Claims
- 1. In a process for the preparation of streptovaricin wherein a streptovaricin-producing strain belonging to the genus Streptomyces is cultured in a medium containing a nitrogen source, an assimilable carbon source and an inorganic salt, the improvement which comprises carrying out the culturing step in a medium containing at least one member selected from the group consisting of fumaric acid and its water soluble salts.
- 2. The process of claim 1 wherein said water soluble salt is selected from the group consisting of potassium fumarate, sodium fumarate, potassium sodium fumarate, monopotassium fumarate, monosodium fumarate, and combinations thereof.
- 3. The process of claim 1 wherein said medium is cultured at a pH of from about 5.5 to 7.5.
- 4. The process of claim 1 wherein said medium is cultured at a temperature of from about 23.degree. C. to 37.degree. C.
- 5. The process of claim 1 wherein said medium is cultured at a temperature of from about 25.degree. C. to 30.degree. C.
- 6. The process of claim 1 wherein said medium is cultured for about 4 to 8 days.
Priority Claims (2)
Number |
Date |
Country |
Kind |
2-14285 |
Jan 1990 |
JPX |
|
2-14286 |
Jan 1990 |
JPX |
|
Parent Case Info
This is a division of application Ser. No. 07/601,875, filed Oct. 23, 1990, now U.S. Pat. No. 5,126,254.
US Referenced Citations (7)
Non-Patent Literature Citations (2)
Entry |
K. L. Rinehart Jr., et al. "Relative Biological Activities of Individual Streptovaricins & Acetates", Biochem. vol. 13, No. 5, pp. 861-867 (1974). |
K. Sasaki et al. "Chemical Modification of Streptovaricins C", J. Antibiotics vol. 29, No. 2, pp. 147-154 (Feb. 1976). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
601875 |
Oct 1990 |
|