Claims
- 1. A compound of the formula II ##STR9## wherein: Ar is (i) phenyl, (ii) phenyl substituted with from one to three substituents independently selected from C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.8 alkylthio, trifluoromethyl, C.sub.1 -C.sub.4 alkylphenyl, phenyl, F, Cl, hydroxy, phenoxy, C.sub.1 -C.sub.4 alkyloxyphenyl, thiophenyl, C.sub.1 -C.sub.4 alkylthiophenyl, N(R.sup.4).sub.2 where each R.sup.4 is independently C.sub.1 -C.sub.6 alkyl or (iii) 1- or 2-napthyl;
- R.sup.1 is hydrogen C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkylphenyl, phenyl or phenyl-substituted with one or two substituents independently selected from Cl, F, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, trifluoromethyl, --N(C.sub.1 -C.sub.4 alkyl).sub.2 or C.sub.1 -C.sub.4 alkylthio;
- R.sup.2 is H, C.sub.1 -C.sub.6 alkyl, benzyl or .alpha.-methylbenzyl; and
- R.sup.5 is H or --CHR.sup.3 OH, where R.sup.3 is (i) H, (ii) C.sub.1 -C.sub.6 alkyl, (iii) phenyl, (iv) phenyl substituted with from one to three substituents independently selected from C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.8 alkylthio, trifluoromethyl, C.sub.1 -C.sub.4 alkylphenyl, phenyl, F, Cl, hydroxy, phenoxy, C.sub.1 -C.sub.4 alkyloxyphenyl, thiophenyl, C.sub.1 -C.sub.4 alkylthiophenyl, N(R.sup.4).sub.2 where each R.sup.4 is independently C.sub.1 -C.sub.6 alkyl or (v) 1- or 2-napthyl.
- 2. The compound of claim 1 wherein Ar is phenyl-substituted with from one to three substituents independently selected from C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.4 alkylphenyl, phenyl, F, Cl, hydroxy, phenoxy or C.sub.1 -C.sub.4 alkylthiophenyl;
- R.sup.2 is H; and
- R.sup.5 is H or --CH.sub.2 OH.
- 3. The compound of claim 2 which is 4-hydroxy-3,5-bis(1,1-dimethylethyl)-.alpha.-[(hydroxymethyl)-thio]benzene ethanamide.
- 4. The compound of claim 2 which is 4-hydroxy-.alpha.-mercapto-3,5-(1,1-dimethylethyl)benzene ethanamide.
Parent Case Info
This application is A 371 of PCT/US96/14101 Sep. 3, 1996.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US96/14101 |
9/3/1996 |
|
|
2/25/1998 |
2/25/1998 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/09305 |
3/13/1997 |
|
|
US Referenced Citations (5)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0 211 670 A2 |
Feb 1987 |
EPX |