Claims
- 1. A process for preparing an injectable emulsion of fluorocarbon particles adapted to carry oxygen in an aqueous vehicle, said process comprising
- a. emulsifying an aqueous physiologically acceptable electrolyte solution containing from about 10 up to at most about 30 W/V %, based on the emulsion, of a fluorocarbon selected from the group consisting of perfluorodecalin, perfluoromethyldecalin and their mixture and from about 3 W/V % to about 5 W/V %, based on the emulsion, of yolk lecithin, and continuing the emulsification until said fluorocarbon particles are dispersed in the aqueous phase and distributed in a particle range size of from about 0.05 to about 1.0 microns by injecting the emulsion with a Manton-Gaulin type injection emulsifier under a pressure of 140 kg/cm.sup.2 at the first stage, under a pressure of 500 kg/cm.sup.2 at the second and third stages, under a pressure of 560 kg/cm.sup.2 at the fourth stage and under a pressure of 140 kg/cm.sup.2 at the fifth stage at 50.degree. C or less;
- b. continuously centrifuging the aqueous emulsion of step (a) with a De Laval type centrifuge at a flow rate of 30 l/hour while setting the mortar and the rotor at 1500 rpm. and 9000 rpm, respectively, or with a Saval type centrifuge at a flow rate of 6 l hour, while setting the centrifuge at 100 .times. g, thereby reducing the particle size of said fluorocarbon particles into particles of the order of about 0.05 to about 0.25 microns and
- c. subjecting the aqueous emulsion of step (b) to sterilization at 110.degree. to 120.degree. C for 15 minutes while rotating said emulsion at 15 rpm, thereby preventing substantial agglomeration of said fluorocarbon particles in said emulsion while sterilizing said emulsion.
- 2. The process of claim 1, wherein the particle size of said fluorocarbon particles following step (c) is of the order of about 0.05 to about 0.375 microns.
- 3. The process of claim 1, wherein the amount of said fluorocarbon is from about 25 to about 30 W/V %.
Priority Claims (2)
Number |
Date |
Country |
Kind |
45-78023 |
Sep 1970 |
JA |
|
46-57003 |
Jul 1971 |
JA |
|
CROSS REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part application of our earlier copending application Ser. No. 177,434, filed Sept. 2, 1971, now abandoned.
Non-Patent Literature Citations (2)
Entry |
science Vol. 152, 1755-1756 (1966). |
Symposium on Inert Liquids for Biological Oxygen Transport-Atlantic City, N.J., Apr. 13, 1969 - Fed. Pro. 1970, pp. 1695-1697, 1758-1763. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
177434 |
Sep 1971 |
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