Patent Grant
7439401
The present invention relates to a new, selective process for the preparation of mono- and bisacylphosphanes, mono- and bisacylphosphane oxides or mono- and bisacylphosphane sulfides.
The European Patent Publication EP1 135 399 B1 describes a process for the preparation of mono- and bisacyiphosphanes, of mono- and bisacylphosphane oxides and of mono- and bisacyiphosphane sulfides, which process comprises first reacting organic P-monohalogeno-phosphanes or P,P-dihalogenophosphanes or mixtures thereof, with an alkali metal or magnesium in combination with lithium, where appropriate in the presence of a catalyst, and then carrying out the reaction with add halides and, in the case of the process for the preparation of oxides, carrying out an oxidation step and, in the case of the preparation of sulfides, reacting the phosphanes so obtained with sulfur. The reaction is usefully carried out in a solvent. The solvent used may be, in particular, ethers which are liquid at normal pressure and room temperature. Examples thereof are dimethyl ether, diethyl ether, methyl-propyl ether, 1,2-dimethoxyethane, bis(2-methoxyethyl)ether, dioxane or tetrahydrofuran. Tetrahydrofuran is preferably used.
The International Application PCT/EP 03/50873, describes a process to prepare cycloorganyl phosphanes of the formula (R1P)n by reacting R1PHal2 with an alkali metal or an alkaline-earth metal in an organic solvent such as toluene in the presence of an activator, e.g. N,N,N′,N′-tetramethylethylenediamine (TMEDA).
Furthermore, PCT/EP 03/50873 describes the preparation of sodium ceatena-oligophosphane-α,ω-diides, e.g. the preparation of Na(L)3[Na5(P2Ph2)3(L)] (L=solvent), which can react with mesitoylchloride (MesCO-Cl) to obtain acylphosphanes of the formula PhP(COMes)2.
H. Schindlbauer et al (Monatshefte Chemie 90 148 [1959]) describes a method for producing phosphanes by reacting R1PHal2 with 4 equivalents of highly dispersed sodium in toluene to obtain R1PNa2 and subsequent reaction with alcohol/water. The alcohol used is ethanol.
The Schindibauer process has the drawback that a considerable amount of undesired by-products are obtained which need to be removed.
Accordingly, there still remains a need for a process to produce acylphosphanes directly from an organic phosphorus halide resulting in a high yield and a substantially complete conversion.
It has been found that the required selectivity can be achieved by using a proton source like sterically hindered alcohols, trialkylamine hydrohalogenes, bisarylamines, malono nitrile, malonic acid esters, amidine hydrohalogene and carboxylic acids.
The invention relates to a process for the preparation of acylphosphanes of formula I
wherein
group;
(1) reacting a phosphorous halide of formula IIa or a phosphorous halide oxide of formula IIb or a phosphorous halide sulfide of formula IIc
(2) subsequent reaction with m acid halides of formula III
wherein R2, Hal and m have the meaning cited above.
In another of its aspect, this invention relates to a process for the preparation of monoacylphosphanes of the formula I′ (compounds of the formula I with n=1 and m=1)
wherein R1, R2 and R3 are as defined above,
by
(1) reacting organic phosphorus halides of formula II′
R1—P(Hal)2 (II′)
(2) subsequent reaction with an acid halide of formula III′
The sequence of addition of the acid halide and the compound R3-Hal can be Interchanged. Thus, it is possible to add first the compound R3-Hal and then the acid halide.
In another of its aspect, this invention relates to a process for the preparation of symmetric bisacylphosphanes of the formula I″ (compounds of the formula I with n=1 and m=2)
wherein R1 and R2 are as defined above by
(1) reacting organic phosphorus halides of formula II″
R1—P(Hal)2 (II″)
(2) subsequent reaction with an acid halide of formula III″
wherein R2 and Hal are as defined above.
In another of its aspect, this invention relates to a process for the preparation of un-symmetric bisacylphosphanes of the formula I′″ (compounds of the formula I with n=1 and m=2)
wherein R1 is as defined above and R2 and R2′ independently of one another are as defined above under R2 with the proviso that R2 is not equal R2′
by
(1) reacting organic phosphorus halides of formula II″
R1—P(Hal)2 (II″)
wherein R1 and Hal are as defined above,
(2) subsequent reaction with an acid halide of formula III″
wherein R2 and Hal are as defined above,
(3) subsequent reaction with a second acid halide III′″
wherein R2′ and Hal are as defined above.
In another of its aspects, this invention also relates to a process for the preparation of mono acylated phosphanes of the formula VI and VI′
where R1, R2, R2′ are defined as above and Me is Li, Na, K,
by
(1) reacting organic phosphorus halides of formula II″
R1—P(Hal)2 (II′)
wherein R1 and Hal are as defined above,
(2) subsequent reaction with an acid halide of formula III″ or III′″
wherein R2, R2′ and Hal am as defined above.
The mono acylated phosphanes of formula VI and VI′ can be isolated by standard techniques known to the person skilled in the art.
Compounds of formula VI and VI′ can serve as starting materials for the synthesis of compounds of formula I′, I″ and I′″ as described above.
In another aspect of the invention step (1) is carried out by reacting diphospanes of the formula (R1)2—P—P(R1)2 or polyphosphanes of the formula [R1P]n, wherein R1 is as defined above and n is ≧3, with an alkali metal in a solvent in the presence of a proton source like sterically hindered alcohols, trialkylamine hydrohalogenes, bisarylamines, malono nitrile, malonic acid esters, amidine hydrohalogene and carboxylic acids; followed by the reaction with acid halides (III, III′, III″, III′″) and/or by reaction with electrophilic compounds R3-Hal.
In another of its aspects, this invention relates to a process for the preparation of acylphosphane oxides and acylphosphane sulfides of formula IV
wherein
The proton source is selected from sterically hindered alcohols, trialkylamine hydro-halogenes, bisarylamines, malono nitrile, malonic acid esters, amidine hydrohalogene and carboxylic acids.
The sterically hindered alcohol is selected from the group consisting of secondary or tertiary C3-C18alcohols, preferably of t-butanol, tert.-amyl-alcohol, 3-methyl-3-pentanol, 3-ethyl-3-pentanol, triphenylmethanol, 3,7-dimethyl-3-octanol, 2-methyl-1-phenyl-2-propenol, 2-methyl-4-phenyl-2-butanol, fenchyl alcohol, 2,4-dimethyl-3-pentanol, 1-dimethylamino-2-propanol or hexylene glycol.
The trialkylamine hydrohalogene is selected from tert. (C1-C8)3N—HCl, preferably trimethylamine hydrochloride, triethylamine hydrochloride or tributylamine hydrochloride.
Suitable alkali metals are lithium, sodium or potassium, preferably sodium. It is also possible to use magnesium in combination with lithium.
C1-C18Alkyl is linear or branched and is, for example, C1-C12-, C1-C8-, C1-C5- or C1-C4alkyl. Examples are methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, pentyl, hexyl, heptyl, 2,4,4-trimethylpentyl, 2-ethylhexyl, octyl, nonyl, decyl, undecyl, dodecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl or octadecyl.
C1-C12-, C1-C5- and C1-C4Alkyl are also linear or branched and have, for example, the meanings cited above up to the corresponding number of carbon atoms.
C2-C18Alkyl, which is interrupted once or several times by non-successive —O—, is interrupted, for example, 1-9, e.g. 1-7, 1-5, 1-3 or 1 or 2, times by —O—, the O atoms always being interrupted by at least one methylene group. The alkyl groups may be linear or branched. The structural units obtained are thus, for example, —CH2—O—CH3, —CH2CH2—O—CH2CH3, —[CH2CH2O]yCH3, where y=1-8, —(CH2CH2OCH2CH3, —CH2—CH(CH3)—O—CH2—CH2CH3 or —CH2—CH(CH3)—O—CH2—CH3.
C2-C18Alkenyl radicals may be mono- or polyunsaturated, linear or branched and are, for example, vinyl, allyl, methallyl, 1,1-dimethylallyl, propenyl, butenyl, pentadienyl, hexenyl or octenyl, preferably vinyl or allyl, R2 defined as C2-C18alkenyl is typically C2-C8—, C2-C8—, preferably C2-C4alkenyl.
C5-C12Cycloalkyl is, for example, cyclopentyl, cyclohexyl, cyclooctyl, cyclododecyl, preferably cyclopentyl and cyclohexyl, more preferably cyclohexyl. C3-C12Cycloalkyl is additionally e.g. cyclopropyl.
C1-C8Alkoxy is linear or branched radicals and is typically methoxy, ethoxy, propoxy, isopropoxy, n-butyloxy, sec-butyloxy, isobutyloxy, tert-butyloxy, pentyloxy, hexyloxy, heptyloxy, 2,4,4-trimethylpentyloxy, 2-ethylhexyloxy or octyloxy, preferably methoxy, ethoxy, propoxy, isopropoxy, n-butyloxy, sec-butyloxy, isobutyloxy, tert-butyloxy, most preferably methoxy.
Halogen is fluoro, chloro, bromo and iodo, preferably chloro and bromo, most preferably chloro.
Examples of O-, S- or N-containing 5- or 6-membered heterocyclic rings are furyl, thienyl, pyrrolyl, oxinyl, dioxinyl or pyridyl. The cited heterocyclic radicals may be substituted by one to five, e.g. by one or two, linear or branched C1-C8alkyl, halogen and/or C1-C8alkoxy. Examples of such compounds are dimethylpyridyl, dimethylpyrrolyl or methylfuryl.
Examples for —N(Ra8)2, —N(R9)2 forming a 5- or 6-membered O-, S- or N-containing heterocyclic rings are:
with R8 as defined above.
Substituted phenyl, naphthyl or biphenyl is substituted by one to five, e.g. by one, two, three or four, preferably by one, two or three, for example linear or branched C1-C8alkyl, linear or branched C1-C8alkoxy or by halogen.
Preferred substituents for phenyl, naphthyl and biphenyl are C1-C4alkyl, preferably methyl, C1-C4alkoxy, more preferably methoxy, and chloro. Particularly preferred substituents are, for example, 2,4,6-trimethylphenyl, 2,6-dichlorophenyl, 2,6-dimethylphenyl or 2,6-dimethoxyphenyl.
R2 is, for example, C1-C18alkyl or phenyl, preferably 2,4,6-trimethylphenyl, 2,6-dimethylphenyl or 2,6-dimethoxyphenyl, most preferably 2,4,6-trimethylphenyl.
R1 and R3 are preferably unsubstituted phenyl, C1-C6alkyl-substituted phenyl or C1-C6alkoxy-substituted phenyl, most preferably phenyl.
R1 defined as C1-C18alkylene is linear or branched alkylene, such as methylene, ethylene, propylene, isopropylene, n-butylene, sec-butylene, isobutylene, tert-butylene, pentylene, hexylene, heptylene, octylene, nonylene, decylene, dodecylene, tetretadecylene, heptadecylene or octadecylene. R1 is preferably C1-C12alkylene, e.g. ethylene, decylene,
If R1 is C2-C18alkylene which is interrupted by one or several non-successive O atoms, then structural units such as —CH2—O—CH2—, —CH2CH2—O—CH2CH2—, —[CH2CH2O]y— are obtained, where y=1-9, —(CH2CH2O)7CH2CH2— or —CH2—CH(CH3—O—CH2—CH(CH3)—.
If alkylene is interrupted by several O atoms, then these O atoms are always separated from each other by at least one methylene group.
Phenyl-C1-C4alkyl is, for example, benzyl, phenylethyl, α-methylbenzyl or α,α-dimethyl-benzyl, preferably benzyl. Phenyl-C1-C2alkyl is particularly preferred.
C1-C4Alkylphenyl is typically tolyl, xylyl, mesityl, ethylphenyl, diethylphenyl, preferably tolyl or mesityl.
C1-C6Alkoxyphenyl is phenyl which is substituted by one to four alkoxy radicals, for example 2,6-dimethoxyphenyl, 2,4-dimethoxyphenyl, 2,4 dipentoxyphenyl, methoxyphenyl, ethoxyphenyl, propoxyphenyl or butoxyphenyl.
Phenylene is 1,4-, 1,2- or 1,3-phenylene, preferably 1,4-phenylene.
If phenylene is substituted, it is mono- to tetra-substituted, e.g. mono-, di- or trisubstituted, preferably mono- or disubstituted, at the phenyl ring. Xylylene is o-, m- or p-xylylene:
and is, for example, mono- to tetrasubstituted, e.g. mono-, di- or trisubstituted, preferably mono- or disubstituted, at the phenyl ring.
Preferred substituents:
In the above-described processes, R1, if n=1, is C1-C12alkyl, cyclohexyl, phenyl or biphenyl, the radicals phenyl and biphenyl being unsubstituted or substituted by one to four C1-C8alkyl and/or C1-C8alkoxy;
R1, if n=2, is C6-C10alkylene, or
R3 is C1-C12alkyl, cyclohexyl, phenyl or biphenyl, the radicals phenyl and biphenyl being un-substituted or substituted by one to four C1-C8alkyl and/or C1-C8alkoxy;
Q is a single bond or —O—, and R4 and R5 are hydrogen.
Compounds to be highlighted in the above processes are those of formula I, wherein R2 is phenyl which is substituted in 2,6- or 2,4,6-position by C1-C4alkyl and/or C1-C4alkoxy.
Compounds of formula I which are particularly preferably used in the above process are those wherein n is 1.
The residue “Hal” is preferably chloro.
Other preferred compounds of formula I in the above process are those, wherein m is defined as the number two, i.e. bisacylphosphane or bisacylphosphane oxides or bisacylphosphane sulfides.
A preferred process is that, wherein in formula, I, n is 1, m is 1 or 2, R1 is phenyl which is un-substituted or substituted by C1-C4alkyl or C1-C8alkoxy, or R1 is C1-C12alkyl; R2 is C1-C18alkyl or phenyl which is substituted by halogen, C1-C4alkoxy or C1-C4alkyl; and R3 is unsubstituted or C1-C4alkyl-substituted phenyl.
In the novel process for the preparation of mono- and bisacylphosphanes, an organic phosphorous halide of formula ha or a phosphorous halide oxide of formula IIb or a phosphorous halide sulfide of formula IIc is first reacted in a solvent with an alkali metal in the presence of a proton source like sterically hindered alcohols, trialkylamine hydrohalogenes, bisarylamines, malono nitrile, malonic acid esters, amidine hydrohalogene and carboxylic acids.
This first step includes two different reaction types, a metallation and a reduction step.
The metallation is carried out by reacting a compound of the formula IIa, IIb, or IIc with an alkali metal in a solvent, whereby a metallized phosphanide of the formula V
R1—P(Me)-P(Me)-R1 (V)
is formed together with cyclic phosphanes (R1P)n, n≧3 as intermediates. Me is lithium, sodium or potassium or magnesium in combination with lithium and R1 is as defined above.
It is useful to employ from 4 to 6 atom equivalents of an alkali metal in solid or molten form, preferably sodium, for the preparation of bisacylphosphanes or monoacylphosphanes prepared from R1PHal2, and 2 to 3 atom equivalents of an alkali metal in solid or molten form for the preparation of monoacylphosphanes prepared from (R1)2PHal. It is not necessary that the alkali metal is highly dispersed.
Catalytic amounts of alkali or earth alkali hydroxides or of Na, K or Li alcoholates or of alcohols, preferably sterically hindered alcohols may be added prior or during the metallation step.
In addition combinations of catalytic amounts of alkali and/or earth alkali metals and/or sterically hindered alcohols may be added prior or during the metallation step.
Catalytic amounts refer to ranges from 0.1-50 mol % with respect to the phosphorous organic compound IIa, IIb or IIc.
The reaction is carried out in an arene solvent such as in benzene, toluene, o-, m- or p-xylene, mesitylene, ethylbenzene, diphenylethane, 1,2,3,4tetrahydronaphtaline (tetraline), isopropylbenzene (cumol) or in mixtures thereof.
The reaction temperature is preferably above the melting temperature of sodium. It is recommended to stirr the reaction mixture.
The reduction is carried out by reacting the intermediate V and/or (R1P)n, n≦3 with a proton source like sterically hindered alcohols, trialkylamine hydrohalogenes, bisarylamines, malono nitrile, malonic acid esters, amidine hydrohalogene and carboxylic acids in the presence of surplus alkali metal from the metallation step whereby a protonated and/or a metallized phosphane (IId) and a protonated and/or metallized diphosphane (IIe) R1—P(H,Me)-P(H,Me)-R1 is formed via different intermediary steps as the main component.
R1, R3, Me, m and n have the meaning cited above,
The amount of the diphosphane (IIe) can be influenced by appropriate addition of the above mentioned catalysts prior, during or after the metallation step. Preferred catalysts are, for example, alkali-or earth alkali hydroxides in amounts of 0.1-10 mol % with respect to the phosphorous organic compound IIa, IIb and IIc. Other preferred catalysts are, for example, Li, Na or K alcoholates, preferably alcoholates of sterically hindered alcohols and most preferably KOH and sterically hindered K-alcoholates in amounts of 5-50 mol % with respect to IIa, IIb and IIc.
In a further embodiment, the process starts with a birch-like reduction of diphospanes of the formula (R1)2—P—P(R1)2 or polyphosphanes of the formula [R1P]n, wherein R1 is as defined above and n is ≧3 with a metal, preferably sodium, in the presence a proton source like sterically hindered alcohols, trialkylamine hydrohalogenes, bisarylamines, malono nitrile, malonic acid esters, amidine hydrohalogene and carboxylic acids to obtain phosphanes of the formula R1PH2 or (R1)2PH. The phosphanes are then reacted with an acid halide or an electrophilic compound R3-Hal.
The above diphospanes of the formula (R1)z—P—P(R1)2 or polyphosphanes of the formula [R1P]n may be prepared as describes in the Int. Application PCT/EP 03150873 by reacting R1PHal2 with an alkali metal or an alkaline-earth metal in an organic solvent such as e.g. in toluene optionally in the presence of an activator such as e.g. N,N,N′,N′-tetramethylethylenediamine (TMEDA) or by reacting R1PHal2 with active zinc in the presence of a solvent.
The reduction step is the essential feature in the above-described novel process, as this step was shown to be largely responsible for the improved selectivity of the whole process.
The reduction step can be carried out in the presence of an activator such as amines (triethylamine, tributylamine, piperidine, morpholine, N-methylpiperidine, N-methyl morpholine) or polyamines such as, for example TMEDA=N,N,N′,N′-tetramethylethylenediamine.
It is useful to employ from 1 to 2 equivalents of a proton source like sterically hindered alcohols, trialkylamine hydrohalogenes, bisarylamines, malono nitrile, malonic acid esters, amidine hydrohalogene and carboxylic acids. The solvent is preferably the same as in the metallation step.
The reaction temperatures are preferably in the range from −20° C. to +160° C., e.g. from 80° C. to 140° C.
The protonated and/or metallized phosphane (IId) and (IIe) obtained as described above is reacted in the next reaction step with acid halides (III, III′, III″, III′″) or with electrophilic compounds R3-Hal to the mono- or bisacylphosphane (I, I′, I″, I′″).
In addition, it is also possible to directly react the metallized phosphanide (V) or the mixture of (V) with the cyclic phosphanes (R1P)n, n>=3, with the acid halides (III, III′, III″, III′″) or with electrophilic compounds R3-Hal to the mono- or bisacyiphosphane (I, I′, I″, I′″).
The solvents used may be, for example, the same as those used above for the first step. However, it is also possible to remove the solvent used in the first step by distillation and to take up the residue in another solvent and then to further process it. It is preferred to work in the same solvent as in the preceding step, preferably in xylene or toluene.
It is possible to add polar or dipolar co-solvents to the reaction mixture during or after the reduction step. Such solvents may be linear or cyclic amides like dimethylacetamide (DMA), n-methyl pyrrolidone (NMP), cydic ureas like 1,3-dimethypropylene urea (DMPU), linear and cyclic glycols like diglyme and dimethoxyethane (DME).
The reaction temperatures for the reaction with the acid halide are usefully in the range from −20° to +80° C.
The mono- or bisacylphosphane of formula I can be isolated by the customary technological methods which are known to the skilled person, for example by filtration, evaporation or distillation. Likewise, the customary methods of purification may be used, for example crystallisation, distillation or chromatography.
However, the phosphanes can also be reacted without isolation to the corresponding mono- or bisacylphosphane oxides or mono- or bisacylphosphane sulfides.
Using the process of this invention it is also possible to prepare mono- and bisacylphosphanes together in one reaction step.
Depending on the substituents used, unsymmetric compounds may be formed by the novel process.
Monoacylphosphane oxides are compounds of the formula I′ corresponding to compounds of the formula I wherein n=1 and m=1.
The residues R1 and R3 may be the same or may be different.
Bisacylphosphane oxides are compounds of the formula I′″ corresponding to compounds of the formula I wherein n=1 and m=2.
The residues R2 and R2′ may be the same or may be different.
By means of the novel process it is furthermore also possible to prepare mixtures of aliphatic and aromatic monoacylphosphanes or mixtures of aliphatic and aromatic bisacylphosphanes.
If required, all of the mixtures may be separated by the processes customarily used in the technology or they may be further used as they are.
This invention also relates to a process for the preparation of mono- and bisacylphosphane oxides or mono- and bisacylphosphane sulfides. This process is first carried out as described above and a mono- or bisacylphosphane (I) is prepared. The crude reaction product (I) can then be further processed without purification and an additional reaction step may be carried out without isolation of the phosphane (I) using the solution of the crude product. If required, the solvent may be changed, for example, by concentrating the solution containing the mono- or bisacylphosphane and taking up the residue in a new solvent. Of course it is also possible to further react above-described unseparated mixtures of compounds of formula (I) to the corresponding oxide or sulfide.
It is recommended to adjust the pH of the reaction mixture prior to the oxidation step to a pH of 2-8, preferabyl to a pH of 3-6 by addition of typical inorganic and/or organic acids or buffer systems.
When preparing the respective oxide (IVa), the oxidation of the phosphane (I) is carried out using the oxidant conventionally used in the technology:
Suitable oxidants are in particular hydrogen peroxide and organic peroxy compounds, for example peracetic acid or t-butylhydroperoxide, air or pure oxygen.
The oxidation is usefully carried out in solution. Suitable solvents are aromatic hydrocarbons, such as benzene, toluene, m-xylene, p-xylene, ethylbenzene or mesitylene, or aliphatic hydrocarbons, such as alkanes and alkane mixtures, e.g. petroleum ether, hexane or cyclohexane. During oxidation, the reaction temperature is preferably kept in the range from 0° to 120° C., preferably from 200 and 80° C.
The reaction products (IVa) can be isolated and purified by conventional processing methods known to the skilled person.
The respective sulfide (IVb) is prepared by reaction with sulfur:
The mono- or bisacylphosphanes (I) are in this case reacted in substance or, where appropriate, in a suitable inert organic solvent with an equimolar to 2-fold molar amount of elementary sulfur. Suitable solvents are for example those described for the oxidation reaction. However, it is also possible to use e.g. aliphatic or aromatic ethers, such as dibutyl ether, dioxane, diethylene glycol dimethyl ether or diphenyl ether, in the temperature range from 200 to 250° C., preferably from 600 to 120° C. The resulting mono- or bisacylphosphane sulfide, or its solution, is usefully freed from any remaining elementary sulfur by filtration. After the solvent is removed, the mono- or bisacylphosphane sulfide can be isolated by distillation, chromatography or recrystallisation in pure form.
As mentioned above, it is also possible to use mixtures of compounds of formula I for the oxidation or reaction to the sulfide. The correspondingly obtained oxide or sulfide mixtures can either be separated by processes customarily used in the technology or may be used as mixtures.
All of the above reactions are usefully carried out with exclusion of air in an inert gas atmosphere, e.g. under nitrogen or argon gas. The respective reaction mixture is usefully also stirred.
The acid halides (III, III′, III″, III′″) or the electrophilic compounds R3-Hal used as starting materials are known substances, some of which are commercially available, or may be prepared in analogy to known compounds.
The preparation of the phosphorus halides (II) is also described in a great number of publications and can be carried out in analogy to the descriptions provided there. In J. Chem. Soc. (1935), 462 and J. Chem. Soc. (1944), 276, W. Davies discloses for example the preparation of aryl phosphorus chlorides by reaction of arylene with phosphorus trichloride in the presence of aluminum trichloride. According to F. Nief, Tetrahedron 47 (1991) 33, 667 or Th. Knapp, Tetrahedron 40(1984) 4, 76, the Grignard reaction of aryl halides with magnesium and phosphorus trichloride is another possibility. According to S. Metzger, J. Org. Chem. 29 (1964), 627, alkylphosphorus chlorides are accessible in the same manner. In Helv. Chim. Act. 36 (1953), 1314, Th. Weil describes the reaction of aryl halides or alkyl halides with magnesium followed by the reaction with zinc chloride and subsequent reaction with phosphorus trichloride. The reaction of aryl halides with butyl lithium and phosphorus trichloride to the corresponding aryl phosphorus chloride is disclosed by G. Whitesides in JACS 96 (1974), 5398. According to Th. Knapp, Tetrahedron 40 (1984) 4, 765, the reaction of the aryl magnesium halide with bis(dimethylamino)phosphorus chloride followed by the reaction with hydrochloric acid also results in the desired starting material. According to A. Burg, U.S. Pat. No. 2,934,564, the same method may also be used for the preparation of the corresponding alkyl phosphorus chlorides.
It is characteristic of the novel process that the individual processing steps can be carried out directly one after the other without the need for isolating and purifying the respective intermediates.
Mixtures such as those described in the process for the preparation of the corresponding phosphanes may also be formed, or may also be specifically produced, in the above-described process for the preparation of mono- or bisacylphosphane oxides or mono- or bis-acylphosphane sulfides. Such mixtures can be separated by methods known in the technology or may be further used in the form of mixtures.
The phosphanes which are accessible by the novel process are important educts for the preparation of the corresponding phosphane oxides and phosphane sulfides. The phosphane oxides and phosphane sulfides are used in the art as initiators in photopolymerisation reactions.
The following examples illustrate the invention in more detail, although it is not intended that the invention be limited to the examples. As in the remaining description and in the patent claims, parts or percentages are by weight, unless otherwise stated.
General Solvents are used as received (without any treatment) or dried over molecular sieves or by azeotropic distillation. The course of the reaction is monitored by 31P-NMR spectroscopy.
formula I′″, R1=phenyl, R2, R2′=mesityl;
a) Metallation of P,P-dichlorophenylphosphine in Toluene at 98-110° C.
Excluding moisture by an argon atmosphere, sodium lumps (20.61 g, 0.896 mol) are suspended at room temperature in toluene (870 g). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 98° C. After formation of a fine sodium suspension P,P-dichlorophenylphosphine (40.10 g, 0.224 mol) is dropwise added over one hour under vigorous stirring. Heating under reflux for an additional 16 h leads to the formation of a yellow precipitate.
b) Protonation/Reduction
The yellow suspension is dropwise treated with tert-butanol (33.20 g, 0.448 mol) over one hour at 98-110° C. Stirring is continued under reflux until all sodium is used up (ca. one hour).
c) Acylation
To the resulting thin, yellow suspension is added 2,4,6-trimethylbenzoyl chloride (82.12 g, 0.450 mol) at such a rate that the temperature is kept at 35-37° C. The mixture is then stirred for another hour at 35-37° C.
d) Oxidation using 30% H2O2 at 40-50° C.
To the resulting thin, light yellow suspension is dropwise added 30% hydrogen peroxide (76.16 g, 0.672 mol) at such a rate that the temperature is kept between 40-50° C. Stirring is continued for 2 h at 40-50° C. The light yellow suspension is treated with 250 g of 5% aqueous NaHCO3, and then stirred for 5 min at 40-50° C. The two phases are separated and the organic phase washed with water (2×250 g). After evaporation of toluene, heptane (150 g) is added, the mixture heated up to 80° C. and then cooled to room temperature. The resulting solid is collected and washed with heptane (2×60 g). 71.0 g (75.7%) of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide are obtained as light yellow powder with a melting point of 130-131° C.
In the following tables conditions and results of typical experiments are summarized which have been conducted based on the procedure described in Example 1. Variations of conditions in synthetic steps indicated in the header of each table are related to the four steps a)-d) described in Example 1.
Abbreviations Conc.: concentration [mol PhPCl2/total weight (in kg) of metallation reaction]; TMBCI=1,3,5-trimethylbenzoyl chloride; Equivalents (eq.) of reagents (Na, etc.) are related to the amount of PhPCl2 (mol) used.
General Yields of bis(2,4,6-trimethylbenzoyl)-phenylphosphine oxide given in Table 2-8 have been calculated from the 1H-NMR spectra of the crude isolated product material. In some cases yields have been further confirmed by the isolation of pure bis(2,4,6-trimethylbenzoyl)-phenylphosphine oxide product via recrystallization from heptane or flash chromatography.
a)DEGDEE = diethylene glycol diethylether.
b)TMEDA = N,N,N′,N′-tetramethylethylenediamine.
a)Additive is added to the reaction mixture prior to the metallation step.
b)TMEDA = N,N,N′,N′-tetramethylethylenediamine.
c)Yield of pure bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide after recrystallization from heptane; melting point 130-131° C.
d)Prior to the oxidation reaction the pH has been adjusted to four.
e)Liquid sodium.
a)Additive is added to the reaction mixture prior to the metallation step.
b)Prior to the oxidation reaction the pH has been adjusted to four.
c)The oxidation has been performed with 1.5 equiv. of peracetic acid solution instead of aqueous 30% hydrogen peroxide.
d)80% yield of pure bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide has been obtained after recrystallization from heptane.
e)3-Methyl-3-pentanol has been distilled off under vacuum during the acylation reaction (ca. 25% of the total amount of 3-methyl-3-pentanol used).
f)3-Methyl-3-pentanol has been distilled off under vacuum during the acylation reaction (ca. 50% of the total amount of 3-methyl-3-pentanol used).
g)82% yield of pure bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide has been obtained after recrystallization from heptane.
h)Yield of pure bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide after recrystallization from heptane.
i)Yield not determined.
a)Triphenylmethanol has been dissolved in a minimum amount of THF prior to the addition to the reaction mixture.
b)NaOtBu (3 equiv.) has been added prior to the acylation reaction.
b)Additive has been added after the reduction/protonation step, followed by additional heating of the reaction mixture.
a)Additive has been added prior to the reduction/protonation step.
b)Additive has been added after the reduction/protonation step, followed by additional heating of the reaction mixture.
c)Metallation reaction has been catalyzed by the addition of 0.02 equiv. of alcohol.
d)Prior to the oxidation reaction the pH has been adjusted to four.
e)The protonation/reduction step has been performed at 150° C.
f)Yield not determined.
g)Yield of pure bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide after purification by flash chromatography.
a)0.15 equiv. of alcohol added prior to the metallation of PhPCl2 with sodium metal.
b)The pH has been adjusted to four prior to the oxidation reaction.
c)The oxidation has been performed with 1.5 equiv. of peracetic acid solution instead of 30% aqueous H2O2.
a)Conc. = 0.7 mol/kg.
b)4.15 eq. Na - addition of 0.5 eq. Li after the protonation/reduction step.
c)4.15 eq. Na - addition of 0.3 eq. Li after the protonation/reduction step.
d)pH has been adjusted after the acylation reaction to the given value by the addition of 1M HCl solution.
a) Metallation of P,P-dichlorophenylphosphine
Excluding moisture by an argon atmosphere, sodium lumps (20.61 g, 0.896 mol) are suspended at room temperature in a mixture of toluene (870 g) and TMEDA (N,N,N′,N′-tetramethylethylenediamine) (31.23 g, 0.268 mol). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 98° C. After formation of a fine sodium suspension P,P-dichlorophenylphosphine (40.10 g, 0.224 mol) is dropwise added over one hour under vigorous stirring. Heating under reflux for an additional 22 h leads to a yellow precipitate.
b) Protonation/Reduction
The yellow suspension is dropwise treated with tert-butanol (33.20 g, 0.448 mol) over one hour at 98-110° C. Stirring is continued under reflux until all of the sodium is used up.
c) Acylation and Neutralisation of TMEDA
To the resulting thin, yellow supension is added 2,4,6-trimethylbenzoyl chloride (82.12 g, 0.450 mol) at such a rate that the temperature is kept at 35-37° C. The mixture is then stirred for another hour at 35-37° C.
Concentrated H2SO4 (27.46 g, 0.270 mol) is dropwise added at room temperature under vigorous stirring at such a rate that the temperature is kept below 40° C. Stirring is continued at room temperature for 10 min.
d) Oxidation using 30% H2O2 at 40-50° C.
To the resulting, thin, light yellow suspension is dropwise added 30% hydrogen peroxide (76.16 g, 0.672 mol) at such a rate that the temperature is kept at 40-50° C. Stirring is continued for 1-2 h at 40-50° C. The light yellow suspension is treated with 250 g of 5% aqueous NaHCO3, and then stirred for 5 min at 40-50° C. The phases are separated and the organic phase washed with water (2×250 g). After evaporation of toluene, heptane (150 g) is added, the mixture heated up to 80° C. and then cooled to room temperature. The resulting solid is collected and washed with heptane (2×60 g). 70.4 g (75%) of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide are obtained as light yellow powder with a melting point of 130-131° C.
a) Metallation of P,P-dichlorophenylphosphine in Toluene at 98-110° C.
Excluding moisture by an argon atmosphere, sodium lumps (21.85 g, 0.940 mol) are suspended at room temperature in toluene (430 g), together with sodium hydroxide (0.09 g). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 98° C. After formation of a fine sodium suspension P,P-dichlorophenylphosphine (41.80 g, 0.224 mol) is dropwise added over 4 h under vigorous stirring. Heating is continued under reflux for ca. 5 h until all P,P-dichlorophenylphosphine has reacted (check by 31P-NMR).
b) Protonation/Reduction
The resulting greenish grey suspension is dropwise treated with tert-butanol (33.40 g, 0.448 mol) over 40 min at 98-110° C. Stirring is continued under reflux until all sodium is used up (ca. one hour).
c) Acylation
To the resulting thin, yellow suspension is added 2,4,6-trimethylbenzoyl chloride (82.53 g, 0.448 mol) at such a rate that the temperature is kept at 35-37° C. The mixture is then stirred for another hour at 35-37° C.
d) Oxidation using 30% H2O2 at 40-50° C.
To the resulting thin, yellow-orange suspension is dropwise added 30% hydrogen peroxide (30.50 g, 0.268 mol) at such a rate that the temperature is kept between 75-80° C. Stirring is continued for 1-2 h at 80° C. The light yellow suspension is treated with 150 g of 1% aqueous NaHCO3, and then stirred for 15 min at 65-70° C. The two phases are separated and the organic phase washed with water (3×80 g). After evaporation of toluene, heptane (150 g) is added, the mixture heated up to 98° C., stirred during 15 min, and then cooled to room temperature. The resulting solid is collected and washed with heptane (2×60 g). 73.8 g (78%) of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide are obtained as light yellow powder with a melting point of 130-131° C.
a) Metallation of P,P-dichlorophenylphosphine in Toluene at 98-110° C.
Excluding moisture by an argon atmosphere, sodium lumps (23.40 g, 1.008 mol) are suspended at room temperature in toluene (280 g), together with 3-methyl-3-pentanol (0.26 g). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 98° C. After formation of a fine sodium suspension P,P-dichlorophenylphosphine (44.50 g, 0.246 mol) is dropwise added over 4.5 h under vigorous stirring. Heating is continued under reflux for ca. 1 h until all P,P-dichlorophenylphosphine has reacted (check by 31P-NMR).
b) Protonation/Reduction
The resulting greenish grey suspension is dropwise treated with 3-methyl-3-pentanol (53.60 g, 0.514 mol) over 40 min at 98-110° C. Stirring is continued under reflux until all sodium is used up (ca. one hour).
c) Acylation
To the resulting thin, yellow suspension is added 2,4,6-trimethylbenzoyl chloride (91.62 g, 0.492 mol) at such a rate that the temperature is kept at 35-37° C. The mixture is then stirred for another hour at 35-37° C.
d) Oxidation using 30% H2O2 at 40-50° C.
To the resulting thin, yellow-orange suspension is first dropwise added H2O (125 g) at room temperature during 10 min. The reaction mixture is heated up to 60° C. followed by the addition of 30% hydrogen peroxide (30.62 g, 0.270 mol) at such a rate that the temperature is kept between 75-80° C. Stirring is continued for 30 min at 80° C. and the aqueous phase separated at 50° C. The light yellow suspension is treated with 77 g of 1% aqueous NaHCO3, and then stirred for 5 min at 40-50° C. The two phases are separated and the organic phase washed with water (3×36 g). After evaporation of toluene and 3-methyl-3-pentanol, heptane (132 g) is added, the mixture heated up to 80° C., stirred during 15 min, and then slowly cooled to room temperature. The resulting solid is collected and washed with heptane (2×25 g). 77.6 g (75.4%) of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide are obtained as light yellow powder with a melting point of 130-131° C.
a) Metallation of P,P-dichlorophenylphosphine in Toluene at 98-110° C.
Excluding moisture by an argon atmosphere, sodium lumps (22.66 g, 0.984 mol) are suspended at room temperature in toluene (280 g), together with potassium tert-butoxide (2.77 g, 0.024 mol). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 98° C. After formation of a fine sodium suspension P,P-dichlorophenylphosphine (44.50 g, 0.246 mol) is dropwise added over 9 h under vigorous stirring. Heating is continued under reflux for 15 min until all P,P-dichlorophenylphosphine has reacted (check by 31P-NMR).
b) Protonation/Reduction
The resulting yellow suspension is dropwise treated with 3-methyl-3-pentanol (51.29 g, 0.492 mol) over 1 h at 98-110° C. Stirring is continued under reflux until all sodium is used up (ca. one hour).
c) Acylation
To the resulting thin, yellow suspension is added 2,4,6-trimethylbenzoyl chloride (91.62 g, 0.492 mol) at such a rate that the temperature is kept at 35-37° C. The mixture is then stirred for another hour at 35-37° C.
d) Oxidation using 30% H2O2 at 40-50° C.
To the resulting thin, yellow-orange suspension is dropwise added H2O (125 g) at room temperature during 10 min. The reaction mixture is heated up to 60° C. followed by the addition of 30% hydrogen peroxide (30.62 g, 0.270 mol) at such a rate that the temperature is kept between 75-80° C. Stirring is continued for 2 h at 80° C. followed by the separation of the aqueous phase at 50° C. The resulting light yellow organic phase is stirred together with 77 g of 1% aqueous NaHCO3 for 5 min at 40-50° C. The two phases are separated and the organic phase washed with water (3×36 g). After evaporation of toluene and 3-methyl-3-pentanol, heptane (132 g) is added, the mixture heated up to 80° C., stirred during 15 min, and then slowly cooled to room temperature. The resulting solid is collected and washed with heptane (2×25 g). 80.3 g (78%) of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide are obtained as light yellow powder with a melting point of 130-131° C.
a) Metallation of P,P-dichlorophenylphosphine in Toluene at 110° C.
Excluding moisture by an argon atmosphere, potassium tert-butoxide (2.84 g, 24.6 mmol) is shortly stirred together with toluene (280 g) at room temperature. Stirring is stopped, and small sodium lumps (23.51 g, 1.021 mol) are added. The reaction mixture is heated up to 105° C. without stirring and kept at this temperature until all sodium is molten. Vigorous stirring is then started and continued until a fine sodium suspension is formed. P,P-dichlorophenylphosphine (44.47 g, 0.246 mol) is dropwise added to the suspension over 9 h at 10° C. under vigorous stirring. Heating is continued for 15 min until all P,P-dichlorophenylphosphine has reacted (check by 31P-NMR).
b) Protonation/Reduction
The resulting yellow suspension is dropwise treated with 3-methyl-3-pentanol (55.14 g, 0.529 mol) over 4 h at 110° C. Stirring is continued at 110° C. until all sodium is used up (ca. 15 min).
c) Acylation
To the resulting light yellow suspension is added 2,4,6-trimethylbenzoyl chloride (91.7 g, 0.492 mol) over 3 h at a temperature of 35-37° C. The mixture is then stirred for another hour at 35-37° C.
d) Oxidation using 30% H2O2 at 40-50° C.
To the resulting thin, yellow suspension is dropwise added H2O (155 g) at 35-37° C. during 30 min. The aqueous phase is then separated from the reaction mixture followed by treatment with an additional amount of H2O (45 g). After stirring for 5 min at 35-37° C. the reaction mixture is heated up to 60° C. followed by the addition of 30% hydrogen peroxide (27.86 g, 0.246 mol) during 2 h at such a rate that the temperature is kept between 78-82° C. Stirring is continued for 2 h at 78-82° C. followed by the separation of the aqueous phase at 65-70° C. The resulting light yellow organic phase is washed with water (3×36 g) at 65-70° C. After evaporation of toluene and 3-methyl-3-pentanol, heptane (100 g) is added under stirring during one hour at 78-82° C., and the mixture slowly cooled to room temperature under stirring. The resulting solid is collected and washed with heptane (2×25 g). 80 g (78%) of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide are obtained as light yellow powder with a melting point of 130-131° C.
a) Metallation of P,P-dichlorophenylphosphine in Toluene at 98-110° C.
Excluding moisture by an argon atmosphere, sodium lumps (22.85 g, 0.984 mol) are suspended at room temperature in toluene (280 g), together with potassium hydroxide (1.61 g, 24.6 mmol) and 3-methyl-3-pentanol (2.54 g, 24.6 mmol). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 98° C. After formation of a fine sodium suspension P,P-dichlorophenylphosphine (44.93 g, 0.246 mol) is dropwise added over 2 h under vigorous stirring. Heating is continued under reflux for 1 h until all P,P-dichlorophenylphosphine has reacted (check by 31P-NMR).
b) Protonation/Reduction
The resulting orange suspension is dropwise treated with 3-methyl-3-pentanol (50.78 g, 0.492 mol) over 1 h at 98-110° C. Stirring is continued under reflux until all sodium is used up (ca. one hour).
c) Acylation
To the resulting thin, yellow suspension is added 2,4,6-trimethylbenzoyl chloride (91.62 g, 0.492 mol) at such a rate that the temperature is kept at 35-37° C. The mixture is then stirred for another hour at 35-37° C.
d) Oxidation using 30% H2O2 at 40-50° C.
To the resulting thin, yellow-orange suspension is dropwise added H2O (125 g) at room temperature during 10 min. The reaction mixture is treated with 30% hydrogen peroxide (41.83 g, 0.369 mol) at such a rate that the temperature is kept between 40-50° C. Stirring is continued for 1 h at 70° C. and the aqueous phase separated at room temperature. The resulting light yellow suspension is washed with 150 ml of 5% aqueous NaHCO3, and twice with 100 ml of H2O. The combined aqueous phases are extracted with toluene (100 ml). Drying of the combined organic phases over Na2SO4, evaporation of toluene and 3-methyl-3-pentanol provides a yellow solid (98.0 g). Heptane (132 g) is added, the mixture heated up to 80° C., stirred during 15 min, and then slowly cooled to room temperature. The resulting solid is collected and washed with heptane (2×40 g). 79.3 g (77%) of bis(2,4,6-trimethylbenzoyl)-phenylphosphine oxide are obtained as light yellow powder with a melting point of 130-131° C.
a) Metallation of P,P-dichlorophenylphosphine in Toluene at 98-110° C.
Excluding moisture by an argon atmosphere, sodium lumps (22.60 g, 0.984 mol) and potassium lumps (0.96 g, 24.6 mmol) are suspended at room temperature in toluene (280 g), together with 3-methyl-3-pentanol (0.25 g, 2.46 mmol). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 98° C. After formation of a fine sodium/potassium suspension P,P-dichlorophenylphosphine (44.50 g, 0.246 mol) is dropwise added over 4 h under vigorous stirring. Heating is continued under reflux for ca. 2 h until all of P,P-dichlorophenylphosphine has reacted (check by 31P-NMR).
Steps b)-d) have been performed as described in Example 4.
a) Metallation of P,P-dichlorophenylphosphine in Toluene at 98-110° C.
Excluding moisture by an argon atmosphere, sodium lumps (22.99 g, 0.984 mol), three times washed with toluene, are suspended at room temperature in toluene (280 g), together with potassium tert-butoxide (2.77 g, 0.024 mol). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 100° C. After formation of a fine sodium suspension, P,P-dichlorophenylphosphine (44.50 g, 0.246 mol) is dropwise added over 3-4 h under vigorous stirring. Heating is continued under reflux for 1 h 15 min until all P,P-dichlorophenylphosphine has reacted (check by 31P-NMR).
b) Protonation/Reduction
The resulting yellow suspension is dropwise treated with 3-methyl-3-pentanol (51.2 g, 0.492 mol) over 1 h 15 min at 98-110° C. Stirring is continued under reflux until all sodium is used up (1 h 30 min). The resulting thin, yellow suspension is kept at room temperature under argon overnight.
c) Acylation
2,4,6-trimethylbenzoyl chloride (45.81 g, 0.246 mol) is added dropwise to the yellow suspension at such a rate that the temperature is kept at 35-37° C. (50 min). The following procedure is now repeated five times: a) addition of toluene, b) distillation of a mixture of toluene/3-methyl-3-pentanol from the reaction mixture under reduced pressure (280 mbar) at 65-75° C. (total amount of toluene added: 830 ml; total amount of liquid removed: 830 ml). Another equivalent of 2,4,6-trimethylbenzoyl chloride (45.81 g, 0.246 mol) is now added dropwise to the yellow suspension at such a rate that the temperature is kept at 35-37° C. (2 h 20 min). The mixture is then stirred for an additional 35 min at 35-37° C.
d) Oxidation using 30% H2O2 at 40-50° C.
To the resulting thin, yellow-orange suspension is dropwise added H2O (125 g) at room temperature during 5 min. The reaction mixture is heated up to 60° C. followed by the addition of 30% hydrogen peroxide (41.9 g, 0.370 mol) at such a rate that the temperature is kept between 75-80° C. Stirring is continued for 1 h 15 min at 70° C. The reaction mixture is extracted once with 150 ml 5% NaHCO3 and two times with 150 ml water. Drying of the organic layer over Na2SO4 and evaporation provides a yellowish oil (103 g). The crude material is crystallized from heptane (132 ml), providing 80.5 g (77%) of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide as light yellow powder.
formula I′″, R1=2,4-dipentoxyphenyl, R2, R2′=mesityl;
a) Metallation of P,P-dichloro-2,4-dipentoxyphenylphosphine in Toluene at 98-1 10° C.
Excluding moisture by an argon atmosphere, sodium lumps (3.1 g, 135 mmol), three times washed with toluene, are suspended at room temperature in toluene (130 ml), together with potassium tert-butoxide (0.39 g, 34.0 mmol). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 100° C. After formation of a fine sodium suspension, P,P-dichloro-2,4-dipentoxyphenylphosphine (11.87 g, 34.0 mmol) dissolved in 20 ml toluene is added dropwise over 34 h under vigorous stirring. Heating is continued under reflux for 17 h.
b) Protonation/Reduction
The resulting dark violet suspension is dropwise treated with 3-methyl-3-pentanol (6.91 g, 68 mmol) over one hour at 98-110° C. Stirring is continued under reflux until all sodium is used up (24 h).
c) Acylation
To the resulting grey/black suspension is added 2,4,6-trimethylbenzoyl chloride (12.34 g, 68 mmol) at such a rate that the temperature is kept at 35-37° C. The mixture is then stirred for another hour at 35-37° C.
d) Oxidation using 30% H2O2 at 40-50° C.
To the resulting green/black suspension is dropwise added H2O (10 g) at 50° C. within 5 min. The reaction mixture is kept at 50-60° C. followed by the addition of 30% hydrogen peroxide (5.73 g, 51 mmol) at such a rate that the temperature is kept between 50-60° C. Stirring is continued for one hour at 50-60° C. The reaction mixture is extracted once with 5% aqueous NaHCO3 and water. Drying of the organic phase over Na2SO4 and evaporation provides 24.0 g of a yellowish oil. One gram of crude material is purified by preparative liquid chromatography (heptane/ethyl acetate 60:40). After evaporation 230 mg of bis(2,4,6-trimethylbenzoyl)-2,4-dipentoxyphenylphosphine oxide are obtained as a yellow oil. The calculated overall yield of the title product is 28%.
(PhP)5 has been prepared as described in the Int. Patent Application PCT/EP 03/50873 by suspending sodium pieces in a mixture of toluene/TMEDA and adding P,P-dichlorophenylphosphine.
a) Metallation and Protonation of Pentaphenylcyclopentaphosphane (PhP)5
Excluding moisture by an argon atmosphere, (PhP)5 (0.26 g, 0.48 mmol) is dissolved in 30 ml of dry toluene. Sodium lumps (0.11 g, 9 4.8 mmol) are added at room temperature and the mixture is heated up to reflux with vigorous stirring starting as soon as the sodium is melted. The resulting suspension is treated with tert-butanol (0.356 g, 4.8 mmol) at 98-110° C. Stirring is continued under reflux until all of the (PhP)5 is used up and PhPH2 is formed. Acylation and oxidation have been performed as described in Example 1.
Disodium (diphenyldiphosphanediide) of the formula [Na(dme)3]+[Na5(P2Ph2)3(dme)3]− has been prepared as described in the Int. Patent Application PCT/EP 03/50873 by suspending sodium pieces in a mixture of toluene/DME and adding P,P-dichlorophenylphosphine.
Crystalline [Na(dme)3]+[Na5(P2Ph2)3(dme)3]31 (3 g) is suspended in toluene (20 mL) and 2,4,6-trimethylbenzoyl chloride (1.5 fold excess) is added such that the reaction temperature does not rise above 40° C. The immediate precipitation of NaCl is observed. The slightly yellow colored solution contains about 60 mol % of acylated products and 40 mol % of cyclooligophosphanes. The fraction of the acylated products is composed of approximately 60 mol % PhP(COMes)2, 30 mol % of Ph2P2(COMes)2 and 10 mol % of the (E1Z)-isomers of (PhPCOMes)− in a molar ratio of 2:1. The fraction of the cyclophosphanes consists of 85 mol % (PhP)5 and 15 mol % (PhP)4.
a) Metallation of P,P-dichlorophenylphosphine
Excluding moisture by an argon atmosphere, sodium lumps (2.58 g, 112 mmol) are suspen-ded at room temperature in a mixture of toluene (17.4 g) and TMEDA (N,N,N′,N′-tetra-methylethylenediamine) (1.62 g, 14.0 mmol). This mixture is heated up to reflux with vigorous stirring starting as soon as the sodium is melted. After formation of a fine sodium suspension, P,P-dichlorophenylphosphine (5 g, 28 mmol) is added dropwise over one hour under vigorous stirring. Heating under reflux for an additional 2.5 h leads to a green/yellow suspension.
b) Acylation
To the resulting thin, green/yellow supension is added 2,4,6-trimethylbenzoyl chloride (10.2 g, 56 mmol) at 0-10° C. The mixture is then stirred for another 1.5 hour at 0-10° C.
c) Oxidation using H2O2 at 80° C.
30% hydrogen peroxide (6.0 g, 53 mmol) is added dropwise to the resulting suspension at room temperature. The mixture is heated up to 80° C. and stirring is continued for 1-2 h. The light yellow suspension is washed with water (2×50 g). After evaporation of toluene, heptane (35 g) is added, the mixture heated up to 80° C. and then cooled to room temperature. The resulting solid is collected and washed with heptane (2×15 g). 3.75 g (32%) of bis(2,4,6-trimethylbenzoyl)phenylphosphane oxide are obtained as light yellow powder with a melting point of 130-131° C.
a) Metallation of P,P-dichlorophenylphosphine Oxide
Excluding moisture by an argon atmosphere, sodium lumps (2.3 g, 0.10 mol) are suspended at room temperature in a mixture of xylene (50 ml) and TMEDA (N,N,N′,N′-tetramethylethylenediamine) (1.47 g, 12.5 mmol). This mixture is heated up to 105-110° C. with vigorous stirring starting as soon as the sodium is melted. After formation of a fine sodium suspension, P,P-dichlorophenylphosphine oxide (4.87 g, 25.0 mmol) is added dropwise over 10 min under vigorous stirring. Heating under reflux for an additional 23 h leads to a yellow precipitate.
b) Acylation
To the resulting yellow supension is added 2,4,6-trimethylbenzoyl chloride (9.13 g, 50 mmol) at 5° C. over 20 min. The mixture is then stirred for another 2 h at 30° C.
c) Oxidation with Hydrogen Peroxide has Been Performed as Described in Example 1.
a) Metallation of P,P-dichlorophenylphosphine in Toluene at 98-110° C.
Excluding moisture by an argon atmosphere, sodium lumps (6.78 g, 0.295 mol) are suspended at room temperature in toluene (100 ml), together with potassium tert-butoxide (827 mg, 7.37 mmol). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 98° C. After formation of a fine sodium suspension P,P-dichlorophenylphosphine (13.2 g, 73.7 mmol) is added during 2 h under vigorous stirring. During the addition, the color of the reaction mixture changed from yellow, to orange, to light yellow and then to gray. Heating is continued under reflux for 6 h until all P,P-dichlorophenylphosphine has reacted (check by 31P-NMR).
b) Protonation/Reduction
The resulting green-yellow suspension is dropwise treated with tert-butanol (14 ml) in toluene (10 ml) over 3 h at 98-110° C. Stirring is continued under reflux for 2 h.
c) Acylation
To the resulting light yellow suspension is dropwise added 2,4,6-trimethylbenzoyl chloride (12.11 g, 66.3 mmol, 0.9 eq.) at room temperature. The suspension is filtered, washed with toluene (10 ml), and the volume of the filtrate reduced to half by solvent evaporation. A light yellow solid precipitated overnight at −18° C. The solid is separated, washed with hexane (20 ml) and then dried under high vacuum for 12 h, giving 9.13 g product. Additional 3.72 g product is isolated from the filtrate by repeated precipitation. According to 1H-NMR the product consists of a mixture of (Z)-enolate/(E)-enolate/tert-butanol 2:1:2 (the (Z)-enolate is tentatively assigned as major isomer).
M.p. (dec.)=156° C. 31P-NMR(d8-THF): δ=79.9, 56.2* (*=main signal).
1H-NMR (d8-THF; *=minor isomer, tentatively assigned as (E)-enolate; **=signals corresponding to tert-butanol): δ=7.82 (m, 2 H. CPh—H); 7.03 (m, 2 H, CPh—H); 6.92 (m, 2 H), CPh—H); 6.89 (m, 2 H*, CPh—H); 6.86 (m, 1 H. CPh—H); 6.70 (m, 1 H*, CPh—H); 6.67 (s, 2 H, CMes—H); 6.58 (s, 2 H*, CMes—H); 3.26 (s, 1 H**, tBuOH); 2.42 (s, 6 H, Mes o-CH3); 2.21 (s, 6 H*, Mes o-CH3); 2.18 (s, 3 H, Mes p-CH3); 2.12 (s, 3 H*, Mes p-CH3); 1.14 (s, 9 H**, tBu CH3).
13C-NMR (d8-THF): δ=231.7 (d, PCO, JCP=53.8 Hz); 220.7 (d, PCO, JCP=68.2 Hz); 150.9 (d, Mes C1, 2JCP=54.3 Hz); 147.7 (d, Mes C1, 2JCP=47.6 Hz); 135.2 (d, JCP=4.7 Hz); 135.0 (d, JCP=1.1 Hz); 134.7 (d, JCP=1.6 Hz); 134.3 (d, Ph, JCP=13.6 Hz); 133.4 (d, Ph, JCP=13.8 Hz); 133.2 (d, JCP=2.5 Hz); 128.2 (s, Mes C3); 128.1 (s, Mes C3); 127.4 (d, Ph, JCP=4.8 Hz); 127.0 (d, JCP=5.1 Hz); 124.3 (d, JCP=1.2 Hz); 123.9 (d, JCP=0.4 Hz); 67.7 (s, tBu); 31.8 (s, tBu CH3); 21.1 (s, Mes p-CH3); 21.0 (s, Mes p-CH3); 20.3 (s, Mes o-CH3); 20.2 (s, Mes o-CH3).
formula I′″, R1=phenyl, R2=mesityl, R2′=2,6-dimethoxy;
a) Metallation of P,P-dichlorophenylphosphine in Toluene at 98-110° C.
Excluding moisture by an argon atmosphere, sodium lumps (6.28 g, 0.270 mol) are suspended at room temperature in toluene (150 ml), together with potassium tert-butoxide (782 mg, 6.76 mmol). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 98° C. After formation of a fine sodium suspension P,P-dichlorophenylphosphine (12.10 g, 67.6 mmol) is dropwise added over 2 h under vigorous stirring. Heating is continued under reflux for 3 h until all P,P-dichlorophenylphosphine has reacted (check by 31P-NMR).
b) Protonation/Reduction
The resulting yellow suspension is dropwise treated with 3-methyl-3-pentanol (13.95 g, 135.2 mmol) over 35 min at 98-110° C. Stirring is continued under reflux until all sodium is used up (ca. 1.5 h).
c) Acylation
To the resulting thin, yellow suspension is added 2,4,6-trimethylbenzoyl chloride (10.45 g, 56.1 mmol) in toluene (20 ml) at such a rate that the temperature is kept at 35-37° C. The mixture is then stirred for 1 h 30 min at 35-37° C. 2,6-dimethoxybenzoyl chloride (12.51 g, 56.1 mmol) in toluene (20 ml) is added at room temperature within 10 min and stirring is continued for 1 h 30 min.
d) Oxidation using 30% H2O2 at Rom Temperature
To the resulting thin, yellow-orange suspension is first dropwise added aqueous 2 M HCl (7 ml) at room temperature. Afterwards, 30% hydrogen peroxide (76.16 g, 0.672 mol) is added at such a rate that the temperature is kept below 35° C. Stirring is continued for 2 h at room temperature. The light yellow suspension is first washed with 42 g of 5% aqueous NaHCO3, and then with water (2×60 ml), and the aqueous phases reextracted with toluene (60 ml). The combined organic phases are dried over MgSO4 and concentrated under vacuum providing a yellow solid. Crystallization (hexane/acetone 2:1) gives 13.4 g (46%) of 2,4,6-trimethylbenzoyl-2,6-dimethoxybenzoyl-phenylphosphine oxide as light yellow solid.
31P-NMR (C6D6): δ=4.6.
1H-NMR (C6D6): δ=8.45-8.51 (m, 2 H); 7.15-7.20 (m, 3 H); 7.02 (t, 1 H); 6.66 (s, 2 H); 6.14 (d, 2 H); 3.18 (s, 6 H); 2.44 (s, 6 H); 2.09 (s, 3 H).
formula I′″, R1=phenyl, R2=mesityl, R2′=tert-butyl;
a) Metallation of P,P-dichlorophenylphosphine
Excluding moisture by an argon atmosphere, sodium pieces (2.07 g, 90.3 mmol) are suspended at room temperature in a mixture of toluene (100 ml) and TMEDA (N,N,N′,N′-tetramethylethylenediamine) (4 ml). This mixture is heated under reflux and under vigorous stirring. P,P-dichlorophenylphosphane (4.02 g, 22.4 mmol) is added and the suspension is heated under reflux for 5 h until a yellow precipitate is formed.
b) Protonation/Reduction
Excluding moisture by an argon atmosphere, tert-butanol (3.32 g, 44.8 mmol) is added at 100° C. over one hour leading to dissolution of the yellow precipitate. The resulting yellow suspension is further stirred under reflux until all sodium is used up.
c) Acylation and Neutralisation of TMEDA
To the yellow suspension is added dropwise under stirring 2,4,6-trimethylbenzoyl chloride (4.09 g, 22.4 mmol) in toluene (15 ml). The reaction temperature is kept at room temperature. The mixture is then stirred for another two hours at room temperature. Pivaloylchloride (2,2-dimethylpropionyl chloride) (2.71 g, 22.4 mmol) is added dropwise under stirring at room temperature. Concentrated H2SO4 (1.48 ml, 26.7 mmol) is added dropwise at a temperature below 45° C.
d) Oxidation
To the resulting suspension is added 30% hydrogen peroxide (6.9 ml, 67.6 mmol) under stirring at such a rate that the temperature does not rise above 55° C. Stirring is continued at 40-50° C. for one hour followed by the addition of water (10 ml). The organic phase is separated, washed twice with water and with 10% NaHCO3, and then dried over Na2SO4. Evaporation yields a yellow oil which is taken up in 30 ml of petroleum ether (40/70)/ethylacetate (9:1). After filtration the title compound is obtained as a yellow solid (5.1 g, 64%) with a melting point of 110-112° C.
31P{1H}-NMR (CDCl3): δ=10.0 (t, 3JPH=9.85 Hz).
1H-NMR (CDCl3): δ=7.88 (m, 2 H, Ph H(2.6)); 7.53 (m, 1 H. Ph H(4)); 7.43 (m, 2 H, Ph H(3,5)); 6.78 (s, 2 H, Mes Her); 2.24 (s, 3 H, p-CH3); 2.18 (s, 6 H, o-CH3); 1.27 (s, 9 H, tBu).
formula I′″, R1=2,4-dipentoxyphenyl, R2=mesityl; R2′=2,6-dimethoxyphenyl
a) Metallation of P,P-dichloro-2,4-dipentoxyphenylphosphine in Toluene at 98-110° C.
Excluding moisture by an argon atmosphere, sodium lumps (1.55 g, 67.6 mmol), three times washed with toluene, are suspended at room temperature in toluene (70 ml), together with potassium hydroxide (powdered) (0.1 g, 1.7 mmol). This mixture is heated up to reflux with vigorous stirring starting as soon as the temperature reaches 100° C. After formation of a fine sodium suspension, P,P-dichloro-2,4-dipentoxyphenylphosphine (6.6 g, 16.9 mmol) dissolved in 10 ml toluene is added dropwise over 3-4 h under vigorous stirring. Heating is continued under reflux for 1 h 40 min.
b) Protonation/Reduction
The resulting dark violet suspension is dropwise treated with 3-methyl-3-pentanol (3.48 g, 33.8 mmol) over 40 min at 95-110° C. Stirring is continued under reflux until all sodium is used up (24 h).
c) Acylation
To the resulting gray suspension is added 2,4,6-trimethylbenzoyl chloride (1.59 g, 8.7 mmol). at such a rate that the temperature is kept at 35-40° C. (31P-NMR spectra shows no more signal for PhPH2). The mixture is then stirred for another 2 h 30 min at 35-40° C. 2,6-dimethoxybenzoyl chloride [1.94 g, 8.7 mmol; dissolved in toluene/tetrahydrofuran (5 ml/1 ml)] is added at 35-40° C. within 60 min and stirring is continued overnight at 35-40° C. The resulting reaction mixture is treated with an additional amount of 2,6-dimethoxybenzoyl chloride [3.77 g, 16.9 mmol; dissolved in toluene/tetrahydrofuran (5 ml/2 ml)] at 35-40° C. within 30 min. Stirring is continued for nine hours at 35-40° C.
d) Removal of Tetrahydrofuran-oxidation using 30% H2O2 at 40-50° C.
To the resulting gray suspension is added 50 ml of toluene. Afterwards, 60 ml of solvent (tetrahydrofuran/toluene-mixture) are removed by distillation (100 mbar/40-50° C.). The gray/yellow suspension is diluted with a small amount of toluene (10 ml), and then dropwise treated with H2O (5 ml) at 50-60° C. within 5 min. Stirring is continued for 10 min at 50-60° C. followed by the addition of 30% hydrogen peroxide (2.87 g, 25.4 mmol) at such a rate that the temperature is kept between 50-60° C. Stirring is continued for 40 min at 50-60° C. The reaction mixture is diluted with water, extracted once with 5% aqueous NaHCO3 and twice with water. Drying of the organic phase over Na2SO4 and evaporation provides 9.3 g of a yellowish oil. Further purification by preparative liquid chromatography (heptane/ethyl acetate 80:20) yields 1.85 g (18%) of pure 2,4,6-trimethylbenzoyl-2,6-dimethoxybenzoyl-2,4-dipentoxyphenylphosphine oxide as a yellow viscous oil.
31P-NMR (C6DE): δ=15.7.
1H-NMR (C6D6): δ=8.2-8.3 (dd, 1 H); 7.03 (t, 1 H); 6.7 (s, 2 H); 6.5-6.6 (d, 1 H); 6.4-6.5 (d, 1 H); 6.1-6.2 (d, 2 H); 3.6-3.8 (m, 4 H); 3.28 (s, 6 H); 2.62 (s, 6 H); 2.12 (s, 3 H); 1.6-1.9 (m, 4 H); 1.2-1.5 (m, 8 H); 0.9-1.0 (2 t, 6H).
formula I′″, R1=phenyl, R2, R2′=tert-butyl;
a) Metallation of Pentaphenylcyclopentaphosphane
Excluding moisture by an argon atmosphere, sodium pieces (0.64 g, 30 mmol), (PPh)5 (1.5 g, 13.88 mmol relative to P) are heated under reflux in a mixture of toluene (50 ml) and of TMEDA (N,N,N′,N′-tetramethylethylenediamine) (2 ml) until a yellow precipitate is formed. (PPh)5 has been prepared as described in the Int. Patent Application PCT/EP 03/50873 by suspending sodium pieces in a mixture of toluene/TMEDA and adding P,P-dichlorophenylphosphane.
b) Protonation/Reduction
Excluding moisture by an argon atmosphere, tert-butanol (2.3 g, 2.2 eq.) is added at 100° C. over 30 min leading to dissolution of the yellow precipitate. The resulting yellow suspension is further stirred under reflux until all sodium is used up.
c) Acylation and Neutralisation of TMEDA
Pivaloylchloride (3.68 g, 2.2 eq) is added dropwise under stirring. The reaction temperature is kept below 70° C. Concentrated H2SO4 (0.9 ml) is added dropwise at a temp. below 45° C.
d) Oxidation
30% aqueous hydrogen peroxide (4.3 ml, 42.1 mmol) is added dropwise under stirring at a temperature below 55° C. Stirring is continued at 40-50° C. for one hour followed by the addition of water (10 ml). The organic phase is separated and washed twice with water and with 10% NaHCO3. The organic phase is dried over Na2SO4. After evaporation and washing with hexane the title compound is obtained as a yellow solid (1.84 g, 45%).
31P-NMR (CDCl3): δ=16.2 (t. 3JPH=10.8 Hz).
1H-NMR (CDCl3): δ=7.80 (m, 2 H. Ph H(2,6)); 7.57 (m, 1 H. Ph H(4)); 7.48 (m, 2 H, Ph H(3,5)); 1.27 (s, 18 H, CH3).
13C-NMR (CDCl3): δ=132,8 (d, 4JCP=3.1 Hz, Ph C4); 132.0 (d, 2JCP=8.3 Hz, Ph C2,6); 128.7 (d, 3JCP=11.4 Hz, Ph C3,5); 126.6 (d, 1JCP=79.2 Hz, Ph C1); 25.6 (s, CH3).
Step b) of Example 2 has been repeated using two equivalents (with regard to P) of ethanol instead of tert-butanol. Gas develops heavily. Selectivity data are obtained by 31P-NMR. The 31P-NMR experiments were conducted on Bruker DPX-250 spectrometers.
31P-NMR(CDCl3): δ = −25.75(s(br),
31P-NMR(CDCl3):
| Number | Date | Country | Kind |
|---|---|---|---|
| 03405551 | Jul 2003 | EP | regional |
| Filing Document | Filing Date | Country | Kind | 371c Date |
|---|---|---|---|---|
| PCT/EP2004/051427 | 7/9/2004 | WO | 00 | 5/3/2006 |
| Publishing Document | Publishing Date | Country | Kind |
|---|---|---|---|
| WO2005/014605 | 2/17/2005 | WO | A |
| Number | Name | Date | Kind |
|---|---|---|---|
| 6399805 | Wolf et al. | Jun 2002 | B2 |
| 6888031 | Leppard et al. | May 2005 | B1 |
| 20050028027 | Kroening et al. | Feb 2005 | A1 |
| 20060229469 | Huttenloch et al. | Oct 2006 | A1 |
| Number | Date | Country |
|---|---|---|
| 1486986 | Apr 2004 | CN |
| 0 040 721 | May 1981 | EP |
| 0032612 | Jun 2000 | WO |
| Number | Date | Country | |
|---|---|---|---|
| 20060247436 A1 | Nov 2006 | US |
