Claims
- 1. A process for preparing amorphous solids of macrolide antibiotics which are stable with the passage of time, said process consisting of spray drying a solution in a volatile organic solvent selected from the group consisting of dichloromethane, 1,1,1-trichloroethane and chloroform of a macrolide antibiotic and at least one cellulose polymer selected from the group consisting of ethyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose.
- 2. The process of claim 1, wherein said solvent is dichloromethane or 1,1,1-trichloroethane.
- 3. The process of claim 1, wherein the amount of said cellulose polymer is about 5 to about 40% by weight based on the weight of the macrolide antibiotic.
- 4. The process of claim 3, wherein the amount of said cellulose polymer is about 10% to about 30% by weight based on the weight of the macrolide antibiotic.
- 5. The process of claim 1, wherein the concentration of the macrolide antibiotic in the volatile organic solvent is about 5 to about 50% by weight.
- 6. The process of claim 5, wherein the concentration of macrolide antibiotic in the volatile organic solvent is about 10 to about 30% by weight.
- 7. The process of claim 1, wherein said cellulose polymer has a molecular weight of above about 1,000.
- 8. The process of claim 1, wherein said spray drying is conducted at a temperature of above about 60.degree. C.
- 9. A composition comprising at least one amorphous solid macrolide antibiotic and a cellulose polymer prepared by the process of claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
50-41822 |
Apr 1975 |
JPX |
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part application of copending U.S. patent application Ser. No. 674,204, filed Apr. 5, 1976, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3962419 |
Mayama et al. |
Jun 1976 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
674204 |
Apr 1976 |
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