Claims
- 1. A process for alleviating proliferative skin diseases which comprises administering to the afflicted human or animal a composition containing as its active component at least one of the compounds selected from the groups consisting of:
- 1. Xanthines of the formula ##STR22## wherein R and R.sub.1 are selected from the group consisting of H, alkyl and hydroxyalkyl containing 1-7 carbon atoms, cycloalkyl containing 3-7 carbon atoms and aralkyl wherein the alkyl portion contains 1-7 carbon atoms, R.sub.2 is selected from the group consisting of H, alkyl (1-4), and a complex with ethylenediamine, and Y is selected from the group consisting of H and thiol; and
- 2.
- 2. Thioxanthines of the formula ##STR23## wherein R.sub.1 is selected from the group consisting of methyl, ethyl, propyl and -CH.sub.2 -CH.dbd.CH.sub.2 ; R.sub.2 is selected from the group consisting of methyl, ethyl, propyl, -CH.sub.2 CH.dbd.CH.sub.2, isopropyl, isobutyl, CH.sub.2 CCH.sub.3 .dbd.CH.sub.2, pentyl, 3-methoxy-propyl, 2-methyl-butyl, hexyl, benzyl, phenyl, phenethyl, and furfuryl; R.sub.3 is selected from the group consisting of hydrogen, methyl and ethyl;
- said compounds being in association with a pharmaceutical carrier wherein said active component is present in an amount in the range of about 0.1 to about 15% w/v which is effective to alleviate a proliferative skin
- disease. 2. A process in accordance with claim 1, wherein said active component is at least one of the compounds selected from Group 1.
- 3. A process in accordance with claim 1, wherein said active component is at least one compound selected from Group 2.
- 4. A process in accordance with claim 1, wherein said active component is administered in conjunction with a permissive dosage of a glucocorticoid.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a Division of Ser. No. 646,633 filed Jan. 5, 1976, and now U.S. Pat. No. 4,034,087; which was a continuation-in-part of Ser. No. 425,065, filed Dec. 12, 1973, now abandoned; and which was a continuation-in-part of Ser. No. 324,012, filed Jan. 16, 1973, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
2994640 |
Zellner |
Aug 1961 |
|
Non-Patent Literature Citations (2)
Entry |
Stein et al., Chem. Abst. vol. 76 (1972), p. 63161t. |
Marks et al., Chem. Abst. vol. 76 (1972), p. 136361v. |
Divisions (1)
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Number |
Date |
Country |
Parent |
646633 |
Jan 1976 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
425065 |
Dec 1973 |
|
Parent |
324012 |
Jan 1973 |
|