Claims
- 1. A process for producing a compound having the formula ##STR16## which comprises reacting a 2-substituted benzoic acid having the formula ##STR17## with a diarylamine having the formula ##STR18## in the presence of the anhydride of an alkanoic acid having from 2 to 5 carbon atoms and an organic base, wherein in the above formulas:
- Q.sub.4 is hydrogen or halo;
- Q.sub.5 is the same as Q.sub.4 ; or di-lower-alkylamino, halo or COX when Q.sub.4, Q.sub.6 and Q.sub.7 are each hydrogen;
- Q.sub.6 is the same as Q.sub.4 ; or di-lower-alkylamino, halo or COX when Q.sub.4, Q.sub.5 and Q.sub.7 are each hydrogen;
- Q.sub.7 is the same as Q.sub.4 ;
- X is hydroxyl, benzyloxy or alkoxy having from 1 to 18 carbon atoms;
- Z is a radical having the formula ##STR19## in which: R.sub.1 is selected from the group consisting of hydrogen, halo, lower-alkyl, lower-alkoxy and di-lower-alkylamino;
- R.sub.2 is lower-alkyl; and
- R.sub.3 is selected from the group consisting of lower-alkyl, benzyl, phenyl and phenyl substituted with a lower-alkyl or lower-alkoxy group; and
- Y.sub.1, Y.sub.2, Y.sub.3 and Y.sub.4 are the same or different and are selected from the group consisting of hydrogen, halo, hydroxyl, lower-alkoxy, alkyl having from 1 to 9 carbon atoms, phenyl-lower-alkyl, COOR.sub.4 and NR.sub.5 R.sub.6 where R.sub.4 and R.sub.5 are hydrogen or lower-alkyl and R.sub.6 is hydrogen, lower-alkyl, cycloalkyl having from 5 to 7 carbon atoms, lower-alkanoyl, phenylsulfonyl or lower-alkyl-substituted phenylsulfonyl.
- 2. A process according to claim 1 wherein said anhydride of an alkanoic acid having from 2 to 5 carbon atoms is acetic anhydride and said organic base is selected from the group consisting of said diarylamine, pyridine and urea.
- 3. A process for producing a compound having the formula ##STR20## which comprises reacting a 2-substituted benzoic acid having the formula ##STR21## with a diarylamine having the formula ##STR22## in the presence of the anhydride of an alkanoic acid having from 2 to 5 carbon atoms and an organic base, wherein in the above formulas:
- Q.sub.4, Q.sub.5, Q.sub.6 and Q.sub.7 are hydrogen;
- Z is 9-julolidinyl; and
- Y.sub.1, Y.sub.2, Y.sub.3 and Y.sub.4 are the same or different and are selected from the group consisting of hydrogen, lower-alkoxy and alkyl having from 1 to 9 carbon atoms.
- 4. A process according to claim 3 wherein said anhydride of an alkanoic acid having from 2 to 5 carbon atoms is acetic anhydride and said organic base is selected from the group consisting of said diarylamine, pyridine and urea.
- 5. 4-Carboxy-2-[2-ethoxy-4-(dimethylamino)benzoyl]benzoic acid.
- 6. 5-Carboxy-2-[2-ethoxy-4-(dimethylamino)benzoyl]benzoic acid.
Parent Case Info
This application is a division of application Ser. No. 19,594 filed Mar. 12, 1979 now U.S. Pat. No. 4,200,313 issued Apr. 29, 1980, in turn a division of application Ser. No. 942,996 filed Sept. 18, 1978, now U.S. Pat. No. 4,187,223 issued Feb. 5, 1980, in turn a continuation-in-part of application Ser. No. 821,927 filed Aug. 4, 1977, now U.S. Pat. No. 4,168,378 issued Sept. 18, 1979, in turn a continuation-in-part of application Ser. No. 755,183 filed Dec. 29, 1976 and now abandoned.
US Referenced Citations (10)
Foreign Referenced Citations (2)
Number |
Date |
Country |
2537776 |
Mar 1976 |
DEX |
46-16 |
Feb 1971 |
JPX |
Divisions (2)
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Number |
Date |
Country |
Parent |
19594 |
Mar 1979 |
|
Parent |
942996 |
Sep 1978 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
821927 |
Aug 1977 |
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Parent |
755183 |
Dec 1976 |
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