Patent Application
20230000764
The present disclosure relates to delivery of nutritional supplements through oral mucosa, and the storage and delivery devices thereof.
Athletes may suffer excessive fluid loss through perspiration during intense exercise, which would result in electrolyte deficiency in addition to dehydration. Low levels of electrolytes in the system can lead to cramping. Salt pills provide large salt doses to overcome this issue. This approach can oversupply the body with sodium to overcome the delay in bioavailability through the GI tract. A mechanism for delivering a smaller dose of electrolytes to the buccal mucosa may provide the needed electrolytes with more rapid bioavailability.
During exercise, the body requires more oxygen than when the body is at rest. When oxygen cannot be delivered to the muscles faster to replace the used oxygen, the muscles will begin to convert the available glucose to lactic acid. This will build up in the muscle, causing fatigue. More rapid delivery of oxygen to the system during exertion can reduce fatigue. Supplemental oxygen therapy has been demonstrated to improve athletic performance and decrease reaction times.
Proper hydration, electrolyte supplements, and supplemental oxygen therapy have proven to be able to improve athletic performance. Therefore, it is desirable to have a means to delivery water, supplements and oxygen without interrupting athletes' activities.
Disclosed herein is a chewable article for oral mucosa delivery of a composition. The present invention also encompasss the kit and the method of use thereof. The chewable article may comprise at least two interconnected portions. A first portion is to provide a chewable base; and a second portion is to house a composition. In one embodiment, the chewable article comprises a chewable base and a composition. The composition may be embedded, coated, integrated, encapsulated or dispersed in the chewable base. The composition may be pressurized, oxygenated, and/or atomized. The composition may be released as an aerosol. The composition may comprise fractions of supplemental nutrients, gas fraction, preservative fraction or enhancer fraction. The composition may comprise water, nutrition, or oxygen. In one embodiment, the chewable system comprises a pressurized capsule that dissolves or ruptures in the mouth to release a burst of the composition. The chewable system may be configured to allow the composition facing to the buccal mucosa.
Disclosed herein is a chewable article for oral mucosa delivery of a composition. The chewable article may comprise two portions. A first portion is to provide a chewable base; and a second portion is to hold the composition to be delivered. The first and second portions are interconnected. In one embodiment, the chewable article comprises a chewable base with the composition embedded, encapsulated, coated, integrated or dispersed therein. The composition may be pressurized, oxygenated, and/or atomized. The composition may be released as an aerosol. In one embodiment, the chewable system comprises a pressurized capsule that dissolves or ruptures in the mouth to release a burst of the composition. The chewable system may be configured to allow the composition facing to the buccal mucosa. The following embodiments/examples are included to demonstrate some specifics of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples that follow represent techniques discovered by the inventor to function well in the practice of the present disclosure, and thus can be considered to constitute preferred modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the present disclosure.
The composition may include any one or any combinations of (i) a nutritional supplement matrix fraction, (ii) a gas fraction, (iii) an enhancer fraction, (iv) a liquid fraction, and (v) a preservative fraction. In one embodiment, the fractions are all mixed or combined and treated to allow oxygen molecules suspended therein for a specific duration of time before being released from a chewable 102. In one embodiment, a chewable 102 may contain 2 ml of the composition. Furthermore, the composition may be in a compressed state in a chewable 102 before being released. The composition may be delivered to a user via one or more perforations 104. A perforation 104 may be any intentional weak point in the chewable 102 designed to rupture when bite pressure is applied to the chewable 102, thus releasing the composition. In one embodiment, the chewable 102 has one or more perforations 104 on one side. The user may place the chewable 102 in their mouth with the perforations 104 facing their cheek. In this example, when the user applies bite pressure to the chewable 102, the composition may be released towards the buccal mucosa. In one embodiment, pressure built inside of the chewable 102 may be sufficient to spray, or otherwise atomize the composition, thus facilitating the absorption of the composition through the buccal mucosa. In one embodiment, the chewable 102 may be a gum. In one embodiment, the chewable 102 maybe a lozenge or a chewable with a hard or candy shell. In one embodiment, the chewable 102 may dissolve in the mouth without chewing. In those embodiments, the perforations 104 may dissolve faster.
The composition, or an oxygenated portion of the composition, may be incorporated into the reservoirs and may be released from the porous bead gum 300 when chewed upon. In one embodiment, a chewable 102 may contain 2 ml of the composition in the form of 25 porous polymeric beads 302 that each contains 0.08 ml of the composition. In one embodiment, one portion of the composition may be contained in the porous polymeric beads 302. A second portion of the composition may be incorperated in the porous beads as either a coating or an ingredient. In one embodiment, the two portions of the composition may have the same ingredients with different release rates. In one embodiment, the first portion of the composition may contain a partial list of the composition's fractions. The second portion of the composition may contain the remaining fractions of the composition. For example, an electrolyte supplement may be a powder coating the porous bead gum 300, and an oxygenated flavoring may be contained in the porous polymeric beads 302. This approach may allow the user to supplement electrolytes on the go while also to receive bursts of oxygen when the porous polymeric beads 302 are ruptured.
The foregoing detailed description of the technology has been presented for purposes of illustration and description. It is not intended to be exhaustive or to limit the technology to the precise form disclosed. Many modifications and variations are possible in light of the above teaching. The described embodiments were chosen in order to best explain the principles of the technology and its practical application to thereby enable others skilled in the art to best utilize the technology in various embodiments and with various modifications as are suited to the particular use contemplated. It is intended that the scope of the technology be defined by the claim.
The terms “or” and “and/or,” as used herein, are to be interpreted as inclusive or meaning any one or any combination. Therefore, “A, B or C” or “A, B and/or C” mean any of the following: “A,” “B” or “C”; “A and B”; “A and C”; “B and C”; “A, B and C.” An exception to this definition will occur only when a combination of elements, functions, steps or acts are in some way inherently mutually exclusive.
The terms “comprising,” “including” and “having” are used interchangeably in this disclosure. The terms “comprising,” “including” and “having” mean to include, but not necessarily be limited to the things so described. The terms “about” or “approximately,” as used in the application and claims, should be understood to include the recited values or a value that is three times greater or one third of the recited values.
The present application claims the priority benefit of U.S. provisional patent application No. 63/208,767 filed Jun. 11, 2021, the disclosure of which is incorporated by reference herein.
| Number | Date | Country | |
|---|---|---|---|
| 63209767 | Jun 2021 | US |
