Claims
- 1. A process for the preparation of a compound of formula whereinR5, R6, R7 independently of one another denote H, alkyl, cycloalkyl, alkenyl, aryl, aralkyl, alkanoyl, benzoyl, heteroaryl, dialkylamino, dialkylaminoalkyl, trialkylammoniumalkyl, cyano, alkyloxycarbonyl, aralkyloxycarbonyl, OH, O-alkyl or O-aryl, wherein the alkyl groups contain 1 to 5 carbon atoms, the cycloalkyl groups contain 3 to 6 carbon atoms, the alkenyl groups contain 2 to 5 carbon atoms, aryl denotes phenyl, or phenyl or naphthyl substituted by methyl or halogen; or R5 and R6 or R6 and R7 together form the group (CH2)2—, —(CH2)3—, —(CH2)4—, —(CH2)5— or —(CH2)2O(CH2)2; and R8 represents H, alkyl with 1 to 5 carbon atoms or cycloalkyl with 3 to 6 carbon atoms or R7+R8 together form the group —(CH2)2—, —(CH2)3—, —(CH2)4—, —(CH2)5— or —(CH2)2 O(CH2)2—; said process comprises reacting under suitable conditions an amide of formula with a piperidine of formula to produce the final product compound and if desired subsequently isolating the product;whereinR5, R6, R7 and R8 have the meaning given above.
- 2. The process according to claim 1 wherein the reaction is carried out in an inert solvent in the presence of a base at temperatures between 20° C. and 120° C. and the reaction time is between 0.5 h and 48 h.
- 3. The process according to claim 2 wherein the inert solvent is chosen from DMF and acetonitrile and the base is chosen from TEA and N-methylmorpholine.
Priority Claims (1)
Number |
Date |
Country |
Kind |
198 24 470 |
May 1998 |
DE |
|
APPLICATION DATA
This application is a divisional of U.S. Ser. No. 09/897,664 Jul. 2, 2001 which is a divisional of U.S. Pat. No. 6,103,719.
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5364943 |
Rosen et al. |
Nov 1994 |
A |
5710155 |
Schnorrenberg et al. |
Jan 1998 |
A |
6294556 |
Schnorrenberg |
Sep 2001 |
B1 |