Claims
- 1. A method for preparing a compound of the formula ##STR5## which method comprises reacting a .gamma.-lactone of the formula ##STR6## under substantially anhydrous conditions with at least one equivalent of an alkoxide of the formula RO.sup.- in the presence of an alcohol of the formula ROH wherein R is the hydrocarbon residue of a C.sub.1 -C.sub.8 alcohol and R.sup.1 is C.sub.1 -C.sub.6 alkyl, trifluoromethyl, benzyl, phenyl, tolyl or trimethylphenyl.
- 2. The method of claim 1 wherein the .gamma.-lactone is suspended or dissolved in a substantially anhydrous reaction medium comprising the alcohol and the alkoxide is formed in situ by addition of at least one equivalent of an alkoxide-forming base.
- 3. The method of claim 2 wherein the base is an alkali metal hydride.
- 4. The method of claim 1 wherein R is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 alkenyl or benzyl.
- 5. The method of claim 1 wherein R.sup.1 is tolyl.
Parent Case Info
This application is a division of application Ser. No. 07/518,384, filed May 3, 1990, now U.S. Pat. No. 5,097,049.
Foreign Referenced Citations (1)
Number |
Date |
Country |
55-120575 |
Sep 1980 |
JPX |
Non-Patent Literature Citations (2)
Entry |
Percy S. Manchand et al., "A Novel Synthesis of the Monobactam Antibiotic Carumonam", J. Org. Chem. 53, 5507-5512 (1988). |
Seiki Saito et al., "Novel Approach to Stereoisomerically Full Set of Optically Pure 2,3-Epoxyesters from Tartaric Acids", Tetrahedron Letters, vol. 27, No. 43, 5249-5252 (1986). |
Divisions (1)
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Number |
Date |
Country |
Parent |
518384 |
May 1990 |
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