Claims
- 1. A method for making a medical device comprising a cellulose acetate hollow fiber semipermeable membrane, the method comprising the steps:
- (a) providing a molten liquid comprising cellulose acetate, a solvent for cellulose acetate, and a non-solvent for cellulose acetate;
- (b) melt-spinning the molten liquid to produce an extruded hollow fiber;
- (c) removing the solvent and the non-solvent from the extruded hollow fiber to provide the hollow fiber with a permeability level;
- (d) impregnating the hollow fiber with a liquid comprising a replasticizing agent that is resistant to drying;
- (e) drying at least a portion of the hollow fiber to facilitate potting of the dried portion;
- (f) potting at least a portion of the dried portion of the hollow fiber in a casing so as to produce a medical device;
- (g) rinsing the hollow fiber with a liquid consisting substantially of water so as to remove the replasticizing agent and to impregnate the hollow fiber with water so as to enable the medical device to be stored while preserving the permeability level of the hollow fiber.
Parent Case Info
This application is a division of application Ser. No. 08/456,345, filed on Jun. 1, 1995, now U.S. Pat. No. 5,645,778, which is a continuation-in-part of application Ser. No. 08/327,431, filed on Oct. 21, 1994, now U.S. Pat. No. 5,643,452, which is a continuation of application Ser. No. 07/976,949, filed on Nov. 16, 1992, now abandoned.
US Referenced Citations (15)
Non-Patent Literature Citations (7)
Entry |
Rowley, "A Screening Study of 12 Biocides for Potential Use With Cellulose Acetate Reverse Osmosis Membranes," Desalination 88:71-83 (1992). |
First Annual Progress Report: Research on Improved Hollow Fiber Artifical Kidney, NIH Contract No. NIH-NIAMDD/70-2302, Nov. 1, 1971. |
Second Annual Progress Report: Research on Improved Hollow Kidney NIH Contract No. NIH-NIAMSS/70-2302, Dec. 31, 1972. |
Third Annual Progress Report: Studies on the Molecular Etiology of Uremia Using High Flux Cellulose Acetate Dialyzers, NIH Contract No. NIH-NIAMDD/70-2302, Aug. 15, 1973. |
Final Report: Research on Improved Hollow-Fiber Artificial Kidney, NIH Contract No. NIH-NIAMDD/70-2302, Dec. 31, 1973. |
Marketing Literature for DUO-FLUX.RTM. Cellulose Acetate Hemodialyzer, Althin CD Medical, Inc. (Date Unknown, but believed to be before filing date of subject application). |
Proceedings of the Second Annual Contractors' Conference of the Artificial Kidney Program of the National Institute of Arthritis and Metabolic Diseases, held Jan. 22-24, 1969, pp. 69-70. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
456345 |
Jun 1995 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
976949 |
Nov 1992 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
327431 |
Oct 1994 |
|