Process for preparing .alpha.-oxy(oxo)sulfides and ethers

BACKGROUND OF THE INVENTION
The present invention relates to .alpha.-oxy(oxo) sulfides and ethers.
There has been considerable work performed related to substances to (or in) various consumable materials including foodstuffs. These substances are used to diminish the use of natural materials, some of which may be in short supply and to provide more uniform properties in the finished product. The following flavor and aroma notes are desirable, particularly in berry fruit flavored foodstuffs, vegetable flavored foodstuffs, spicey foodstuffs and citrus fruit flavored foodstuffs:
Aroma
Green/spicey, Sweet, Fruity, Fresh/fruity, Gooseberry, Concord grape, Grape, Almond, Nutty, Cereal-like, Lachrymatory onion-like, Oniony, Green onion-like, Leek, Broccoli-like, Grapefruit, Celery stalk-like, Floral, Rosey, Woody, Blackcurrant, Buchu leaf oil-like, Citronellal-like, Neroli-like, Burgamot-like, Violet leaves-like, Jasmin-like, Melony, Cucumber-like, Green, Vegetable, Sweet/floral.
Flavor
Spicey, Sweet, Fruity, Milk caramel-like (dulce de leche-like), Gooseberry, Broccoli-like, Nutty, Cereal-like, Oniony, Grape, Concord grape, Citrusy, Grapefruit-like, Green fruit-like, Manadarin-like, Petitgrain-like, Blackcurrant, Minty, Astringent, Coriander-like, Green, Piney, Citronellal-like, Violet leaves-like, Melony, Green fruit-like, Cucumber, Green, Floral, Floral/green, Vegetable, Garlic. Furthermore there is a continuing search for materials having desirable fragrance properties. Such materials are sought either to replace costly natural materials or to provide new fragrances or perfume types which have not heretofore been available. Especially desirable qualities for substances having interesting hyacinth fragrances, or narcisse fragrances, or violet fragrances, or oriental vetivert fragrances, or otto of rose fragrances are stability and persistence, particularly in a wide variety of perfumed articles (e.g., soaps, detergents and powders), perfume compositions and colognes, ease of manufacture and intensity of aroma. Prior to this last decade it was the general option among those skilled in the art that compounds containing the mercapto or --SH moiety or substituted mercapto or -SR moiety (where R is an organic group such as alkyl or acetyl) were desirable for use in conjunction with foodstuff flavors only where alliaceous flavors were concerned, or where meaty flavors were concerned or where coffee-type flavors were concerned, and were not desirable for use in conjunction with other more delicate type flavors, e.g., blackcurrant, citrus and vegetable. However, within the last decade certain mercapto compounds have been ascertained to be useful, for example, in blackcurrent and buchu leaf oil-like flavors. In addition, within the last decade such compounds have been ascertained to be highly useful in perfumery also.
Thus, for example, British Pat. Nos. 1,423,914 and 1,423,915 issued on Feb. 4, 1976, teach that certain mercapto derivatives which are aliphatic or cycloaliphatic compounds having the formula: ##STR3## wherein X.sup.1 represents a hydroxyl group or an acyl-oxy group, and X.sup.2 represents a hydrogen atom; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be the same or different and each represents a hydrogen atom or a univalent aliphatic hydrocarbyl group; or R.sup.1 and R.sup.3 or R.sup.4, together with the intervening carbon atoms, constitute a cycloaliphatic ring, are useful as perfuming agents as exemplified by adding 3-methylthio-hexanol to a perfume base composition of the "Fleuri" type wherein the 3-methylthio-hexanol is said to give rise to a green, fruity aroma reminiscent of that of rhubarb.
Furthermore, for example, Canadian Pat. No. 983,050 issued on Feb. 3, 1976, teaches that 3,7-dimethyl-octa-2,6-dienyl-mercaptan (thiogeraniol) of the formula: ##STR4## is used in making up a "synthetic buchu leaf oil" and imparts to a lavender type composition a greener and more herbal fragrance. USSR Pat. No. 345,677 teaches that para-menthane-8-thiol-3-one is useful as a synthetic black current flavoring for foodstuffs. This compound has the structure: ##STR5## German Offenlegungschrift Pat. No. 2,316,456, published on Oct. 1, 1973 discloses the use of certain thio alcohols or their corresponding esters in perfumery and in perfumed articles, such as detergents, cosmetics and waxes. Such mercapto alcohols having the generic structure: wherein R.sub.1 is a hydrocarbon moiety having from 1 up to 7 carbon atoms and R.sub.2 is one of hydrogen, methyl or ethyl.
U.S. Pat. Nos. 3,950,429 issued on Apr. 13, 1976, and 3,952,062 issued on Apr. 20, 1976, disclose certain alkylthiosubstituted oxo-terpenoids having 10 carbon atoms in the terpenoid skeleton as useful in perfumery and in flavors, particularly for providing vegetable notes. The generic structure of the compounds is as follows: ##STR6## wherein R.sup.1 represents hydrogen or together with R.sup.4 represents a C--C bond,
R.sup.2 represents hydrogen or together with R.sup.6 represents a dimethylmethylene group, or, when
R.sup.6 is isopropyl, together with R.sup.5 represents a C--C bond,
R.sup.3 represents hydrogen or together with R.sup.6 represents a dimethylmethylene group,
R.sup.4 represents hydrogen or together with R.sup.1 represents a C--C bond,
R.sup.5 represents hydrogen or, when R.sup.6 signifies isopropyl, together with R.sup.2 represents a C--C bond,
R.sup.6 represents isopropyl or together with R.sup.2 or with R.sup.3 represents a dimethylmethylene group,
R.sup.7 represents methyl,
X represents a C--C double bond taking the place of a C--C single bond,
m = 0 to 2,
Y represents oxo bound to a primary or secondary C-atom and Z represents mercapto or lower alkylthio located in the .beta.-position to the carbonyl function,
provided that when R.sup.2, R.sup.3 and R.sup.5 represent hydrogen, R.sup.6 represents isopropyl, R.sup.4 together with R.sup.1 represents a C--C bond, Y is .beta. to the carbon atom bearing the substituent R.sup.7, m=o, Z is .alpha. to the carbon atom bearing the substituent R.sup.5 and .beta. to the carbon atom bearing the substituent R.sup.3, then Z represents alkylthio.
However, none of the disclosure of the prior art contains a teaching to the effect that compounds having the generic structure: ##STR7## where X is one of: ##STR8## Z is one of sulfur or oxygen; where R.sub.1 and R.sub.2 are taken separately, R.sub.1 is hydrogen or methyl, and R.sub.2 is methyl; and where R.sub.1 and R.sub.2 are taken together, R.sub.1 and R.sub.2 form phenyl moietiesl and Y is one of C.sub.1 --C.sub.4 alkyl, C.sub.3 or C.sub.4 alkenyl, acetyl, methoxycarbonylmethyl, or 1,3-diethylacetonyl
have the ability to create the following aroma and flavor notes in foodstuffs:
Aroma
Green/spicey, Sweet, Fruity, Fresh/fruity, Gooseberry, Concord grape, Grape, Almond, Nutty, Cereal-like, Lachrymatory onion-like, Oniony, Green onion-like, Leek, Broccoli-like, Grapefruit, Celery stalk-like, Floral, Rosey, Woody, Blackcurrant, Buchu leaf oil-like, Citronellal-like, Neroli-like, Bergamot-like, Violet leaves-like, Jasmin-like, Melony, Cucumber-like, Green, Vegetable, Sweet/floral.
Flavor
Spicey, Sweet, Fruity, Milk caramel-like (dulce de leche-like), Gooseberry, Broccoli-like, Nutty, Cereal-like, Oniony, Grape, Concord grape, Citrusy, Grapefruit-like, Green fruit-like, Mandarin-like, Petitgrain-like, Blackcurrant, Minty, Astringent, Coriander-like, Green, Piney, Citronellal-like, Violet leaves-like, Melony, Green fruit-like, Cucumber, Green, Floral, Floral/green, Vegetable, Garlic.
Furthermore, other substituted mercaptans in the prior art which are shown to be useful in perfumery are indicated to have rhubarb-like, or berry, or other floral-type fragrances, e.g., ionone and irone derivatives having the structure: ##STR9##
Furthermore, certain .alpha.-mercaptoketones disclosed in the prior art, but only in meat flavors. Thus, U.S. Pat. No. 3,773,524 issued on Nov. 20, 1973, discloses the use of .alpha.-ketothiols of the formula: ##STR10## wherein R.sub.1 is methyl or ethyl; and R.sub.2 and R.sub.3 are hydrogen, methyl or ethyl to alter the meat flavor and aroma of foodstuffs. U.S. Pat. No. 3,892,878, issued on July 1, 1975, discloses the use of certain hydroxy-mercaptoalkanes to alter the flavor of foodstuffs, for example, 2-mercapto-3-butanol used in meat flavors. The genus disclosed by U.S. Pat. No. 3,892,878 is as follows: ##STR11## wherein X is oxygen or sulfur, n is 0 or 1, R.sub.1 -R.sub.7 are the same or different and each is hydrogen or lower alkyl of 1-4 carbon atoms, a and b are the same or different and each represents an integer of from 0 to 10 when n is 0 and when n is 1, a and b are the same or different and each represents an integer of from 1 to 10. 3-mercaptoheptanon-4 is disclosed per se in U.S. Pat. No. 2,888,487, issued on May 26, 1959. 3-mercapto-2,6-dimethyl-heptan-4-one is disclosed in Chem. Abstracts 6478 (d) Vol. 62, 1965 (abstract of Asinger, Diem and Schaefer, Monatsh. Chem. 95 (4-5), 1335-54 (1964). Beilstein E-IV-1 discloses 2-mercapto-2,4-dimethyl-pentan-3-on page 4039, 1-mercapto-octan-2-on at page 4040; and 1-mercapto-nonan-2-on at 4052 and 1-mercapto-undecan-2-on at page 4060.
U.S. Pat. No. 3,922,366 issued on Nov. 25, 1975, discloses the enhancement of foodstuffs by addition of a small but effective flavor modifying of a compound of the general formula: ##STR12## wherein R.sub.1 is hydrogen or alkyl and R.sub.2 is alkyl or furfuryl. The flavor nuances which are enhanced or altered are those which are found in coffee flavors and aromas.
Furthermore, none of the disclosure of the prior art contains a teaching to the effect that compounds having the generic structure: ##STR13## wherein R is one of methyl or hydrogen; X is one of ##STR14## and Y is one of methyl, methallyl having the structure: ##STR15## n-propyl, 2-methyl-1-propyl or acetyl, has the ability to create an intense sweet and/or green and/or floral and/or herbal and/or vegetative and/or basil-like and/or minty and/or melony and/or grapefruit and/or fruity and/or alliaceous aroma with yara and/or neroli and/or verdima nuances as is carried out using the instant invention. Furthermore, other substituted mercaptans in the prior art which are shown to be useful in perfumery and other mercaptans in the prior art which are shown to be useful in perfumery are indicated to have rhubarb-like or berry or other type floral fragrances; e.g., ionone and irone derivatives having the structure: ##STR16## as disclosed in British Pat. No. 1,327,320, published on Aug. 22, 1973, wherein one of the dashed lines represents a double bond, and where R is hydrogen or alkyl.
THE INVENTION
The invention comprises one or more compounds having the structure: ##STR17## wherein X is one of: ##STR18## z is one of sulfur or oxygen; when R.sub.1 and R.sub.2 are taken separately, R.sub.1 is hydrogen or methyl, and R.sub.2 is methyl; and when R.sub.1 and R.sub.2 are taken together, R.sub.1 and R.sub.2 form phenyl moieties; and Y is one of C.sub.1 -C.sub.4 alkyl, C.sub.3 or C.sub.4 alkenyl, acetyl, methoxycarbonylmethyl, or 1,3-diethylacetonyl the specific embodiments of which are described hereinafter by way of example and in accordance with which it is now preferred to practice the invention.
Such .alpha.-oxy(oxo) sulfides and ethers are obtained by reacting an alkanone with SO.sub.2 Cl.sub.2 to form an .alpha.-chloroketone; reacting the .alpha.-chloroketone with either an alkali metal mercaptide or an alkali metal alkoxide (depending on whether Z is sulfur or oxygen) to form either an .alpha.-oxo sulfide or an .alpha.-oxo ether -- which can be used for its food flavor properties; or, if desired, reacting the resulting .alpha.-oxo sulfide -- or .alpha.-oxo ether -- with a reducing agent such as an alkali metal borohydride in order to obtain an .alpha.-oxy sulfide -- or an .alpha.-oxy ether. -- Thus, the aforementioned reaction sequence is illustrated as follows: ##STR19## wherein X is one of: ##STR20## Z is one of sulfur or oxygen; when R.sub.1 and R.sub.2 are taken separately, R.sub.1 is hydrogen or methyl, and R.sub.2 is methyl; and when R.sub.1 and R.sub.2 are taken together, R.sub.1 and R.sub.2 form phenyl moieties; and Y is one of C.sub.1 -C.sub.4 alkyl, C.sub.3 or C.sub.4 alkenyl, acetyl, methoxycarbonylmethyl, or 1,3-diethylacetonyl.
The reaction between the SO.sub.2 Cl.sub.2 and the ketone preferably takes place in the absence of a solvent at a temperature of between 15.degree. and 40.degree. C. The SO.sub.2 Cl.sub.2 is preferably added to the ketone. At the end of the reaction, the reaction mass is worked up, the chlorinated ketone being distilled in vacuo.
The resulting chlorinated ketone is then reacted with either an alkali metal mercaptide or an alkali metal alkoxide. Preferably the alkali metal mercaptide is sodium mercaptide, preferably which is prepared by reaction of sodium methylate with an appropriate mercaptan in methanol. Preferably the alkali metal alkoxide is sodium methoxide. The chlorinated ketone is preferably contained in an inert solvent, e.g. in a methanolic solution. Preferably the methanolic solution of chlorinated ketone is slowly added to the pre-prepared alkali metal mercaptide or alkali metal alkoxide at a temperature of between 0.degree. and 30.degree. C; preferably between 15.degree. C and 30.degree. C. The reaction mass is then extracted with a solvent such as methylene chloride, and the resulting extract is then worked up using evaporation and distillation techniques or GLC trapping whereby the .alpha.-oxo sulfide -- or .alpha.-oxo ether (as the case may be) is recovered. The resulting .alpha.-oxo sulfide or ether -- is then used ("as is") for its flavor properties; or it may be further reacted with a reducing agent such as an alkali metal borohydride, conveniently sodium borohydride. The reaction with sodium borohydride takes place in an inert solvent such as anhydrous ethanol at a temperature of between 20.degree. and 35.degree. C. A solution in anhydrous ethanol of the .alpha.-oxo sulfide or ether -- is added to a solution in anhydrous ethanol of the alkali metal borohydride. The reaction is carried out over a period of time of between two and ten hours. At the end of the reaction, the reaction mass is concentrated and is then admixed with water. The resulting mixture is then acidified to a pH of between 2 and 3 and then extracted with an inert extraction solvent such as methylene chloride. The methylene chloride extract is then dried, evaporated, and the resulting .alpha.-oxy sulfide or ether is distilled in vacuo or isolated by GLC trapping.
Alternatively, the .alpha.-chloro-ketone may be reacted with an alkali metal hydrosulfide such as sodium hydrosulfide or an alkali metal hydroxide such as sodium hydroxide to form the corresponding .alpha.-mercapto-ketone or .alpha.-hydroxy-ketone. The .alpha.-mercapto-ketone or .alpha.-hydroxy-ketone may then be reacted with base (e.g., sodium methoxide) to form the alkali metal salt. The alkali metal salt of the .alpha.-mercapto-ketone or .alpha.-hydroxyketone is then reacted with an alkyl or alkenyl halide (e.g., methallyl chloride) thereby forming the desired .alpha.-oxo sulfide or .alpha.-oxo ether which may then, if desired, be used as such for its organoleptic properties, or it can be reduced with an alkali metal borohydride (e.g., sodium borohydride) to the corresponding .alpha.-oxy sulfide or .alpha.-oxy ether. -- This reactive sequence is illustrated as follows: ##STR21## Specific examples of .alpha.-oxy(oxo) sulfides and ethers produced using the afore-mentioned processes and their food flavor properties are as follows (as set forth in Table I below):
TABLE I__________________________________________________________________________COMPOUND STRUCTURE FLAVOR PROPERTY__________________________________________________________________________3-methylthio-4- heptanone ##STR22## Green, piney,Neroli-like fruity, blackcurrant, bucchu-like and concord grape aroma character- istic and a sweet, fruity blackcurrant, concord grape-like, minty and astringent flavor characteristics at 1.0 ppm3-propylthio-4- heptanol ##STR23## "Violet leaves," melon, cucumber, green, fruity, vegetable and floral aroma characteristics with violet leaves, melon, cucumber, green, citrus, vegetable, garlic flavor character- istics with a lasting mouthfeel.3-isobutylthio-4- heptanone ##STR24## Sweet/floral, citrus, fruity, neroli, bergamot, jasmin aroma character- istic with a green/floral minty, petitgrain, fruity, citrus, sulfury flavor characteristic at 2 ppm.3-propylthio-4- heptanone ##STR25## Sweet, floral, jasmin and berry-like aroma characteristic with sweet/floral, jasmin, grapefruit and black- currant flavor character- istic at 2 ppm.3-(methallylthio)-2,6- dimethyl-4-heptanone ##STR26## Citrus, grapefruit, floral, celery stalk-like rosey aroma character- istic with citrus, grape- fruit, floral, spicey, green/fruity, astringent flavor characteristic at 2 ppm.3-crotylthio-2,6- dimethyl-4- heptanone ##STR27## Floral, citronellal-like, citrus, grapefruit, woody aroma character- istic and a citrus, grapefruit, coriander- like flavor character- istic at 3 ppm.3-allylthio-2,6- dimethyl-4- heptanone ##STR28## A sweet, grapefruit, floral, citrus, green/ spicey, neroli-like aroma characteristic with a sweet, citrus, floral/ green, citronellal-like, "decaying fruit-"like flavor characteristic at 4 ppm.3[ (methoxycarbonyl)- methylthio]-4- heptanone ##STR29## At 10 ppm, a sweet, sulfury, nutty, meaty, cereal aroma character and a sweet, meaty, nutty, cereal flavor characteristic with an outstanding mouthfeel effect.3-methoxy-4-heptanone ##STR30## At 3 ppm, a sweet, fruity, gooseberry-l ike, grape, almond aroma character with a sweet, fruity, gooseberry-like, nutty, grape flavor character.1-propylthio-1,3- diphenyl-2- propanone ##STR31## At 0.5 ppm, a green onion aroma with a lachrymating onion and biting effect and a sweet, rubbery, meaty flavor character- istic; at 2 ppm the garlic aroma dominates along with the fresh onion notes.(1,3-diethylacetonyl) (1,3-diisopropylacetonyl) sulfide ##STR32## At 10 ppm, a grapefruit, floral and woody aroma character with a sweet, sulfury, grapefruit-like, mandarin flavor character- istic and bitter nuances.3-acetylthio-4- heptanone ##STR33## At 1 ppm a fresh fruity, blackcurrant-l ike, buchu leaf oil-like, aroma with meaty and sulfury nuances and a fresh fruit, black- currant-like flavor characteristic with an oniony aftertaste.__________________________________________________________________________
TABLE II______________________________________COMPOUND STRUCTURE AROMA______________________________________3-methylthio-4- heptanol ##STR34## At 1% in food grade ethanol, a sweet, green, floral, herbal, vegetative note.3-methylthio-4- heptanone ##STR35## At 1% in food grade ethanol a green, minty, herbaceous note with vegetative basil notes3-propylthio-4- heptanol ##STR36## Fatty, cucumber, onion (scallion, shallot) aroma with some green melon and floral nuances.3-thioacetyl-2,6- dimethyl-4- heptanone ##STR37## At 1% in food grade ethanol, a sweet, meaty, vegetable aroma with somewhat of a grape- fruit topnote.3-isobutylthio-4- heptanone ##STR38## Evaluated at 1% in food grade ethanol, a meaty, onion aroma with a green, spicey and peppery nuance and an underlying bergamot note.3-isobutylthio-2,6- dimethyl-4-heptanol ##STR39## Evaluated at 1% in food grade ethanol, a vegetable, green, horseradish, somewhat rubbery, onion-like aroma containing notes of hyacinth and narcisse.3-methylthio-2,6- dimethyl-4-heptanone ##STR40## Evaluated at 1% in food grade ethanol, a sweet, sulfurous, slightly floral and woody aroma with a fruity and berry nuance.3-(methallylthio)- 2,6-dimethyl- 4-heptanone ##STR41## At 1% in ethanol, a fruity, grapefruit, somewhat floral aroma with underlying yara neroli notes and bready, vegetative nuances.______________________________________
One or more of the aforementioned .alpha.-oxy(oxo)sulfides having the structure: ##STR42## wherein X is one of: ##STR43## R is one of ethyl or hydrogen, and Y is one of methyl, methallyl, acetyl, -- 1-propyl or 2-methyl-1-propyl is an olfactory agent and can be incorporated into a wide variety of compositions each of which will be enhanced or augmented by its sweet, green, floral, herbal, vegetative, basil-like, minty, melony, grapefruit, fruity and/or alliaceous notes and/or yara, neroli and/or verdima nuances.
The .alpha.-oxy(oxo) sulfides -- or mixture of .alpha.-oxy(oxo) sulfides -- can be added to perfume compositions as pure compounds or can be added to mixtures of materials in fragrance-imparting compositions to provide a desired fragrance character to a finished perfume material. The perfume and fragrance compositions obtained according to this invention are suitable in a wide variety of perfumed articles and can also be used to enhance, modify or reinforce natural fragrance materials. It will thus be appreciated that the .alpha.-oxy(oxo) sulfides -- of our invention is(are) useful as olfactory agent(s) and fragrance(s).
The term "perfume composition" is used herein to mean a mixture of compounds, including, for example, natural oils, synthetic oils, alcohols, aldehydes, ketones, ester, lactones, nitriles, are frequently hydrocarbons which are admixed so that the combined odors of the individual components produce a pleasant or desired fragrance. Such perfume compositions usually contain (a) the main note or the "bouguet" or foundation-stone of the composition; (b) modifiers which round-off and accompany the main note; (c) fixatives which include odorous substances which lend a particular note to the perfume throughout all stages of evaporation, and substances which retard evaporation and (d) top-notes which are usually low-boiling, fresh-smelling materials. Such perfume compositions of our invention can be used in conjunction with carriers, vehicles, solvents, dispersants, emulsifiers, surface-active agents, aerosol propellants, and the like.
In perfume compositions the individual components contribute their particular olfactory characteristics, but the overall effect of the perfume composition will be the sum of the effect of each ingredient. Thus, one or more of the .alpha.-oxy(oxo) sulfides -- of our invention can be used to alter, augment, modify or enhance the aroma characteristics of a perfume composition or a perfumed article, or example, by highlighting or moderating the olfactory reaction contributed by another ingredient of the composition.
The amount of one or more of the .alpha.-oxy(oxo) sulfides -- of our invention which will be effective in perfume compositions depends upon many factors, including the other ingredients, their amounts and the effects which are desired. It has been found that perfume compositions containing as much as 2% or as little as 0.005% by weight of the mixtures or compounds of this invention, or even less can be used to impart a buchu leaf oil-like aroma or a grapefruit oil-like aroma to soaps, cosmetics and other products. The amount employed will depend upon considerations of cost, nature of the end products, the effect desired in the finished product, and the particular fragrance sought.
One or more of the .alpha.-oxy(oxo) sulfides of our invention as disclosed herein can be used alone, in a fragrance modifying composition, or in a perfume composition as an olfactory component in detergents anionic detergents, cationic detergents, and nonionic detergents) and soaps; space deodorants; perfumes; colognes, bath preparations such as bath oil, bath salts; hair preparations such as lacquers, brilliantines, pomades and shampoos; cosmetic preparations such as creams, deodorants, hand lotions, sun screens; powders such as talcs, dusting powders, face powders and the like. When one or more of the .alpha.-oxy(oxo) sulfides -- of our invention is used in perfumed articles such as the foregoing, it can be used in amounts of 0.01% or lower. Generally, it is preferred not to use more than about 2% in the finished perfumed article, since the use of too much will tend to unbalance the total aroma and will needlessly raise the cost of the article.
When the .alpha.-oxy(oxo) sulfide and ether -- compound or compounds of our invention are used as food flavor adjuvants, or are used to augment or enhance the flavor or aroma characteristics of foodstuffs, the nature of the co-ingredients included with the said .alpha.-oxy(oxo) sulfides and ethers in formulating the product composition will also serve to augment the organoleptic characteristics of the ultimate foodstuff treated therewith.
As used herein in regard to flavors, the term "augment" in its various forms means "supplying or imparting flavor character or note to otherwise bland, relatively tasteless substances or augmenting the existing flavor characteristic where a natural flavor is deficient in some regard or supplementing the existing flavor impression to modify its quality, character or taste."
As used herein in regard to food flavors, the term "enhance" is used herein to mean the intensification of a flavor or aroma characteristic or note without the modification of the quality thereof. Thus, "enhancement" of a flavor or aroma means that the enhancement agent does not add any additional flavor note.
As used herein the term "foodstuff" includes both solids and liquids, and ingestible materials or chewable but non-ingestible materials such as chewing gum. Such materials usually do, but need not, have nutritional value. Thus, foodstuffs include soaps, convenience foods, beverages, gelatin desserts, dairy products, candies, vegetables, cereals, soft drinks, snacks and the like.
Substances suitable for use herein as co-ingredients or flavoring adjuvants are well known in the art for such use, being extensively described in the relevant literature. Apart from the requirements that any such materials be organoleptically compatible with the .alpha.-oxy(oxo) sulfides and ethers, -- non-reactive with the .alpha.-oxy(oxo) sulfides and ethers -- of our invention and "ingestibly" acceptable and thus non-toxic or otherwise non-deleterious, nothing particularly critical resides in the selection thereof. Accordingly, such materials which may in general be characterized as flavoring adjuvants or vehicles comprise broadly stabilizers, thickeners, surface active agents, conditioners, other flavorants and flavor intensifers.
Stabilizer compounds include preservatives, e.g., sodium chloride; antioxidants, e.g., calcium and sodium ascorbate, ascorbic acid, butylated hydroxyanisole (mixture of 2 and 3 tertiary-butyl-4-hydroxyanisole), butylated hydroxy toluene (2,6-di-tertiary-butyl-4-methyl phenol), propyl gallate and the like and sequestrants, e.g., citric acid.
Thickener compounds include carriers, binders, protective colloids, suspending agents, emulsifiers and the like, e.g., agaragar, carrageenan; cellulose and cellulose derivatives such as carboxymethyl cellulowe and methyl cellulose; natural and synthetic gums such as gum arabic, gum tragacanth; gelatin, proteinaceous materials; lipids; carbohydrates; starches, pectins and emulsifiers, e.g., mono- and diglycerides of fatty acids, skim milk powder, hexoses, pentoses, disaccharides, e.g., sucrose corn syrup and the like.
Surface active agents include emulsifying agents, e.g., fatty acids such as capric acid, caprylic acid, palmitic acid, myristic acid and the like, mono-and diglycerides of fatty acids, lecithin, defoaming and flavor-dispersing agents such as sorbitan monostearate, potassium stearate, hydrogenated tallow alcohol and the like.
Conditioners include compounds such as bleaching and maturing agents, e.g., benzoyl peroxide, calcium peroxide, hydrogen peroxide and the like; starch modifiers such as peracetic acid, sodium chlorite, sodium hypochlorite, propylene oxide, succinic anhydride and the like, buffers and neutralizing agents, e.g., sodium acetate, ammonium bicarbonate, ammonium phosphate, citric acid, lactic acid, vinegar and the like; colorants, e.g., carminic acid, cochineal, tumeric and curcuma and the like; firming agents such as aluminum sodium sulfate, calcium chloride and calcium gluconate; texturizers, anti-caking agents, e.g., aluminum calcium sulfate and tribasic calcium phosphate; enzymes; yeast foods, e.g., calcium lactate and calcium sulfate; nutrient supplements, e.g, iron salts such as ferric phosphate, ferrous gluconate and the like, riboflavin, vitamins, zinc sources such as zinc chloride, zinc sulfate and the like.
Other flavorants and flavor intensifiers include organic acids, e.g., actetic acid, formic acid, 2-hexenoic acid, benzoic acid, n-butyric acid, caproic acid, caprylic acid, cinnamic acid, isobutyric acid, isovaleric acid, alpha-methyl-butyric acid, propionic acid, valeric acid, 2-methyl-2-pentenoic acid, and 2-methyl-3-pentenoic acid; ketones and aldehydes, e.g., acetaldehyde, acetophenone, acetone, acetyl methyl carbinol, acrolein, n-butanal, crotonal, diacetyl, beta, beta-dimethyl-acrolein, n-hexanal, 2-hexenal, cis-3-hexenal, 2-heptanal, 4-(p-hydroxyphenyl)-2-butanone, alpha-ionone, beta-ionone, methyl-3-butanone, 2-pentanone, 2-pentenal and propanal; alcohols such as 1-butanal, benzyl alcohol, 1-borneol, trans-2-buten-1-ol, ethanol, geraniol, 1-hexanal, 2-heptanol, trans-2-hexenol-1, cis-3-hexen-1-ol, 3-methyl-3-buten-1-ol, 1-pentenol, 1penten-3-ol, p-hydroxyphenyl-2-ethanol, isoamyl alcohol, isofenchyl alcohol, phenyl-2-ethanol, alpha-terpineol, cisterpineol hydrate; esters, such as butyl acetate, ethyl acetate, ethyl acetoacetate, ethyl benzoate, ethyl butyrate, ethyl caproate, ethyl cinnamate, ethyl crotonate, ethyl formate, ethyl isobutyrate, ethyl isovalerate, ethyl alpha-methylbutyrate, ethyl propionate, ethyl salicylate, trans-2-hexenyl acetate, hexyl acetate, 2-hexenyl butyrate, hexyl butyrate, isoamyl acetate, isopropyl butyrate, methyl acetate, methyl butyrate, methyl caproate, methyl isobutyrate, alpha-methylbutyrate, propyl acetate, amyl acetate, amyl butyrate, benzyl salicylate, dimethyl anthranilate, ethyl methylphenylglycidate, ethyl succinate, isobutyl cinnamate and terpenyl acetate; essential oils, such as jasmine absolute, rose absolute, orris absolute, lemon essential oil, Bulgarian rose, yara yara, natural raspberry oil and vanilla; lactones; sulfides, e.g., methyl sulfide and other materials such as maltol, pulegone mercaptan, .alpha.-phellandrene, ethyl maltol, 2,2,4,4,6,6-hexamethyl-S-trithiane, acetoin and acetals, (e.g., 1,1-diethoxyethane, 1,1-dimethoxyethane and dimethoxymethane.)
The specific flavoring adjuvant selected for use may be either solid or liquid depending upon the desired physical form of the ultimate product, i.e., foodstuff, whether simulated or natural, and should, in any event, be capable of providing an environment in which the .alpha.-oxy(oxo) sulfides and ethers can be dispersed or admixed to provide a homogeneous medium. In addition, selection of one or more flavoring adjuvants, as well as the quantities thereof, will depend upon the precise organoleptic character desired in the finished product. Thus, in the case of flavoring compositions, ingredient selection will vary in accordance with the foodstuff to which the flavor and aroma are to be imparted. In contradistinction, in the preparation of solid products, e.g., simulated foodstuffs, ingredients capable of providing normally solid compositions should be selected such as various cellulose derivatives.
As will be appreciated by those skilled in the art, the amount of .alpha.-oxy(oxo) sulfides and ethers employed in a particular instance can vary over a relatively wide range whereby to its desired organoleptic effects having reference to the nature of the product are achieved. Thus, correspondingly, greater amounts would be necessary in those instances wherein the ultimate food composition to be flavored is relatively bland to the taste, whereas relatively minor quantities may suffice for purposes of enhancing the composition merely deficient in natural flavor or aroma. The primary requirement is that the amount selected to be effective, i.e., sufficient to alter the organoleptic characteristics of the parent composition, whether foodstuff per se or flavoring composition.
The use of insufficient quantities of 60-oxy(oxo) sulfides and ethers will, of course, substantially vitiate any possibility of obtaining the desired results while excess quantities prove needlessly costly and in extreme cases, may disrupt the flavor-aroma balance, thus providing self-defeating. Accordingly, the terminology "effective amount" and "sufficient amount" is to be accorded a significance in the context of the present invention consistent with the obtention of desired flavoring effects.
Thus, and with respect to ultimate food compositions, it is found tht quantities of .alpha.-oxy(oxo) sulfides and ethers ranging from a small but effective amount, e.g., about 0.1 parts per million up to about 50 parts per million by weight based on total composition (more preferably, from about 0.2 ppm up to about 10 ppm) are suitable. Concentrations in excess of the maximum quantity stated are not normally recommended, since they fail to prove commensurate enhancement of organoleptic properties. In those instances, wherein the .alpha.-oxy(oxo) sulfides and ethers are added to the foodstuff as an integral component of a flavoring composition, it is, of course, essential that the total quantity of flavoring composition employed be sufficient to yield an effective .alpha.-oxy(oxo) sulfide and ether concentration in the foodstuff product.
Food flavoring compositions prepared in accordance with the present invention preferably contain the .alpha.-oxy(oxo) sulfides and ethers in concentrations ranging from about 0.1% up to about 15% by weight based on the total weight of said flavoring composition.
The compositions described herein can be prepared according to conventional techniques well known as typified by cake batters and fruit drinks and can be formulated by merely admixing the involved ingredients within the proportions stated in a suitable blender to obtain the desired consistence, homogeneity of dispersion, etc. Alternatively, flavoring compositions in the form of particulate solids can be conveniently prepared by mixing the .alpha.oxy(oxo) sulfides and ethers with, for example, gum arabic, gum tragacanth, carageenan and the like, and thereafter spray-drying the resultant mixture whereby to obtain the particular solid product. Pre-prepared flavor mixed in powder form, e.g., a fruit-flavored powder mix, are obtained by mixing the dried solid components, e.g., starch, sugar and the like, and .alpha.-oxy(oxo) sulfides and ethers in a dry blender until the requisite degree of uniformity is achieved.
It is presently preferred to combine with the .alpha.-oxy(oxo) sulfides and ethers, the following adjuvants:
p-Hydroxybenzyl acetone;
Geraniol;
Acetaldehyde;
Maltol;
Ethyl methyl phenyl glycidate;
Benzyl acetate;
Dimethyl sulfide;
Vanillin;
Methyl cinnamate;
Ethyl pelargonate;
Methyl anthranilate;
Isoamyl acetate;
Isobutyl acetate;
Alpha ionone;
Ethyl butyrate;
Acetic acid;
Gamma-undecalactone;
Naphthyl ethyl ether;
Diacetyl;
Ethyl acetate;
Anethole;
Isoamyl butyrate;
Cis-3-hexenol-1;
2-Methyl-2-pentenoic acid;
Elemecine (4-allyl-1,2,6-trimethoxy benzene);
Isoelemecine (4-propenyl-1,2,6-trimethoxy benzene);
2-(4-hydroxy-4-methylpentyl) norbornadiene prepared according to U.S. Application for Letters Patent 461,703 fuled on Apr. 17, 1974;
Natural blackcurrant juice;
Buchu leaf oil;
.alpha.-phellandrene;
Cis-3-hexen-1-ol;
Terpinenol-4;
Ethyl maltol;
Methyl benzoate;
Benzaldehyde;
Coriander oil;
.alpha.-ionone;
Ethyl heptanoate;
Methyl anthranilate;
Ethyl anthranilate;
Cinnamic alcohol;
Amyl valerinate;
Cinnamyl propionate;
Rhodinyl acetate;
Methyl .beta.-hydroxy butyrate;
Ethyl .beta.-hydroxy butyrate;
2-phenyl-3-carboethoxyfuran;
Cyclohexyl disulfide;
Grapefruit oil;
Nootkatone;
Bergamot oil;
Citral;
Amyl alcohol;
5-phenyl-4-pentenal;
5-phenyl-2-pentenal;
Allyl caproate;
2-(n-pentyl) thiazole;
2-(i-butyl) thiazole;
2-(i-propyl) thiazole;
2-(n-propyl) thiazole;
2-phenyl-4-pentenal;
2-phenyl-4-pentenaldimethylacetal;
Methional;
4-methylthiobutanal;
2-ethyl-3-acetylpyrazine;
Tetramethyl pyrazine;
2-methyl pyrazine;
trans-2-hexenal;
Hydrolyzed vegetable protein;
Monosodium glutamate;
Dimethyl disulfide;
Methyl propyl disulfide;
Methyl propenyl disulfide;
Methyl allyl disulfide;
Allyl propyl disulfide;
Propyl propenyl disulfide;
Dipropyl disulfide;
disulfide;
Propyl propenyl trisulfide;
Thiopropanal-S-oxide;
Thiobutanal-S-oxide;
Thioethanol-S-oxide;
Thiohexanal-S-oxide; and
Propyl propene thiosulfonate.

The following examples are given to illustrate embodiments of the invention as it is presently preferred to practice it. It will be understood that these examples are illustrative and that the invention is not to be considered as restricted thereto except as indicated in the appended claims.
EXAMPLE I
(A) PREPARATION OF 3-CHLORO-4-HEPTANONE ##STR44##
Into a 3000 ml, three-necked, round-bottom flask, equipped with mechanical stirrer, 500 ml addition funnel, Y-tube, pot thermometer and gas outlet tube with rubber tubing leading over a stirring solution of 10% sodium hydroxide is added 1000g 4-heptanone. Addition of 434 g of SO.sub.2 Cl.sub.2 drop-wise into the 4-heptanone is commenced while maintaining the pot temperature in the range of 22.degree.-34.degree. C and is continued over a period of two hours. A water aspirator vacuum is applied to the reaction mass in order to pull the acidic gases; sulfur dioxide and hydrogen chloride, over the sodium hydroxide solution.
The reaction mass is periodically sampled using GLC analysis until such time as about 25% chlorinated ketone product is found to be present.
While maintaining the reaction mass at 15.degree. C, 1000 ml saturated sodium chloride is added to the mixture, and the mixture is then stirred for a period of 10 minutes. The reaction mass is then transferred to a 5-liter separatory funnel and shaken well, whereupon the organic and aqueous phases separate.
The lower aqueous phase (approximately 1000 ml) has a pH of about 1. The upper organic phase is washed with 700 ml saturated sodium bicarbonate solution to a pH of 6-7. The organic phase is then dried over 50 grams anhydrous sodium sulfate and filtered yielding a yellow oil weighing 1063 grams. The organic layer is determined to contain 24.9% chlorinated ketone and 68.1% original ketone starting material. This material is then vacuum distilled by first adding it to a 2000 ml, three-necked, round-bottom flask equipped with a 2.5 .times. 60 cm vacuum jacketed column packed with 6 mm Raschig Rings, and then equipped with an automatic reflux head, a pot thermometer, a heating mantle, a vacuum pump and a dry-ice trap. Fractionation data is as follows:
______________________________________Vacuum Pot Vapor Weight of Cut. Reflux(mmHg) Temp. Temp. Fraction No. Ratio______________________________________62 80 71 51.0 g 1 60:4062 81.5 71 149.0 g 2 40:6058 82.5 70 157.5 g 3 30:7059 89.5 70 175.0 g 4 30:7059 96 75 110 g 5 30:7059 100 80 24.5 g 6 50:5058 101 90 16.0 g 7 50:5058 102 94 37.5 g 8 30:7055 103 94 144.5 g 9 30:7054 110 95 85.0 g 10 30:7054 119 102 28.0 g 11 30:7015 140 80 45.0 g 12 30:70______________________________________
GLC analysis on each of cuts 5-12 (conditions 8' .times. 1/4" SE-30 column) yields the following information:
__________________________________________________________________________ Percent Percent Percent Percent High Percent High Percent High Percent HighCut low 4- 3-Cl Boiler Boiler Boiler BoilerNo. Boilers Heptanone 4-Heptanone (A) (B) (C) (D)__________________________________________________________________________5 0.09 96.15 2.97 -- -- -- --7 50% 50%8 -- 9.28 87.09 2.43 0.57 -- --9 -- trace 95.78 3.22 1.00 -- --10 -- -- 91.38 4.89 3.34 0.21 --11 -- -- 69.14 7.27 19.88 3.71 --12 -- -- 8.32 2.07 49.28 39.69 0.47__________________________________________________________________________
Cuts 8, 9 and 10 are blended (weight 266.5 gms) and are analyzed as follows:
______________________________________0.95% 4-heptanone93.89% 3-chloro-4-heptanone3.60% high boiler A1.57% high boiler B______________________________________
EXAMPLE I
(B) PREPARATION OF 3-THIOACETYL-4-HEPTANONE ##STR45##
Into a 25 ml, three-necked, round-bottom flask equipped with magnetic stirrer, nitrogen inlet tube, 6 inches Vigreux column with coton plug and pot thermometer is added a solution of 0.27 grams sodium methoxide in 3 ml anhydrous methanol (0.005 moles sodium methoxide). Under dry nitrogen, 0.38 grams of thioacetic acid dissolved in 3 ml anhydrous methanol (0.005 moles thioacetic acid) is then added to the sodium methoxide solution over a 2-minute period. A solution of 3-chloro-4-heptanone in methanol (0.75 grams 3-chloro-4-heptanone dissolved in one ml anhydrous methanol) prepared according to Part A, supra (cuts 8, 9 and 10 blended) is then added to the reaction mass which becomes turbid. Stirring is continued for a period of one hour, whereupon GLC analysis (condition: 8 feet .times. 1/4 inches SE-30 column) yields the following data:
______________________________________15.6% 3-chloro-4-heptanone3.0% chloro heptanone, high boiler77.67% major peak2.37% late peak______________________________________
With stirring, 15 ml water is added to the reaction mass which then splits up into two phases, an aqueous phase and an organic phase. The pH of the aqueous phase is 5-6. The organic phase is extracted with two 10 ml portions of methylene chloride. The methylene chloride extracts are combined and washed with 5 ml saturated sodium chloride solution. The organic phase is then dried over anhydrous sodium sulfate and concentrated in a rotary evaporator using water aspirator vacuum yielding 0.65 grams of a dark amber oil. GLC trapping of the major peak (Conditions: 8 ft .times. 1/4 inches SE-30 column operated at 120.degree. C, programmed at 5.degree. C/minute) yields a compound having a molecular weight of 188 and having a mass spectral analysis, NMR analysis and IR analysis which causes confirmation of the structure: ##STR46##
The NMR spectrum is set forth in FIG. 1. The IR spectrum is set forth in FIG. 2.
The NMR analysis is as follows:
______________________________________ ##STR47##0.92 ppm (t) CH.sub.3CH.sub.2 6H0.96 (t) CH.sub.3CCS2.01-1.44 (m) CH.sub.2 4H2.39 (s) ##STR48## 5H2.53 (m) ##STR49##4.20 (t) OCHCSCO 1H______________________________________
The IR analysis is as follows:
620 cm.sup.-1, 950, 1125, 1350, 1450, 1690, 2320, 2870, 2930, 2960.
Material prepared similarly to above example was vacuum distilled yielding 99.3% pure product (boiling point 93.5-94.5.degree. C at 2.8 mm Hg). The thus-distilled material has the same physical properties as set forth above for 3-thioacetyl-4-heptanone.
EXAMPLE I
(C) PREPARAtION OF 3-THIOMETHYL-4-HEPTANONE ##STR50##
Into a 50-ml, three-necked, round-bottom flask equipped with magnetic stirrer, dry ice condenser, pot thermometer, cold water bath, reflux condenser with nitrogen inlet tube and nitrogen bubbler, is placed a solution of 0.54 grams of sodium methoxide in 6 ml anhydrous methanol (0.01 moles sodium methoxide). The sodium methoxide solution is then cooled using the cold-water bath to a temperature of 25.degree. C. The nitrogen flow is ceased and methyl mercaptan in methanol (0.48 grams methyl mercaptan in 6 ml anhydrous methanol, 0.01 moles methyl mercaptan) is added to the reaction mass while maintaining same at 24.degree. C. At 24.degree. C, a solution of 1.49 grams of 3-chloro-4-heptanone in 2 ml anhydrous methanol (0.01 moles 3-chloro-4-heptanone) is added to the reaction mass. The 3-chloro-4-heptanone is produced according to the process set forth in part (A), supra. The reaction mass is maintained, with stirring, at 25.degree. C for a period of one hour and 15 minutes. At the end of this period, the reaction mass is flushed with nitrogen. The reaction mass is then concentrated on a rotary evaporator using a water aspirator vacuum to approximately 5 ml.
Distilled water (15 ml) is then added to the concentrated reaction mixture whereupon the reaction mixture forms into two phases; an oil phase and an aqueous phase. The pH of the aqueous phase is in the range of 5-6. The oil phase is then extracted with two 12-ml portions of n-hexane and the phase are separated. The hexane extracts are combined, washed with water (5 ml), dried over anhydrous sodium sulfate, gravity filtered and concentrated on a rotary evaporator to a weight of 1.29 grams. The resulting product contains 90.1% 3-thiomethyl-4-heptanone by GLC analysis having the structure: ##STR51## as confirmed by NMR, IR and mass spectral analyses of trapped compound.
The NMR spectrum is set forth in FIG. 3. The IR spectrum is set forth in FIG. 4.
The NMR analysis is as follows:
______________________________________ ##STR52##0.94 ppm (t) CH.sub.3CH.sub.2 6H0.97 (t) CH.sub.3CCS1.68 (m) CH.sub.2 4H1.92 (s) CH.sub.3S 3H2.60 (m) ##STR53## 2H3.08 (t) ##STR54## 1H______________________________________
The IR analysis is as follows:
1360 cm.sup.-1, 1375, 1455, 1690, 2330, 2880, 2930, 2960.
Material prepared similarly to above example was vacuum distilled yielding 99.2% pure product (boiling point 78.degree.-78.5.degree. C at 8.5 mm Hg). The thus-distilled material has the same physical properties as set forth above for 3-thiomethyl-4-heptanone.
EXAMPLE I
(D) PREPARATION OF 3-THIOMETHYL-4-HEPTANOL ##STR55##
Into a 25 ml, three-necked, round-bottom flask equipped with magnetic stirrer, nitrogen inlet tube, reflux condenser, pot thermometer, and cold water bath, is added a solution of 0.10 grams sodium borohydride (NaBH.sub.4) dissolved in 4 ml anhydrous ethyl alcohol (0.00265 moles sodium borohydride). While maintaining the pot temperature at 25.degree. C, a solution of 0.8 grams of 3-thiomethyl-4-heptanone -- in 3.5 ml anhydrous ethyl alcohol is added to the sodium borohydride-ethanol solution over a 1-minute period. The reaction mass then warms up to about 30.degree. C and is maintained at a temperature of between 25.degree. and 30.degree. C for a period of about 1.5 hours. At the end of this period another 0.05 grams (0.00133 moles) of sodium borohydride and 2 ml ethanol is added.
After 10 minutes of stirring while maintaining the reaction mass at 25.degree. C, the reaction mass is then worked up as follows. The reaction mixture is concentrated to about 4 ml of a thick slurry using water aspirator vacuum. The resulting thick slurry is then combined with 12 ml water thereby causing the solid to dissolve, and the reaction mass to -- exist in -- two phases; an aqueous phase and an organic phase. The aqueous phase is acidified to a pH of 2-3 using -- 10% HCl solution. The organic phase is extracted with two 12-ml portions of methylene chloride. The extracts are then combined, washed with 8 ml water, dried over anhydrous sodium sulfate, gravity filtered and then concentrated on a rotary evaporator (using water aspirator vacuum) to a weight of 0.58 grams. The desired product is trapped out on an 8 feet .times. 1/4 inches SE-30 GLC column, and MS, NMR and IR analysis confirm that the resulting compound has the structure: ##STR56##
The NMR spectrum is set forth in FIG. 5. The infrared spectrum is set forth in FIG. 6.
The NMR analysis is as follows:
______________________________________0.94 ppm (t) CH.sub.3 -- CH.sub.2 -- 6H1.06 (t) CH.sub.3 -- C-- C-- S--1.51 (m) -- CH.sub.2 -- 6H2.06 (s) CH.sub.3 -- S-- 3H2.36 (m) HC-- S-- 2H2.62 (broad) -- OH3.52 (m) HC-- O-- 1H______________________________________
The IR analysis is as follows:
980 cm.sup.-1, 1010, 1065, 1370, 1430, 1450, 2320, 2860, 2920, 2960, 3440.
Material prepared similarly to above example was vacuum distilled yielding 99.5% pure product (boiling points 64.degree.-64.5.degree. C at 1.5 mm Hg). The thus-distilled material has the physical properties as set forth above for 3-thiomethyl-4-heptanol.
EXAMPLE II
PREPARATION OF 3-METHALLYLTHIO-2,6-DIMETHYL-4-HEPTANONE
(A) Preparation of 3-chloro-2,6-dimethyl-4-heptanone ##STR57##
Into a one-liter, three-necked, round-bottom flask equipped with "Y" tube, pot thermometer, mechanical stirrer, 125 ml addition funnel, gas outlet tube, cold water bath and water aspirator vacuum is added 356 grams of 2,6-dimethyl-4-heptanone (2.4 moles). Over a period of one hour, 67.5 grams (40 ml; 0.5 moles) of SO.sub.2 Cl.sub.2 is slowly added to the ketone with stirring while maintaining the reaction mass temperature in the range of 23.degree.-35.degree. C.
The reaction mass is then evacuated slowly using water aspirator vacuum thereby removing most of the acidic gases resulting from the foregoing reaction.
The reaction mass is then transferred to a one-necked, one-liter, round-bottom flask and the last traces of acidic gases are removed thus yielding 371 grams of product. The reaction mass is then transferred to a 500 ml, three-necked, round bottom flask equipped with a 2.0 .times. 30 cm distillation column packed with 1/8 inch helices, reflux head, magnetic stirrer, heating mantle and vacuum pump and the resulting 3-chloro-2,6-dimethyl-4-heptanone is fractionally distilled at a vapor temperature of 106.degree.-107.degree. C and a pressure of 45-46 mm Hg yielding a product of 97% purity as confirmed by GLC, mass spectral, NMR and IR analyses.
EXAMPLE II
B. Preparation of 3-mercapto-2,6-dimethyl-4-heptanone ##STR58##
Into a 250 ml, round bottom, three-necked flask equipped with magnetic stirrer, pot thermometer, 6 inch Vigreux distillation column with gas outlet at top leading over 200 ml 10% sodium hydroxide solution, H.sub.2 S gas inlet tube (sub-surface), "Y" tube, 50 ml addition funnel, gas bubbler, and dry ice-isopropyl alcohol bath, and cold water bath is added a solution of 11.6 grams of sodium methoxide dissolved in 90 ml anhydrous methanol. The sodium methoxide solution is cooled to a temperature of -15.degree. C using the dry ice-isopropanol bath. While maintaining the temperature of the sodium methoxide solution at -10.degree. to -5.degree. C, hydrogen sulfide is bubbled into the reaction mass over a period of 2 hours. While continuing to bubble in hydrogen sulfide and maintaining the reaction mass at a temperature in the range of -5.degree. to -9.degree. C, the 3-chloro-2,6-dimethyl-4-heptanone prepared in Part A of this example (18.2 grams; 0.100 moles) is added slowly to the reaction mass from the addition funnel over a period of 13 minutes. The reaction mass is then maintaned at a temperature of 0.degree.-26.degree. C for a period of 4 hours (25.degree.-26.degree. C for the last 1.5 hours).
The reaction mass is then concentrated to approximately 25 ml (thick slurry) using a rotary evaporator and water aspirator vacuum. 85 ml distilled water is then added to the reaction mass, with stirring, while maintaining the temperature at 25.degree. C, thereby yielding a turbid yellow solution. 85 grams of 10% aqueous sodium hydroxide is then added to the resulting mixture whereupon the temperature rises from 25.degree. to 28.degree. C (pH = 10-11). The basic aqueous solution is then extracted with two 70 ml portions of methylene chloride and the extracts are combined, dried and concentrated yielding 1.7 grams of an oil. The basic aqueous solution is then acidified with 115 ml 10% hydrochloride acid to a pH of 1-2. This is then extracted with four 50 ml portions of methylene chloride. The methylene chloride extracts are combined and washed with two 35 ml portions of saturated sodium chloride (to a pH of 5) and dried over anhydrous sodium sulfate. The resulting mixture is gravity filtered and concentrated on a rotary evaporator to yield 15.5 grams of product containing 96.1% 3-mercapto-2,6-dimethyl-4-heptanone as confirmed by mass spectral, NMR and IR analyses. This material is vacuum distilled at a vapor temperature of 77.5.degree.-78.degree. C and a pressure of 6 mm Hg.
EXAMPLE II
C. Preparation of 3-methallylthio-2,6-dimethyl-4-heptanone ##STR59##
Into a 25 ml, three-necked, round bottom flask equipped with magnetic stirrer, "Y" tube, nitrogen inlet, reflux condenser with cotton plug, cold water bath and warm water bath is added a solution of 0.162 grams of sodium methoxide dissolved in 2 ml anhydrous methanol. Over a period of 1 minute is added a solution of 0.522 grams of 3-mercapto-2,6-dimethyl-4-heptanone dissolved in 3 ml anhydrous methanol, with stirring. After stirring 12 minutes at 24.degree.-25.degree. C, a solution of 0.3 grams of 3-chloro-2-methylpropene in 1 ml anhydrous methanol is added. With a water bath, the resulting reaction mass is warmed to 31.degree. C and the reaction mass is then stirred while maintaining the temperature in the range of 23.degree.-30.degree. C for a period of 2 hours.
The reaction mass is then concentrated on a rotary evaporator using water aspirator vacuum to approximately 4 ml yielding a slurry. To the slurry is added 8 ml water and the solid dissolves. The reaction mass is then acidified to a pH of 1-2 with 3 drops of 10% hydrochloric acid. The reaction mass is then extracted with three 8 ml portions of methylene chloride and the extracts are combined, washed with 10 ml water, dried over anhydrous sodium sulfate and gravity filtered. The extracts are concentrated on a rotary evaporator to yield 0.54 grams of a white oil contaning 93.6% by GLC of 3-methallylthio-2,6-dimethyl-4-heptanone as confirmed by MS, IR and NMR analyses of trapped product.
The NMR spectrum is set forth in FIG. 7. The infrared spectrum is set forth in FIG. 8.
The mass spectral analysis is as follows:
______________________________________m/e Relative Intensity______________________________________41 2955 44.sup.357 37.sup.669 1085 43.sup.587 93.sup.2109 33142 44.sup.4143 100.sup.1M 228 28______________________________________
The NMR analysis is as follows:
______________________________________1.92 ppm, 2.06 (2 doublets) ##STR60## 12H1.78 (s) CCH.sub.3 3H2.12 (m) methine protons 2H2.47 (t) CH.sub.2 2H2.82 (d) ##STR61## 1H3.01 (s) CCH.sub.2S 2H4.86 (s) ##STR62## 2H______________________________________
The IR analysis is as follows:
890 cm.sup.-1, 1035, 1160, 1200, 1225, 1285, 1360, 1380, 1400, 1460, 1640, 1695, 2870, 2960, 3080.
Material prepared similarly to above example was vacuum distilled yielding 99.8% pure product (boiling point 100.degree.-100.5.degree. C at 1.3 mm Hg). The thus-distilled material has the same physical properties as set forth above for 3-methallylthio2,6-dimethyl-4-heptanone.
EXAMPLE II
D. PREPARATION OF 3-CROTYLTHIO-2,6-DIMETHYL-4-HEPTANONE ##STR63##
Into a 25 ml, three-necked, round bottom flask equipped with magnetic stirrer, reflux condenser, nitrogen inlet tube and cold water bath is placed a solution of 0.162 grams (0.003 moles) of sodium methoxide dissolved in 2 ml anhydrous methanol. Using the cooling bath the temperature of the sodium methoxide solution is cooled to 23.degree. C at which point a solution of 0.52 grams (0.003 moles) of 3-mercapto-2,6-dimethyl-4-heptanone in 2 ml anhydrous methanol is added to the sodium methoxide solution. While maintaining the temperature of the reaction mass at 24.degree.-29.degree. C and over a period of 2 minutes, a solution of 0.300 grams of 80% crotyl chloride dissolved in 2 ml anhydrous methanol (0.0026 moles crotyl chloride) is added to the reaction mass with stirring. The reaction mass is continued to be stirred for a period of 2.5 hours and is then concentrated on a rotary evaporator using water aspirator vacuum to 2 ml product (solid/oil slurry). Nine ml water is added to the reaction mass thereby dissolving the solid. The oil is extracted with three 8 ml portions of methylene chloride and the extracts are combined and washed with 6 ml water. The methylene chloride extracts are then dried over anhydrous sodium sulfate, gravity filtered and concentrated on a rotary evaporator to 0.59 grams pale yellow oil. The major product is isolated using GLC apparatus (8 feet .times. 1/4 inch Carbowax column). NMR, mass spectral and IR analyses yield the information that the resulting material is 3-crotylthio-2,6-dimethyl-4-heptanone having the structure; ##STR64##
The NMR spectrum is set forth in FIG. 9. The infrared spectrum is set forth in FIG. 10.
The mass spectral analysis is as follows:
______________________________________m/e Relative Intensity______________________________________41 2055 90.sup.257 37.sup.585 36.sup.687 100.sup.189 33141 22142 45.sup.4143 63.sup.3M 228 13______________________________________
The NMR analysis is as follows:
______________________________________0.84 ppm, 1.08 (doublets) CH.sub.3 12H1.70 (d) CCH.sub.3 3H2.14 (m) methine protons 2H2.48 (m) CH.sub.2CO 2H2.82 (d) OCHCS 1H2.99 (m) CCH.sub.2S 2H5.50 (m) olefinic protons 2H______________________________________
The infrared analysis is as follows:
960 cm.sup.-1, 1035, 1135, 1160, 1285, 1360, 1380, 1400, 1465, 1,695, 2870, 2930, 2960, 3020.
EXAMPLE II
E. PREPARATION OF 3-ALLYLTHIO-2,6-DIMETHYL-4-HEPTANONE ##STR65##
Into a 25 ml, round-bottom, three-necked flask equipped with magnetic stirrer, reflux condenser, nitrogen inlet tube and cold water bath is placed a solution of 0.162 grams (0.003 moles) of sodium methoxide dissolved in 2 ml anhydrous methanol. Using the water bath the temperature of the sodium methoxide solution is reduced to 23.degree. C. At 23.degree. C a solution of 0.522 grams (0.003 moles) of 3-mercapto-2,6-dimethyl-4-heptanone dissolved in 3 ml anhydrous methanol is added to the sodium methoxide solution. Subsequent to the additon of the mercapto ketone, after stirring for 15 minutes at 23.degree. C, a solution of 0.40 grams (0.0033 moles) of allyl bromide dissolved in 2 ml anhydrous methanol is added to the reaction mass with stirring. The reaction mass warms to 33.degree. C and is continued to be stirred at 25.degree.-33.degree. C for a period of 2 hours. It is concentrated on a rotary evaporator using water aspirator vacuum to a volume of 3 ml, thus yielding a white slurry. Eight ml water is then added to the slurry thereby dissolving the solid therein. One drop of 10% HCl is added to the resulting material thereby reducing the pH from about 9 to about 5. The reaction mass now existing in two phases is extracted with three 8 ml volumes of methylene chloride. The extracts are combined and washed with 6 ml water and then dried over anhydrous sodium sulfate, gravity filtered and concentrated on a rotary evaporator to a weight of 0.55 grams (pale yellow oil). GLC analysis (8 feet .times. 1/4 inch SE-30 column), NMR, IR and mass spectral analyses of GLC isolated material confirm that the resulting product is 97% product, 3-allylthio-2,6-dimethyl-4-heptanone, having the structure: ##STR66##
The NMR spectrum is illustrated in FIG. 11. The infrared spectrum is illustrated in FIG. 12.
The mass spectral analysis is as follows:
______________________________________m/e Relative Intensity______________________________________41 33.sup.555 2457 32.sup.669 1873 40.sup.385 3087 43.sup.295 30129 100.sup.1142 38.sup.4M 214 17______________________________________
The NMR analysis is as follows:
______________________________________0.84 ppm, 1.08 (doublets) CH.sub.3 12H2.14 (m) methine protons 2H2.48 (m) CH.sub.2CO 2H2.84 (d) CHCS 1H3.04 (m) CCH.sub.2S 2H5.22-5.04 (m) ##STR67## 2H5.96-5.56 (m) ##STR68## 1H______________________________________
The IR analysis is as follows:
914 cm.sup.-1, 980, 1035, 1160, 1360, 1380, 1465, 1695, 2870, 2930, 2960.
EXAMPLE II
F. PREPARATION OF (1,3-DIETHYL ACETONYL) (1,3-DIISOPROPYLACETONYL) SULFIDE ##STR69##
Into a 50 ml, round bottom, three-necked flask equipped with magnetic stirrer, pot thermometer, "Y" tube, nitrogen inlet tube, reflux condenser with cotton plug, and water bath is placed a solution of 0.65 grams (0.012 moles) of sodium methoxide dissolved in 10 ml anhydrous methanol. While maintaining the temperature of the reaction mass at 24.degree.-27.degree. C, a solution of 2.1 grams of 3-mercapto-2,6-dimethyl-4-heptanone dissolved in 12 ml anhydrous methanol is added to the sodium methoxide solution. 1.78 grams of 3-chloro-4-heptanone is then added to the reaction mass with stirring over a period of 2 minutes, the reaction mass temperature rising to 38.degree. C. Two ml anhydrous methanol used as rinse is then added to the reaction mass, and with -- stirring the reaction mass temperature cools to 25.degree. C. The reaction mass is continued to be stirred at 25.degree. C for a period of 5 hours. At this point 25 ml distilled water is added, and the resulting solid dissolves. The oil phase is extracted with three 15 ml portions of methylene chloride, and the extracts are combined and washed with one 10 ml portion of water. The extracts are then dried over anhydrous sodium sulfate and gravity filtered and concentrated on a rotary evaporator using water aspirator vacuum to a weight of 3.20 grams (yellow oil). GLC analysis (8 feet .times. 1/4 inch SE-30 column), NMR, IR and mass spectral analyses of GLC isolated material yield the information that the resulting product is 85% pure and has the structure: ##STR70##
The NMR spectrum is set forth in FIG. 13. The IR spectrum is set forth in FIG. 14.
The mass spectral analysis is as follows:
______________________________________m/e Relative Intensity______________________________________41 50.sup.643 82.sup.355 3357 89.sup.271 56.sup.585 100.sup.1114 67.sup.4145 39201 36M 286 29______________________________________
The NMR analysis is as follows:
______________________________________1.07 ppm, 0.86 CH.sub.3 18H1.62 CH.sub.2+ methine protons 6H2.46 CH.sub.2CO 4H3.15 and 2.96 ##STR71## 2H______________________________________
The IR analysis is as follows:
1155 cm.sup.-1, 1360, 1380, 1460, 1700, 2870, 2930, 2960.
EXAMPLE II
G. PREPARATION OF 3-[(METHOXYCARBONYL)METHYLTHIO]-2,6-DIMETHYL-4-HEPTANONE ##STR72##
Into a 50 ml, round-bottom, three-necked flask equipped with magnetic stirrer, pot thermometer, "Y" tube, nitrogen inlet tube, reflux condenser with cotton plug, H.sub.2 SO.sub.4 bubbler for nitrogen, and cold water bath is added a solution of 0.65 grams of sodium methoxide dissolved in 10 ml anhydrous methanol. At a reaction mass temperature of 25.degree.-28.degree. C and over a period of one minute, with stirring, is added a solution of 2.1 grams of 3-mercapto-2,6--dimethyl-4-heptanone dissolved in 2 ml anhydrous methanol. After stirring 8 minutes, 1.30 grams of methylchloroacetate (0.012 moles) is added over a period of 2 minutes to the reaction mass; the temperature of the reaction mass rising to 38.degree. C. The reaction mass is allowed to cool to 24.degree. C and is stirred for a period of 2 hours.
Distilled water (25 ml) is then added to the reaction mass whereupon the solid present dissolves. The organic phase is then extracted with three 15 ml methylene chloride portions. The combined extracts are washed with one 10 ml portion of water and dried over anhydrous sodium sulfate and gravity filtered. The filtered extracts are then concentrated on a rotary evaporator using water aspirator vacuum to a weight of 2.67 grams (pale yellow oil). GLC trapping of the major component (Conditions: 8' .times. 1/4" SE-30 column), with mass spectral, IR and NMR analyses confirm that the resulting product has the structure: ##STR73##
The NMR spectrum is set forth in FIG. 14(A). The IR spectrum is set forth in FIG. 14(B).
The mass spectral analysis is as follows:
______________________________________m/e Relative Intensity______________________________________29 1141 24.sup.643 1255 2457 53.sup.385 46.sup.4101 100.sup.1129 32.sup.5161 75.sup.2M 246 21______________________________________
The NMR analysis is as follows:
______________________________________0.94, 1.10 ppm ##STR74## 12 H2.12 ##STR75## 2 H2.50 ##STR76## 2 H3.03 ##STR77## 1 H3.19 ##STR78## 2 H3.70 ##STR79## 3 H______________________________________
The IR analysis is as follows:
1145 cm.sup.-1, 1185, 1285, 1360, 1375, 1430, 1460, 1695, 1735, 2860, 2920, 2960.
EXAMPLE II
(H) PREPARATION OF 3-[(METHOXYCARBONYL)METHYLTHIO]-4-HEPTANONE ##STR80##
Into a 50 ml, three-necked, round-bottom flask equipped with magnetic stirrer, pot thermometer, "Y" tube, nitrogen inlet tube, reflux condenser with cotton plug and cold water bath is placed a solution of 1.08 grams of sodium methoxide dissolved in 11 ml anhydrous methanol (0.02 moles sodium methoxide). Over a period of 2 minutes, and at a temperature of 25.degree.-30.degree. C, 2.12 grams (0.02 moles) of methyl thioglycolate dissolved in 2 ml anhydrous methanol is added to the reaction mass with stirring. After 5 minutes, 2.97 grams of 3-chloro-4-heptanone is then added to the reaction mass with stirring while the temperature of the reaction mass warms to 40.degree. C. The reaction mass then cools to 35.degree. C and is stirred in the temperature range of 25.degree.-35.degree. C for a period of 2 1/2 hours.
25 ml water is then added to the reaction mass with stirring, and the solid present therein dissolves (pH = 6-7). The reaction mass is extracted with three 20 ml volumes of methylene chloride, and the methylene chloride extracts are combined and washed with one 10 ml portion of water. The methylene chloride extracts are then dried over anhydrous sodium sulfate, gravity filtered and concentrated on a rotary evaporator using water aspirator vacuum to a weight of 3.77 grams (light yellow oil). GLC analysis (Conditions: 8 feet .times. 1/4 inch SE-30 column) indicates 92.0% product. NMR, mass spectral and IR analyses of GLC isolated material confirm that the resulting product is: ##STR81##
The mass spectral analysis is as follows:
______________________________________m/e Relative Intensity______________________________________27 1141 2143 54.sup.445 1255 1171 59.sup.387 100.sup.1115 41.sup.5147 90.sup.2M 218 35.sup.6______________________________________
The NMR analysis is as follows:
______________________________________0.98 ppm methyl protons 6H2.06-1.46 CH.sub.2 4H2.60 CH.sub.2CO 2H3.22 SCH.sub.2CO 3H3.30 OCHCS3.72 ##STR82## 3H______________________________________
The IR analysis is as follows:
1000 cm.sup.-1, 1150, 1185, 1275, 1430, 1450, 1695, 1730, 2860, 2920, 2960.
The NMR spectrum is set forth in FIG. 15. The infrared spectrum is set forth in FIG. 16.
EXAMPLE II
(I) PREPARATION OF 3-THIOACETYL-2,6-DIMETHYL-4-HEPTANONE ##STR83##
Into a 25 ml, three-necked, round-bottom flask equipped with magnetic stirrer, nitrogen inlet tube at top of 6inch Vigreux column, reflux condenser with cotton plug, pot thermometer, water bath and heating mantle is placed a solution containing 0.27 grams of sodium methoxide (0.005 moles) in 3 ml anhydrous methanol. To the sodium methoxide solution is added a solution of 0.38 grams (0.005 moles) of thioacetic acid in 3 ml anhydrous methanol, with stirring, while maintaining the reaction mass temperature in the range of 23.degree.-25.degree. C. The addition takes place over a period of 10 minutes. While maintaining the reaction mass temperature at 23.degree. C, a solution of 0.883 grams (0.005 moles) of 3-chloro-2,6-dimethyl-4-heptanone (prepared according to Part A) in 2 ml anhydrous methanol is added to the reaction mass. While maintaining the reaction mass temperature between 35.degree. and 45.degree. C and over a period of 3 hours, the reaction mass is stirred. At the end of the 3-hour period only 6% of product is formed. The reaction mass is then refluxed at 66.degree.-76.degree. C for a period of 12 hours, at which point it is indicated by GLC, NMR, IR and mass spectral analyses that 3-thioacetyl-2,6-dimethyl-4-heptanone is formed in an amount of 65%.
The reaction mass is then concentrated on a rotary evaporator using water aspirator vacuum to 4 ml of an oily product. Ten ml water is then added, and the solid dissolves. The oil layer is extracted with three 8 ml portions of methylene chloride, and the extracts are combined and washed with one 8 ml water portion. The extracts are then dried over anhydrous sodium sulfate, gravity filtered and concentrated yielding 0.54 grams of a yellow oil. The desired product is trapped on a GLC SE-30 column (Conditions: 8' .times. 1/4").
The NMR analysis is as follows:
______________________________________1.01-0.88 ppm Methyl protons 12H2.42-2.03 Methine protons2.44 ##STR84## 7H2.40 ##STR85##4.14 ##STR86##______________________________________
The infrared analysis is as follows:
6.20 cm.sup.-1, 950, 1100, 1130, 1360, 1380, 1465, 1695, 2870, 2930, 2960.
The mass spectral analysis is as follows:
______________________________________m/e Relative Intensity______________________________________41 14.sup.543 40.sup.355 1257 60.sup.285 100.sup.189 27.sup.4131 12.sup.6141 9173 11M 216 7______________________________________
The NMR spectrum is set forth in FIG. 16(A). The infrared spectrum is set forth in FIG. 16(B).
EXAMPLE III
A. Preparation of 3-propylthio-4-heptanone. ##STR87##
Into a 50 ml, three-necked, round bottom flask equipped with magnetic stirrer, reflux condenser, nitrogen inlet tube, pot thermometer and cold water bath, is placed a solution of 0.54 grams of sodium methoxide dissolved in 6 ml anhydrous methanol (0.01 moles of sodium methoxide). The sodium methoxide solution is cooled using the water bath to 25.degree. C. A solution of 0.76 grams of n-propyl mercaptan dissolved in 6 ml anhydrous methanol (0.01 moles n-propyl mercaptan) is then added to the sodium methoxide/ methanol solution, and the temperature rises to 28.degree. C. 1.5 g (0.01 moles) 3-chloro-4-heptanone dissolved in 2 ml anhydrous methanol is then added, and the temperature of the reaction mass rises to 38.degree. C, whereupon it is cooled using the water bath to a temperature in the range of 25.degree.-30.degree. C. The reaction mass is then stirred under nitrogen for a period of 6 hours.
The reaction mass is then concentrated to a volume of 4 ml using a rotary evaporator to which water aspirator vacuum is applied. 9 ml distilled water is then added to the reaction mass concentrate whereupon the solid dissolves. The oil phase is extracted with three 8 ml portions of methylene chloride, and the extracts are combined and washed with 8 ml of water and dried over anhydrous sodium sulfate and filtered and then concentrated. GLC, MS, NMR and IR analyses of trapped product yield the information that the subject material is 3-propylthio-4-heptanone.
The NMR spectrum is set forth in FIG. 17. The IR spectrum is set forth in FIG. 18.
The NMR analysis is as follows:
______________________________________0.87 - 1.04 ppm superimposed CH.sub.3 9H signals1.63 (m) CH.sub.2 6H2.38 (t) CH.sub.2S 2H2.60 (t) ##STR88## 2H3.11 (t) OCHCS 1H______________________________________
The IR analysis is as follows:
1130 cm.sup.-1, 1165, 1290, 1360, 1380, 1405, 1460, 1700, 2880, 2940, 2960.
The mass spectral analyses is as follows:
______________________________________m/e Relative Intensity______________________________________ 41 20.sup.4 43 26.sup.3 55 5 71 10 75 35.sup.2114 10117 100.sup.1118 10.sup.6119 9M 188 16.sup.5______________________________________
Material prepared similarly to above example was vacuum distilled yielding 98.4% pure product (boiling point 72.degree.-73.degree. C at 1.5 mm Hg). The thus-distilled material has the same physical properties as set forth above for 3-propylthio-4-heptanone.
B. Preparation of 3-propylthio-4-heptanol ##STR89##
Into a 25 ml, three-necked, round bottom flask equipped with magnetic stirrer, reflux condenser, pot theremometer, and nitrogen inlet (for flushing with dry nitrogen) is added a solution of 0.15 grams of sodium borohydride dissolved in 6 ml anhydrous methanol (0.004 moles sodium borohydride). With stirring, a solution of 1.0 grams of 3-propylthio-4-heptanone dissolved in 4 ml anhydrous ethyl alcohol is added to the sodium borohydride solution which then warms to 28.degree. C. The reaction mass is stirred for a period of 2 hours at 25.degree. C and then concentrated on a rotary evaporator (using water aspirator vacuum) to a volume of 4 ml yielding an oily solid. 8 ml water is then added to the solid, with stirring, and the solid dissolves yielding two phases: an oil phase and a water phase. The resulting reaction mass is acidified with 10% hydrochloric acid to a pH of between 2 and 3. The oil phase is extracted with three 8 ml volumes of methylene chloride, and the extracts are combined and washed with 8 ml water. The extracts are then dried over anhydrous sodium sulfate, filtered and concentrated to a weight of 0.79 grams (water-white oil). GLC, IR, mass spectral and NMR analyses after GLC trapping (Conditions: 8 feet .times.1/4inch SE-30 column) yield the information that the crude material is 96% product having the structure 3-propylthio-4-heptanol.
The NMR spectrum is set forth in FIG. 19. The IR spectrum is set forth in FIG. 20.
The NMR analysis is as follows:
______________________________________1.13-0.96 superimposed methyl protons 9H signals1.44 (m) -- CH.sub.2 -- 8H2.47 (s) -- OH2.49 (m) HC -- S -- CH.sub.2 -- 4H3.50 (m) HC -- O -- 1H______________________________________
The IR analysis is as follows:
1290 cm.sup.-1, 1380, 1460, 2880, 2940, 2970, 3460.
Material prepared similarly to above example was vacuum distilled yielding 99.8% pure product (boiling point 65.degree. C at 0.4 mm Hg). The thus-distilled material has the same physical properties as set forth above for 3-propylthio-4-heptanol.
EXAMPLE IV
PREPARATION OF 3-ISOBUTYLTHIO-4-HEPTANONE ##STR90##
Into a 50 ml, three-necked, round bottom flask equipped with magnetic stirrer, reflux condenser, pot thermometer, water bath, -- 15 cm Vigreux column with nitrogen inlet at top is added a solution of 0.54 grams of sodium methoxide (0.01 moles) in 6 ml anhydrous methanol. The reaction mass is cooled to 25.degree. C and a solution of 0.90 grams of isobutyl mercaptan (2-methyl-1-propanethiol) dissolved in 6 ml anhydrous methanol is added over a period of one minute. After keeping the reaction mass at 24.degree. C with stirring for a period of 10 minutes, 1.50 grams of 3-chloro-4-heptanone dissolved in 2 ml anhydrous methyl alcohol (0.01 moles of 3-chloro-4-heptanone) is added to the reaction mass which then warms to 37.degree. C. The reaction mass is allowed to cool to a temperature of 24.degree. C and stirred at that temperature for a period of 6 hours.
The reaction mass is then concentrated on a rotary evaporator using water aspirator vacuum to a volume of 4 ml yielding an oily solid. Ten ml water is then added, and the solid dissolves yielding two phases: an oil phase and an aqueous phase. The oil phase is extracted with three 9 ml. portions of methylene chloride, and the extracts are combined and washed with 9 ml water. The extracts are then dried over anhydrous sodium sulfate, filtered and concentrated to a weight of 1.78 grams.
Mass spectral, infrared, NMR and IR analyses yield the information that the reaction mass contains 90.9% product which is 3-isobutylthio-4-heptanone.
The NMR spectrum is set forth in FIG. 21. The IR spectrum is set forth in FIG. 22.
The NMR analysis is as follows:
______________________________________0.96 ppm (d) ##STR91##0.98 (t) CH.sub.3CH.sub.2 12H0.91 (t) ##STR92##1.70 (m) ##STR93## 5H2.26 (d) SCH.sub.2 2H2.60 (t) ##STR94## 2H3.10 (t) OCHCS 1H______________________________________
The IR analysis is as follows:
1365 cm.sup.-1, 1380, 1460, 1700, 2880, 2940, 2960.
EXAMPLE V
A. PREPARATION OF 1-CHLORO-1,3-DIPHENYL-2-PROPANONE ##STR95##
Into a 250 ml, three-necked flask equipped with 15 cm Vigreux column with vacuum outlet at top, pot thermometer, magnetic stirrer, 125 ml addition funnel and cold water bath is placed 99 grams (0.470 moles) of 1,3-diphenylacetone. Over a period of 11/2 hours, 21.2 grams (0.157 moles) of SO.sub.2 Cl.sub.2 is added while maintaining the reaction temperature in the range of 23.degree.-30.degree. C, and with stirring. At the end of the addition of the SO.sub.2 Cl.sub.2, water aspirator vacuum is applied to remove the acidic gases, HCl and SO.sub.2. An additional 21.2 grams of SO.sub.2 Cl.sub.2 is then added over a 45 minute period, but allowing the reaction temperature to rise to a maximum of 38.degree. C (without cooling). The reaction mass is then stirred for an additional hour while maintaining the temperature thereof at 24.degree.-38.degree. C and acidic gases are again removed using water aspirator vacuum, over a perod of 2 hours. The reaction mass is then transferred to a 250 ml, three-necked, round bottom flask equipped with pot thermometer, nitrogen inlet capillary tube, 1.8 .times. 30 cm distillation column packed with 1/4 helices, reflux distillation head, vacuum pump and heating mantle. After 15 minutes of distillation, the packed column was replaced with a 2.8 .times. 30 cm Vigreux column. Four cuts were removed at a vacuum of 0.2-0.5 mm Hg, and a vapor temperature of 153.degree.-163.degree. C.
Thin layer chromatography was carried out on the fractions since the GLC analysis cannot distinguish between the chlorinated derivative and the starting material. TLC and mass spectral analyses yield the information that the distillate is a mixture of starting material and the desired product, having the structure: ##STR96##
B. PREPARATION OF 1-PROPYLTHIO-1,3-DIPHENYL=2-PROPANONE ##STR97##
Into a 50 ml, three-necked, round-bottom flask equipped with magnetic stirrer, "Y" tube, reflux condenser, pot thermometer and nitrogen inlet tube is placed a solution of 0.54 grams sodium methoxide dissolved in 6 ml anhydrous methanol. The reaction mass is cooled and remains at 25.degree. C while a solution of 0.76 grams of n-propylmercaptan (0.01 moles) dissolved in 6 ml anhydrous methanol is added to the sodium methalate solution. A solution of 2.5 grams of the mixture of 1-chloro-1,3-diphenyl-2-propanone and 1,3-diphenyl-2-propanone dissolved in 3 ml anhydrous methanol (prepared according to the procedure of Part A) and is added to the reaction mass while allowing the reaction mass to warm to a temperature of 29.degree. C.
The reaction mass is maintained at a temperature of between 25.degree. and 39.degree. C over a period of 4 hours. At the end of the four-hour period the reaction mixture is concentrated on a rotary evaporator using water aspirator vacuum to a slurry which is an amber liquid and a white solid. Ten ml water are added to the mixture in order to dissolve the solid. The organic phase is then extracted with three 8 ml portions of methylene chloride, and the extracts are combined amd washed with two 8 ml portions of water. The combined extracts are dried over anhydrous sodium sulfate, gravity filtered and concentrated on a rotary evaporator using water aspirator vacuum to yield an orange amber oil weighing 2.2 grams. GLC analysis (8 .times. 1/4 SE-30 column) as well as mass spectral, IR, NMR and thin layer chromatography (30% diethyl ether in hexane) analyses confirm that the desired product (isolated by GLC trapping) is 1-propylthio-1,3-diphenyl-2-propanone, having the structure: ##STR98##
The NMR spectrum is set forth in FIG. 23. The IR spectrum is set forth in FIG. 24.
The mass spectral analysis is as follows:
______________________________________m/e Relative Intensity______________________________________ 43 8.sup.5 65 7.sup.6 91 47.sup.2118 6123 20.sup.3165 100.sup.1166 14.sup.4167 5210 5M 284 9______________________________________
The NMR analysis is as follows:
______________________________________0.88 ppm (t) CH.sub.3 3H1.49 (m) CH.sub.2 2H2.34 (t) CH.sub.2S 2H3.76 (AB) ##STR99## 2H4.68 (s) ##STR100## 1H7.32-7.01 (m) aromatic protons 10H______________________________________
The IR analysis is as follows:
690 cm.sup.-1, 1450, 1490, 1710, 2920, 2960, 3020.
Material prepared similarly to above example was vacuum distilled yielding 98.5% pure product (boiling point 160.degree.-163.degree. C at 0.4 mm Hg). The thus-distilled material has the same physical properties as set forth above for 1-propylthio-1,3-diphenyl-2-propanone.
EXAMPLE IV
(A) PREPARATION OF 3-METHYLATHIO-2,6-DIMETHYL-4-HEPTANONE ##STR101##
Into a 50 ml, three-necked, round bottom flask equipped with pot thermometer, magnaetic stirrer, gas inlet tube (subsurface), gas bubbler, methyl mercaptan gas cylinder, 15 cm Vigreux column, gas outlet tube leading to 10% sodium hydroxide solution, and cold water bath is added a solution of 0.54 grams of sodium methoxide in 12 ml anhydrous methanol (0.01 moles sodium methoxide). The reaction mass warms to 30.degree. C, and it is cooled to 23.degree. C using the cold water bath. Over a period of 20 minutes the methyl mercaptan is bubbled in below the surface of the liquid while maintaining the temperature of the reaction mass at 22.degree.-23.degree. C. The reaction flask is then flushed with dry nitrogen, and a solution of 1.77 grams of 3-chloro-2,6-dimethyl-4-heptanone dissolved in 2 ml anhydrous methanol is then added to the reaction mass. The reaction mass remains at 23.degree.-25.degree. C and is stirred at that temperature for a period of 2.5 hours. GLC analysis indicates 79% product. The reaction mass is then warmed to 35.degree. C and maintained at 28.degree.-35.degree. C for another 1.5 hours.
The reaction mass is then concentrated to a volume of 5 ml using a rotary evaporator to which water aspirator vacuum is applied. 15 ml distilled water is then added to dissolve the solid yielding a two phase mixture (an aqueous phase and an organic phase). The reaction mass is then extracted with three 10 ml portions of methylene chloride, and the extracts are combined and washed with 10 ml of water. The combined extracts are then dried over anhydrous sodium sulfate, gravity filtered and concentrated on a rotary evaporator to a weight of 1.56 grams. GLC, MS, NMR and IR analyses yield the information that the resulting material is 89.6% product, 3-methylthio-2,6-dimethyl-4-heptanone. The pure material is trapped out using preparative GLC (conditions: 8 .times. 1/4 SE-30 column).
The NMR spectrum is set forth in FIG. 25. The IR spectrum is set forth in FIG. 26.
The mass spectral analysis is as follows:
______________________________________m/e Relative Intensity______________________________________ 41 8.sup.5 55 32.sup.2 57 12.sup.3 61 5 69 5 85 7.sup.6102 6103 100.sup.1104 6M 188 10.sup.4______________________________________
The NMR analysis is as follows:
______________________________________0.94, 1.08 ppm Methyl protons 12H1.90 CH.sub.3S 3H2.37-1.96 Methine protons 2H2.49 ##STR102## 2H2.78 ##STR103## 1H______________________________________
The IR analysis is as follows:
1035 cm.sup.-1, 1160, 1360, 1380, 1400, 1465, 1695, 2870, 2920, 2960
B. PREPARATION OF 3-METHYLTHIO-2,6-DIMETHYL-4-HEPTANOL ##STR104##
Into a 25 ml, three-necked, round bottom flask equipped with magnetic stirrer, reflux condenser, pot thermometer, warm water bath, nitrogen inlet (to flush with dry nitrogen) is placed a solution of 0.10 grams (0.00265 moles) of sodium borohydride dissolved in 4 ml anhydrous ethanol. Over a period of 1 minute with stirring, at 23.degree. C, a solution of 0.9 grams of 3-thiomethyl-2,6-dimethyl-4-heptanone in 4 ml anhydrous ethanol (prepared according to Part A) is added to the reaction mass. The reaction mass remains at 23.degree. C for a period of one hour, and then is warmed to a temperature of 31.degree. and maintained at 24.degree.-31.degree. C for a period of 25 hours, after which time 0.2 grams additional sodium borohydride dissolved in 6 ml anhydrous ethanol is added. The reaction mass is continued to be stirred for a period of 3 hours at which time it is determined by GLC analysis (8 inches .times. 1/4 inch SE-30 column) that the reaction mass contains 56.9% desired product. After adding another 0.15 grams of sodium borohydride dissolved in 5 ml anhydrous ethanol with stirring, and stirring the reaction mass for a period of 4 hours at room temperature, it is determined that 73.4% desired product exists.
The reaction mass is then concentrated on a rotary evaporator (using water aspirator vacuum) to a 4 ml volume slurry. Six ml water is added to the resulting slurry and the solid dissolves. The reaction mass now exists in two phases; an aqueous phase and an organic phase. The reaction mass is neutralized with 10% HCl solution to a pH of 5-6. The oil is extracted with two 20 ml portions of methylene chloride. The extracts are washed with water, dried over anhydrous sodium sulfate, gravity filtered and concentrated on a rotary evaporator to a weight of 0.58 grams (pale yellow liquid). GLC, MS, NMR and IR analyses yield the information that the resultant product contains 79.1% 3-methylthio-2,6-dimethyl-4-heptanol. The pure material is trapped out using preparative GLC (Conditions: 8 inches .times. 1/4 inch SE-30 column) and has the structure: ##STR105##
The NMR spectrum is set forth in FIG. 27. The infrared spectrum is set forth in FIG. 28.
The mass spectral analysis is as follows:
______________________________________m/e Relative Intensity______________________________________ 43 21 55 55.sup.4 56 25.sup.6 57 35.sup.5 61 19 69 21 89 68.sup.3103 100.sup.1104 77.sup.2M 190 19______________________________________
The NMR analysis is as follows:
______________________________________1.12 ppm - 0.90 methyl protons 12H1.34 methine protons 2H1.92 -- CH.sub.2 -- 2H2.16 CH.sub.3 -- S -- 3H2.36 S -- HC -- C -- O -- 1H3.84 HC -- O -- 1H______________________________________
The IR analysis is as follows:
1050 cm.sup.-1 1360, 1385, 1460, 2860, 2920, 2950, 3460.
EXAMPLE VII
PREPARATION OF 3-METHOXY-4-HEPTANONE ##STR106##
A solution of 1.5 grams of 3-chloro-4-heptanone in 3 ml anhydrous methanol (0.01 moles 3-chloro-4-heptanone) is placed into a 25 ml, three-necked, round bottom flask equipped with magnetic stirrer, pot thermometer, reflux condenser (with drying tube), 10 ml addition funnel with nitrogen inlet at top an ice water-salt bath, and nitrogen bubbler. The 3-chloro-4-heptanone solution is cooled to a temperature of between 0.degree. and 1.degree. C. Into the 10 ml addition funnel is placed a solution of 0.54 grams of sodium methoxide dissolved in 7 ml anhydrous methanol (0.01 moles sodium methoxide). Over a period of one hour, while maintaining the reaction mass at a temperature of between 0.degree. and 1.degree. C, the sodium methoxide solution is added to the 3-chloro-4-heptanone. The reaction mass is then permitted to warm up to room temperature. It is then vacuum filtered thereby separating the white precipitate from the filtrate. The white solid precipitate is washed with 25 ml methylene chloride, and the washings are combined with the filtrate prior to concentration. After concentration of the filtrate, the concentrate is dried over anhydrous sodium sulfate and further concentrated to a weight of 1.0 grams (white oil). The major peak is isolated by GLC trapping (8 inches .times. 1/4 inch SE-30 column). NMR, IR and mass spectral analyses confirm that the resulting material has the structure: ##STR107##
The NMR spectrum is set forth in FIG. 29. The IR spectrum is set forth page in FIG. 30.
The NMR analysis is as follows:
______________________________________0.95 ppm (t) CH.sub.3 6H1.64 (m) CH.sub.2 4H2.49 (t) ##STR108## 2H3.36 (s) CH.sub.3O 3H3.54 (t) ##STR109## 1H______________________________________
The infrared analysis is as follows:
1090 cm.sup.-1, 1120, 1195, 1355, 1375, 1450, 1710, 2820, 2880, 2940, 2960.
EXAMPLE VIII
RASPBERRY FLAVOR FORMULATION
The following basic raspberry flavor formulation is produced:
______________________________________Ingredient Parts by Weight______________________________________Vanillin 2.0Maltol 5.0Parahydroxybenzylacetone 5.0Alpha-ionone (10% in propylene glycol) 2.0Ethyl Butyrate 6.0Ethyl Acetate 16.0Dimethyl Sulfide 1.0Isobutyl Acetate 13.0Acetic Acid 10.0Acetaldehyde 10.0Propylene Glycol 930.0______________________________________
3-methoxy-4-heptanone produced according to Example VII is added to half of the above formulation at the rate of 0.2%. The formulation with the 3-methoxy-4-heptanone produced according to Example VII is compared with the formulation without the 3-methoxy-4-heptanone produced according to Example VII at the rate of 0.01 percent (100 ppm) in water and evaluated by a bench panel.
The flavor containing the 3-methoxy-4-heptanone produced according to Example VII is found to have a substantially more pleasant and better raspberry aroma. It is the unanimous opinion of the bench panel that the chemical, 3-methoxy-4-heptanone produced according to Example VII, rounds the flavor out and contributes to a very natural fresh aroma and taste as found in full ripe raspberries. Accordingly, the flavor with the addition of the 3-methoxy-4-heptanone produced according to Example VII is considered as substantially better than the flavor without the 3-methoxy-4-heptanone produced according to Example VII.
EXAMPLE IX
The following formulations are produced:
______________________________________Formulation A 1.9 gm Natural black currant juice, concentrate 0.1 gm Natural black currant esters10.0 ml Sugar Syrup 32.degree. Beq.s. 100 ml Spring waterFormulation B 1.9 gm Natural black currant juice, concentrate 0.1 gm Buchu leaf oil 0.1% (ethanol 95%)10.0 ml Sugar Syrup 32.degree. Beq.s. 100 ml Spring waterFormulation C 1.9 gm Natural black currant juice, concentrate 0.1 gm Niribine* 10% (ethanol 95%)10.0 ml Sugar Syrup 32.degree. Beq.s. 100 ml Spring water *Niribine is produced by distilling an alcoholic macerate of black curren buds.
Formulation D 1.9 gm Natural black currant juice, concentrate 0.1 gm 3-methylthio-4-heptanone10.0 ml Sugar Syrup 32.degree. Beq.s. 100 ml Spring WaterFormulation E 1.9 gm Natural black currant juice, concentrate10.0 ml Sugar Syrup 32.degree. Beq.s. 100 ml Spring Water______________________________________
Each of the above-mentioned formulations is compared with one another by a panel composed of 10 tasters. Formulation E is generally considered by the panel to be flat and not very characteristic for fresh black currant. Formulations B, C and D are considered as having substantially fresh and more pleasant notes than formulation E. In summary, formulation D is preferred as the best black currant flavor, the material 3-methylthio-4-heptanone can be used at rates of one-tenth of that of Buchu leaf oil in black currant juice.
It is further to be concluded that 3-methylthio-4-heptanone can successfully replace Bucchu leaf oil, Niribine and/or natural black currant esters wherever the ingredient is used in reinforced black currant juices, substituted black currant juices and imitation black currant flavors.
EXAMPLE X
BASIC BLACK CURRANT FORMULATION
3-(methallylthio)-2,6-dimethyl-4-heptanone produced according to Example II(C) has been added to a basic black currant flavor formulation at the rate of 1.5%. Both flavors have been compared in water at the rate of 200 ppm and evaluated by a bench panel. The flavor containing 3-(methallylthio)-2,6-dimethyl-4-heptanone has had the characteristic aroma and taste of ripe black currants or fresh black currant juice. This typical note was not present in the basic black currant formulation. Therefore all members of the panel preferred the flavor containing 3-(methallylthio)-2,6-dimethyl-4-heptanone. Detailed below is the Basic Black Currant Formulation to which is added 3-(methallylthio)-2,6-dimethyl-4-heptanone at the rate of 1.5%.
______________________________________Ingredient Parts by Weight______________________________________Cis-3-hexen-1-ol 5Alpha-phellandrene 1.5Terpineol-4 10% (in ethyl alcohol) 3Para-hydroxy benzyl acetone 5Vanillin 2Ethyl maltol 6Methyl benzoate 2Benzaldehyde 2Benzylpropionate 4Isobutylacetate 5Coriander oil 0.5Ethylbutyrate 8Dimethylsulfide 3Fusel oil 8Acetic acid 10Alpha-ionone 10% (in ethyl alcohol) 0.5Ethyl heptanoate 0.5Propylene glycol 934 1000______________________________________
EXAMPLE XI
(A) 120 grams of the flavor composition of Example X is emulsified in a solution containing 300 gm gum acacia and 700 gm water. The emulsion is spray-dried with a Bowen Lab Model Drier utilizing 250 c.f.m. of air with an inlet temperature of 500.degree. F, an outlet temperature of 200.degree. F, and a wheel speed of 50,000 r.p.m.
(B) The following mixture is prepared:
______________________________________Ingredient Parts by Weight______________________________________Liquid flavor composition ofExample X 25Propylene glycol 1Cab-O-Sil M-5 (Brand of Silica 3produced by the Cabot Corporation 3of 125 High Street, Boston,Mass. 02110;Physical properties: Surface area: 200 m.sup.2 /gm Nominal Particle size: 0.012 microns Density: 2.3 lbs./cu.ft.)Ethyl cellulose 8______________________________________
The Cab-O-Sil and ethyl cellulose is dispersed in the liquid flavor composition of Example X with vigrorous stirring, thereby resulting in a viscous liquid. 65 Parts by weight of the powdered flavor composition of Part A is then blended into said viscous liquid, with stirring, at 25.degree. C for a period of 30 minutes resulting in a dry, free flowing, sustained release flavor powder.
EXAMPLE XII
CHEWING GUM
100 parts by weight of chicle are mixed with 4 parts by weight of the flavor prepared in accordance with Example XI. 300 Parts of sucrose and 100 parts of corn syrup are added. Mixing is effected in a ribbon blender with jacketed side walls of the type manufactured by the Baker Perkins Co.
The resultant chewing gum blend is then manufactured into strips 1 inch in width and 0.1 inches in thickness. The strips are cut into lengths of 3 inches each. On chewing, the chewing gum has a pleasant, long-lasting black currant flavor.
EXAMPLE XIII
CHEWABLE VITAMIN TABLETS
The flavor material produced according to Example XI is added to a Chewable Vitamin Tablet Formulation at a rate of 5 gm/Kg which Chewable Vitamin Tablet Formulation is prepared as follows:
In a Hobart Mixer, the following materials are blended to homogeneity:
______________________________________ Gms/1000 Tablets______________________________________Vitamin C (ascorbic acid) as ascorbic acid-sodium ascorbate mixture 1:1 70.0Vitamin B.sub.1 (thiamine mononitrate) asRocoat thiamine mononitrate 331/3%(Hoffman la Roche) 4.0Vitamin B.sub.2 (riboflavin) as Rocoat riboflavin331/3% 5.0Vitamin B.sub.6 (pyridoxine hydrochloride) asRocoat pyridoxine hydrochloride 331/3% 4.0Niacinamide as Rocoat niacinamide 331/3% 33.0Calcium pantothenate 11.5Vitamin B.sub.12 (cyanocobalamin) as Merck0.1% in gelatin 3.5Vitamin E (dl-alpha tocopheryl acetate) asdry Vitamin E acetate 331/3% Roche 6.6d-Biotin 0.044Certified lake color 5.0Flavor of Example XI 2.5Sweetener - sodium saccharin 1.0Magnesium stearate lubricant 10.0Mannitol q.s. to make 500.0______________________________________
Preliminary tablets are prepared by slugging with flat-faced punches and grinding the slugs to 14 mesh. 13.5 g dry Vitamin A Acetate and 0.6 g Vitamin D are then added as beadlets. The entire blend is then compressed using concave punches at 0.5 g each.
Chewing of the resultant tablets yields a pleasant, long-lasting, consistently strong black currant flavor for a period of 12 minutes.
EXAMPLE XIV
0.5% 3-propylthio-4-heptanone is added to a commercial quality of grapefruit oil. The oils with and without this chemical are compared in water at the rate of 10 ppm. The aroma and taste characteristics of the modified oil is considered as much more characteristic of grapefuit peel than of the oil without this chemical. Therefore, a bench panel unanimously prefers the oil containing 3-propylthio-4-heptanone.
EXAMPLE XV
The following mixture is prepared:
______________________________________Ingredients Parts by Weight______________________________________Methyl anthranilate 11.0Ethyl acetate 9.0Ethyl anthranilate 2.5Ethyl butyrate 2.0Ethyl methyl phenyl glycidate 1.5Cinnamic alcohol 0.3Cognac oil 0.1Ethyl alcohol 73.6______________________________________
The above mixture is judged to be an accetable grape flavor when evaluated in a sweetened and acidified aqueous tasting solution. 1.5 Parts of 3-methylthio-4-heptanone is added to the above flavor and a significant improvement in aroma and taste is noted. When this is evaluated in the afore-mentioned tasting solution, it is judged to have an improved grape character and grape fidelity. It contains more fresh concord grape character, true fruitiness with a nuance of wine. In addition, it is judged to be a more rounded and natural flavor, superior to the product made without the addition of 3-methylthio-4-heptanone in both aroma and taste.
Similar results obtained when using 2.5 parts of 3-methoxy-4-heptanone prepared according to Example VII.
EXAMPLE XVI
BASIC BLACK CURRANT FORMULATION
3-Acetylthio-4-heptanone has been added to a basic black currant flavor formulation at the rate of 1.5%. Both flavors have been compared in water at the rate of 200 ppm and evaluated by a bench panel. The flavor containing 3-acetylthio-4-heptanone has had the characteristic aroma and taste of ripe black currants of fresh black currant juices. This typical note was not present in the basic black currant formulation. Therefore all members of the panel preferred the flavor containing 3-acetylthio-4-heptanone. Detailed below is the Basic Black Currant Formulation to which is added 3-acetylthio-4-heptanone at the rate of 1.5%:
______________________________________Ingredient Parts by Weight______________________________________Cis-3-hexen-1-ol 5Alpha-phellandrene 1.5Terpineol-4 10% (in ethyl alcohol) 3Para-hydroxy benzyl acetone 5Vanillin 2Ethyl maltol 6Methyl benzoate 2Benzaldehyde 2Benzylpropionate 4Isobutylacetate 5Coriander oil 0.5Ethylbutyrate 8Dimethylsulfide 3Fusel oil 8Acetic acid 10Alpha-ionone 10% (in ethyl alcohol) 0.5Ethyl heptanoate 0.5Propylene glycol 934 1000______________________________________
EXAMPLE XVII
GRAPEFRUIT FLAVOR
The following formulation is prepared:
______________________________________Ingredients Parts by Weight______________________________________Grapefruit oil 92Bergamot oil 2Citral 3Amyl alcohol 1Ethyl acetate 1(1,3-diethylacetonyl) (1,3-diisopropylacetonyl)sulfide 1______________________________________
When the above grapefuit formulation is added to water at the rate of 1%, an excellent grapefruit drink is prepared. The (1,3-diethylacetonyl)(1,3-diisopropylacetonyl)sulfide gives a fruitier peeliness to the instant formulation thereby rendering it more desirable. The effect rendered by the (1,3-diethylacetonyl)(1,3-diisopropylacetonyl)sulfide can also be rendered by using 0.5 parts of 3-methylthio-4-heptanone or 3-propylthio-4-heptanone or 3-(methallylthio)-2,6-dimethyl-4-heptanone or 3-crotylthio-2,6-dimethyl-4-heptanone or 3-allylthio-2,6-dimethyl-4-heptanone.
EXAMPLE XVIII
3-Propylthio-4-heptanol is added to a commercial instant tomato soup mix ("Tomatancreme Suppe," C. H. Knorr, Heilbrown, West Germany) at the rate of 2 ppm (based on the weight of the soup as ready to eat, produced by adding 80 g. of the dry soup mix to 1,000 ml water and then bringing the resulting mixture to a boil). A second "control" is prepared which is identical to the initial sample except for the absence of the 3-propylthio-4-heptanol. A four member panel of flavorists compared the control to the soup containing 3-propylthio-4-heptanol. All four members of the panel indicated a strong preference for the tomato soup containing the 3-propylthio-4-heptanol. All four members of the panel indicated that the soup containing the 3-propylthio-4-heptanol includes a fresh tomato note which is not present in the soup prepared without using the 3-propylthio-4-heptanol.
EXAMPLE XIX
1-propylthio-1,3-diphenyl-2-propanone is dissolved in 95% ethanol to provide a 2% solution, and is held at room temperature for 24 hours. It is then diluted with water to 0.1% and this solution has an aroma of fresh green onions.
Various water solutions are prepared, as shown in the following Table II and evaluated for taste:
Table II______________________________________Concentration (ppm) Evaluation______________________________________0.002 Green Onion character; near threshold level0.010 Fresh green onion taste______________________________________
The material is added to a chicken broth to obtain a concentration of 0.010 ppm, and it is found that the chicken taste is deepened and that a light onion aftertaste is added. Increasing the concentration to 0.030 ppm adds an onion aroma, and the fresh onion taste is dominating.
Repetition of the foregoing with beef broth shows no significant difference at 0.010 ppm; a slightly lachrymatory aroma and an improved general taste at 0.030 ppm; and a dominating onion note with the beef broth changed to onion soup at 0.2 ppm.
It is judged that this flavor additive can replace all flavor areas where fresh onion is used, and it is interesting enough to be used alone to develop onion soup flavor characteristic.
EXAMPLE XX
Three meat-loaf type products are prepared according to the following formulation:
______________________________________Ingredient Amount______________________________________TVP, minced 1 cupGround beef 1 cupWater 1 cupBeef suet 1/3 cupBread crumbs, dry, unflavored 1 cupWhole milk 1 cupEgg albumen 3 tbsp.Salt 11/4 tbsp.Black pepper 1/4 tsp.Catsup 1/4 cupWater 32 ml.______________________________________
The "TVP" is a texturized vegetable protein mixture made by Archer-Daniels-Midland Company.
Three separate portions prepared according to the foregoing formulation are made into three meat loaves. Loaf A contains no additional additive, Loaf B contains 32 ml of fresh pressed onion juice to replace the 32 ml of water, and Loaf C contains 0.6 ppm of 1-propylthio-1,3-diphenyl-2-propanone.
The three loaves are baked at 350.degree. F for one hour and evaluated for flavor by a panel of twelve judges. The consensus of the judges is that Loaves B and C are superior to Loaf A because the onion character B and C enhances the overall taste and covers the dry, cardboard-like cereal character of Loaf A. It is accordingly apparent that the product of this invention is a valuable ingredient for a wide variety of flavors and types of foodstuffs.
EXAMPLE XXI
A white bread dough mix is prepared by mixing 1350 g wheat flour and 800 ml water. To the mix is added:
______________________________________Ingredient Amount (grams)______________________________________Yeast 27.0Sodium chloride 27.0Sucrose 67.5Shortening 54Non-fat dry milk powder 40.5Yeast food (Arkady; Manufacturedby Fleischmann, Div. ofStandard Brands) 0.50Softening agent (succinylatedmonoglycerides; Manufacturedby Kraft Div. of NationalDairy Products Corporation) 3.4______________________________________
The dough is then mixed for 8 minutes, 3-[(methoxycarbonyl)methylthio]-4-heptanone (8 grams) is then mixed with the resulting product for a period of 8 minutes. The dough is then allowed to rise for 45 minutes at 40.degree. C. The dough is then baked for 45 minutes at 210.degree. C.
The breadstuff product obtained has a flavor note reminiscent of the crust of home made Italian bread and has acceptable and persistent flavor properties for a period of one week and has good flavor characteristics when spread with margarine.
By way of comparison, breadstuffs similarly prepared by omitting the sulfur-free amino acid-cyclic ketone reaction product and the 3-[(methoxycarbonyl)methylthio]-4-heptanone have a flat taste, show typical flavlor deterioration on storage during a period of one week and require an expensive butter spread to provide an acceptable flavor.
EXAMPLE XXII
A. PREPARATION OF 3-ISOBUTYLTHIO-2,6-DIMETHYL-4-HEPTANONE ##STR110##
Into a 50 ml, three-necked, round bottom flask equipped with pot thermometer, magnetic stirrer, gas inlet tube (for nitrogen) at top of 15 cm Vigreux column, nitrogen bubbler and cold water bath is added a solution of 0.54 grams (0.01 moles) of sodium methoxide dissolved in 6 ml anhydrous methanol. The solution is cooled to 24.degree. C and a solution of 0.90 grams (0.01 moles) of isobutyl mercaptan dissolved in 6 ml anhydrous methanol is then added to the reaction mass. After stirring at 24.degree. C for a period of 10 minutes, a solution of 1.77 grams of 3-chloro-2,6-dimethyl-4-heptanone dissolved in 2 ml anhydrous methanol is added to the reaction mass with stirring at 24.degree.-25.degree. C. The reaction mass is then stirred for a period of 8 hours.
The reaction mass is then concentrated on a rotary evaporator using water aspirator vacuum to 5 ml of a thick oil/solid slurry. 15 ml water is added and the solid dissolves. The resulting liquid mixture being in 2 phases; an aqueous phase and an organic phase. The reaction mass is then extracted with three 10 ml portions of methylene dichloride and the extracts are combined and washed with 8 ml water. The extracts are then dried over anhydrous sodium sulfate, gravity filtered and concentrated on a rotary evaporator to a weight of 1.89 grams (pale yellow oil). GLC, NMR, IR and mass spectral analyses yield the information that the resulting product is 79.2% 3-isobutylthio-2,6-dimethyl-4-heptanone.
The NMR analysis is as follows:
______________________________________0.94 ppm, 1.10 methyl protons 18 H2.26 - 1.60 methine protons 3 H2.26 CH.sub.2S 2 H2.50 ##STR111## 2 H2.80 ##STR112## 1 H______________________________________
The IR analysis is as follows:
1035 cm.sup.-1, 1160, 1285, 1360, 1380, 1460, 1700, 2870, 2930, 2960.
1035 cm.sup.-1,
The mass spectral analysis is as follows:
______________________________________m/e Relative Intensity______________________________________29 741 11.sup.555 17.sup.457 42.sup.269 685 889 33.sup.3145 100.sup.1146 9.sup.6M 230 8______________________________________
The NMR spectrum is set forth in FIG. 30(A). The IR spectrum is set forth in FIG. 30(B).
B. PREPARATION OF 3-ISOBUTYLTHIO-2,6-DIMETHYL-4-HEPTANOL ##STR113##
Into a 25 ml, three-necked, round bottom flask equipped with magnetic stirrer, reflux condenser, pot thermometer and nitrogen inlet tube to flush with dry nitrogen, is added a solution of 0.1 grams (0.00265 moles) of sodium borohydride dissolved in 4 ml anhydrous ethanol. While the temperature of the sodium borohydride solution is at 24.degree. C, a solution of 1.1 grams of 3-isobutylthio-2,6-dimethyl-4-hetpanone (prepared according to Part A) dissolved in 4 ml anhydrous ethanol is added to the reaction mass slowly. The reaction mass is then stirred for a period of 6.5 hours.
The reaction then shows 30% product (3-isobutylthio-2,6-dimethyl-4-heptanol) by GLC analysis. An additional 0.2 grams of sodium borohydride dissolved in 6 ml anhydrous ethanol is added, and the reaction mass is continued to be stirred for a period of 4 hours. GLC analysis shows 59% product. Another 0.15 grams of sodium borohydride in 5 ml anhydrous ethanol is added and stirred for an additional 4 hours. GLC analysis then shows 78% product.
The reaction mixture is then concentrated on a rotary evaporator using water aspirator vacuum to 5 ml of an oily solid. 6 ml water is then added and the solid dissolves yielding two liquid phases; an organic phase and an aqueous phase. The reaction mass is neutralized with 10% HCl to a pH of 5. The oil is then extracted with 20 ml methylene dichloride, and the extracts are washed with water. The extracts are then dried over anhydrous sodium sulfate, filtered and concentrated on a rotary evaporator to a weight of 0.82 grams (pale yellow oil). GLC analysis indicates that the material is 86.4% product. NMR and IR analyses of GLC trapped compound yield the information that the product is 3-isobutylthio-2,6-dimethyl-4-heptanol.
The NMR spectrum is set forth in FIG. 31. The IR spectrum is set forth in FIG. 32.
The NMR analysis is as follows:
______________________________________1.10-0.89 ppm superimposed CH.sub.3 18 H signals1.34 (m) methine 3 H protons1.84 (m) CH.sub.2CO 2 H2.44 (m) CH.sub.2S, HCS 3 H2.79 (broad) OH 1 H3.72 (m) ##STR114## 1 H______________________________________
The IR analysis is as follows:
1055 cm.sup.-1, 1365, 1385, 1465, 2880, 2930, 2960, 3460.
EXAMPLE XXIII
OTTO OF ROSE PERFUME FORMULATION
The following mixture is prepared:
______________________________________Ingredients Parts by Weight______________________________________Phenyl acetic acid 5Hydroxycitronellal 10Geraniol 125Citronellol 150Phenyl ethyl alcohol 50Phenyl ethyl acetate 4Ethyl phenyl acetate 5Citronellyl formate 20Geranyl acetate 25Linalool 15Terpineol 10Eugenol 3Phenyl acetaldehyde dimethyl acetal 5Benzyl acetate 3Guaiacwood Oil 53-methylthio-4-heptanone produced accordingto the process of Part "C" of Example I 10______________________________________
The 3-methylthio-4-heptanone, produced according to the process of Part "C" of Example I imparts a green, fruity, spicy topnote so characteristic of rose otto to this formulation.
EXAMPLE XXIV
ORIENTAL VETIVERT
The following mixture is prepared:
______________________________________Ingredients Parts by Weight______________________________________Orange oil Florida 150Lemon Oil 75Oil of bitter orange 100Grapefruit oil 200Neroli oil 20Isocyclemone E (a product producedaccording to the process of Example VIof U.S. Pat. 3,907,321, issued onSept. 23, 1975, which comprises reactingmyrcene with 3-methyl-3-pentene-2-one in -the presence of aluminumchloride andthen cyclizing the resulting Diels-Alderadduct.) 40Gamma methyl ionone 15Ylang estra 5Auralva (The Shiff base of methyl anthranilateand hydroxy citronellal, specificallydescribed in Section 1735 of Arctancer,"Perfume and Flavor Chemicals (AromaChemicals)" 1969) 15Lyral 4-(4-methyl,4-hydroxyamyl) .DELTA..sup.3 -cyclohexene carboxaldehyde 30Grisalva (produced by the 50% sulfuric acidtreatment of 3-ethyl-1[2,2,6-trimethyl-cyclohexene-5-yl-1]hexen-3-ol-6) 103-(methallylthio)-2,6-dimethyl-4-heptanone,produced according to the process ofExample II(C). 50______________________________________
The 3-(methallylthio)-2,6-dimethyl-4-heptanone, produced according to the process of Example II(C) imparts a sweet, orange-flower, green beta vetivone, woody character to this composition.
EXAMPLE XXV
NARCISSE FORMULATION
The following mixture is prepared:
______________________________________Ingredient Parts by Weight______________________________________Benzyl alcohol 50Benzyl benzoate 25Terpineol 30Nerol 15Phenyl ethyl alcohol 50Geraniol 40Linalool 50Para cresyl phenyl acetate 10Benzyl acetate 6Acetyl isoeugenol 20Heliotropin 30Ylang extra 5Para cresol 13-methylthio-4-heptanol, produced accordingto the process of Example I, Part "D" 20______________________________________
The 3-methylthio-4-heptanol, produced according to the process of Example I, Part "D" imparts a green, floral, tobacco-like oriental middle and undertone necessary for narcisse.
EXAMPLE XXVI
COMPARISON OF SUBSTITUTED THIOHEPTANONES AND THEIR CORRESPONDING ALCOHOLS
3-methylthio-4-heptanone (hereinafter referred to as "chemical I") has a powerful green, minty, herbaceous odor.
3-methylthio-4-heptanol (hereinafter referred to as "chemical II") has a green, floral, herbal odor, about one-fifth the strength of chemical I.
3(methallylthio)2,6-dimethyl-4-heptanone (hereinafter referred to as "chemical III") has a floral, herbaceous aroma with a fruity, grapefruit (nootkatone) character.
The foregoing materials, chemicals I, II and III may be used in perfumery to give unusual and novel effects to various fragrance types. They are useful in creating modern blends which are in some cases far removed from the classical concepts of perfumery. The use of chemicals I, II and III may be demonstrated in the following modern herbal formulation:
______________________________________Ingredients A B C______________________________________Oakmoss Absolute 50% in diethyl-phthalate 20 20 20.alpha.-methyl-3,4-methylene-dioxy-hydrocinnamic aldehyde 10 10 10methyl dihydrojasmonate (producedby Firmenich et Cie of Geneva,Switzerland) 100 100 100Coumarin 20 20 20Musk Ketone 80 80 80Isocyclocitral (10% indiethylphthalate) 10 10 10Galbanum Oil (10% in diethyl-phthalate) 6 6 6Rosemary Oil 10 10 10Pine Needle Oil 60 60 60Fir Balsam Absolute (10% indiethyl(phthalate) 10 10 10Bergamot Oil 60 60 60Lemon Oil 14 14 14Benzyl Acetate 468 460 460Linalool 80 80 80Indol (10% in diethylphthalate) 6 6 6Undecalactone (10% in diethyl-phthalate) 12 12 12Ylang Ylang Oil 32 32 32Alkylthio chemical I 2 -- --Alkylthio chemical II -- 10 --Alkylthio chemical III -- -- 10______________________________________
The addition of 0.2% by weight of chemical I gives increased strength to the fragrance as well as modifying the herbal character and rendering it unusual and novel. The material can be used in perfumery at from approximately 1 ppm (0.0001%) up to approximately 1%.
The weaker alcohol, chemical II, is added to the fragrance at 1% by weight. The addition of this material gives a softer effect but alters the herbal effect to an unusal and novel character. Chemical II may be used in perfumery from approximately 0.01% to 5% by weight. For special effects up to 50 % may be used.
The addition of 1% of chemical III gives quite a different effect. In this case the herbal character is not altered as in the other examples, but the citrus notes are enhanced and strengthened. This chemical may be used in perfumery from approximately 0.01% to 10% by weight. For special effects up to 50% may be used.
In all cases of the above examples, the fragrance is improved by the addition of the alkylthio materials chemicals I, II and III and rendered more desirable and novel.
EXAMPLE XXVII
PREPARATION OF SOAP COMPOSITIONS
100 grams of soap chips are mixed with 1 gram of the chemical set forth in Table II below until a substantially homogeneous composition is obtained. The perfumed soap composition manifests an aroma according to the aroma set forth in Table II below:
______________________________________Compound Aroma______________________________________3-methylthio-4-heptanol A sweet, green, floral, herbal, vegetative aroma with an underlying verdima nuance.3-methylthio-4-heptanone A green, minty, herbaceous aroma with basil nuances.3-propylthio-4-heptanol A green aroma with floral nuances.3-thioacetyl-2,6-dimethyl- A grapefruit oil-like aroma.4-heptanone3-isobutylthio-4-heptanone A green, spicey and peppery aroma with an underlying bergamot note.3-isobutylthio-2,6-dimethyl- A green aroma containing notes4-heptanol of hyacinth and narcisse.3-methylthio-2,6-dimethyl- A sweet, slightly floral and4-heptanone woody aroma with fruity and berry nuances.3-(methallylthio)-2,6- A fruity, grapefruit, somewhatdimethyl-4-heptanone floral aroma with underlying yara and neroli notes and bready, vegetative nuances.______________________________________
EXAMPLE XXVIII
PREPARATION OF A DETERGENT COMPOSITION
A total of 100 grams of a detergent powder (a non-ionic detergent powder containing a proteolytic enzyme prepared according to Example I of Canadian Patent 985,190 issued on Mar. 9, 1976) is mixed with 0.15 grams of the .alpha.-oxy(oxo) sulfides set forth in Table III below until a substantially homogeneous composition is obtained. This composition has an excellent aroma as defined in Table III below:
______________________________________Compound Aroma______________________________________3-methylthio-4-heptanol A sweet, green, floral, herbal, vegetative aroma with an underlying verdima nuance.3-methylthio-4-heptanone A green, minty, herbaceous aroma with basil nuances.3-propylthio-4-heptanol A green aroma with floral nuances.3-thioacetyl-2,6-dimethyl- A grapefruit oil-like aroma.4-heptanone3-isobutylthio-4-heptanone A green, spicey and peppery aroma with an underlying bergamot note.3-isobutylthio-2,6-dimethyl- A green aroma containing notes4-heptanol of hyacinth and narcisse.3-methylthio-2,6-dimethyl- A sweet, slightly floral and4-heptanone woody aroma with fruity and berry nuances.3-(methallylthio)-2,6- A fruity, grapefruit, somewhatdimethyl-4-heptanone floral aroma with underlying yara and neroli notes and bready, vegetative nuances.______________________________________
EXAMPLE XXIX
PREPARATION OF COSMETIC POWDER COMPOSITIONS
Cosmetic powders are prepared by mixing in a ball mill 100 grams of talcum powdwer with 0.25 grams of each of the compounds set forth in Table IV below. Each of these powders has an excellent aroma as set forth in Table IV below.
Table IV______________________________________Compound Aroma______________________________________3-methylthio-4-heptanol A sweet, green, floral, herbal, vegetative aroma with an underlying verdima nuance.3-methylthio-4-heptanone A green, minty, herbaceous aroma with basil nuances. -3-propylthio-4-heptanol A green aroma with floral nuances. -3-thioacetyl-2,6-dimethyl- A grapefruit oil-like aroma.4-heptanone3-isobutylthio-4-heptanone A green, spicey and peppery aroma with an underlying bergamot note.3-isobutylthio-2,6-dimethyl- A green aroma containing notes4-heptanol of hyacinth and narcisse.3-methylthio-2,6-dimethyl- A sweet slightly floral and4-heptanone woody aroma with fruity and berry nuances.3-(methallylthio)-2,6- A fruity, grapefruit, somewhatdimethyl-4-heptanone floral aroma with underlying yara and neroli notes and bready, vegetative nuances.______________________________________
EXAMPLE XXX
PERFUMED LIQUID DETERGENT
Concentrated liquid detergents with rich, pleasant aromas as set forth in Table V below are prepared containing 0.10%, 0.15% and 0.20% of an .alpha.-oxy(oxo) sulfide as set forth in table V below. They are prepared by adding and homogeneously admixing the appropraite quantity of .alpha.-oxy(oxo) sulfide in the liquid detergent. The liquid detergents are all produced using anionic detergents containing a 50:50 mixture of sodium lauroyl sarcosinate and potassium N-methyl lauroyl tauride. The detergents all possess a pleasant fragrance as defined in the table below, the intensity increasing with greater concentration of .alpha.-oxy(oxo) sulfide of this invention.
______________________________________Compound Aroma______________________________________3-methylthio-4-heptanol A sweet, green, floral, herbal, vegetative aroma with an underlying verdima nuance.3-methylthio-4-heptanone A green, minty, herbaceous aroma with basil nuances.3-propylthio-4-heptanol A green aroma with floral nuances.3-thioacetyl-2,6-dimethyl- A grapefruit oil-like aroma.4-heptanone3-isobutylthio-4-heptanone A green, spicey and peppery aroma with an underlying bergamot note.3-isobutylthio-2,6-dimethyl- A green aroma containing notes4-heptanol of hyacinth and narcisse.3-methylthio-2,6-dimethyl- A sweet, slightly floral and4-heptanone woody aroma with fruity and berry nuances.3-(methallylthio)-2,6- A fruity, grapefruit, somewhatdimethyl-4-heptanone floral aroma with underlying yara and neroli notes and bready, vegetative nuances.______________________________________
EXAMPLE XXXI
An .alpha.-oxy(oxo) sulfide as set forth in Table VI below is incorporated in a cologne at a concentration of 2.5% in 85% aqueous ethanol; and into a handkerchief perfume at a concentration of 20% (in 95% aqueous ethanol). A distinct and definite strong fragrance as set forth in Table VI below is imparted to the cologne and to the handkerchief perfume:
______________________________________Compound Aroma______________________________________3-methylthio-4-heptanol A sweet, green, floral, herbal, vegetative aroma with an underlying verdima nuance.3-methylthio-4-heptanone A green, minty, herbaceous aroma with basil nuances.3-propylthio-4-heptanol A green aroma with floral nuances.3-thioacetyl-2,6-dimethyl- A grapefruit oil-like aroma.4-heptanone3-isobutylthio-4-heptanone A green, spicey and peppery aroma with an underlying bergamot note.3-isobutylthio-2,6-dimethyl- A green aroma containing notes4-heptanol of hyacinth and narcisse.3-methylthio-2,6-dimethyl- A sweet, slightly floral and4-heptanone woody aroma with fruity and berry nuances.3-(methallylthio)-2,6- A fruity, grapefruit, somewhatdimethyl-4-heptanone floral aroma with underlying yara and neroli notes and bready, vegetative nuances.______________________________________
BRIEF DESCRIPTION OF THE DRAWINGS:
FIG. 1 is the NMR spectrum for the product of Example I(B) wherein 3-thioacetyl-4-heptanone is produced.
FIG. 2 is the IR spectrum for the product of Example I(B) wherein 3-thioacetyl-4-heptanone is produced.
FIG. 3 is the NMR spectrum for the product of Example I(C) wherein 3-thiomethyl-4-heptanone is produced.
FIG. 4 is the IR spectrum for the product of Example I(C) wherein 3-thiomethyl-4-heptanone is produced.
FIG. 5 is the NMR spectrum for the product of Example I(D) wherein 3-thiomethyl-4-heptanol is produced.
FIG. 6 is the IR spectrum for the product of Example I(D) wherein 3-thiomethyl-4-heptanol is produced.
FIG. 7 is the NMR spectrum for the product of Example II(C) wherein 3-methallylthio-2,6-dimethyl-4-heptanone is produced.
FIG. 8 is the IR spectrum for the product of Example II(C) wherein 3-methallylthio-2,6-dimethyl-4-heptanone is produced.
FIG. 9 is the NMR spectrum for the product of Example II(D) wherein 3-crotylthio-2,6-dimethyl-4-heptanone is produced.
FIG. 10 is the IR spectrum for the product of Example II(D) wherein 3-crotylthio-2,6-dimethyl-4-heptanone is produced.
FIG. 11 is the NMR spectrum for the product of Example II(E) wherein 3-allylthio-2,6-dimethyl-4-heptanone is produced.
FIG. 12 is the IR spectrum for the product of Example II(E) wherein 3-allylthio-2,6-dimethyl-4-heptanone is produced.
FIG. 13 is the NMR spectrum for the product of Example II(F) wherein (1,3-diethylacetonyl)(1,3-diisopropylacetonyl)sulfide is produced.
FIG. 14 is the IR spectrum for the product of Example II(F) wherein (1,3-diethylacetonyl)(1,3-diisopropylacetonyl)sulfide is produced.
FIG. 14(A) is the NMR spectrum for the product of Example II(G) wherein 3-[ (methoxycarbonyl)methylthio]-2,6-dimethyl-4-heptanone is produced.
FIG. 14(B) is the IR spectrum for the product of Example II(G) wherein 3-[ (methoxycarbonyl)methylthio]-2,6-dimethyl-4-heptanone is produced.
FIG. 15 is the NMR spectrum for the product of Example II(H) wherein 3-[ (methoxycarbonyl)methylthio]-4-heptanone is produced.
FIG. 16 is the IR spectrum for the product of Example II(H) wherein 3-[ (methoxycarbonyl)methylthio]-4-heptanone is produced.
FIG. 16(A) is the NMR spectrum for the product of Example II(I) wherein 3-thioacetyl-2,6-dimethyl-4-heptanone is produced.
FIG. 16(B) is the IR spectrum for the product of Example II(I) wherein 3-thioacetyl-2,6-dimethyl-4-heptanone is produced.
FIG. 17 is the NMR spectrum for the product of Example III(A) wherein 3-propylthio-4-heptanone is produced.
FIG. 18 is the IR spectrum for the product of Example III(A) wherein 3-propylthio-4-heptanone is produced.
FIG. 19 is the NMR spectrum for the product of Example III(A) wherein 3-propylthio-4-heptanol is produced.
FIG. 20 is the IR spectrum for the product of Example III(A) wherein 3-propylthio-4-heptanol is produced.
FIG. 21 is the NMR spectrum for the product of Example IV wherein 3-isobutylthio-4-heptanone is produced.
FIG. 22 is the IR spectrum for the product of Example IV wherein 3-isobutylthio-4-heptanone is produced.
FIG. 23 is the NMR spectrum for the product of Example V(B) wherein 1-propylthio-1,3-diphenyl-2-propanone is produced.
FIG. 24 is the IR spectrum for the product of Example V(B) wherein 1-propylthio-1,3-diphenyl-2-propanone is produced.
FIG. 25 is the NMR spectrum for the product of Example VI(A) wherein 3-methylthio-2,6-dimethyl-4-heptanone is produced.
FIG. 26 is the IR spectrum for the product of Example VI(A) wherein 3 -methylthio-2,6-dimethyl-4-heptanone is produced.
FIG. 27 is the NMR spectrum for the product of Example VI(B) wherein 3-methylthio-2,6-dimethyl-4-heptanol is produced.
FIG. 28 is the IR spectrum for the product of Example VI(B) wherein 3-methylthio-2,6-dimethyl-4-heptanol is produced.
FIG. 29 is the NMR spectrum for the product of Example VII wherein 3-methoxy-4-heptanone is produced.
FIG. 30 is the IR spectrum for the product of Example VII wherein 3 -methoxy-4-heptanone is produced.
FIG. 30(A) is the NMR spectrum for the product of Examples XXII(A) wherein 3-isobutylthio-2,6-dimethyl-4-heptanone is produced.
FIG. 30(B) is the IR spectrum for the product of Example XXII(A) wherein 3-isobtuylthio-2,6-dimethyl-4-heptanone is produced.
FIG. 31 is the NMR spectrum for the product of Example XXII(B) wherein 3-isobutylthio-2,6-dimethyl-4-heptanol is produced.
FIG. 32 is the IR spectrum for the product of Example XXII(B) wherein 3-isobutylthio-2,6-dimethyl-4-heptanol is produced.

Number	Name	Date
2327966	Morey	Aug 1943
2831032	Tilles	Apr 1958
4065408	Evers et al.	Dec 1977

Process for preparing .alpha.-oxy(oxo)sulfides and ethers

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Reagents for Organic Synthesis, Fieser Fieser, 1967, pp. 1128, 1049.
Organic Chemistry of Bivalent Sulfur, Reid, II, 1960, p. 24.
Preparative Organic Chemistry, Hilgetag et al., p. 634.