Claims
- 1. A composition comprising Competence Stimulating Peptide (CSP) and sucrose.
- 2. The composition according to claim 1, further comprising at least one substance selected from the group consisting of an orally acceptable carrier, an anti-caries agent, and mixtures thereof.
- 3. The composition according to claim 1, further comprising an orally acceptable carrier and an anti-caries agent.
- 4. The composition according to claim 1, wherein the CSP in the composition is present in an amount from about 0.05% to about 30% w/w.
- 5. The composition according to claim 1, wherein the composition is in a form selected from the group consisting of a mouthwash solution, an abrasive dentifrice gel, a chewing gum, a nonabrasive dentifrice gel, a nonabrasive gel composition, and a soft drink.
- 6. The composition according to claim 2, wherein the anti-caries agent is selected from the group consisting of water insoluble noncationic antimicrobial agents, non-steroidal anti-inflammatory drugs, fluoride reagents, histidine-rich polypeptides, casein, urea, calcium lactate, calcium glycerophosphate, non-immunogenic amino acid segments of proline-rich proteins, monoclonal antibodies of S. mutans.
- 7. A method of treatment or prophylaxis of a condition associated with the attachment of S. mutans to teeth of a subject, comprising the step of administering to the subject a composition containing CSP in an amount effective to reduce the attachment of S. mutans to teeth.
- 8. The method of claim 7, wherein the composition further comprises at least one substance selected from a group consisting of sucrose, an orally acceptable carrier, an anti-caries agent, and mixtures thereof.
- 9. The method of claim 7, wherein the composition further comprises sucrose.
- 10. The method of claim 7, wherein the composition further comprises sucrose, an orally acceptable carrier, and an anti-caries agent.
- 11. The method of claim 7, wherein the CSP in the composition is present in an amount from about 0.05% to about 30% w/w.
- 12. The method of claim 7, wherein the condition is selected from the group consisting of dental caries or endocarditis.
- 13. The method of claim 8, wherein the anti-caries agent is selected from the group consisting of water insoluble noncationic antimicrobial agents, non-steroidal anti-inflammatory drugs, fluoride reagents, histidine-rich polypeptides, casein, urea, calcium lactate, calcium glycerophosphate, non-immunogenic amino acid segments of proline-rich proteins, monoclonal antibodies of S. mutans.
- 14. A medicament for the treatment or prophylaxis of a condition associated with the attachment of S. mutans to teeth, comprising CSP in an amount effective to reduce the attachment of S. mutans to teeth.
- 15. The medicament of claim 14, wherein the medicament further comprises at least one substance selected from a group consisting of sucrose, an orally acceptable carrier, an anti-caries agent, and mixtures thereof.
- 16. The medicament of claim 14, wherein the medicament further comprises sucrose.
- 17. The medicament of claim 14, wherein the medicament further comprises sucrose, an orally acceptable carrier, and an anti-caries agent.
- 18. The medicament of claim 14, wherein the CSP is present in an amount between about 0.05% to about 30% w/w.
- 19. The medicament of claim 14, wherein the condition is selected from the group consisting of dental caries or endocarditis.
- 20. The medicament of claim 15, wherein the anti-caries agent is selected from the group consisting of water insoluble noncationic antimicrobial agents, non-steroidal anti-inflammatory drugs, fluoride reagents, histidine-rich polypeptides, casein, urea, calcium lactate, calcium glycerophosphate, non-immunogenic amino acid segments of proline-rich proteins, monoclonal antibodies of S. mutans.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Application No. 60/393,712 filed Jul. 3, 2002, which is incorporated herein by reference in its entirety.
Provisional Applications (1)
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Number |
Date |
Country |
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60393712 |
Jul 2002 |
US |