Claims
- 1. A method for preparing a crosslinked collagen-glycosaminoglycan composite material, comprising:
- a. soaking collagen in an aqueous acidic solution having a pH of below about six;
- b. contacting said solution with a crosslinking agent; and
- c. contacting a source of glycosaminoglycan with said solution.
- 2. In the method of preparing crosslinked collagen-glycosaminoglycan composite material, the improvement of contacting collagen, which has been soaked in an aqueous acidic solution, with a crosslinking agent prior to contacting said collagen and said crosslinking agent with glycosaminoglycan.
- 3. A method of claims 1 or 2 wherein said aqueous acidic solution comprises acetic acid.
- 4. A method of claims 1 or 2 wherein said crosslinking agent comprises glutaraldehyde.
- 5. A method of claims 1 or 2 wherein said glycosaminoglycan is selected from the following group: chondroitin 6-sulfate, chondroitin 4-sulfate, heparin, heparin sulfate, keratan sulfate, dermatan sulfate, or chitin.
- 6. A crosslinked collagen-glycosaminoglycan composite material made by the methods of claims 1 or 2.
DESCRIPTION
The invention described herein was supported in whole or in part by a grant from the National Institutes of Health.
US Referenced Citations (4)