Claims
- 1. A method for treating patients having premalignant or precancerous epithelial lesions to retard the progression of these lesions into carcinomas comprising administering to said patient a composition containing a compound selected from the group consisting of 9-cis-retinoic acid, its pharmaceutically acceptable salts, and its pharmaceutically acceptable hydrolyzable esters said compound being administered in an amount effective to treat said lesions.
- 2. The method of claim 1 wherein said composition is administered orally.
- 3. The method of claim 2 wherein compound is administered at a daily amount dose of from 0.01 mg to 3 mg per kg body weight.
- 4. The method of claim 3 wherein said lesions are leukoplakias of the oral cavity.
- 5. The method of claim 3 wherein said composition is administered in an oral unit dosage form containing 1 mg to 50 mg of the compound.
- 6. The method of claim 5 wherein said oral unit dosage form is a capsule or tablet.
- 7. A method for treating tumors of epithelial origin in patients to retard the development of these tumors comprising administering to said patient a composition containing a compound selected from the group consisting of 9-cis-retinoic acid, its pharmaceutically acceptable salts, and its pharmaceutically acceptable hydrolyzable esters, said compound being administered in an amount effective to retard the development of said tumors.
- 8. The method of claim 7 wherein said composition is administered orally.
- 9. The method of claim 8 wherein said compound is administered at a daily dose of from 0.01 mg to 3 mg per kg body weight.
- 10. The method of claim 9 wherein said tumors are selected from the group consisting of epithelial tumors of the breast, skin, colon, bladder, esophagus, stomach, larynx, lung or oral cavity.
- 11. The method of claim 9 wherein said composition is administered in an oral unit dosage form containing 1 mg to 50 mg of the compound.
- 12. The method of claim 11 wherein said oral unit dosage form is a capsule or tablet.
- 13. The method of claim 10 wherein said tumors are tumors of the breast.
- 14. A composition in unit dosage form for oral administration comprising as an active ingredient a compound selected from the group consisting of 9-cis retinoic acid, pharmaceutically acceptable salts thereof and pharmaceutically acceptable hydrolyzable esters thereof and a pharmaceutically acceptable carrier suitable for oral administration, said active ingredient being present in said unit dosage form in an amount of from about 1 mg to 50 mg wherein said unit dosage form is a tablet or capsule.
Parent Case Info
This is a continuation of application Ser. No. 07/823,741 filed Jan. 22, 1992, now abandoned.
Foreign Referenced Citations (1)
Number |
Date |
Country |
1335867 |
Oct 1973 |
GBX |
Continuations (1)
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Number |
Date |
Country |
Parent |
823741 |
Jan 1992 |
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