on the basis of fatty acid) BTMAB, and 0.3 g (1 wt %) of hydroquinone. The mixture is allowed to warm under argon atmosphere for about 15 minutes in an oil bath preheated to 120° C. Glycidyl methacrylate (GMA, 15.63 g (1.1 equivalent)) is subsequently added dropwise using a dropping funnel. The reaction progress is monitored over 6 hours by TLC. Due to the competing side reactions, further addition of up to 0.1 equivalent of GMA and additional reaction time may be utilized to ensure all of the RA reacted. Two major oxirane ring-opening products are produced as the reaction proceeded to completion within a total of 8-10 hours. To prepare the purified sample for characterizations, the dark-colored reaction mixture is allowed to cool to room temperature and passed through a short silica (200 mesh) column using 20% ethyl acetate in methylene chloride to remove the catalyst and dark brown particulates. A yellowish brown liquid (RA-GMA) is obtained (yield 75-87%).
Before the dropwise addition (46.25 g, 0.3 mol; 3 equivalent to RA) of methacrylic anhydride (MAA) to the product mixture from above, a catalytic amount (0.12 g, 1 mol %) of 4-(dimethylamino)pyridine (DMAP), 30.35 g triethylamine (TEA) (3 molar excess), and 1 wt % hydroquinone are added. The reaction is allowed to proceed optimally at 70° C. and monitored by TLC for 4-6 hours under argon atmosphere. TLC determined the presence of one major product in addition to some minor impurities that account for unreacted excess methacrylic anhydride, residual traces of GMA and dimethacrylates. The reddish brown reaction mixture is dissolved in ˜300 mL of methylene chloride and washed with 500 mL (6ט80 mL) each of distilled H2O, 10% (v/v) dilute hydrochloric acid, saturated sodium bicarbonate (NaHCO3) solution and saturated brine. The organic phase is dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure at no more than 60° C., yielding ˜40 g yellowish-dark brown liquid product MARA-GMA (mixture of 2a & 2b). To prevent premature gelation, the product is stored in a closed container, away from direct sunlight, UV, and heat sources.
Another embodiment is depicted in Scheme 4, which illustrates the synthesis of the acrylate compounds 3 & 4 in a three-step process. After 28 g HFA and 21.2 g sodium carbonate are mixed well in 20 mL methylene chloride (CH2Cl2), 73.6 g meta-chloroperoxybenzoic acid (m-CPBA, 75 wt %) dissolved in CH2Cl2 at 0.1 g/ml concentration is added dropwise at a reaction temperature below 15° C., and then the reaction is reacted for 4 hours to complete the epoxidation. The reaction mixture is washed with 10 wt % sodium sulfite and then by 10 wt % aqueous sodium bicarbonate. CH2Cl2 is removed by in vacuum rotary evaporation and 30 g product epoxidized hempseed oil fatty acid (EHFA, 96% yield) is obtained.
31.2 g EHFA, 0.46 g, BTMAB, and 0.3 g (1 wt %) of hydroquinone is mixed well in flask. After the mixture is protected under argon atmosphere and placed in an oil bath of 120° C. for about 15 minutes, glycidyl methacrylate (GMA, 15.63 g (1.1 equivalent)) is added dropwise. The reaction progress is monitored over 6 hours by TLC. Next, the reaction mixture is purified by silica gel column to remove the impurity by ethyl acetate and methylene chloride, then product EHFA-GMA is obtained with the yield 87%.
45.4 g EHFA-GMA, 1.15 g BTMAB, and 0.9 g (2 wt %) of hydroquinone is mixed and allowed to warm under argon atmosphere for about 15 minutes in an oil bath preheated to 100° C. The mixture of acrylic acid/acrylic anhydride (R═H) or methyl acrylic acid/methacrylic anhydride (R═CH3) (acid/anhydride=0.15 mol/0.3 mol) is added dropwise into the reaction mixture. The reaction progress is monitored over 6 hours by TLC. Subsequently, the reaction mixture is purified by silica gel column to remove the impurity by ethyl acetate and methylene chloride, then products 3 and 4 are obtained with the yield 65% and 72%, respectively.
Another embodiment is depicted in Scheme 5, which depicts silane-modified acrylated or methacrylated FA through residual hydroxyls. As depicted, the result in Scheme 2 (referred to as (1)), RA-GMA (an intermediary in Scheme 3, prior to reacting with MAA), and 3 & 4 (EHFA-AA/MA-GMA, a derivative from the intermediary in Scheme 4) is reacted with an acrylate silane group to form AHFA-GMA-A-Silane (Scheme 5-I), RA-GMA-A-Silane (Scheme 5-II), or EHFA-AA/MA-GMA-A-Silane (Scheme 5-III), respectively. A methacrylate functional group may also be utilized to produce AHFA-GMA-MA-Silane, RA-GMA-MA-Silane, or EHFA-AA/MA-GMA-MA-Silane when using methacrylate silane as the silane agent.
The fatty acid derivatives with multi-acrylic silane groups are prepared by the following general procedure. The reactions are carried out in a flask equipped with a stirrer, dropping funnel, thermometer, and reflux condenser capped with a drying tube. Silane agent is mixed with AHFA-GMA, RA-GMA, or EHFA-AA/MA-GMA at a molar ratio of 1:1 to 1:4 (based on the hydroxyl groups containing in the reagents), and the mixture is stirred for 2-3 h at 90-100° C. Liberated methanol is distilled off under reduced pressure (on a rotary evaporator), giving the products with the yield of 67-75%.
Another embodiment is depicted in Scheme 6, which depicts silane-modified (meth)acrylate FA through residual hydroxyls. This process is similar to Scheme 5; however, vinyl functional silane replaces acrylate/methacrylate-silane to produce AHFA-GMA-V-Silane, RA-GMA-V-Silane, and EHFA-AA/MA-H-V-Silane.
The fatty acid derivatives with multi-vinyl silane groups are prepared by the following general procedure. The reactions are carried out in a flask equipped with a stirrer, dropping funnel, thermometer, and reflux condenser capped with a drying tube. Silane agent is mixed with AHFA-GMA, RA-GMA or EFA-AA/MA-GMA-H at a molar ratio of 1:1 to 1:4 (based on the hydroxyl groups containing in the reagents), and the mixture is stirred for 2-3 h at 90-100° C. Liberated methanol is distilled off under reduced pressure (on a rotary evaporator), giving the products with the yield of 77-85%.
Yet another embodiment is depicted in Scheme 7, which depicts fatty acid-derived epoxy (dimer acid-derived, and fatty acid-derived diacid and triacid). In one embodiment, the dimer acid (DA) is reacted with epichlorohydrin (ECH) to form DA-diepoxy (as shown in Scheme 7-I). In another embodiment, the FA is first reacted with either acrylic acid or fumaric acid to produce fatty acid-derived diacid (FA-diacid) and fatty acid-derived triacid (FA-triacid), which are then reacted with ECH to produce a FA-diepoxy or FA-triepoxy (as shown in Scheme 7-II & 7-III).
The preparation of DA-diepoxy follows a general procedure stated here. To a 50 mL flask equipped with reflux condenser, magnetic stirrer, and thermometer are charged 3.74 g DA, 18.5 g epichlorohydrin, and 0.023 g benzyltriethyl ammonium chloride. The reaction temperature is raised to 117° C. and the reaction continued at that temperature for 2 h. After the mixture is cooled to 60° C., 0.8 g sodium hydroxide and 1.12 g calcium oxide is charged. The mixture is stirred at 60° C. for 3 h and then filtered by diatomaceous earth (e.g., Celite®) and filter paper. The solid is discarded. After the excess epichlorohydrin is distilled under vacuum at 100° C. from the filtrate, a light yellowish liquid product is obtained with a yield of 85%-90%. Since the dimer fatty acid is a mixture of various isomers with similar structures, DA-diepoxy is not further purified and utilized as prepared.
The preparations of FA-triacid follow a general procedure stated here. 129 g crude adduct of fumaric acid and conjugated FA is dissolved in 500 mL acetone and neutralized by 50% NaOH solution drop by drop until the pH value reaches 7. After the acetone is removed, the precipitated tricarboxylic acid is extracted with ethyl acetate. The organic layer is neutralized using HCl and dried by NaSO4 for 12 h and then the ethyl acetate is removed using a vacuum rotary evaporator to obtain a white solid FA-triacid (yield: 99%).
3.5 g FA-triacid, 18.5 g epichlorohydrin, and 0.061 g benzyltriethyl ammonium chloride are added to a 50-mL flask. The reaction temperature is raised to 117° C. and the reaction continued for 2 h. After the mixture is cooled to 60° C., 1.2 g sodium hydroxide and 1.68 g calcium oxide are charged. The mixture is stirred at 60° C. for 3 h and then filtered with powder Celite. After the excess epichlorohydrin is distilled under vacuum at 100° C. from the filtrate, a yellowish viscous product (4.56 g) is obtained. The product is purified using a silica gel column (ethyl acetate:hexane=1:4 v/v) to receive 4.00 g of FA-triepoxy (yield: 88%) with an epoxide equivalent weight 193 g/mol (theory: 187 g/mol).
Fatty acids (100 g) and hydroquinone (0.25 g) are charged into a flask. The temperature is raised to 160° C., and acrylic acid (24.7 g) is added slowly. The reaction is continued for 5 h at 160° C. after all the acrylic acid is added. The excess acrylic acid is first removed using a rotary evaporator under vacuum, and then the crude product is distilled under a 5 mmHg vacuum. The fraction between 210 to 240° C. is collected, receiving 103 g of yellowish liquid FA-diacid (yield: 97%).
The preparations of FA-diepxoy and FA-triepoxy follow a general procedure describe here. The synthesis of FA-diepoxy is similar to that of FA-triepoxy. The product is purified using a silica gel column (ethyl acetate:hexane=1:4 v/v), and the yield of pure FA-diepoxy is 85%. The EEW of FA-diepoxy is 235 g/mol (theory: 231 g/mol).
Yet another embodiment is depicted in Scheme 8, which depicts silane modified epoxy (dual curing, moisture curable). The DA is reacted with the silane-modified epoxy to produce the DA-silane-epoxy.
The silicon epoxy compound 59 g, DA 50 g, toluene 75 g, trifluoroacetic acid 0.37 g are charged into a 250 mL flask equipped with a nitrogen gas, thermometer and Dimroth condenser. The reaction is first conducted at 120° C. under stirring for 1 hour; subsequently, the temperature is gradually raised to 140° C. by distillation removing the generated methanol with toluene. The reaction is continued for 3 hours at 140° C., and then the remaining toluene is distilled off under reduced pressure. A transparent liquid product of 88 g (yield 78%, DA-diepoxy-Silane) is obtained.
In another embodiment, depicted in Scheme 9, fatty acid-derived thio-compounds are utilized as curing agents (e.g., mercaptopropionic acid). The EHFA (such as a HFA reacted with m-CPBA above) undergoes methanolysis prior to being reacted with 2-chloroethanol. The intermediary is then reacted with mercaptopropionic acid to produce the FA-derived thio compound.
MEHFA is synthesized by oxirane ring opening reaction via refluxing EHFA (100 g) with excess methanol (136 g) in the presence of tetra-fluoroboric acid catalyst. The molar ratio of epoxy groups to methanol is 1:11. The concentration of the catalyst is 1% of the total weight of the EHFA and methanol. HFA, methanol and catalyst (amount of each reagent as described above) are added into a flask, then stirred and reflux for 1 h. After being cooled to room temperature, ammonia (30% in water) is added to neutralize the reaction mixture pH to 7. The solvent is removed on a rotary evaporator under a low vacuum at 60-95° C. The product of MEHFA is obtained with a yield of ˜98%.
Hydroquinone (3.0 g) and NaOH (8 g) are added to the mixture of 75.2 g MEHFA and 48.3 g 2-chloroethanol at room temperature and under stirring. After the mixture is refluxed for 4 h, it is cooled down to room temperature and filtered to remove the precipitate. The filtrate is added to a large amount of water, and the product MEHFA-triol is precipitated (yield ˜83%).
The mixture of MEHFA-triol (42.0 g), 3-Mercaptopropionic acid (40.0 g), and 1 wt % p-toluenesulfonic acid (p-TSA) solution (200 mL) in toluene in a 500 mL flask is refluxed for 4 h. After being cooled down, the mixture is extracted by ethyl estate, and the organic layer is washed by water. After the solvent is removed by rotatory evaporator, the resulting solid is dried by MgSO4 to give the product 5 (yield: 73-89%).
Another embodiment is depicted in Scheme 10, which depicts the utilization of sulfur (mercapto) functional silane. The intermediary depicted in Scheme 9 is reacted with mercapto-functional silane instead of mercaptopropionic acid to produce the FA-mercapto-functional silane. The reaction procedure is similar to that in Scheme 5. MEHFA-triol-silane is obtained with a yield of ˜79-85%.
Unless otherwise state above, tolerances for mass, volume, temperature, pH, molarity, and time is ±10.
As shown in Table 1, because of its long fatty chain, the cured DA-diepoxy resin alone exhibited a low glass transition temperature, Tg (43° C.), flexural strength (4.4 MPa) and modulus (0.12 GPa) (Table 1). In contrast, the cured rigid DGEAPA displayed high Tg (185° C.), flexural strength (108.5 MPa) and modulus (3.11 GPa). Addition of dimer acid-derived epoxy may flexibilize and toughen the rosin-derived epoxy resin. From the application perspective, the mixed epoxies containing 20-40 wt % of DA-diepoxy exhibit overall high performance. The results suggest that the rigid DGEAPA and the flexible DA-diepoxy are complementary in many physical properties and the mixture of the two in appropriate ratios may result in well-balanced properties.
Both FA-diepoxy and FA-triepoxy are liquid at room temperature and have lower viscosity than that of the commercial bisphenol A epoxy resin D.E.R.™ 332 (DER332). They also exhibited higher reactivity than DER332 during curing. After curing with the same curing agent, nadic methyl anhydride, the resulting resins exhibited Tgs as follows: DER332 (168° C.) >FA-triepoxy (131° C.)>FA-diepoxy (80° C.)>epoxidized soybean oil (ESO, 37° C.) as shown in Table 2. The difference in thermal and mechanical properties for the FA-derived resins is likely attributed to the difference in their crosslink densities. That also explains why the Tg of the cured FA-diepoxy (80° C.) was lower than that of the cured FA-triepoxy (131° C.) but higher than that of ESO (37° C.). Because DER332 is a more rigid molecule than FA-triepoxy, it exhibited the highest Tg among all the cure epoxies presented. Results from bending tests indicate that the cured FA-triepoxy and DER332 had similar flexural strengths, but the latter had higher elastic modulus. In contrast, the cured FA-diepoxy exhibited a lower flexural strength but a comparable modulus to that of the cured FA-triepoxy. TGA results indicate that the FA-derived epoxies exhibited thermal stability similar to that of DER332. The results also demonstrate that FA-diepoxy and FA-triepoxy are superior to ESO for epoxy applications.
aat yielding point.
bat breaking point. From K. Huang, P. Zhang, J. Zhang, S. Li, M. Li, J. Xia, Y. Zhou, Green Chemistry 2013, 15, 2466-2475
Referring to
In some embodiments, a purified sample is produced. The dark-colored reaction mixture may be cooled to room temperature and then passed through a short silica (200 mesh) column using 20% ethyl acetate in methylene chloride to remove the catalyst and dark brown particulates. A yellowish brown liquid is obtained.
Referring to
In some embodiments, the resultant is purified. The reddish brown reaction mixture is dissolved in ˜300 mL of methylene chloride and washed with 500 mL (6ט80 mL) each of distilled H2O, 10% (v/v) dilute hydrochloric acid, saturated sodium bicarbonate (NaHCO3) solution and saturated brine. The organic phase is dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure at no more than 60° C., yielding ˜40 g yellowish-dark brown liquid product (MARA-GMA). To prevent premature gelation, the product is stored in a closed container, away from direct sunlight, UV, and heat sources.
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The dimer acid, fatty acid-derived diacid, or fatty acid-derived triacid are then reacted with epichlorohydrin to produce an epoxy (block 606). If a dimer acid, a 50 mL flask equipped with reflux condenser, magnetic stirrer, and thermometer may be charged with 3.74 g DA, 18.5 g epichlorohydrin, and 0.023 g benzyltriethyl ammonium chloride. The reaction temperature may then be raised to 117° C. and the reaction continued at that temperature for 2 h. The mixture may be cooled to 60° C., 0.8 g sodium hydroxide and 1.12 g calcium oxide is charged. The mixture may then be stirred at 60° C. for 3 h and then filtered by diatomaceous earth (e.g., Celite®) and filter paper. The solid is discarded. After the excess epichlorohydrin is distilled under vacuum at 100° C. from the filtrate, a light yellowish liquid product of DA-diepoxy is obtained. If a FA-triacid, 3.5 g FA-triacid, 18.5 g epichlorohydrin and 0.061 g benzyltriethyl ammonium chloride are added to a 50-mL flask are added. The reaction temperature is raised to 117° C. and the reaction continued for 2 h. After the mixture is cooled to 60° C., 1.2 g sodium hydroxide and 1.68 g calcium oxide are charged. The mixture is stirred at 60° C. for 3 h and then filtered with powder Celite. After the excess epichlorohydrin is distilled under vacuum at 100° C. from the filtrate, a yellowish viscous product (4.56 g) is obtained. The product is purified using a silica gel column (ethyl acetate:hexane=1:4 v/v) to receive 4.00 g of FA-triepoxy with an epoxide equivalent weight 193 g/mol (theory: 187 g/mol). The synthesis of FA-diepoxy may be similar to that of FA-triepoxy. The product may be purified using a silica gel column (ethyl acetate:hexane=1:4 v/v), and the yield of pure FA-diepoxy may be 85%. The EEW of FA-diepoxy is 235 g/mol (theory: 231 g/mol). The monomer production process 600 then ends (done block 608).
Referring to
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This application claims benefit under 35 U.S.C. 119 to U.S. application Ser. No. 62/384,819, entitled “PREPARATION OF VEGETABLE OIL-BASED MONOMERS FOR USE IN THERMOSETTING RESINS”, filed on Sep. 8, 2016, and incorporated herein by reference in its entirety.
| Number | Date | Country | |
|---|---|---|---|
| 62384819 | Sep 2016 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 15697957 | Sep 2017 | US |
| Child | 16669583 | US |
