Claims
- 1. A process for inverting the configuration at the optically active carbon atom (*) in a compound of the formula I ##STR10## which comprises converting this compound by formylation into optically active compounds of the formula II ##STR11## while maintaining the configuration at the carbon atom (*), converting this compound, by treatment with a strong acid or an acid halide, into optically active cyclic compounds of the formula III ##STR12## in which X.crclbar. represents the anion of a strong acid or a halogen atom, and converting these oxazolinium derivatives (III), by acid or alkyline hydrolysis into the optically active compound of the formula IV ##STR13## possessing the same structure as the starting material I, but having an opposite configuration at the carbon atom (*).
- 2. The process as claimed in claim 1, wherein the acid halide used is sulfuryl chloride, thionyl bromide, thionyl chloride, phosphorus trichloride, phosphorous oxychloride, phosphorus pentachloride, toluenesulfonyl chloride or methanesulfonyl chloride.
- 3. The process as claimed in claim 1, wherein cyclization is carried out within the temperature range from +50.degree. C. to 150.degree. C. using a strong acid.
- 4. The process as claimed in claim 1, wherein cyclization is carried out within the temperature range from -20.degree. to 80.degree. C. using an acid halide.
Priority Claims (1)
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3229046 |
Aug 1982 |
DEX |
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Parent Case Info
This is a continuation of Ser. No. 519,746, filed 8-2-83, and now abandoned.
US Referenced Citations (5)
Foreign Referenced Citations (1)
Number |
Date |
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7605A1 |
Mar 1981 |
EPX |
Non-Patent Literature Citations (1)
Entry |
Chem. Abs. 84 (7): 43593 x (1976)-Abstract of Japanese Patent 74 75,545 to Muro et al., for Inverting Steric Configurations of Aminoalcohols. |
Continuations (1)
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519746 |
Aug 1983 |
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