Claims
- 1. Process for the preparation of an aminophenol with a functional or functionalizable substituent para to the amino group, said process comprising reacting (i) an aminophenol having no substituent in the para position to the amino group, with (ii) an unhindered, non-enolizable aldehyde selected from the class consisting of
- (a) R.sup.4 OOC--CHO, wherein R.sup.4 is hydrogen or an alkyl or aryl group having up to 30 carbon atoms, and
- (b) an arylaldehyde; and (iii) a reactant selected from the class consisting of thiols and sulfinic acids and their metal salts; said process being conducted in the presence of an acid promoter having sufficient acidity to form a salt of said aminophenol.
- 2. Process of claim 1 wherein said aminophenol reactant has the formula ##STR23##
- 3. Process of claim 1 wherein said non-enolizable aldehyde has the formula R.sup.4 OOC--CHO.
- 4. Process of claim 3 wherein said non-enolizable aldehyde is HOOC--CHO.
- 5. Process of claim 3 wherein said non-enolizable aldehyde is an arylaldehyde.
- 6. Process of claim 1 for the preparation of ##STR24## said process comprising reacting 5-chloro-2-hydroxyaniline hydrochloride, glyoxylic acid monohydrate, and p-toluenethiol.
- 7. Process of claim 1 for the preparation of ##STR25## comprising reacting 2-aminophenol, benzaldehyde, and sodium benzenesulfinate in ethanol.
"CROSS-REFERENCE TO RELATED APPLICATION
This application is a division of application Ser. No. 380,347, filed July 17, 1989 now U.S. Pat. No. 4,940,812."
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3779763 |
Lau |
Dec 1973 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
0385271 |
Sep 1990 |
EPX |
2069498 |
Aug 1981 |
GBX |
Non-Patent Literature Citations (2)
Entry |
Chemical Abstracts, vol. 64, No. 3, Jan. 31, 1966, col. 3471 a-c, "Reactions of Anils with Vinyl Butyl Sulfide", Povarov et al. |
Grillot et al., "Condensation of Throphenols and Formaldehyde with Some Aromatic Amines", CA 54,5530i, 1960. |
Divisions (1)
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Number |
Date |
Country |
Parent |
380347 |
Jul 1989 |
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