Claims
- 1. A device to perform a cryoablation procedure, comprising:
an ablation catheter, including:
an inlet lumen; a balloon coupled to a distal end of the inlet lumen; and an outlet lumen coupled to the balloon; a source of working fluid, the source of working fluid having an outlet coupled to the inlet lumen and an inlet coupled to the outlet lumen; an in-line gas sensor coupled to the inlet lumen or the outlet lumen to detect the presence of gases in the working fluid.
- 2. The device of claim 1, wherein the sensor is selected from the group consisting of: oxymetry sensors, polargraphic sensors, optical sensors, and similar sensors.
- 3. The device of claim 1, further comprising a patient sensor coupled to the patient for measuring a characteristic of gas in a blood vessel of the patient.
- 4. The device of claim 3, wherein the sensor is selected from the group consisting of: respired gas sensors, oxymetry sensors, and similar sensors.
- 5. A method of making a working fluid for use in a cryogenic endovascular procedure, comprising:
diffusing a substantially pure noble gas into the fluid for a period of time; and de-pressurizing an environment adjacent the fluid such that at least a partial vacuum is achieved.
- 6. The method of claim 5, further comprising agitating the fluid during at least one of the diffusing and de-pressurizing.
- 7. The method of claim 6, wherein the agitating includes stirring.
- 8. The method of claim 5, wherein the diffusing occurs for a period of time of between about 20 and 30 minutes.
- 9. The method of claim 5, wherein the de-pressurizing occurs for a period of time of between about 5 and 10 minutes.
- 10. The method of claim 5, wherein the gas is USP grade or better of helium.
- 11. The method of claim 5, wherein the partial vacuum is between about 15″ to 20″ of Hg.
- 12. The method of claim 9, wherein the de-pressurizing occurs for a period of time of about 5 minutes.
- 13. The method of claim 5, wherein the diffusing and de-pressurizing are performed within a continuously circulating source of working fluid.
- 14. The method of claim 13, further comprising sensing a presence of dissolved gases during the circulating with an in-line gas sensor.
- 15. A method of preparing a perfluorocarbon-containing fluid for a biomedical use, comprising:
diffusing a gas into the perfluorocarbon-containing fluid for a period of time between about 20 and 30 minutes; and de-pressurizing an environment adjacent the fluid such that at least a partial vacuum is achieved for a period of time between about 0 and 10 minutes.
- 16. A method of preparing a perfluorocarbon-containing fluid for a biomedical use, comprising:
diffusing oxygen-gas into the perfluorocarbon-containing fluid for a period of time greater than about 5 seconds; and de-pressurizing an environment adjacent the fluid such that at least a partial vacuum is achieved for a period of time between about 0 and 10 minutes.
- 17. A method of preparing a perfluorocarbon-containing fluid for a biomedical use, comprising:
diffusing a noble gas into the perfluorocarbon-containing fluid for a period of time, between about 20 and 30 minutes; de-pressurizing an environment adjacent the fluid such that at least a partial vacuum is achieved for a period of time between about 0 and 10 minutes; de-pressurizing an environment adjacent the fluid such that at least a partial vacuum is achieved and diffusing oxygen gas into the perfluorocarbon-containing fluid for a period of time greater than about 5 seconds.
- 18. A method of preparing a perfluorocarbon-containing fluid for a biomedical use, comprising:
providing a perfluorocarbon-containing fluid; adding a surfactant to the perfluorocarbon-containing fluid, the surfactant having a bifunctional character, the bifunctionality caused by a hydrophilic portion of the surfactant and a fluorinated portion of the surfactant.
- 19. The method of claim 18, wherein the perfluorocarbon-containing fluid is Galden fluid.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation-in-part of the following co-pending U.S. patent application Ser. Nos. 09/787,599, filed Mar. 21, 2001, entitled “Method and Device for Performing Cooling-or Cryo-Therapies for, e.g., Angioplasty with Reduced Restenosis or Pulmonary Vein Cell Necrosis to Inhibit Atrial Fibrillation”; 09/516,319, filed Mar. 1, 2000, entitled “Method and Device for Performing Cooling-or Cryo-Therapies for, e.g., Angioplasty with Reduced Restenosis or Pulmonary Vein Cell Necrosis to Inhibit Atrial Fibrillation”; 09/785,243, filed Feb. 16, 2001, entitled “Circulating Fluid Hypothermia Method and Apparatus”; 09/757,124, filed Jan. 8, 2001, entitled “Inflatable Catheter for Selective Organ Heating and Cooling and Method of Using the Same”; 09/566,531, filed May 8, 2000, entitled “Method of Making Selective Organ Cooling Catheter”; 09/650,940 filed Aug. 30, 2000, entitled “Selective Organ Hypothermia Method and Apparatus”; 09/932,402, filed Aug. 17, 2001, entitled “Method and Device for Performing Cooling- or Cryo-Therapies for, e.g., Angioplasty with Reduced Restenosis or Pulmonary Vein Cell Necrosis to Inhibit Atrial Fibrillation Employing Microporous Balloon”; 10/110,360, filed Apr. 10, 2002, entitled “Method and Device for Performing Cooling- or Cryo-Therapies for, e.g., Angioplasty with Reduced Restenosis or Pulmonary Vein Cell Necrosis to Inhibit Atrial Fibrillation Employing Tissue Protection”; and 10/086,585, filed Feb. 28, 2002, entitled “Method and Device for Performing Employing Tissue Protection”; and 10/086,585, filed Feb. 28, 2002, entitled “Method and Device for Performing Cooling- or Cryo-Therapies for, e.g., Angioplasty with Reduced Restenosis or Pulmonary Vein Cell Necrosis to Inhibit Atrial Fibrillation Employing Tissue Protection”. This application is also a continuation-in-part and utility conversion of Provisional Application Serial Nos.: 60/272,550 filed Mar. 1, 2001, entitled “Method and Apparatus for Inhibiting Tissue Damage During Cryo-Ablation”, and 60/273,095 filed Mar. 2, 2001, entitled “Annular Ring Balloon for Pulmonary Vein Cryoplasty”, all of the above are incorporated herein by reference in their entirety.
Provisional Applications (1)
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Number |
Date |
Country |
|
60273095 |
Mar 2001 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09787599 |
Mar 2001 |
US |
Child |
10200028 |
Jul 2002 |
US |