Claims
- 1. A process to prepare azabicylobutane from an azetidine comprising reacting an aza substituted, 3-substituted azetidine in an aqueous alkali media to eliminate the aza and 3-position substituents and to effect cyclization between the aza nitrogen and 3- carbon positions to form the azabicylobutane.
- 2. The process of claim 1 wherein the aza substituent is an acyl group and the 3-position carbon substituent is a halogen.
- 3. The process of claim 2 wherein the 3-position carbon substituent is chlorine.
- 4. The process of claim 1 wherein the 3- position carbon substituent is a sulfate ester.
- 5. The process of claim 1 wherein the azetidine is N-acetyl,3-chloroazetidine.
- 6. The process of claim 1 wherein the azetidine is 3-sulfato, aza-azetidinium sulfate.
- 7. The process of claim 1 wherein the aqueous alkali is aqueous potassium hydroxide.
- 8. The process of claim 1 wherein the process is carried out at a temperature of 80 degrees C.
STATEMENT OF GOVERNMENT INTEREST
The invention described herein may be manufactured, used or licensed by or for the United States Government for governmental purposes without payment to the inventor(s) of any royalties.
Foreign Referenced Citations (1)
Number |
Date |
Country |
1802209 |
May 1970 |
DEX |
Non-Patent Literature Citations (2)
Entry |
Marchand, A.P., "A Novel Approach to the Synthesis of 1, 3, 3-Trinitroazeine" J. Org. Chem. (1995) vol. 60, pp. 4943-4946. |
Hortmann, A.G., "1-Azabicyclobutanes. Synthesis and Reactions" J. Amer. Chem. Soc. vol. 94 No. 8, pp. 2758-2765, Apr. 1972. |