Claims
- 1. A method for graphic visualization and/or diagnosis of a thrombus, comprising administering a particulate MR-contrast medium to a patient, and after a sufficient amount of contrast medium has accumulated in the thrombus and/or the adjoining vessel wall and surrounding area to enhance an MR image thereof, taking a nuclear spin tomogram of the thrombus and/or the adjoining vessel wall and surrounding area, wherein the particulate contrast medium contains ultrasmall superparamagnetic iron oxide particles having a mean particle diameter of less than 50 nm.
- 2. A method according to claim 1, wherein the nuclear spin tomogram is taken as a Ti-weighted image.
- 3. A method according to claim 1, wherein the nuclear spin tomogram is taken as a T2- or T2* -weighted image.
- 4. A method according to claim 1, wherein the particulate contrast medium contains superparamagnetic iron oxide particles having a mean particle diameter of about 25 nm.
- 5. A method according to claim 1, wherein 200 μmol of contrast medium is administered to the patient.
- 6. A method according to claim 1, wherein the nuclear spin tomogram is taken about 24 hours after the administration of the contrast medium.
Parent Case Info
This application claims the benefit of the filing date of U.S. Provisional Application Serial No. 60/235,553 filed Sep. 27, 2000.
US Referenced Citations (6)
Foreign Referenced Citations (4)
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Non-Patent Literature Citations (3)
Entry |
Schmitz et al. “SPIO-enhanced MR Angiography for the Detection of Venous Thrombi in an Animal Model,” Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr Mar;170(3):316-21 (1999).* |
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Provisional Applications (1)
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Number |
Date |
Country |
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60/235553 |
Sep 2000 |
US |