Claims
- 1. A process for the preparation of a 7-amino-cephalosporin compound of formula ##STR12## or a salt thereof, which comprises removing the 7-side chain from a compound of the formula ##STR13## or a salt thereof to form said 7-amino-cephalosporin compound in high yield and purity.
- 2. In a process for the preparation of a 7-amino-cephalosporin compound of formula ##STR14## from Cephalosporin C or desacetyl Cephalosporin C by N-acylation of the 7-(aminoadipoyl) group and conversion of the 3-position substituent into a 3-pyridiniummethyl group to form a compound of formula ##STR15## in which R is an acyl group, followed by removal of the 7-(acylaminoadipoyl) group, wherein the improvement comprises the N-benzoylation of the 7-aminoadipoyl) group to form a compound wherein R is benzoyl and the production of the 7-amino-cephalosporin compound in high yield and purity.
- 3. In a process for the preparation of a 7-acylamido-3-pyridiniummethyl cephalosporin from a compound of formula ##STR16## in which R represents an acyl group; or a salt thereof, wherein the R containing 7-(acylaminoadipoyl) group is removed from said compound to form a corresponding 7-amino compound which is acylated to form said 7-acylamido-3-pyridiniummethyl cephalosporin; wherein the improvement comprises removing a 7-(benzoylaminoadipoyl) group from a compound of said formula wherein R is a benzoyl group to obtain said 7-acylamino-3-pyridinium compound in high yield.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8122147 |
Jul 1981 |
GBX |
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Parent Case Info
This application is a division of application Ser. No. 399,328, filed on Jul. 19, 1982, now U.S. Pat. No. 4,563,523.
US Referenced Citations (11)
Divisions (1)
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Number |
Date |
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Parent |
399328 |
Jul 1982 |
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