Claims
- 1. An process for preparing benzimidazole-type compounds of general formula (I)
- 2. A process as claimed in claim 1 wherein the pH of the first extraction step b) ranges from 10.50 to 11.50.
- 3. A process as claimed in claim 1 wherein the oxidizing agent is selected from m-chloroperoxybenzoic acid, monoperoxyphthalate, hydrogen peroxide (with or without catalysts), permanganates, N-chloro or N-bromo succinimide, 1,3-dibromo-5,5-dimethylhydantoin, 2-hydroperoxyhexafluoro-2-propanol, iodosylbenzene, manganese(III) acetylacetonate, oxygen (with or without catalysts), ozone, peroxy monosulfate, ruthenium tetroxide, perborate, periodate, acyl nitrates, tert-butylhydroperoxide, dimethyl dioxiranes, hypochlorite, cerium ammonium nitrate, 2-nitrobenzenesulfinyl chloride/potassium superoxide, N-sulfonyloxaziridines, sodium bromite, or benzoyl peroxide.
- 4. A process as claimed in claim 3 wherein the oxidizing agent is m-chloroperoxybenzoic acid.
- 5. A process as claimed in claim 1 wherein the benzimidazole-type compounds of formula (I) is selected from rabeprazole, omeprazole, pantoprazole, lansoprazole, and esomeprazole.
- 6. A process as claimed in claim 5 wherein the benzimidazole-type compounds of formula (I) is rabeprazole.
- 7. A process as claimed in claim 6 wherein the pH of the first extraction step b) ranges from 10.70 to 11.20.
- 8. A process for removing sulfones of formula (III), wherein R1 and R2 are the same as or different from each other and are selected from hydrogen, methoxy or difluoromethoxy, R3, R4 and R5 are the same as or different from each other and are selected from hydrogen, methyl, methoxy, methoxypropoxy or trifluoroethoxy,
- 9. A process as claimed in claim 8 wherein the pH of the extraction step ranges from 10.50 to 11.50.
- 10. A process as claimed in claim 8 wherein the sulfoxide of formula (I) is rabeprazole.
- 11. A process as claimed in claim 9 wherein the sulfoxide of formula (I) is rabeprazole.
- 12. A process as claimed in claim 6 wherein the pH of the first extraction step b) ranges from 10.85 to 10.95.
- 13. A process as claimed in claim 2 wherein the oxidizing agent is selected from m-chloroperoxybenzoic acid, monoperoxyphthalate, hydrogen peroxide (with or without catalysts), permanganates, N-chloro or N-bromo succinimide, 1,3-dibromo-5,5-dimethylhydantoin, 2-hydroperoxyhexafluoro-2-propanol, iodosylbenzene, manganese(III) acetylacetonate, oxygen (with or without catalysts), ozone, peroxy monosulfate, ruthenium tetroxide, perborate, periodate, acyl nitrates, tert-butylhydroperoxide, dimethyl dioxiranes, hypochlorite, cerium ammonium nitrate, 2-nitrobenzenesulfinyl chloride/potassium superoxide, N-sulfonyloxaziridines, sodium bromite, or benzoyl peroxide.
- 14. A process as claimed in claim 13 wherein the benzimidazole-type compounds of formula (I) is rabeprazole.
Priority Claims (1)
Number |
Date |
Country |
Kind |
01202696.9 |
Jul 2001 |
EP |
|
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application is the national stage of Application No. PCT/EP02/07693, filed Jul. 9, 2002, which application claims priority from EPO Application No. 01202696.9, filed Jul. 16, 2001.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/EP02/07693 |
7/9/2002 |
WO |
|